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Chikungunya

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181. Plasmodium co-infection protects against chikungunya virus-induced pathologies (PubMed)

Plasmodium co-infection protects against chikungunya virus-induced pathologies Co-infection with Plasmodium and chikungunya virus (CHIKV) has been reported in humans, but the impact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure to Plasmodium suppresses CHIKV-associated pathologies in mice. Mechanistically, Plasmodium infection induces IFNγ, which reduces viraemia of a subsequent CHIKV infection and suppresses tissue viral load and joint inflammation

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2018 Nature communications

182. Vector competence of Aedes bromeliae and Aedes vitattus mosquito populations from Kenya for chikungunya virus (PubMed)

Vector competence of Aedes bromeliae and Aedes vitattus mosquito populations from Kenya for chikungunya virus Kenya has experienced outbreaks of chikungunya in the past years with the most recent outbreak occurring in Mandera in the northern region in May 2016 and in Mombasa in the coastal region from November 2017 to February 2018. Despite the outbreaks in Kenya, studies on vector competence have only been conducted on Aedes aegypti. However, the role played by other mosquito species (...) in transmission and maintenance of the virus in endemic areas remains unclear. This study sought to determine the possible role of rural Aedes bromeliae and Aedes vittatus in the transmission of chikungunya virus, focusing on Kilifi and West Pokot regions of Kenya.Four day old female mosquitoes were orally fed on chikungunya virus-infected blood at a dilution of 1:1 of the viral isolate and blood (10(6.4) plaque-forming units [PFU]/ml) using artificial membrane feeder (Hemotek system) for 45 minutes

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2018 PLoS neglected tropical diseases

183. Severe Manifestations of Chikungunya Fever in Children, India, 2016. (PubMed)

Severe Manifestations of Chikungunya Fever in Children, India, 2016. Chikungunya is a relatively benign disease, and a paucity of literature on severe manifestations in children exits. We describe a cohort of pediatric chikungunya fever patients in New Delhi, India, who had severe sepsis and septic shock, which can develop during the acute phase of illness.

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2018 Emerging Infectious Diseases

184. Local and regional dynamics of chikungunya virus transmission in Colombia: the role of mismatched spatial heterogeneity. (PubMed)

Local and regional dynamics of chikungunya virus transmission in Colombia: the role of mismatched spatial heterogeneity. Mathematical models of transmission dynamics are routinely fitted to epidemiological time series, which must inevitably be aggregated at some spatial scale. Weekly case reports of chikungunya have been made available nationally for numerous countries in the Western Hemisphere since late 2013, and numerous models have made use of this data set for forecasting and inferential (...) purposes. Motivated by an abundance of literature suggesting that the transmission of this mosquito-borne pathogen is localized at scales much finer than nationally, we fitted models at three different spatial scales to weekly case reports from Colombia to explore limitations of analyses of nationally aggregated time series data.We adapted the recently developed Disease Transmission Kernel (DTK)-Dengue model for modeling chikungunya virus (CHIKV) transmission, given the numerous similarities

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2018 BMC Medicine

185. Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014. (PubMed)

Excess mortality profile during the Asian genotype chikungunya epidemic in the Dominican Republic, 2014. In 2014 there was a large chikungunya epidemic in the Dominican Republic, with 539 099 reported cases and 6 deaths. Although chikungunya is considered a low-mortality disease, studies have suggested this is an underestimation. This study assessed deaths associated with the epidemic.Mortality data were obtained from the National Statistics Office, the surveillance system for acute febrile (...) illnesses, and the National Epidemiological Surveillance System. Expected all-cause mortality by age group was estimated using the years 2010-2012 as the baseline. The excess deaths were calculated as the difference between observed and expected deaths during the epidemic.The mortality rate increased during the chikungunya epidemic in 2014. There was a strong correlation between monthly excess of deaths and chikungunya cases (Pearson's r=0.89). There was an excess of deaths (>99% confidence interval

2018 Transactions of the Royal Society of Tropical Medicine & Hygiene

186. Misdiagnosis of Chikungunya Virus Infection: Comparison of Old and Younger Adults. (PubMed)

Misdiagnosis of Chikungunya Virus Infection: Comparison of Old and Younger Adults. To assess the frequency of diagnostic errors in older adults presenting to the emergency department (ED) with symptoms suggestive of Chikungunya virus infection (CVI) and to compare the rates of misdiagnosis of older and younger adults.Cross-sectional study performed in the University Hospitals of Martinique from retrospective cases.Emergency department.Individuals aged 65 and older who attended the ED

2018 Journal of the American Geriatrics Society

187. Experimental risk assessment for chikungunya virus transmission based on vector competence, distribution and temperature suitability in Europe, 2018. (PubMed)

Experimental risk assessment for chikungunya virus transmission based on vector competence, distribution and temperature suitability in Europe, 2018. BackgroundOver the last decade, the abundant distribution of the Asian tiger mosquito Aedes albopictus in southern Europe and the import of chikungunya virus (CHIKV) by infected travellers has resulted in at least five local outbreaks of chikungunya fever in France and Italy. Considering the ongoing spread of Ae. albopictus to central Europe, we

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2018 Euro Surveillance

188. Chikungunya chronic disease: a systematic review and meta-analysis. (PubMed)

Chikungunya chronic disease: a systematic review and meta-analysis. Chikungunya is a mosquito-borne disease caused by an arthritogenic alphavirus, with four genotypes: East Central South African (ECSA), West African, ECSA-diverged or Indian Ocean Lineage (IOL) and Asian lineage. Overall, the disease is self-limited; however, in some patients, joint pain and other non-specific symptoms can last for months or years. This systematic review and meta-analysis aims to estimate the proportion (...) of people that self-report chikungunya-related chronic non-specific symptoms.Medline, EMBASE, Global Health Library and Scopus were searched for articles published before March 2017. Case-control, cohort, cross-sectional, clinical trials studies and outcome-independent case series were eligible. It was estimated that the proportion of patients who did not recover, by virus genotype, and by the time between disease onset and assessment of chronic symptoms.A total of 38 studies were included in the review

2018 Transactions of the Royal Society of Tropical Medicine & Hygiene

189. Maternal and infant death after probable vertical transmission of chikungunya virus in Brazil - case report. (PubMed)

Maternal and infant death after probable vertical transmission of chikungunya virus in Brazil - case report. Chikungunya virus infection in neonates is relatively rare and can lead to death.We report the occurrence of the first death of a mother and child after probable vertical transmission of chikungunya virus in Brazil. A 28-year-old pregnant woman with hypertension presented with symptoms compatible with an arboviral disease at 34 weeks' gestation. She developed preeclampsia with severe (...) respiratory failure which resulted in the emergency cesarean section, and the patient died 12 days after the onset of symptoms. The pre-term newborn weighed 2535 g, with an Apgar score of 4/8. He was referred to the neonatal ICU with neutrophilia and thrombocytopenia, several seizure episodes, and hemorrhagic disorders, which resulted in death. Chikungunya IgM antibody was detected in the cerebrospinal fluid.We present the first documented maternal and neonatal death in Brazil after probable chikungunya

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2018 BMC Infectious Diseases

190. Chikungunya on kidney transplant recipients: Is it the same? (PubMed)

Chikungunya on kidney transplant recipients: Is it the same? Chikungunya virus (CHIKV) infection is an acute febrile illness with polyarthralgia and arthritis. There are few data about CHIKV infection in kidney transplant recipients (KTR). We report the largest case series of CHIKV infection in this population.We retrospectively analyzed 32 cases of CHIKV infection in KTR between January 2016 and December 2017 at Hospital Universitário Walter Cantídio of Federal University of Ceará.All patients

2018 Transplantation

191. Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil (PubMed)

Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil The current triple epidemic caused by dengue, zika and chikungunya constitutes a serious health problem in Brazil. The aim of this study was to investigate acute samples (up to the 7 days of symptoms) from patients presenting acute fever syndrome suspected as arboviral infection and characterize the clinical and laboratorial profile during (...) the co-circulation of dengue, zika and chikungunya in Campo Grande, Mato Grosso do Sul (MS), midwest region of Brazil.All suspected cases (n=134) were tested by using serological and molecular diagnostic tests including DENV, ZIKV and CHIKV RT-PCR, Dengue nonstructural protein 1 (NS1) antigen capture ELISA, anti- DENV IgM ELISA and anti-CHIKV IgM ELISA. In addition, clinical, hematological and biochemical parameters of infected patients were analyzed. It was observed that 79.1% of the blood samples

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2018 PLoS currents

192. The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series (PubMed)

The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We (...) investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil.We studied adults who had developed a new neurological condition following suspected Zika virus infection between 1st November 2015 and 1st June 2016. Cerebrospinal fluid (CSF), serum, and urine were tested for evidence of Zika, chikungunya, and dengue viruses.Of 35 patients studied, 22 had evidence of recent arboviral infection. Twelve had positive PCR or IgM for Zika, five

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2018 PLoS neglected tropical diseases

193. In Vivo Evaluation of Withania somnifera–Based Indian Traditional Formulation (Amukkara Choornam), Against Chikungunya Virus–Induced Morbidity and Arthralgia (PubMed)

In Vivo Evaluation of Withania somnifera–Based Indian Traditional Formulation (Amukkara Choornam), Against Chikungunya Virus–Induced Morbidity and Arthralgia Chikungunya viral fever results in extreme morbidity and arthralgia in affected individuals. Currently, modern medicines providing symptomatic relief for the acute febrile phase and the chronic arthritic phase are only options available. Traditional Indian medical system, however, uses specific formulations for treatment (...) of this infection; one such polyherbal formulation used to treat the postpyretic phase of chikungunya is amukkara choornam. The current study was undertaken to study the efficacy of amukkara choornam in the treatment of chikungunya in C57BL/6J mice. The formulation when administered to chikungunya-infected mice relieved morbidity and joint swelling. Analysis of virus clearance in brain and joint tissues on formulation treatment revealed a direct correlation of viral load in brain to morbidity during infection

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2018 Journal of Evidence-based Integrative Medicine

194. Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island (PubMed)

Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island Prolonged fatigue is increasingly reported among chikungunya virus (CHIKV)-infected populations. We investigated the relationships between CHIKV exposure, long-lasting rheumatic musculoskeletal pain (LRMSP) and chronic fatigue. 1094 participants (512 CHIKV seropositive and 582 seronegative) of the TELECHIK population-based cohort were analysed considering the duration (...) at the onset of the infection, weighted prevalence rates of LRMSP, ICF and CFS-like illness were respectively of 32.9%, 38.7% and 23.9%, and of 8.7%, 8.5% and 7.4% among initially asymptomatic peers (P < 0.01, respectively). Each of the three outcomes was highly attributable to chikungunya (PAF of 43.2%, 36.2% and 41.0%, respectively). In the sub-cohort of CHIKV-infected subjects, LRMSP, ICF and CFS-like illness, which overlapped in 70%, accounted for 53% of the chronic manifestations. In addition

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2018 Epidemiology and infection

195. Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models (PubMed)

Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models Chikungunya virus (CHIKV) is a reemerging arbovirus capable of causing explosive outbreaks of febrile illness, polyarthritis, and polyarthralgia, inflicting severe morbidity on affected populations. CHIKV can be genetically classified into 3 major lineages: West African (WA); East, Central, and South African (ECSA); Indian Ocean (IOL); and Asian (...) . Taken together, our data suggest that Asian/American CHIKV strains are less virulent than those in the Asian, ECSA, and WA lineages and that despite differences in virulence, IOL-based vaccine strains offer robust cross-protection against strains from other lineages. Further research is needed to elucidate the genetic basis for variation in CHIKV virulence in the A129 mouse model and to corroborate this variation with human pathogenicity.IMPORTANCE Chikungunya virus (CHIKV) is a reemerging human

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2018 mBio

196. Excess Mortality and Causes Associated with Chikungunya, Puerto Rico, 2014-2015. (PubMed)

Excess Mortality and Causes Associated with Chikungunya, Puerto Rico, 2014-2015. During 2014-2015, a total of 31 deaths were associated with the first chikungunya epidemic in Puerto Rico. We analyzed excess mortality from various causes for the same months during the previous 4 years and detected 1,310 deaths possibly attributable to chikungunya. Our findings raise important questions about increased mortality rates associated with chikungunya.

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2018 Emerging Infectious Diseases

197. New insights into chikungunya virus emergence and spread from Southeast Asia (PubMed)

New insights into chikungunya virus emergence and spread from Southeast Asia 29535302 2018 11 15 2018 11 15 2222-1751 7 1 2018 03 14 Emerging microbes & infections Emerg Microbes Infect New insights into chikungunya virus emergence and spread from Southeast Asia. 26 10.1038/s41426-018-0024-2 Pyke Alyssa T AT 0000-0003-3512-4321 Public Health Virology Laboratory, Forensic and Scientific Services, Coopers Plains, 4108, QLD, Australia. Alyssa.Pyke@health.qld.gov.au. Moore Peter R PR Public Health (...) Virology Laboratory, Forensic and Scientific Services, Coopers Plains, 4108, QLD, Australia. McMahon Jamie J Public Health Virology Laboratory, Forensic and Scientific Services, Coopers Plains, 4108, QLD, Australia. eng Editorial 2018 03 14 United States Emerg Microbes Infect 101594885 2222-1751 IM Aedes virology Animals Asia, Southeastern epidemiology Chikungunya Fever epidemiology transmission virology Chikungunya virus genetics isolation & purification physiology Humans Mosquito Vectors virology

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2018 Emerging Microbes & Infections

198. Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal (PubMed)

Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal Arboviruses spillover into humans either as a one-step jump from a reservoir host species into humans or as a two-step jump from the reservoir to an amplification host species and thence to humans. Little is known about arbovirus transmission dynamics in reservoir and amplification hosts. Here we elucidate the role of monkeys in the sylvatic, enzootic cycle of chikungunya virus (CHIKV) in the region around Kédougou, Senegal

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2018 Nature communications

199. Identification of infection by Chikungunya, Zika, and Dengue in an area of the Peruvian coast. Molecular diagnosis and clinical characteristics (PubMed)

Identification of infection by Chikungunya, Zika, and Dengue in an area of the Peruvian coast. Molecular diagnosis and clinical characteristics To assess the presence of Dengue, Chikungunya, and Zika in serum samples of patients with acute febrile illness in Piura, Peru and describe the most common clinical features.Dengue was the most common arbovirus detected in 170/496 (34.3%), followed by Zika in 39/496 (7.9%) and Chikungunya in 23/496 (4.6%). Among the 170 samples positive for Dengue (...) the northern coast of Peru. It has also been determined the presence of Zika and Chikungunya in our population, which may suggest the circulation of other arboviruses that have not been detected.

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2018 BMC research notes

200. Spatio-temporal coherence of dengue, chikungunya and Zika outbreaks in Merida, Mexico (PubMed)

Spatio-temporal coherence of dengue, chikungunya and Zika outbreaks in Merida, Mexico Response to Zika virus (ZIKV) invasion in Brazil lagged a year from its estimated February 2014 introduction, and was triggered by the occurrence of severe congenital malformations. Dengue (DENV) and chikungunya (CHIKV) invasions tend to show similar response lags. We analyzed geo-coded symptomatic case reports from the city of Merida, Mexico, with the goal of assessing the utility of historical DENV data

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2018 PLoS neglected tropical diseases

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