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Chikungunya

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41. IL-27 in patients with Chikungunya fever: A possible chronicity biomarker? (Abstract)

IL-27 in patients with Chikungunya fever: A possible chronicity biomarker? Although many patients with chikungunya virus disease (CHIKVD), an arboviral disease characterized by sudden fever and incapacitating poliartralgia, develop chronic articular symptoms, the mechanisms involved in CHIKVD's chronification and its possible biomarkers remain poorly understood. Interleukin (IL)-17A, IL-21, IL-22, IL-29, and transforming growth factor (TGF)-β have been implicated in the pathogenesis of other (...) ), articular manifestations upon evaluation, and no previous history of inflammatory rheumatologic diseases, along with 49 healthy age- and sex-matched controls. We tested anti-Chikungunya IgM and IgG antibodies and measured IL-17A, IL-21, IL-22, IL-27, IL-29, and TGF-β serum levels with specific ELISA kits.IL-27, IL-17A, and IL-29 appeared in most patients but not in controls. IL-27 serum levels were higher in patients with chronic symptoms (median: 523.0 pg/mL [62.5-1,048]) than in ones in the acute

2019 Acta Tropica

42. Using Big Data to Monitor the Introduction and Spread of Chikungunya, Europe, 2017. Full Text available with Trip Pro

Using Big Data to Monitor the Introduction and Spread of Chikungunya, Europe, 2017. With regard to fully harvesting the potential of big data, public health lags behind other fields. To determine this potential, we applied big data (air passenger volume from international areas with active chikungunya transmission, Twitter data, and vectorial capacity estimates of Aedes albopictus mosquitoes) to the 2017 chikungunya outbreaks in Europe to assess the risks for virus transmission, virus

2019 Emerging Infectious Diseases

43. Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms. (Abstract)

Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms. To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus in a Latin American cohort.A cross-sectional follow-up of 120 patients from an initial cohort of 500 patients who reported joint pain 2 years after infection from the Atlántico Department, Colombia. Patients were clinically diagnosed as having chikungunya virus during (...) the 2014-2015 epidemic, and baseline and follow-up symptoms at 40 months were evaluated in serologically confirmed cases.Of the initial 500 patients enrolled in the study, 482 had serologically confirmed chikungunya infection. From this group, 123 patients reported joint pain 20 months after infection, and 54% of those patients reported continued joint pain 40 months after infection. Therefore, 1 out of every 8 people who tested serologically positive for chikungunya infection had persistent joint pain

2019 Journal of Rheumatology

44. Travellers as sentinels of chikungunya epidemics: a family cluster among Finnish travellers to Koh Lanta, Thailand, January 2019. Full Text available with Trip Pro

Travellers as sentinels of chikungunya epidemics: a family cluster among Finnish travellers to Koh Lanta, Thailand, January 2019. In January 2019, five of 11 travellers to Koh Lanta, Thailand, contracted chikungunya, symptoms starting 4 days after presumed transmission. Four cases were hospitalised, one child treated in intensive care; 6 weeks after disease onset, all three adults have persistent arthralgias/arthritis, incapacitating for two. Together with a recent report of eight chikungunya

2019 Euro Surveillance

45. Increased risk of chikungunya infection in travellers to Thailand during ongoing outbreak in tourist areas: cases imported to Europe and the Middle East, early 2019. Full Text available with Trip Pro

Increased risk of chikungunya infection in travellers to Thailand during ongoing outbreak in tourist areas: cases imported to Europe and the Middle East, early 2019. We report nine travellers with confirmed chikungunya virus infection, returning from tourist areas of Thailand to Sweden, Switzerland, the United Kingdom, Romania, Israel and France, diagnosed in January and February 2019. These sentinel tourists support the intensification of chikungunya virus circulation in Thailand and highlight

2019 Euro Surveillance

46. Global Outbreaks and Origins of a Chikungunya Virus Variant Carrying Mutations Which May Increase Fitness for <i>Aedes aegypti</i>: Revelations from the 2016 Mandera, Kenya Outbreak. Full Text available with Trip Pro

Global Outbreaks and Origins of a Chikungunya Virus Variant Carrying Mutations Which May Increase Fitness for Aedes aegypti: Revelations from the 2016 Mandera, Kenya Outbreak. In 2016, a chikungunya virus (CHIKV) outbreak was reported in Mandera, Kenya. This was the first major CHIKV outbreak in the country since the global reemergence of this virus in Kenya in 2004. We collected samples and sequenced viral genomes from this outbreak. All Kenyan genomes contained two mutations, E1:K211E

2019 American Journal of Tropical Medicine & Hygiene

47. Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India. Full Text available with Trip Pro

Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India. We conducted a diagnostic surveillance study to identify Plasmodium, dengue virus, chikungunya virus, and Orientia tsutsugamushi infections among febrile patients who underwent triage for malaria in the outpatient department at Ispat General Hospital, Rourkela, Odisha, India.Febrile patients were enrolled from January 2016-January 2017. Blood smears and small volumes (...) or vacutainers of blood were collected from study participants to carry out diagnostic assays. Malaria was diagnosed using rapid diagnostic tests (RDT), microscopy, and PCR. Dengue, chikungunya, and scrub typhus infections were identified using rapid diagnostic test kits and ELISA.Nine hundred and fifty-four patients were prospectively enrolled in our study. The majority of patients were male (58.4%) and more than 15 years of age (66.4%). All 954 enrollees underwent additional testing for malaria; a subset

2019 BMC Infectious Diseases

48. Low to medium-low risk perception for dengue, chikungunya and Zika outbreaks by infectious diseases physicians in France, Western Europe. Full Text available with Trip Pro

Low to medium-low risk perception for dengue, chikungunya and Zika outbreaks by infectious diseases physicians in France, Western Europe. Many tropical countries are currently experiencing dengue (DEN), chikungunya (CHIK) and also more recently Zika (ZIKA) epidemics (particularly in Latin America). Although the risk of transmission and spread of these infections in temperate regions remains a controversial issue, vector-borne diseases have been widely reported in the media and have been

2019 BMC Public Health

49. The Potential Impact of Chikungunya Virus Outbreaks on Blood Transfusion. Full Text available with Trip Pro

The Potential Impact of Chikungunya Virus Outbreaks on Blood Transfusion. Chikungunya virus (CHIKV) is responsible for large periodic epidemics in both endemic and nonendemic areas where competent mosquitoes are present. Transmission of CHIKV by transfusion during explosive outbreaks has never been documented, and the true impact of CHIKV infection on blood transfusion during an outbreak is unknown. Considerations include not only transfusions in the active outbreak areas but also returning (...) travelers to nonendemic areas. Because there are no documented cases of transfusion-transmitted CHIKV, there are no standard guidelines regarding transfusion policies during a chikungunya fever outbreak. We review current information from studies during outbreaks with the goal of estimating the potential effect of different blood safety interventions (eg, querying donors for possible CHIKV exposure, chikungunya fever-related symptoms, screening for CHIKV RNA).Copyright © 2019. Published by Elsevier Inc.

2019 Transfusion medicine reviews

50. Cytokines and chemokines triggered by Chikungunya virus infection in human patients during the very early acute phase. (Abstract)

Cytokines and chemokines triggered by Chikungunya virus infection in human patients during the very early acute phase. The immune response against the Chikungunya virus (CHIKV) during the very early acute phase is not fully elucidated. Therefore we explored the cytokine and chemokine profile triggered by CHIKV in infected patients.Cytokines, chemokines and C5a anaphylatoxin were analysed in serum from CHIKV-infected patients during the viraemic phase (mean 2.97±1.27 d after illness onset

2019 Transactions of the Royal Society of Tropical Medicine & Hygiene

51. Isovaleric acid and avicequinone-C are Chikungunya virus resistance principles in <i>Glycosmis pentaphylla</i> (Retz.) Correa. Full Text available with Trip Pro

Isovaleric acid and avicequinone-C are Chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa. Oral administration of tender leaf extract of Glycosmis pentaphylla is traditionally known to prevent the chikungunya virus infection. Even with wide usage, the antiviral components in this plant are neither identified nor characterized. This study was carried out with the objectives of profiling the phytocompounds in this plant through LC-MS/MS and to identify (...) the active antiviral constituents and their drug-likeliness through molecular docking.Phytocompounds were extracted hydro-alcoholically from powdered plant parts and analyzed using LC-MS/MS. Based on mass-to-charge ratio from LC-MS/MS, compounds were identified and used as ligands for molecular docking against chikungunya target proteins. The active principles were subjected to ADME/T analysis to verify their drug-likeliness.The docking results and ADME/T evaluation showed that the compounds, isovaleric

2019 Journal of Vector Borne Disease

52. A patent perspective on chikungunya. (Abstract)

A patent perspective on chikungunya. Chikungunya is a viral disease caused by chikungunya virus (CHIKV) belonging to the Alphavirus genus and transmitted to humans by mosquitoes of Aedes spp. Nearly 40 countries in Asia, Africa, Europe, and the Americas have documented chikungunya cases. Most recent severe outbreaks have occurred in Indian Ocean islands of Réunion and Mauritius and India. There is no specific drug treatment for the disease, neither is there a standardized vaccine available (...) for prevention of the disease. The present review gives a global perspective on patents filed pertaining to chikungunya. The United States has been the top patent filing jurisdiction followed by China, Europe, and India. The patents have been classified into categories of therapeutics, diagnostics, and vaccines. Maximum patent documents fall under the therapeutics category, in which patent applications are predominantly related to chemically derived drugs. They include nucleic acid analogues, various other

2019 Acta Tropica

53. Epidemiology of Dengue, Chikungunya, and Zika Virus Disease in U.S. States and Territories, 2017. (Abstract)

Epidemiology of Dengue, Chikungunya, and Zika Virus Disease in U.S. States and Territories, 2017. Dengue, chikungunya, and Zika viruses, primarily transmitted by Aedes species mosquitoes, have caused large outbreaks in the Americas, leading to travel-associated cases and local mosquito-borne transmission in the United States. We describe the epidemiology of dengue, chikungunya, and noncongenital Zika virus disease cases reported from U.S. states and territories in 2017, including 971 dengue (...) cases, 195 chikungunya cases, and 1,118 Zika virus disease cases. Cases of all three diseases reported from the territories were reported as resulting from local mosquito-borne transmission. Cases reported from the states were primarily among travelers, with only seven locally acquired mosquito-transmitted Zika virus disease cases reported from Texas (n = 5) and Florida (n = 2). In the territories, most dengue cases (n = 508, 98%) were reported from American Samoa, whereas the majority

2019 American Journal of Tropical Medicine & Hygiene

54. Pilates method in the treatment of patients with Chikungunya fever: a randomized controlled trial. (Abstract)

Pilates method in the treatment of patients with Chikungunya fever: a randomized controlled trial. The aim of this study was to evaluate the effects of the Pilates method on the reduction of pain, improvement of joint function, and quality of life of patients with chronic Chikungunya fever.This is a randomized, controlled, blind trial for the evaluators.The study was conducted at the Advanced Laboratory in Physical Education and Health at Federal University of Pernambuco, Brazil.A total of 51

2019 Clinical rehabilitation Controlled trial quality: uncertain

55. Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist. Full Text available with Trip Pro

Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist. The mosquito-borne chikungunya virus (CHIKV) causes acute pain and joint inflammation, and in recent years the virus has caused large epidemics in previously CHIKV-free geographic areas. To advance the understanding of host factors that antagonize CHIKV, we show that synthetic agonist of liver X receptor (LXR-623) inhibits CHIKV replication by upregulating the cholesterol exporter ABCA1

2019 Antimicrobial Agents and Chemotherapy

56. Chikungunya Fever Outbreak, Zhejiang Province, China, 2017. Full Text available with Trip Pro

Chikungunya Fever Outbreak, Zhejiang Province, China, 2017. We report a disease outbreak caused by chikungunya virus in Zhejiang Province, China, in August 2017. Phylogenic analysis indicated that this virus belonged to the Indian Ocean clade of the East/Central/South African genotype and was imported by a traveler returning from Bangladesh.

2019 Emerging Infectious Diseases

57. Chikungunya, a risk factor for Guillain-Barré syndrome. (Abstract)

Chikungunya, a risk factor for Guillain-Barré syndrome. In a matched case-control study where 24 cases developed Guillain-Barré syndrome (GBS) during the 2014 chikungunya outbreak in the French West Indies and 72 controls were blood donors who donated their blood at the same period, Chikungunya infection was a risk factor for GBS (OR 8.3, 95% CI 2.3-29.7, p=0.001).© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved

2019 Clinical Infectious Diseases

58. Sustained Low-Level Transmission of Zika and Chikungunya Viruses after Emergence in the Fiji Islands. Full Text available with Trip Pro

Sustained Low-Level Transmission of Zika and Chikungunya Viruses after Emergence in the Fiji Islands. Zika and chikungunya viruses were first detected in Fiji in 2015. Examining surveillance and phylogenetic and serologic data, we found evidence of low-level transmission of Zika and chikungunya viruses during 2013-2017, in contrast to the major outbreaks caused by closely related virus strains in other Pacific Island countries.

2019 Emerging Infectious Diseases

59. No chikungunya virus infections among Dutch long-term travellers to (sub)tropical countries: a prospective study 2008-2011. Full Text available with Trip Pro

No chikungunya virus infections among Dutch long-term travellers to (sub)tropical countries: a prospective study 2008-2011. Chikungunya is an arthropod-borne viral disease now identified in over 60 countries in Asia, Africa, Europe, and the Americas. Chikungunya virus (CHIKV) has spread in the last 15 years to many countries, causing large local outbreaks. CHIKV infection can be clinically misdiagnosed in areas where dengue and/or Zika infections occur. Prospective studies are necessary (...) of anti-CHIKV IgG in the pre-travel sample, suggestive of previous CHIKV infection, was found for 3/603 participants (0.5%); all three had been previously travelling in either Africa or Asia. In one traveler who visited Latin America, a seroconversion was found (0.2%) but the CHIKV neutralisation test was negative, making the incidence rate 0.No chikungunya virus infections were found in this 2008-2011 prospective cohort of long-term travellers. We recommend the research be repeated, particularly

2019 BMC Infectious Diseases

60. Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil. Full Text available with Trip Pro

Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil. In seroconversion panels obtained from patients from Brazil, diagnostic testing for Zika virus infection was improved by combining multiple antibody isotypes, techniques, and antigens, but sensitivity remained suboptimal. In contrast, chikungunya virus diagnostic testing was unambiguous. Recurrent recent arbovirus infections suggested by serologic data and unspecific symptoms highlight the need for exhaustive

2019 Emerging Infectious Diseases

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