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2. Chikungunya virus infection

Chikungunya virus infection Chikungunya virus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Chikungunya virus infection Last reviewed: February 2019 Last updated: November 2018 Summary Notifiable condition. It is important to distinguish from dengue fever and Zika virus infection, which are transmitted by the same vector. Most patients fully recover, but some develop chronic joint disease characterised (...) of antibodies. Real-time reverse transcription polymerase chain reaction can be used to determine whether a patient is infected with chikungunya, Zika, or dengue virus in one test. Co-infection may occur. There is no specific vaccine or treatment. Avoidance of mosquito bites is the best method of prevention. Definition Chikungunya virus (also known as CHIKV) is an alphavirus transmitted by the Aedes species of mosquitoes. Chikungunya means 'that which bends up' in the Makonde language (spoken in a border

2018 BMJ Best Practice

3. Chikungunya virus infection

Chikungunya virus infection Chikungunya virus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Chikungunya virus infection Last reviewed: February 2019 Last updated: November 2018 Summary Notifiable condition. It is important to distinguish from dengue fever and Zika virus infection, which are transmitted by the same vector. Most patients fully recover, but some develop chronic joint disease characterised (...) of antibodies. Real-time reverse transcription polymerase chain reaction can be used to determine whether a patient is infected with chikungunya, Zika, or dengue virus in one test. Co-infection may occur. There is no specific vaccine or treatment. Avoidance of mosquito bites is the best method of prevention. Definition Chikungunya virus (also known as CHIKV) is an alphavirus transmitted by the Aedes species of mosquitoes. Chikungunya means 'that which bends up' in the Makonde language (spoken in a border

2018 BMJ Best Practice

4. Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. (PubMed)

Evidence for chikungunya and dengue transmission in Quelimane, Mozambique: Results from an investigation of a potential outbreak of chikungunya virus. In January 2016, health authorities from Zambézia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study to investigate a potential chikungunya outbreak in the city of Quelimane.From February to June

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2018 PLoS ONE

5. Mosquito Exposure and Chikungunya and Dengue Infection among Travelers during the Chikungunya Outbreak in the Americas. (PubMed)

Mosquito Exposure and Chikungunya and Dengue Infection among Travelers during the Chikungunya Outbreak in the Americas. AbstractTravelers are at risk for arbovirus infection. We prospectively enrolled 267 Department of Defense beneficiaries traveling to chikungunya-outbreak regions in the Americas between December 2013 and May 2015 and assessed travel characteristics and serologic exposure to chikungunya virus (CHIKV) and dengue virus (DENV). Ten ill-returning travelers were also assessed

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2017 American Journal of Tropical Medicine & Hygiene

6. Chikungunya and Neonatal Immunity: Fatal Vertically Transmitted Chikungunya Infection. (PubMed)

Chikungunya and Neonatal Immunity: Fatal Vertically Transmitted Chikungunya Infection. AbstractChikungunya is a mosquito-borne infectious disease that has emerged as a global pathogen. The virus can pass vertically from mother to child especially during the perinatal period, with an intrapartum vertical transmission rate of 50%. Approximately half of the neonates infected with chikungunya present with severe symptoms and infrequently death. This report summarizes two severe cases of vertically (...) transmitted neonatal chikungunya infection. One case was confirmed by real-time reverse transcription polymerase chain reaction and the other fulfilled clinical and epidemiological criteria. Both infants presented on day 3 with abdominal distension, reduced perfusion pressure, and hypotension; acrocyanosis progressing to ischemic digits; and respiratory distress. Both died within 24-48 hours of presentation. The severity of symptoms observed is likely due to a combination of contamination of the fetal

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2017 American Journal of Tropical Medicine & Hygiene

7. Treatment of chikungunya chronic arthritis: A systematic review.

Treatment of chikungunya chronic arthritis: A systematic review. Chikungunya (CHIK) is a tropical arbovirus, transmitted by the female mosquito Aedes aegypti and Aedes albopictus. In Brazil, there have been cases reported since 2014. The initial manifestations of this virus are sudden onset high fever, headache, chills, rashes, myalgia and intense joint pain. Usually, CHIK presents the acute and chronic phases, the latter characterized by bilateral polyarthralgia, which can last for months

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2018 Revista da Associacao Medica Brasileira (1992)

8. Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases (PubMed)

Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases The recent emergence and re-emergence of viral infections transmitted by vectors-Zika, chikungunya, dengue, Japanese encephalitis, West Nile, yellow fever and others-is a cause for international concern. Using as examples Zika, chikungunya and dengue, we summarise current knowledge on characteristics of the viruses and their transmission, clinical features, laboratory diagnosis, burden, history (...) , possible causes of the spread and the expectation for future epidemics. Arboviruses are transmitted by mosquitoes, are of difficult diagnosis, can have surprising clinical complications and cause severe burden. The current situation is complex, because there is no vaccine for Zika and chikungunya and no specific treatment for the three arboviruses. Vector control is the only comprehensive solution available now and this remains a challenge because up to now this has not been very effective. Until we

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2018 BMJ global health

9. A systematic review of individual and community mitigation measures for prevention and control of chikungunya virus. (PubMed)

A systematic review of individual and community mitigation measures for prevention and control of chikungunya virus. Chikungunya is a mosquito-borne virus transmitted by mosquitoes from the Aedes genus. The virus, endemic to parts of Asia and Africa, has recently undergone an emergence in other parts of the world where it was previously not found including Indian Ocean Islands, Europe, the Western Pacific and the Americas. There is no vaccine against chikungunya virus, which means (...) that prevention and mitigation rely on personal protective measures and community level interventions including vector control.A systematic review (SR) was conducted to summarize the literature on individual and community mitigation and control measures and their effectiveness. From a scoping review of the global literature on chikungunya, there were 91 articles that investigated mitigation or control strategies identified at the individual or community level. Of these, 81 were confirmed as relevant

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2019 PLoS ONE

10. A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty’s Syndrome (PubMed)

A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty’s Syndrome Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoid arthritis (RA).We report a patient with well-characterized CHIKF followed 2 months later by chronic CHIK

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2018 Rheumatology and therapy

11. Virus load and clinical features during the acute phase of Chikungunya infection in children. (PubMed)

Virus load and clinical features during the acute phase of Chikungunya infection in children. Chikungunya virus (CHIKV) infection is a long known mosquito-borne disease that is associated with severe morbidity, characterized by fever, headache, rashes, joint pain, and myalgia. It is believed that virus load has relation with severity of clinical features.We performed this study to assess the relationship between virus load and clinical features in children during the acute phase of CHIKV

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2019 PLoS ONE

12. Treatment of Chronic Chikungunya Arthritis With Methotrexate: A Systematic Review

Treatment of Chronic Chikungunya Arthritis With Methotrexate: A Systematic Review Chikungunya virus infection is a rapidly emerging global viral infection that can cause chronic, debilitating arthritis that in some ways mimics rheumatoid arthritis. The aim of this study was to evaluate the available evidence regarding the efficacy and safety of methotrexate (MTX), a therapy that is widely used in rheumatoid arthritis, for the treatment of chronic chikungunya arthritis.A systematic literature (...) search was performed to identify all published trials that evaluated MTX as monotherapy or combination therapy in patients with chronic chikungunya arthritis. PubMed, SciELO, Scopus, and Cochrane Library databases were searched from study inception to August 2017. We also searched Google Scholar, the International Clinical Trials Registry Platform Search Portal, and clinicaltrials.gov.Among 131 possibly relevant studies, 6 met our criteria for evaluation: 4 were retrospective studies, 1 was a non

2018 EvidenceUpdates

13. Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial. (PubMed)

Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial. Chikungunya fever is an emerging viral disease and substantial threat to public health. We aimed to assess the safety, tolerability, and immunogenicity of a live-attenuated, measles-vectored chikungunya vaccine (MV-CHIK).In this double-blind, randomised, placebo-controlled and active-controlled phase 2 trial, we (...) , which was maintained by use of sterile saline as a placebo injection. The primary endpoint was immunogenicity, defined as the presence of neutralising antibodies against chikungunya virus, at day 56, which is 28 days after one or two immunisations. The primary endpoint was assessed in all participants who completed the study without major protocol deviations (per-protocol population) and in all randomised participants who received at least one study treatment (modified intention-to-treat population

2018 Lancet

14. Potential entry inhibitors of the envelope protein (E2) of Chikungunya virus: in silico structural modeling, docking and molecular dynamic studies (PubMed)

Potential entry inhibitors of the envelope protein (E2) of Chikungunya virus: in silico structural modeling, docking and molecular dynamic studies Chikungunya fever is an arboviral infection caused by the Chikungunya virus (CHIKV) and is transmitted by Aedes mosquito. The envelope protein (E2) of Chikungunya virus is involved in attachment of virion with the host cell. The present study was conceptualized to determine the structure of E2 protein of CHIKV and to identify the potential viral

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2017 Virusdisease

15. Zika and chikungunya virus infections in hematopoietic stem cell transplant recipients and oncohematological patients (PubMed)

Zika and chikungunya virus infections in hematopoietic stem cell transplant recipients and oncohematological patients Aedes mosquitoes are well adapted in domestic environments and widespread in tropical regions. Since 2015, Brazil has been experiencing a triple epidemic of dengue (DENV), chikungunya (CHKV), and Zika (ZIKV) viruses. The last 2 viruses are likely following the path of DENV, which has been endemic in most parts of the country since the 1980s. Given this triple epidemic, we

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2017 Blood advances

16. Successful Live Kidney Transplantation After Chikungunya Disease in the Donor (PubMed)

Successful Live Kidney Transplantation After Chikungunya Disease in the Donor 29270535 2019 02 26 2468-0249 2 6 2017 Nov Kidney international reports Kidney Int Rep Successful Live Kidney Transplantation After Chikungunya Disease in the Donor. 1250-1253 10.1016/j.ekir.2017.06.003 Moura-Neto José Andrade JA Clinical and Academic Unit of Nephrology, Hospital Universitário Pedro Ernesto, Rio de Janeiro State University, Rio de Janeiro, Brazil. CSB Group of Nephrology, Salvador, Brazil. de Souza

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2017 Kidney international reports

17. A clinical report on mixed infection of malaria, dengue and chikungunya from New Delhi, India (PubMed)

A clinical report on mixed infection of malaria, dengue and chikungunya from New Delhi, India Arthropod-borne infections like malaria, dengue and chikungunya fever are transmitted by mosquitoes. The present report describes an unusual case of mixed infection with malaria, dengue and chikungunya viruses in a 21 year old male patient from New Delhi, India during monsoon season of 2016. The malarial fever was diagnosed by thin slide microscopy and antigen test. Chikungunya virus IgM was detected (...) in the sample by the card test. Dengue and chikungunya viruses were further confirmed by RT-PCR for CprM and E1 gene respectively. Phylogenetic analysis clustered the study dengue virus serotype 3 sequence in the genotype III. Thus, the mono infections can not be differentiated from concurrent infections on the basis of clinical symptoms, the appropriate laboratory diagnosis is essential for the accurate pathogen confirmation. Precise and appropriate identification of the multiple pathogens in such clinical

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2017 Virusdisease

18. Surveillance for Chikungunya and Dengue During the First Year of Chikungunya Virus Circulation in Puerto Rico. (PubMed)

Surveillance for Chikungunya and Dengue During the First Year of Chikungunya Virus Circulation in Puerto Rico. After chikungunya virus (CHIKV) transmission was detected in Puerto Rico in May 2014, multiple surveillance systems were used to describe epidemiologic trends and CHIKV-associated disease. Of 28 327 cases reported via passive surveillance, 6472 were tested for evidence of CHIKV infection, and results for 4399 (68%) were positive. Of 250 participants in household cluster investigations (...) , 70 (28%) had evidence of recent CHIKV infection. Enhanced surveillance for chikungunya at 2 hospitals identified 1566 patients who tested positive for CHIKV, of whom 10.9% were hospitalized. Enhanced surveillance for fatal cases enabled identification of 31 cases in which CHIKV was detected in blood or tissue specimens. All surveillance systems detected a peak incidence of chikungunya in September 2014 and continued circulation in 2015. Concomitant surveillance for dengue demonstrated low

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2016 Journal of Infectious Diseases

19. Longitudinal Analysis of Natural Killer Cells in Dengue Virus-Infected Patients in Comparison to Chikungunya and Chikungunya/Dengue Virus-Infected Patients (PubMed)

Longitudinal Analysis of Natural Killer Cells in Dengue Virus-Infected Patients in Comparison to Chikungunya and Chikungunya/Dengue Virus-Infected Patients Dengue virus (DENV) is the most prominent arbovirus worldwide, causing major epidemics in South-East Asia, South America and Africa. In 2010, a major DENV-2 outbreak occurred in Gabon with cases of patients co-infected with chikungunya virus (CHIKV). Although the innate immune response is thought to be of primordial importance

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2016 PLoS neglected tropical diseases

20. Seroprevalence of Anti-Chikungunya Virus Antibodies in Children and Adults in Managua, Nicaragua, After the First Chikungunya Epidemic, 2014-2015 (PubMed)

Seroprevalence of Anti-Chikungunya Virus Antibodies in Children and Adults in Managua, Nicaragua, After the First Chikungunya Epidemic, 2014-2015 Chikungunya is a viral disease transmitted by Aedes aegypti and Ae. albopictus mosquitoes. In late 2013, chikungunya virus (CHIKV) was introduced into the Caribbean island of St. Martin. Since then, approximately 2 million chikungunya cases have been reported by the Pan American Health Organization, and most countries in the Americas report (...) autochthonous transmission of CHIKV. In Nicaragua, the first imported case was described in July 2014 and the first autochthonous case in September 2014. Here, we conducted two studies to analyze the seroprevalence of anti-CHIKV antibodies after the first chikungunya epidemic in a community-based cohort study (ages 2-14 years) and in a cross-sectional survey of persons aged ≥15 years in the same area of Managua, Nicaragua. Routine annual serum samples collected from 3,362 cohort participants in March/April

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2016 PLoS neglected tropical diseases

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