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1. Chikungunya virus infection

Chikungunya virus infection Chikungunya virus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Chikungunya virus infection Last reviewed: February 2019 Last updated: November 2018 Summary Notifiable condition. It is important to distinguish from dengue fever and Zika virus infection, which are transmitted by the same vector. Most patients fully recover, but some develop chronic joint disease characterised (...) of antibodies. Real-time reverse transcription polymerase chain reaction can be used to determine whether a patient is infected with chikungunya, Zika, or dengue virus in one test. Co-infection may occur. There is no specific vaccine or treatment. Avoidance of mosquito bites is the best method of prevention. Definition Chikungunya virus (also known as CHIKV) is an alphavirus transmitted by the Aedes species of mosquitoes. Chikungunya means 'that which bends up' in the Makonde language (spoken in a border

2018 BMJ Best Practice

2. Chikungunya virus infection

Chikungunya virus infection Chikungunya virus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Chikungunya virus infection Last reviewed: February 2019 Last updated: November 2018 Summary Notifiable condition. It is important to distinguish from dengue fever and Zika virus infection, which are transmitted by the same vector. Most patients fully recover, but some develop chronic joint disease characterised (...) of antibodies. Real-time reverse transcription polymerase chain reaction can be used to determine whether a patient is infected with chikungunya, Zika, or dengue virus in one test. Co-infection may occur. There is no specific vaccine or treatment. Avoidance of mosquito bites is the best method of prevention. Definition Chikungunya virus (also known as CHIKV) is an alphavirus transmitted by the Aedes species of mosquitoes. Chikungunya means 'that which bends up' in the Makonde language (spoken in a border

2018 BMJ Best Practice

4. Chikungunya virus infection in Aruba: Diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia. (Full text)

Chikungunya virus infection in Aruba: Diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia. Chikungunya virus (CHIKV) emerged in Aruba for the first time in 2014. We studied the clinical presentation of acute CHIKV infection and the contribution of serologic and molecular assays to its diagnosis. In a cohort of confirmed CHIKV cases, we analysed the frequency, duration and predictors of post-chikungunya chronic polyarthralgia (pCHIK-CPA), defined as joint pains

2018 PLoS ONE PubMed abstract

5. Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. (Full text)

Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. In January 2016, health authorities from Zambézia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study to investigate a potential chikungunya outbreak in the city of Quelimane.From February to June

2018 PLoS ONE PubMed abstract

6. Incidence of articular pain and arthritis after chikungunya fever in the Americas: A systematic review of the literature and meta-analysis. (Abstract)

Incidence of articular pain and arthritis after chikungunya fever in the Americas: A systematic review of the literature and meta-analysis. To estimate the incidence of chronic articular symptoms after chikungunya virus infection of patients from the American continent.We performed a systematic review of the literature using the MEDLINE, Web of Science and Scopus databases. We included only cohort studies conducted in the American continent reporting the incidence of chronic articular symptoms (...) after chikungunya virus acute infection. The quality of the selected studies was evaluated through the Newcastle-Ottawa Scale for non-randomized studies and relevant data were extracted. The pooled incidence of post-chikungunya chronic symptoms was estimated using a random-effect model meta-analysis. Heterogeneity was assessed by Q of Cochrane and its P-value, Tau2 and I2. Subgroup analysis was performed, and studies were stratified by quality, sample size, region, country, period of follow-up

2020 Joint bone spine

7. Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial. (Abstract)

Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial. Chikungunya virus (CHIKV) is a mosquito-borne Alphavirus prevalent worldwide. There are currently no licensed vaccines or therapies.To evaluate the safety and tolerability of an investigational CHIKV virus-like particle (VLP) vaccine in endemic regions.This was a randomized, placebo-controlled, double-blind, phase 2 clinical trial to assess the vaccine VRC-CHKVLP059-00-VP (CHIKV (...) is the dilution of sera that inhibits 50% infection in viral neutralization assay-geometric mean titers (GMTs) of neutralizing antibodies of the vaccine group (46; 95% CI, 34-63) and the placebo group (43; 95% CI, 32-57). Eight weeks following the first administration, the EC50 GMT in the vaccine group was 2005 (95% CI, 1680-2392) vs 43 (95% CI, 32-58; P < .001) in the placebo group. Durability of the immune response was demonstrated through 72 weeks after vaccination.Among healthy adults in a chikungunya

2020 JAMA

8. Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases (Full text)

Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases The recent emergence and re-emergence of viral infections transmitted by vectors-Zika, chikungunya, dengue, Japanese encephalitis, West Nile, yellow fever and others-is a cause for international concern. Using as examples Zika, chikungunya and dengue, we summarise current knowledge on characteristics of the viruses and their transmission, clinical features, laboratory diagnosis, burden, history (...) , possible causes of the spread and the expectation for future epidemics. Arboviruses are transmitted by mosquitoes, are of difficult diagnosis, can have surprising clinical complications and cause severe burden. The current situation is complex, because there is no vaccine for Zika and chikungunya and no specific treatment for the three arboviruses. Vector control is the only comprehensive solution available now and this remains a challenge because up to now this has not been very effective. Until we

2018 BMJ global health PubMed abstract

9. A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty’s Syndrome (Full text)

A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty’s Syndrome Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoid arthritis (RA).We report a patient with well-characterized CHIKF followed 2 months later by chronic CHIK

2018 Rheumatology and therapy PubMed abstract

10. Treatment of chikungunya chronic arthritis: A systematic review. (Full text)

Treatment of chikungunya chronic arthritis: A systematic review. Chikungunya (CHIK) is a tropical arbovirus, transmitted by the female mosquito Aedes aegypti and Aedes albopictus. In Brazil, there have been cases reported since 2014. The initial manifestations of this virus are sudden onset high fever, headache, chills, rashes, myalgia and intense joint pain. Usually, CHIK presents the acute and chronic phases, the latter characterized by bilateral polyarthralgia, which can last for months

2018 Revista da Associacao Medica Brasileira (1992) PubMed abstract

11. Mosquito Exposure and Chikungunya and Dengue Infection among Travelers during the Chikungunya Outbreak in the Americas. (Full text)

Mosquito Exposure and Chikungunya and Dengue Infection among Travelers during the Chikungunya Outbreak in the Americas. AbstractTravelers are at risk for arbovirus infection. We prospectively enrolled 267 Department of Defense beneficiaries traveling to chikungunya-outbreak regions in the Americas between December 2013 and May 2015 and assessed travel characteristics and serologic exposure to chikungunya virus (CHIKV) and dengue virus (DENV). Ten ill-returning travelers were also assessed

2017 American Journal of Tropical Medicine & Hygiene PubMed abstract

12. Chikungunya and Neonatal Immunity: Fatal Vertically Transmitted Chikungunya Infection. (Full text)

Chikungunya and Neonatal Immunity: Fatal Vertically Transmitted Chikungunya Infection. AbstractChikungunya is a mosquito-borne infectious disease that has emerged as a global pathogen. The virus can pass vertically from mother to child especially during the perinatal period, with an intrapartum vertical transmission rate of 50%. Approximately half of the neonates infected with chikungunya present with severe symptoms and infrequently death. This report summarizes two severe cases of vertically (...) transmitted neonatal chikungunya infection. One case was confirmed by real-time reverse transcription polymerase chain reaction and the other fulfilled clinical and epidemiological criteria. Both infants presented on day 3 with abdominal distension, reduced perfusion pressure, and hypotension; acrocyanosis progressing to ischemic digits; and respiratory distress. Both died within 24-48 hours of presentation. The severity of symptoms observed is likely due to a combination of contamination of the fetal

2017 American Journal of Tropical Medicine & Hygiene PubMed abstract

13. Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil. (Full text)

Circulation of chikungunya virus East/Central/South African lineage in Rio de Janeiro, Brazil. The emergence of chikungunya virus (CHIKV) has raised serious concerns due to the virus' rapid dissemination into new geographic areas and the clinical features associated with infection. To better understand CHIKV dynamics in Rio de Janeiro, we generated 11 near-complete genomes by means of real-time portable nanopore sequencing of virus isolates obtained directly from clinical samples. To better

2019 PLoS ONE PubMed abstract

14. Retrospective investigation of antibodies against chikungunya virus (CHIKV) in serum from febrile patients in Mozambique, 2009-2015: Implications for its prevention and control. (Full text)

Retrospective investigation of antibodies against chikungunya virus (CHIKV) in serum from febrile patients in Mozambique, 2009-2015: Implications for its prevention and control. Longitudinal data and trends about chikungunya virus (CHIKV) are critical for its control, however in Mozambique very few studies were conducted over 5 decades, between 1957 and 2013. In this study, we retrospectively investigated the occurrence, geographical distribution and trend of anti-CHIKV antibodies between 2009 (...) and 2015 in Mozambique using serum samples from febrile patients.A total of 895 serum samples collected from febrile patients for measles and rubella surveillance between 2009 and 2015 in 127 districts of Mozambique were retrospectively tested for IgM and IgG antibodies against CHIKV using a commercially available ELISA.The median age of patients was 2 years (IQR: 1-5 years) and 44.2% (395/895) of them were female. We found that 54 (6.0%) of samples were positive for anti-IgM chikungunya, and 160 (17.9

2019 PLoS ONE PubMed abstract

15. An epidemic of chikungunya in northwestern Bangladesh in 2011. (Full text)

An epidemic of chikungunya in northwestern Bangladesh in 2011. In November 2011, a government hospital physician in Shibganj sub-district of Bangladesh reported a cluster of patients with fever and joint pain or rash. A multi-disciplinary team investigated to characterize the outbreak; confirm the cause; and recommend control and prevention measures.Shibganj's residents with new onset of fever and joint pain or rash between 1 September and 15 December 2011 were defined as chikungunya fever (...) healthcare from outpatient clinics. CHIKV was isolated from two cases and phylogenetic analyses of full genome sequences placed these viruses within the Indian Ocean Lineage (IOL). Molecular analysis identified mutations in E2 and E1 glycoproteins and contained the E1 A226V point mutation.The consistently high attack rate by age groups suggested recent introduction of chikungunya in this community. Mosquito control efforts should be enhanced to reduce the risk of continued transmission and to improve

2019 PLoS ONE PubMed abstract

16. Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar. (Full text)

Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar. The objective of this study is to characterize the seroprevalence of anti-dengue (DENV) and anti-chikungunya (CHIKV) antibodies among blood donors residing in Qatar who are Middle East and North Africa (MENA) nationals and non-nationals. Sera were collected from adult blood donors in Qatar from 2013 to 2016 and tested for anti-DENV and anti-CHIKV IgG using commercial microplate enzyme-linked

2019 PLoS ONE PubMed abstract

17. Virus load and clinical features during the acute phase of Chikungunya infection in children. (Full text)

Virus load and clinical features during the acute phase of Chikungunya infection in children. Chikungunya virus (CHIKV) infection is a long known mosquito-borne disease that is associated with severe morbidity, characterized by fever, headache, rashes, joint pain, and myalgia. It is believed that virus load has relation with severity of clinical features.We performed this study to assess the relationship between virus load and clinical features in children during the acute phase of CHIKV

2019 PLoS ONE PubMed abstract

18. Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial. (Abstract)

Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial. Chikungunya fever is an emerging viral disease and substantial threat to public health. We aimed to assess the safety, tolerability, and immunogenicity of a live-attenuated, measles-vectored chikungunya vaccine (MV-CHIK).In this double-blind, randomised, placebo-controlled and active-controlled phase 2 trial, we (...) , which was maintained by use of sterile saline as a placebo injection. The primary endpoint was immunogenicity, defined as the presence of neutralising antibodies against chikungunya virus, at day 56, which is 28 days after one or two immunisations. The primary endpoint was assessed in all participants who completed the study without major protocol deviations (per-protocol population) and in all randomised participants who received at least one study treatment (modified intention-to-treat population

2018 Lancet Controlled trial quality: predicted high

19. Chikungunya Virus Infection Outcome: A Systematic Review of Host Genetics. (Abstract)

Chikungunya Virus Infection Outcome: A Systematic Review of Host Genetics. Background: Chikungunya virus (CHIKV) is a global concern, inducing chikungunya fever and trigging an arthritogenic chronic phase beyond some severe forms. Outcomes of CHIKV infections in humans are dependent on genetic variations. Here, a systematic review was performed to show evidence of genetic variations on infection outcomes of patients.Methods: Searches were performed in Scopus, SciELO, MEDLINE/PubMed, Web

2020 Immunological investigations

20. A systematic review of individual and community mitigation measures for prevention and control of chikungunya virus. (Full text)

A systematic review of individual and community mitigation measures for prevention and control of chikungunya virus. Chikungunya is a mosquito-borne virus transmitted by mosquitoes from the Aedes genus. The virus, endemic to parts of Asia and Africa, has recently undergone an emergence in other parts of the world where it was previously not found including Indian Ocean Islands, Europe, the Western Pacific and the Americas. There is no vaccine against chikungunya virus, which means (...) that prevention and mitigation rely on personal protective measures and community level interventions including vector control.A systematic review (SR) was conducted to summarize the literature on individual and community mitigation and control measures and their effectiveness. From a scoping review of the global literature on chikungunya, there were 91 articles that investigated mitigation or control strategies identified at the individual or community level. Of these, 81 were confirmed as relevant

2019 PLoS ONE PubMed abstract

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