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1. Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum. (Full text)

Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum. Protein SUMOylation regulates multiple processes involved in the differentiation and maturation of cells and tissues during development. Despite this, relatively little is known about the spatial and temporal regulation of proteins that mediate SUMOylation and deSUMOylation in the CNS. Here we monitor the expression of key SUMO pathway proteins and levels of substrate protein SUMOylation in the forebrain (...) and cerebellum of Wistar rats during development. Overall, the SUMOylation machinery is more highly-expressed at E18 and decreases thereafter, as previously described. All of the proteins investigated are less abundant in adult than in embryonic brain. Furthermore, we show for first time that the profiles differ between cerebellum and cerebrum, indicating differential regional regulation of some of the proteins analysed. These data provide further basic observation that may open a new perspective of research

2019 PLoS ONE PubMed

2. Senescence-associated-β-galactosidase staining following traumatic brain injury in the mouse cerebrum. (Full text)

Senescence-associated-β-galactosidase staining following traumatic brain injury in the mouse cerebrum. Primary and secondary traumatic brain injury (TBI) can cause tissue damage by inducing cell death pathways including apoptosis, necroptosis, and autophagy. However, similar pathways can also lead to senescence. Senescent cells secrete senescence-associated secretory phenotype proteins following persistent DNA damage response signaling, leading to cell disorders. TBI initially activates (...) the cell cycle followed by the subsequent triggering of senescence. This study aims to clarify how the mRNA and protein expression of different markers of cell cycle and senescence are modulated and switched over time after TBI. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, immunohistochemical analysis, and real-time PCR to examine the time-dependent changes in expression levels of proteins and mRNA, related to cell cycle and cellular senescence markers, in the cerebrum during

2019 PLoS ONE PubMed

3. Tell me twice: A multi-study analysis of the functional connectivity between the cerebrum and cerebellum after repeated trait information.

Tell me twice: A multi-study analysis of the functional connectivity between the cerebrum and cerebellum after repeated trait information. This multi-study analysis (6 fMRI studies; 142 participants) explores the functional activation and connectivity of the cerebellum with the cerebrum during repeated behavioral information uptake informing about personality traits of different persons. The results suggest that trait repetition recruits activity in areas belonging to the mentalizing (...) and executive control networks in the cerebrum, and the executive control areas in the cerebellum. Cerebral activation was observed in the executive control network including the posterior medial frontal cortex (pmFC), the bilateral prefrontal cortex (PFC) and bilateral inferior parietal cortex (IPC), in the mentalizing network including the bilateral middle temporal cortex (MTC) extending to the right superior temporal cortex (STC), as well as in the visual network including the left cuneus (Cun

2018 NeuroImage

4. Silicon Foreign Body in the Cerebrum of a Rhesus Macaque (Macaca mulatta) (Full text)

Silicon Foreign Body in the Cerebrum of a Rhesus Macaque (Macaca mulatta) A male rhesus macaque with a cephalic chamber implant for neurophysiology recording presented with hemiparesis affecting the left thoracic and pelvic limbs at approximately 5 wk after craniotomy surgery. MRI indicated a 1×2-cm ovoid cerebrocortical cystic lesion immediately subjacent to the right hemisphere craniotomy and recording chamber. Transdural aspiration of sterile transudate and resultant decompression resolved

2018 Comparative medicine PubMed

5. Innovative Imaging of Cerebrum and Muscle (iCAM) Repeatability Study

Innovative Imaging of Cerebrum and Muscle (iCAM) Repeatability Study Innovative Imaging of Cerebrum and Muscle (iCAM) Repeatability Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Innovative Imaging (...) of Cerebrum and Muscle (iCAM) Repeatability Study (iCAM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03548168 Recruitment Status : Recruiting First Posted : June 7, 2018 Last Update Posted : June 8, 2018 See Sponsor: Ohio

2018 Clinical Trials

6. Expansion of a Myeloma-associated Lesion from Orbita to the Cerebrum (Full text)

Expansion of a Myeloma-associated Lesion from Orbita to the Cerebrum 29391338 2018 08 27 2018 11 13 1308-5263 35 1 2018 Mar 01 Turkish journal of haematology : official journal of Turkish Society of Haematology Turk J Haematol Expansion of a Myeloma-associated Lesion from Orbita to the Cerebrum. 92-93 10.4274/tjh.2017.0283 Demircioğlu Sinan S Necmettin Erbakan University Meram Faculty of Medicine, Department of Hematology, Konya, Turkey. Aydoğdu Demet D Necmettin Erbakan University Meram (...) Faculty of Medicine, Department of Radiology, Konya, Turkey. Çeneli Özcan Ö Necmettin Erbakan University Meram Faculty of Medicine, Department of Hematology, Konya, Turkey. eng Case Reports Letter Orbitadan Serebruma Kadar Uzanan Miyelom ile İlişkili Lezyon. 2018 02 02 Turkey Turk J Haematol 9606065 1300-7777 0 Biomarkers, Tumor IM Antineoplastic Combined Chemotherapy Protocols therapeutic use Biomarkers, Tumor Brain Neoplasms diagnosis secondary Cerebrum pathology Female Humans Magnetic Resonance

2018 Turkish Journal of Hematology PubMed

7. Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum (Full text)

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer's disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum. Sortilin changes were characterized in postmortem brains with antibodies against the extracellular and intracellular C-terminal domains. The two antibodies exhibited identical (...) labeling in normal human cerebrum, occurring in the somata and dendrites of cortical and hippocampal neurons. The C-terminal antibody also marked extracellular lesions in some aged and all AD cases, appearing as isolated fibrils, mini-plaques, dense-packing or circular mature-looking plaques. Sortilin and β-amyloid (Aβ) deposition were correlated overtly in a region/lamina- and case-dependent manner as analyzed in the temporal lobe structures, with co-localized immunofluorescence seen at individual SPs

2017 Frontiers in neuroanatomy PubMed

8. Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis (Full text)

Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis A 74-year-old woman developed bilateral uveitis with high Epstein-Barr virus (EBV) DNA load in the vitreous fluid without lymphoma cells. Four years after the onset, T2-weighted contrast-enhanced MRI revealed hyperintense lesions in the right occipital and parietal lobe. A biopsy resulted in the diagnosis of extranodal NK/T-cell lymphoma nasal type (ENKL). The repeat region of LMP1

2017 Internal Medicine PubMed

9. Diffusion tensor image segmentation of the cerebrum provides a single measure of cerebral small vessel disease severity related to cognitive change (Full text)

Diffusion tensor image segmentation of the cerebrum provides a single measure of cerebral small vessel disease severity related to cognitive change Cerebral small vessel disease (SVD) is the primary cause of vascular cognitive impairment and is associated with decline in executive function (EF) and information processing speed (IPS). Imaging biomarkers are needed that can monitor and identify individuals at risk of severe cognitive decline. Recently there has been interest in combining several (...) magnetic resonance imaging (MRI) markers of SVD into a unitary score to describe disease severity. Here we apply a diffusion tensor image (DTI) segmentation technique (DSEG) to describe SVD related changes in a single unitary score across the whole cerebrum, to investigate its relationship with cognitive change over a three-year period. 98 patients (aged 43-89) with SVD underwent annual MRI scanning and cognitive testing for up to three years. DSEG provides a vector of 16 discrete segments describing

2017 NeuroImage : Clinical PubMed

10. Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart (Full text)

Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart Legumain (EC 3.4.22.34) is an asparaginyl endopeptidase. Legumain activity has been detected in various mouse tissues including the kidney, spleen and epididymis. Legumain is overexpressed in the majority of human solid tumors and transcription of the legumain gene is regulated by the p53 tumor suppressor in HCT116 cells. The legumain activity is also increased under (...) acid conditions in Alzheimer's disease brains. DJ-1/PARK7, a cancer- and Parkinson's disease-associated protein, works as a coactivator to various transcription factors, including the androgen receptor, p53, PSF, Nrf2, SREBP and RREB1. Recently, we found that legumain expression, activation and cleavage of annexin A2 are regulated by DJ-1 through p53. In this study, we found that the expression levels of legumain mRNA were increased in the cerebrum, kidney, spleen, heart, lung, epididymis, stomach

2017 Biochemistry and Biophysics Reports PubMed

11. Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates (Full text)

Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates The subplate (SP) was the last cellular compartment added to the Boulder Committee's list of transient embryonic zones [Bystron I, Blakemore C, Rakic P (2008) Nature Rev Neurosci 9(2):110-122]. It is highly developed in human and nonhuman primates, but its origin, mode, and dynamics of development, resolution, and eventual extinction are not well understood because human postmortem

2016 Proceedings of the National Academy of Sciences of the United States of America PubMed

12. Evidence of cellular stress and caspase-3 resulting from a combined two-frequency signal in the cerebrum and cerebellum of Sprague-dawley rats (Full text)

Evidence of cellular stress and caspase-3 resulting from a combined two-frequency signal in the cerebrum and cerebellum of Sprague-dawley rats Multiple simultaneous exposures to electromagnetic signals induced adjustments in mammal nervous systems. In this study, we investigated the non-thermal SAR (Specific Absorption Rate) in the cerebral or cerebellar hemispheres of rats exposed in vivo to combined electromagnetic field (EMF) signals at 900 and 2450 MHz.Forty rats divided into four groups

2016 Oncotarget PubMed

13. Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study.

Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study. Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study. (MAVARIC) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2016 Clinical Trials

14. The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus. (Full text)

The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus. OBJECTIVE The relationship of the white matter tracts to the lateral ventricles is important when planning surgical approaches to the ventricles and in understanding the symptoms of hydrocephalus. The authors' aim was to explore the relationship of the white matter tracts of the cerebrum to the lateral ventricles using fiber dissection technique and MR tractography and to discuss these findings in relation (...) a consistent relationship to the lateral ventricles. CONCLUSIONS Knowledge of the relationship of the white matter tracts of the cerebrum to the lateral ventricles should aid in planning more accurate surgery for lesions within the lateral ventricles.

2016 Journal of Neurosurgery PubMed

15. Cerebrum

Cerebrum Cerebrum Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cerebrum Cerebrum Aka: Cerebrum , Cerebral Hemisphere II. Anatomy (...) (in at or ) Lewis (1918) Gray's Anatomy 20th ed (in at or ) IV. References Netter (1997) Atlas Human Anatomy, ICON Learning, p. 99-101 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Cerebrum." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Cerebral hemisphere structure (body structure) (C0228174) Definition (FMA) One of two bilateral, largely symmetrical

2018 FP Notebook

16. Gene expression microarray data from mouse CBS treated with rTMS for 30 days, mouse cerebrum and CBS treated with rTMS for 40 days (Full text)

Gene expression microarray data from mouse CBS treated with rTMS for 30 days, mouse cerebrum and CBS treated with rTMS for 40 days This data article contains complementary tables related to the research article study entitled, 'Effects of repetitive transcranial magnetic stimulation on ER stress-related genes and glutamate, γ-aminobutyric acid, and glycine transporter genes in mouse brain' (Ikeda et al. (2017) [1]), which showed that rTMS modulates glutamate, GABA and glycine transporters (...) and regulates ER stress-related genes. Here, we provide accompanying data collected using Affymetrix GeneChip microarrays to identify changes in gene expression in mouse CBS treated with rTMS for 30 days (Tables 1-21) and mouse cerebrum (Tables 22-57) and CBS (Tables 58-94) treated with rTMS for 40 days.

2018 Data in brief PubMed

17. Gene expression microarray data from mouse cerebrum treated with rTMS for 30 days (Full text)

Gene expression microarray data from mouse cerebrum treated with rTMS for 30 days This data article contains complementary tables related to the research article entitled, 'Effects of repetitive transcranial magnetic stimulation on ER stress-related genes and glutamate, γ-aminobutyric acid, and glycine transporter genes in mouse brain' (Ikeda et al. (2017) [1]), which showed that rTMS modulates glutamate, GABA and glycine transporters and regulates ER stress-related genes. Here we provide (...) accompanying data collected using Affymetrix GeneChip microarrays to identify changes in gene expression in mouse cerebrum treated with rTMS for 30 days (Tables 1-10).

2017 Data in brief PubMed

18. Sexual dimorphism of sulcal morphology of the ferret cerebrum revealed by MRI-based sulcal surface morphometry (Full text)

Sexual dimorphism of sulcal morphology of the ferret cerebrum revealed by MRI-based sulcal surface morphometry The present study quantitatively assessed sexual dimorphism of cortical convolution and sulcal morphology in young adult ferrets by MRI-based sulcal surface morphometry. Ex vivo T1-weighted (short TR/TE) MRI of the ferret cerebrum was acquired with high spatial resolution at 7-tesla. The degree of cortical convolution, evaluated quantitatively based on 3D MRI data by sulcation index (...) of the sulcal infolding, which is reflected by local cortical expansion in the ferret cerebrum. In particular, male-favored sulcal infolding with expansion of the temporo-parieto-occipital neocortex may be relevant to the human cerebral cortex regarding visuo-spatial and emotion processing, which are known to differ between sexes. The present results will provide fundamental information assessing sex-related changes in the regional sulcal infolding, when ferrets with experimentally-induced gyrification

2015 Frontiers in neuroanatomy PubMed

19. Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum (Full text)

Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum Microbleeds are a common finding in aged human brains. In Alzheimer's disease (AD), neuritic plaques composed of β-amyloid (Aβ) deposits and dystrophic neurites occur frequently around cerebral vasculature, raising a compelling question as to whether, and if so, how, microvascular abnormality and amyloid/neuritic pathology might be causally related. Here we used a guinea pig model of cerebral microembolism (...) to explore a potential inductive effect of vascular injury on neuritic and amyloid pathogenesis. Brains were examined 7-30 days after experimental microvascular embolization occupying ~0.5% of total cortical area. Compared to sham-operated controls, glial fibrillary acidic protein immunoreactivity was increased in the embolized cerebrum, evidently around intracortical vasculature. Swollen/sprouting neurites exhibiting increased reactivity of nicotinamide adenine dinucleotide phosphate diaphorase

2015 Oncotarget PubMed

20. Age-related intraneuronal accumulation of αII-spectrin breakdown product SBDP120 in the human cerebrum is enhanced in Alzheimer's disease. (PubMed)

Age-related intraneuronal accumulation of αII-spectrin breakdown product SBDP120 in the human cerebrum is enhanced in Alzheimer's disease. Spectrins are a part of cytoskeletal platform that lines the intracellular side of plasma membrane, which can be proteolyzed by calcium-sensitive enzymes including calpains and caspases. Caspase-3 mediated αII-spectrin proteolysis results in the release of a 120kDa spectrin breakdown product (SBDP120), known to occur in conditions with cell death. In rodents (...) formation in stressful conditions with and without apparent neuronal death. These results confirm an age-related intraneuronal SBDP120 accumulation in the human cerebrum that is enhanced in AD. This neuronal change appears to occur independent of amyloid deposition, tau pathology and overt neuronal death. Copyright © 2015 Elsevier Inc. All rights reserved.

2015 Experimental Gerontology

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