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Chikungunya

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61. East/Central/South African Genotype in a Chikungunya Outbreak, Dhaka, Bangladesh, 2017. Full Text available with Trip Pro

East/Central/South African Genotype in a Chikungunya Outbreak, Dhaka, Bangladesh, 2017. In 2017, an unprecedented increase in febrile illness was observed in Dhaka, Bangladesh. Real-time reverse transcription PCR confirmed that 603 (40.2%) of 1,500 cases were chikungunya fever. Phylogenetic analysis revealed circulation of the non-A226V East/Central/South African genotype of chikungunya virus in Bangladesh.

2019 Emerging Infectious Diseases

62. Duplex nucleic acid test for the detection of chikungunya and dengue RNA viruses in blood donations. Full Text available with Trip Pro

Duplex nucleic acid test for the detection of chikungunya and dengue RNA viruses in blood donations. Chikungunya (CHIKV) and dengue (DENV) viruses are primarily mosquito-borne, but transfusion transmission can occur (DENV) or is likely (CHIKV). In the absence of commercially available blood screening assays, a variety of strategies to ensure recipient safety in the face of expanding CHIKV and/or DENV outbreaks have been used.Performance of cobas CHIKV/DENV, a qualitative RNA detection assay

2019 Transfusion

63. Epidemiology of chikungunya based on laboratory surveillance data-India, 2016-2018. (Abstract)

Epidemiology of chikungunya based on laboratory surveillance data-India, 2016-2018. We analysed the laboratory surveillance data generated by the network of virology laboratories from January 2016 to July 2018 to describe the epidemiology of chikungunya in India.Suspected patients reporting to virology laboratories are investigated for the presence of immunoglobulin M (IgM) antibodies against chikungunya virus (CHIKV) as evidence of recent infection. We analysed the data to describe (...) the distribution of seropositive individuals by time, place and demographic characteristics.Of the 49 380 sera tested from suspected patients, 20.5% were seropositive. CHIKV IgM positivity was seen throughout the year, with a peak between September and December. The laboratories diagnosed 28 outbreaks of chikungunya during the study period.Laboratory surveillance data indicate continued transmission of CHIKV in many regions of India.

2019 Transactions of the Royal Society of Tropical Medicine & Hygiene

64. Spectrum of neurological complications in chikungunya fever: experience at a tertiary care centre and review of literature. (Abstract)

Spectrum of neurological complications in chikungunya fever: experience at a tertiary care centre and review of literature. Chikungunya (CHIK) has re-emerged as a potential neurotropic virus, with outbreaks recently being reported from many parts of India. The present study was conducted to study the spectrum and outcome of neurological complications in patients of CHIK during the 2016 outbreak in Delhi. A total of 42 cases seropositive for IgM CHIK antibodies by MAC-ELISA and developing

2019 Tropical Doctor

65. Spatial Dynamics of Chikungunya Virus, Venezuela, 2014. Full Text available with Trip Pro

Spatial Dynamics of Chikungunya Virus, Venezuela, 2014. Since chikungunya virus emerged in the Caribbean region in late 2013, ≈45 countries have experienced chikungunya outbreaks. We described and quantified the spatial and temporal events after the introduction and propagation of chikungunya into an immunologically naive population from the urban north-central region of Venezuela during 2014. The epidemic curve (n = 810 cases) unraveled within 5 months with a basic reproductive number of 3.7 (...) and a radial spread traveled distance of 9.4 km at a mean velocity of 82.9 m/day. The highest disease diffusion speed occurred during the first 90 days, and space and space-time modeling suggest the epidemic followed a particular geographic pathway with spatiotemporal aggregation. The directionality and heterogeneity of transmission during the first introduction of chikungunya indicated existence of areas of diffusion and elevated risk for disease and highlight the importance of epidemic preparedness

2019 Emerging Infectious Diseases

66. Immunogenicity and Efficacy of a Measles Virus-vectored Chikungunya Vaccine in Nonhuman Primates. Full Text available with Trip Pro

Immunogenicity and Efficacy of a Measles Virus-vectored Chikungunya Vaccine in Nonhuman Primates. Chikungunya virus (CHIKV) infection can result in chikungunya fever (CHIKF), a self-limited acute febrile illness that can progress to chronic arthralgic sequalae in a large percentage of patients. A new Measles virus-vectored vaccine was developed to prevent CHIKF and we tested it for immunogenicity and efficacy in a nonhuman primate (NHP) model.Nine cynomolgus macaques were immunized and boosted (...) with the Measles virus-vectored chikungunya vaccine or sham-vaccinated. Sera were taken at multiple times during the vaccination phase to assess antibody responses against CHIKV. Macaques were challenged with a dose of CHIKV previously shown to cause fever and viremia, and core body temperature, viremia and blood cell and chemistry panels were monitored.The vaccine was well tolerated in all macaques, and all seroconverted (high neutralizing antibody [PRNT80 titers 40-640] and ELISA titers) after the boost

2019 Journal of Infectious Diseases

67. Secondary lower limbs lymphedema in patients with Chikungunya fever. Full Text available with Trip Pro

Secondary lower limbs lymphedema in patients with Chikungunya fever. Chikungunya fever (CHIKF) is an arbovirus characterized by acute fever, myalgia and polyarthralgia. Lymphedema in the lower limbs (LL) was observed in several patients during an outbreak of CHIKF in the state of Pernambuco (Brazil) in 2016. No reports on lymphatic vessels disease due to CHIKF have been described. The aim of the study was to follow lymphatic abnormalities in the LL of 16 patients with CHIKF, using

2019 Medicine

68. A Large Scale Biorational Approach Using Bacillus thuringiensis israeliensis (Strain AM65-52) for Managing Aedes aegypti Populations to Prevent Dengue, Chikungunya and Zika Transmission. Full Text available with Trip Pro

A Large Scale Biorational Approach Using Bacillus thuringiensis israeliensis (Strain AM65-52) for Managing Aedes aegypti Populations to Prevent Dengue, Chikungunya and Zika Transmission. Aedes aegypti is a container-inhabiting mosquito and a vector of dengue, chikungunya, and Zika viruses. In 2009 several cases of autochthonous dengue transmission were reported in Key West, Florida, USA prompting a comprehensive response to control A. aegypti. In Key West, larvae of this mosquito develop

2017 PLoS ONE

69. Concomitant transmission of dengue, chikungunya and Zika viruses in Brazil: Clinical and epidemiological findings from surveillance for acute febrile illness. Full Text available with Trip Pro

Concomitant transmission of dengue, chikungunya and Zika viruses in Brazil: Clinical and epidemiological findings from surveillance for acute febrile illness. Since their emergence in the Americas, chikungunya (CHIKV) and Zika (ZIKV) viruses co-circulate with dengue virus (DENV), hampering clinical diagnosis. We investigated clinical and epidemiological characteristics of arboviral infections during the introduction and spread of CHIKV and ZIKV through northeastern Brazil.Surveillance (...) %; ZIKV: 13, 1.4%; and FLAV: 20, 2.1%), and 23 (2.4%) co-infections (DENV/CHIKV: 13, 1.4%; CHIKV/FLAV: 9, 0.9%; and DEN/ZIKV: 1, 0.1%). An additional 133 (14.0%) patients had serological evidence for a recent arboviral infection. Patients with Zika presented rash (69.2%) and pruritus (69.2%) more frequently than those with dengue (37.5% and 31.2%, respectively) and chikungunya (22.9% and 14.7%, respectively) (P<0.001 for both comparisons). Conversely, arthralgia was more common in chikungunya (94.9

2018 Clinical Infectious Diseases

70. ARBOVIRUS INVESTIGATION IN PATIENTS FROM MATO GROSSO DURING ZIKA AND CHIKUNGUNYA VIRUS INTRODUTION IN BRAZIL, 2015-2016. (Abstract)

ARBOVIRUS INVESTIGATION IN PATIENTS FROM MATO GROSSO DURING ZIKA AND CHIKUNGUNYA VIRUS INTRODUTION IN BRAZIL, 2015-2016. Arboviruses have become a major public health concern in Brazil, especially after Zika virus (ZIKV) and Chikungunya virus (CHIKV) introduction, leading to massive epidemics. We conducted an investigation of arboviruses in patients with acute febrile illness for less than five days in Mato Grosso state (MT) during the period of ZIKV and CHIKV dissemination in Brazil

2018 Acta Tropica

71. Evaluation of pain, functional capacity and kinesiophobia in women in the chronic stage of chikungunya virus infection: a cross-sectional study in northeastern Brazil. (Abstract)

Evaluation of pain, functional capacity and kinesiophobia in women in the chronic stage of chikungunya virus infection: a cross-sectional study in northeastern Brazil. Arboviral diseases have been considered a global public health problem due to their growing territorial dispersion and impact on the population around the world. Individuals affected by the chikungunya virus go through an acute febrile illness associated with severe pain and long-lasting polyarthralgia. After the initial stage (...) , infected individuals may progress to the chronic stage, which has an epidemic character and a high rate of disability and reduced mobility, impacting negatively on their quality of life. The aim of this study was to evaluate the relationship between pain, functional capacity, and kinesiophobia in individuals in the chronic stage of chikungunya virus infection. A cross-sectional study was conducted in the city of Natal, in Rio Grande do Norte, Brazil, between July and September 2018. The participants

2018 Acta Tropica

72. A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control. (Abstract)

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control. Chikungunya fever is a mosquito-borne viral illness characterized by a sudden onset of fever associated with joint pains. It was first described in the 1950s during a Chikungunya virus (CHIKV) outbreak in southern Tanzania and has since (re-) emerged and spread to several other geographical areas, reaching large populations and causing massive epidemics (...) and a particular focus is placed upon the diagnostic handling in the case of ZIKV and DENV co-circulating. Natural and synthetic compounds under evaluation for treatment of chikungunya disease, including drugs already licensed for other purposes, are also discussed. Finally, previous and current vaccine strategies, as well as the control of the CHIKV transmission through an integrated vector management, are reviewed in some detail.Copyright © 2018 Elsevier B.V. All rights reserved.

2018 Acta Tropica

73. Clinical and Epidemiologic Patterns of Chikungunya Virus Infection and Coincident Arboviral Disease in a School Cohort in Haiti, 2014-2015. Full Text available with Trip Pro

Clinical and Epidemiologic Patterns of Chikungunya Virus Infection and Coincident Arboviral Disease in a School Cohort in Haiti, 2014-2015. Beginning in December 2013, an epidemic of chikungunya virus (CHIKV) infection spread across the Caribbean and into virtually all countries in the Western hemisphere, with >2.4 million cases reported through the end of 2017.We monitored a cohort of school children in rural Haiti from May 2014, through February 2015, for occurrence of acute undifferentiated

2018 Clinical Infectious Diseases

74. An infection cocktail: malaria, dengue, chikungunya and Japanese encephalitis. (Abstract)

An infection cocktail: malaria, dengue, chikungunya and Japanese encephalitis. Vector-borne diseases cause a significant burden on healthcare facilities. An increasing number of cases reported with multiple co-infections only add to the ordeal. The presence of co-infection may modify clinical and laboratory parameters significantly making diagnosis and treatment a challenge. Cases of malaria and dengue with other infections such as chikungunya, leptospirosis and hepatitis have been reported (...) previously. We report a case of acute febrile illness with altered sensorium which was eventually diagnosed to have quadruple infection with malaria, dengue, chikungunya and Japanese encephalitis. This may be the first case with four concurrent vector-borne infections, all of which are transmitted by mosquitoes.

2018 Tropical Doctor

75. Local and regional dynamics of chikungunya virus transmission in Colombia: the role of mismatched spatial heterogeneity. Full Text available with Trip Pro

Local and regional dynamics of chikungunya virus transmission in Colombia: the role of mismatched spatial heterogeneity. Mathematical models of transmission dynamics are routinely fitted to epidemiological time series, which must inevitably be aggregated at some spatial scale. Weekly case reports of chikungunya have been made available nationally for numerous countries in the Western Hemisphere since late 2013, and numerous models have made use of this data set for forecasting and inferential (...) purposes. Motivated by an abundance of literature suggesting that the transmission of this mosquito-borne pathogen is localized at scales much finer than nationally, we fitted models at three different spatial scales to weekly case reports from Colombia to explore limitations of analyses of nationally aggregated time series data.We adapted the recently developed Disease Transmission Kernel (DTK)-Dengue model for modeling chikungunya virus (CHIKV) transmission, given the numerous similarities

2018 BMC Medicine

76. Severe Manifestations of Chikungunya Fever in Children, India, 2016. Full Text available with Trip Pro

Severe Manifestations of Chikungunya Fever in Children, India, 2016. Chikungunya is a relatively benign disease, and a paucity of literature on severe manifestations in children exits. We describe a cohort of pediatric chikungunya fever patients in New Delhi, India, who had severe sepsis and septic shock, which can develop during the acute phase of illness.

2018 Emerging Infectious Diseases

77. Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya

Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya (CHIKGENE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03690648 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

78. Emergency response of four transfusion centers during the last Chikungunya outbreak in Italy. (Abstract)

Emergency response of four transfusion centers during the last Chikungunya outbreak in Italy. Between September 15 and November 11, 2017, the area of Rome was subjected to cessation of donation in an area of approximately 1,300,000 inhabitants and with a 5-day quarantine for the rest of metropolitan areas due to Chikungunya virus (CHIKV) outbreak. Quarantine was applied to red blood cell (RBC) and plasma units while platelet concentrates (PCs) were subjected to pathogen inactivation methods

2018 Transfusion

79. Chikungunya virus outbreak in Sint Maarten: Long-term arthralgia after a 15-month period. Full Text available with Trip Pro

Chikungunya virus outbreak in Sint Maarten: Long-term arthralgia after a 15-month period. The first chikungunya (CHIK) epidemic in the Americas was reported in December 2013. Chikungunya virus (CHIKV) causes an acute febrile illness and is transmitted to humans by Aedes mosquitoes. Although earlier studies have described long-term clinical manifestations of CHIK patients infected with the East/Central/South African (ECSA) genotype, little is known about persistent manifestations (...) in the Caribbean region, for which the Asian genotype is responsible. The objective of this study was to describe the presence of persisting clinical manifestations, specifically arthralgia, in CHIKV-infected patients on the Caribbean Island, Sint Maarten, 15 months after onset of the disease.This retrospective cohort study included confirmed CHIK patients that were recorded by the participating general practitioners (GPs) during the chikungunya outbreak in 2014 in Sint Maarten. Between March and July 2015, 15

2018 Journal of Vector Borne Disease

80. Monitoring arbovirus in Thailand: surveillance of dengue, chikungunya and Zika virus, with a focus on coinfections. (Abstract)

Monitoring arbovirus in Thailand: surveillance of dengue, chikungunya and Zika virus, with a focus on coinfections. Infections caused by arboviruses such as dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) frequently occur in tropical and subtropical regions. These three viruses are transmitted by Aedes (Ae.) aegypti and Ae. albopictus. In Thailand, the highest incidence of arbovirus infection and the high circulation of Aedes mosquito mainly occurs in the Southern

2018 Acta Tropica

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