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Chikungunya

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61. Screening for Chikungunya virus infection in aged people: Development and internal validation of a new score. (PubMed)

Screening for Chikungunya virus infection in aged people: Development and internal validation of a new score. This study aimed to derive and validate a score for Chikungunya virus (CHIKV) infection screening in old people admitted to acute care units.This study was performed in the Martinique University Hospitals from retrospective cases. Patients were aged 65+, admitted to acute care units for suspected CHIKV infection in 2014, with biological testing using Reverse Transcription Polymerase

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2017 PLoS ONE

62. Differential inhibitory and activating NK cell receptor levels and NK/NKT-like cell functionality in chronic and recovered stages of chikungunya. (PubMed)

Differential inhibitory and activating NK cell receptor levels and NK/NKT-like cell functionality in chronic and recovered stages of chikungunya. The role of natural killer (NK; CD3-CD56+)/NKT (CD3+CD56+)-like cells in chikungunya virus (CHIKV) disease progression/recovery remains unclear. Here, we investigated the expression profiles and function of NK and NKT-like cells from 35 chronic chikungunya patients, 30 recovered individuals, and 69 controls. Percentage of NKT-like cells was low (...) in chronic chikungunya patients. NKp30+, CD244+, DNAM-1+, and NKG2D+ NK cell percentages were also lower (MFI and/or percentage), while those of CD94+ and NKG2A+ NKT-like cells were higher (MFI and/or percentage) in chronic patients than in recovered subjects. IFN-γ and TNF-α expression on NKT-like cells was high in the chronic patients, while only IFN-γ expression on NK cells was high in the recovered individuals. Furthermore, percentage of perforin+NK cells was low in the chronic patients. Lower

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2017 PLoS ONE

63. Behavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16. (PubMed)

Behavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16. The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control

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2017 PLoS ONE

64. A Large Scale Biorational Approach Using Bacillus thuringiensis israeliensis (Strain AM65-52) for Managing Aedes aegypti Populations to Prevent Dengue, Chikungunya and Zika Transmission. (PubMed)

A Large Scale Biorational Approach Using Bacillus thuringiensis israeliensis (Strain AM65-52) for Managing Aedes aegypti Populations to Prevent Dengue, Chikungunya and Zika Transmission. Aedes aegypti is a container-inhabiting mosquito and a vector of dengue, chikungunya, and Zika viruses. In 2009 several cases of autochthonous dengue transmission were reported in Key West, Florida, USA prompting a comprehensive response to control A. aegypti. In Key West, larvae of this mosquito develop

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2017 PLoS ONE

65. The neutralizing role of IgM during early Chikungunya virus infection. (PubMed)

The neutralizing role of IgM during early Chikungunya virus infection. The antibody isotype IgM appears earlier than IgG, within days of onset of symptoms, and is important during the early stages of the adaptive immune response. Little is known about the functional role of IgM during infection with chikungunya virus (CHIKV), a recently reemerging arbovirus that has caused large global outbreaks. In this study, we studied antibody responses in 102 serum samples collected during CHIKV outbreaks

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2017 PLoS ONE

66. Chikungunya and bilateral sacroiliitis–is there a link? (PubMed)

Chikungunya and bilateral sacroiliitis–is there a link? 28293463 2018 11 13 2147-9720 4 1 2017 Mar European journal of rheumatology Eur J Rheumatol Chikungunya and bilateral sacroiliitis-is there a link? 81-82 10.5152/eurjrheum.2015.0071 Nisar Muhammad K MK Department of Rheumatology, Luton and Dunstable University Hospital National Health Service Foundation Trust (NHSFT), Luton, United Kingdom. Packianathan Christabel C Department of Rheumatology, Luton and Dunstable University Hospital

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2016 European journal of rheumatology

67. Erratum to: Chikungunya: a reemerging infection spreading during 2010 dengue fever outbreak in National Capital Region of India (PubMed)

Erratum to: Chikungunya: a reemerging infection spreading during 2010 dengue fever outbreak in National Capital Region of India [This corrects the article DOI: 10.1007/s13337-016-0314-z.].

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2016 Virusdisease

68. Complete Genome Sequences of Two Chikungunya Viruses Imported into China (PubMed)

Complete Genome Sequences of Two Chikungunya Viruses Imported into China Here, we isolated two chikungunya virus strains (SZ1050 and SZ1239) from patients infected with chikungunya virus who were returning to China from India and Indonesia, respectively. Strain SZ1050 was classed in the Indian Ocean lineage, and strain SZ1239 belonged to the Asian lineage. No A226V mutation in the envelope protein E1 was found in either strain.Copyright © 2018 Zhang et al.

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2018 Genome Announcements

69. Chikungunya in U.S. Travelers: A Double Challenge (PubMed)

Chikungunya in U.S. Travelers: A Double Challenge 29978782 2018 11 14 1476-1645 99 1 2018 Jul The American journal of tropical medicine and hygiene Am. J. Trop. Med. Hyg. Chikungunya in U.S. Travelers: A Double Challenge. 239 10.4269/ajtmh.18-0170 Simon Fabrice F Laveran Military Teaching Hospital. Demoux Anne-Laurence AL Nord University Teaching Hospital. eng Journal Article United States Am J Trop Med Hyg 0370507 0002-9637 2018 7 7 6 0 2018 7 7 6 0 2018 7 7 6 0 ppublish 29978782 10.4269/ajtmh

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2018 The American journal of tropical medicine and hygiene

70. Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses (PubMed)

Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses Chikungunya virus (CHIKV) is a mosquito-transmitted RNA alphavirus causing major outbreaks of infectious chronic inflammatory rheumatisms (CIR). Recently, methotrexate (MTX), a disease modifying anti-rheumatic drug has been used successfully to treat patients suffering from rheumatoid-like arthritis post-CHIK but its

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2018 PLoS neglected tropical diseases

71. Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika (PubMed)

Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and zika Once Aedes aegypti and Aedes albopictus mosquitoes that spread Chikungunya virus, dengue virus, and Zika virus are infected with Wolbachia, they have reduced egg laying rates, reduced transmission abilities, and shorter lifespans. Since most infected mosquitoes are only infectious in the last few days of their lives, shortening a mosquito's lifespan by a day or two can greatly (...) reduce their abilities to spread mosquito-borne viral diseases, such as Chikungunya, dengue fever, and Zika. We developed a mathematical model to compare the effectiveness of the wMel and wAlbB strains of Wolbachia for controlling the spread of these viruses. The differences among the diseases, mosquitoes, and Wolbachia strains are captured by the model parameters for the mosquito-human transmission cycle. Moreover, the model accounts for the behavior changes of infectious population created

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2018 PLoS neglected tropical diseases

72. Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic (PubMed)

Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic Chikungunya virus (CHIKV) has been detected sporadically since the 1950s and includes three distinct co-circulating genotypes. In late 2013, the Asian genotype of CHIKV was responsible for the Caribbean outbreak (CO) that rapidly became an epidemic throughout the Americas. There is a limited understanding of the molecular evolution of CHIKV in the Americas during this epidemic. We sequenced 185

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2018 PLoS neglected tropical diseases

73. Clinical Forms of Chikungunya Virus Infection: The Challenge and Utility of a Consensus Definition (PubMed)

Clinical Forms of Chikungunya Virus Infection: The Challenge and Utility of a Consensus Definition 30076697 2018 11 14 1476-1645 99 2 2018 Aug The American journal of tropical medicine and hygiene Am. J. Trop. Med. Hyg. Clinical Forms of Chikungunya Virus Infection: The Challenge and Utility of a Consensus Definition. 552-553 10.4269/ajtmh.18-0468a Dramé Moustapha M Faculty of Medicine, University of Reims Champagne-Ardenne, Reims, France. Kanagaratnam Lukshe L Faculty of Medicine, University

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2018 The American journal of tropical medicine and hygiene

74. Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus (PubMed)

Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus Chikungunya virus has emerged as one of the most important global arboviral threats over the last decade. Inspite of large scale morbidity, with long lasting polyarthralgia, so far no licensed vaccine or antiviral is available. CHIKV nsP2 protease is crucial for processing of viral nonstructural polypeptide precursor to release enzymes required for viral

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2018 Scientific reports

75. Enzyme-linked immunosorbent assay using recombinant envelope protein 2 antigen for diagnosis of Chikungunya virus (PubMed)

Enzyme-linked immunosorbent assay using recombinant envelope protein 2 antigen for diagnosis of Chikungunya virus Chikungunya (CHIKV) virus is an important mosquito-borne virus causing outbreaks of acute febrile illness with arthropathy. The detection of specific antibodies against CHIKV is used for diagnosis after the acute viremic phase of the disease. However, a major challenge for serologic diagnosis of CHIKV and other alphaviruses is the cross-reactivity of antibodies to common antigens

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2018 Virology journal

76. An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope (PubMed)

An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope Chikungunya virus (CHIKV) is the most common alphavirus infecting humans worldwide, causing acute and chronically debilitating arthralgia at a great economic expense.To facilitate our study of CHIKV, we generated a mCherry tagged replication-competent chimeric virus, CHIKV 37997-mCherry. Single particle cryoEM demonstrated icosahedral organization of the chimeric virus and the display of mCherry proteins

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2018 PLoS neglected tropical diseases

77. Lessons learned of emerging Chikungunya virus in two populations of social vulnerability of the Colombian tropics: epidemiological analysis (PubMed)

Lessons learned of emerging Chikungunya virus in two populations of social vulnerability of the Colombian tropics: epidemiological analysis Notwithstanding the strong epidemiological impact of the Chikungunya in the Colombian Caribbean, in 2014, not the entire population were affected in the same way. This study describe the demographic, socio-economic, clinical and epidemiological aspects of the de Chikungunya in Ovejas and Corozal, two neighboring municipalities with high vulnerability (...) in health in the Colombian Caribbean.A cross-sectional study was performed in February 2015. A convenience sampling was carried out in 971 families affected with chikungunya. Also, a socio-demographics, clinical and epidemiological questionnaire was carried out for people who met the definition of suspected Chikungunya clinical case. For the statistical analysis, data and variables, frequencies, proportions and means were compared in the two municipalities studied. A logistic regression model

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2018 Archives of Public Health

78. Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 (PubMed)

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 Chikungunya virus (CHIKV), a mosquito-borne human pathogen, causes a disabling disease characterized by severe joint pain that can persist for weeks, months, or even years in patients. The nonstructural protein 3 (nsP3) plays essential roles during acute infection, but little is known about the function of nsP3 during chronic disease (...) and cellular protein complexes has implications for the study of the pathogenic consequences of lingering CHIKV infection and the development of strategies to mitigate the burden of chronic musculoskeletal disease brought about by a medically important arthropod-borne virus (arbovirus).IMPORTANCE Chikungunya virus (CHIKV) is a reemerging alphavirus transmitted by mosquitos and causes transient sickness but also chronic disease affecting muscles and joints. No approved vaccines or antivirals are available

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2018 Journal of virology

79. Seroprevalence of Dengue and Chikungunya Virus Antibodies, French Polynesia, 2014-2015. (PubMed)

Seroprevalence of Dengue and Chikungunya Virus Antibodies, French Polynesia, 2014-2015. We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014-2015. Dengue virus seroprevalence was ≈60% among schoolchildren and >83% among the general population; chikungunya virus seroprevalence was <3% before and 76% after Zika virus emergence (2013). Dengue virus herd immunity may affect Zika virus infection and pathogenesis.

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2018 Emerging Infectious Diseases

80. The Burden of Dengue Fever and Chikungunya in Southern Coastal Ecuador: Epidemiology, Clinical Presentation, and Phylogenetics from the First Two Years of a Prospective Study. (PubMed)

The Burden of Dengue Fever and Chikungunya in Southern Coastal Ecuador: Epidemiology, Clinical Presentation, and Phylogenetics from the First Two Years of a Prospective Study. Here, we report the findings from the first 2 years (2014-2015) of an arbovirus surveillance study conducted in Machala, Ecuador, a dengue-endemic region. Patients with suspected dengue virus (DENV) infections (index cases, N = 324) were referred from five Ministry of Health clinical sites. A subset of DENV-positive index (...) acute or recent DENV infections in associates. Of associates with acute DENV infections, 68% reported dengue-like symptoms, with the highest prevalence of symptomatic acute infections in children aged less than 10 years. The first chikungunya virus (CHIKV) infections were detected on epidemiological week 12 in 2015; 43.1% of index cases and 3.5% of associates had acute CHIKV infections. No Zika virus infections were detected. Phylogenetic analyses of isolates of DENV from 2014 revealed genetic

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2018 American Journal of Tropical Medicine & Hygiene

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