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Cerebrovascular Accident Risk in Women

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41. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

excess in utero. This may have long-term effects, particularly on female offspring. Fetal hyperandrogenism maydisturbepigeneticprogramming,inparticularthosegenes regulating reproduction and metabolism. Data in relation to the risk of miscarriage in women with PCOS are con?icting, althoughmiscarriageratesaregenerallythoughttobecompa- rable with other subfertile populations (29, 30). When pregnancy occurs in women with PCOS, there is a higher incidence of gestational diabetes (GDM) (40% to 50 (...) with PCOS (20). Conclusions(Agreement) Both amenorrheic and oligomenorrheic women may occa- sionally ovulate (level B). Menstrual cycles in women with PCOS may become more regular later in life (level B). Irregular menses are associated with increased metabolic risk (level B). The greater the menstrual irregularity, the more severe the PCOS phenotype (level B). Disagreement The time needed before regular menstrual cycles occur in young women. The extent to which irregular menses (especially amenor

2012 Society for Assisted Reproductive Technology

42. A Pilot Study of the Combination of Entinostat With Capecitabine in High Risk Breast Cancer After Neo-adjuvant Therapy

is unable or unwilling to participate in a study related procedure. Subject is a prisoner. Subject has evidence or history of an uncontrolled bleeding disorder. Patients with chronic bleeding disorders that are controlled with treatment or not clinically relevant are allowed. Subjects with history of CNS disease including primary brain tumor, seizures not controlled with standard medical therapy, or history of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA), or subarachnoid (...) A Pilot Study of the Combination of Entinostat With Capecitabine in High Risk Breast Cancer After Neo-adjuvant Therapy A Pilot Study of the Combination of Entinostat With Capecitabine in High Risk Breast Cancer After Neo-adjuvant Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2018 Clinical Trials

43. Pilot Study of Glembatumumab Vedotin Following Doxorubicin and Cytoxan as Neo-adjuvant Therapy in Gp-NMB-expressing High Risk Triple Negative Breast Cancer

as judged by the investigator. Patients diagnosed with triple negative breast cancer, (stages II-III, or high risk T1c disease) found to have gpNMB expression at or above 25%), and who are appropriate candidates for neo-adjuvant therapy. Patients must be willing to undergo lumpectomy (with radiation therapy) or mastectomy following neo-adjuvant therapy. Subjects may be female or male. ECOG Performance Status of 0-2. Age ≥ 18 years. Subject must have a life expectancy ≥ 6 months. Absolute neutrophil (...) year following last dose of study drug. a. WOCBP includes any female who has experienced menarche and who has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or is not postmenopausal [defined as amenorrhea ≥ 12 consecutive months; or women on hormone replacement therapy with documented serum follicle stimulating hormone (FSH) level > 35 mIU/mL] i. Prior to study enrollment, WOCBP must be advised of the importance of avoiding

2018 Clinical Trials

44. Efficacy and Safety Study of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Naïve Subjects Who Require Red Blood Cell Transfusions

) score of 0, 1, or 2. Females of childbearing potential (FCBP), defined as a sexually mature woman who: 1) has not undergone a hysterectomy or bilateral oophorectomy or 2) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (ie, has had menses at any time in the preceding 24 consecutive months), must: Have two negative pregnancy tests as verified by the investigator prior to starting study therapy (...) surgery prior to randomization. Subject with history of cerebrovascular accident (including ischemic, embolic, and hemorrhagic cerebrovascular accident), transient ischemic attack, deep venous thrombosis (DVT; including proximal and distal), pulmonary or arterial embolism, arterial thrombosis or other venous thrombosis within 6 months prior to randomization Note: prior superficial thrombophlebitis is not an exclusion criterion. New-onset seizures or poorly controlled seizures within 12 weeks prior

2018 Clinical Trials

45. Period prevalence, risk factors and consequent injuries of falling among the Saudi elderly living in Riyadh, Saudi Arabia: a cross-sectional study. Full Text available with Trip Pro

to fall than those who did not. Participants who mentioned 'not having stressors were associated with less frequent falls (aOR 0.62; 95% CI 0.39 to 0.97). Cerebrovascular accidents were strongly associated with falls with an estimated OR of 2.75 (95% CI 1.18 to 6.43). Moreover, osteoporosis, poor vision and back pain were found to be predictors for falls among the elderly.49.9% of elderly Saudis had experienced one or more falls during a 12-month period. Several preventable risk factors could (...) . In addition, this study described the most common risk factors and consequent injuries of falls.A cross-sectional survey was carried out in Riyadh, using a convenient sampling. The targeted population were Saudi citizens who were 60 years or above. Over a 6-month period, 1182 individuals were sampled (545 men and 637 women).The 1-year prevalence of falling among old Saudis (>=60 years) was 49.9%. Our results show that 74% of the participants who experienced falls had postfall injuries. Old participants

2018 BMJ open

46. Ifetroban in Treating Patients With Malignant Solid Tumors at High Risk of Metastatic Recurrence

. Current symptomatic congestive heart failure (New York Heart Association > class II), unstable cardiac arrhythmia requiring therapy (e.g. medication or pacemaker), unstable angina (e.g. new, worsening or persistent chest discomfort), or uncontrolled hypertension (systolic > 160 mmHg or diastolic > 100mmHg). Or any of the following occurring within 6 months (180 days) prior to first dose of study drugs: Myocardial infarction, coronary/peripheral artery bypass graft, cerebrovascular accident (...) Ifetroban in Treating Patients With Malignant Solid Tumors at High Risk of Metastatic Recurrence Ifetroban in Treating Patients With Malignant Solid Tumors at High Risk of Metastatic Recurrence - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

47. Cardiovascular risk factors in adults with congenital heart defects - Recognised but not treated? An analysis of the German National Register for Congenital Heart Defects. (Abstract)

Defects was systematically screened for ACHD patients with established cardiovascular risk factors or documented acquired cardiovascular conditions. Data were analyzed with regard to the according medical treatment.Overall, 539 patients were included (mean age 38.4 ± 17.7 years, 49.2% female). Diabetes was present in 57 pts. (10.6%), arterial hypertension in 113 pts. (21.0%), hyperlipidaemia in 81 pts. (15.0%) and obesity in 271 pts. (50.2%). 31 pts. (5.8%) were smokers. Coronary artery disease (...) was established in 16 pts. (3.0%), peripheral vascular disease in 9 pts. (1.7%), and cerebrovascular accidents in 141 pts. (26.2%). Out of the patients with coronary artery disease only 81.3% received antithrombotic treatment. Only 18.8% were prescribed a statin. Of the pts. with peripheral arterial disease, 44.4% received an antiplatelet drug, and only 22.2% were on a statin. Patients with arterial hypertension received antihypertensive drugs in 66.4%.Primary and secondary prevention of acquired

2018 International journal of cardiology

48. A Phase Ib/IIa Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations

, laboratory abnormality, or psychiatric illness that would exclude the subject from participation or interfere with study treatment, monitoring and compliance such as: Unstable angina pectoris, symptomatic congestive heart failure (NYHA III or IV), myocardial infarction ≤ 6 months prior to first study drug, clinically significant and uncontrolled cardiac arrhythmia (e.g. atrial fibrillation/flutter ventricular cardiovascular physiology is allowed), cerebrovascular accidents ≤ 6 months before study drug (...) A Phase Ib/IIa Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations A Phase Ib/IIa Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study

2018 Clinical Trials

49. The Management of Dyslipidemia for Cardiovascular Risk Reduction (Lipids)

-to-severe systolic chronic heart failure (CHF), a limited life expectancy (LE) ( age 35 and women > age 45, including a lipid profile and a risk calculation. Strong For 2 A We recommend against routine screening for dyslipidemia outside of the context of a cardiovascular risk assessment. Strong Against 3 D For risk calculation, we suggest a 10-year risk calculator. Weak For 4 C We suggest that patients being considered for statin therapy be assessed for other CVD risk factors, including, but not limited (...) prevention. Comparative research studies are needed to clarify the role of statin dose in primary prevention. Assessment of Cardiovascular Risk and Pharmacotherapy for Primary Prevention (Patients without a history of ASCVD or ACS) Recommendations 1. We recommend CVD risk screening for men > age 35 and women > age 45, including a lipid profile and a risk calculation. Strong For 2. We recommend against routine screening for dyslipidemia outside of the context of a cardiovascular risk assessment. Strong

2014 VA/DoD Clinical Practice Guidelines

50. Cardiovascular risk assessment by FRS and SCORE in Iranian adult population Full Text available with Trip Pro

average 10-year risk of coronary artery disease (FRS) and 10-year risk of fatal coronary and cerebrovascular accidents (SCORE) in the 25 to 64 year-old population was 13.82 and 0.72 respectively. The relative frequency of the intermediate- and high- risk subjects was 25.8 and 22.6% based on FRS and 9.2 and 1.8% based on SCORE respectively. Average FRS and SCORE were significantly higher among men than women, but were not significantly different among urban and rural residents.A significant proportion (...) Cardiovascular risk assessment by FRS and SCORE in Iranian adult population Handling the growing epidemic of coronary heart disease in developing nations hinges on primary prevention, which logistically requires directing preventive interventions to those at the highest risk. Therefore, implementing cardiovascular risk assessment profiles is crucial to distinguish high risk groups who truly need extensive preventive measures. We aimed to draw a picture of the cardiovascular risk profiles

2017 Journal of diabetes and metabolic disorders

51. Effect of Tibet Rhodiola Capsule on Hypoxia and Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea

(GFR<30ml/min), moderate and severe chronic obstructive pulmonary disease, and pulmonary arterial hypertension; Patients with malignant tumors, lymphoma and neuropsychiatric disorders; Patients with major surgery or trauma within 3 months, and active bleeding or cerebrovascular accident within 6 months; History of anemia (hemoglobin<90g/L) or thrombocytopenia (thrombocyte <90×10^9/L); Breastfeeding, pregnant, or potentially fertile women; Patients who have known to be allergic to Tibet Rhodiola (...) Effect of Tibet Rhodiola Capsule on Hypoxia and Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea Effect of Tibet Rhodiola Capsule on Hypoxia and Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

52. A Safety and Efficacy Study of Pracinostat and Azacitidine in Patients With High Risk Myelodysplastic Syndromes

function criteria: Current unstable arrhythmia requiring treatment. History of symptomatic congestive heart failure (New York Heart Association [NYHA] Class III or IV). History of myocardial infarction, pulmonary embolism or cerebrovascular accident within 6 months of enrollment. Current unstable angina. Prior treatment for MDS with HDAC inhibitors Zolinza (vorinostat), Belenodaq (belinostat), Farydak (panobinostat), Istodax (romidepsin/depsipetide), or investigational agent with significant action (...) A Safety and Efficacy Study of Pracinostat and Azacitidine in Patients With High Risk Myelodysplastic Syndromes A Safety and Efficacy Study of Pracinostat and Azacitidine in Patients With High Risk Myelodysplastic Syndromes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

53. Active Surveillance With or Without Apalutamide Treatment in Low Risk Prostate Cancer

cancer in situ currently in complete remission) within 5 years prior to randomization Severe/unstable angina, myocardial infarction, symptomatic congestive heart failure, arterial or venous thromboembolic events (e.g., pulmonary embolism, cerebrovascular accident including transient ischemic attacks), or clinically significant ventricular arrhythmias within 6 months prior to randomization Uncontrolled hypertension (SBP≥160 mmHg or DBP≥90 mmHg). Patients with a history of uncontrolled hypertension (...) Active Surveillance With or Without Apalutamide Treatment in Low Risk Prostate Cancer Active Surveillance With or Without Apalutamide Treatment in Low Risk Prostate Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2017 Clinical Trials

54. Cardiovascular Disease Prevention in Women: Evidence-Based Guidelines For

per minute among women in the United States (6). These repre- sent 421,918 deaths, more women’s lives than were claimed by cancer, chronic lower respiratory disease, Alzheimer disease, and accidents combined (6). Reversing a trend of the past 4 decades, CHD death rates in U.S. women 35 to 54 years of age now actually appear to be increasing, likely because of the effects of the obesity epidemic (4). CVD rates in the United States are signi?cantly higher for black females compared with their white (...) to develop these guidelines is based on trials of CHD prevention. Future guidelines should consider recommenda- tions for speci?c outcomes of particular importance in women, such as stroke. Each year, 55,000 more women die of stroke than men, and before 75 years of age. Stroke accounts for a higher proportion of CVD events than CHD in females, whereas the ratio is the opposite for males. Women have unique risk factors for stroke such as pregnancy and hormone therapy, have a greater prevalence

2011 American College of Cardiology

55. MKSAP: 74-year-old woman with altered mental status

patients. Although she last took glimepiride more than 24 hours before her presentation with altered mental status, she was dehydrated, thus prolonging the glucose-lowering effects of this insulin secretagogue for several days. Although patients with diabetes are at increased risk for atherosclerotic cardiovascular disease, this patient does not have focal abnormalities suggesting a cerebrovascular accident, and stroke itself is not a common cause of isolated altered mental status. Levothyroxine also (...) but confused. Mucous membranes are dry. Her neck is supple. Cardiac examination reveals no murmurs. Her chest is clear to auscultation. Bowel sounds are present, and mild tenderness to palpation is noted throughout the abdomen. There is no rebound or guarding. There are no focal neurologic deficits. Laboratory studies are pending. Which of the following is the most likely cause of this patient’s altered mental status? A. Cerebrovascular accident B. Hypoglycemia C. Hypothyroidism D. Statin toxicity MKSAP

2017 KevinMD blog

56. anti10a Levels in Women Treated With LMWH in the Postpartum Period

Thromboembolism Drug: clexane (LMWH) Phase 4 Detailed Description: pregnancy and postpartum period are associated with increased risk of thromboembolism. this risk is further increased in women with thrombophilia. This risk is higher in the postpartum period compared with pregnancy period, especially the risk for pulmonary embolism (PE). The American College Of Obstetrics and Gynecologists, The American college of chest physicians and The Royal College of obstetricians and gynecologists recommend using low (...) molecular weight heparin during the postpartum period in women with thrombophilia and women with risk factor for developing thromboembolism. there is no specific guidelines regarding the best protocol based on the level of anti-10 a. This study will compare between two protocols based on anti-10a levels. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 116 participants Allocation: Randomized Intervention Model: Parallel Assignment

2016 Clinical Trials

57. Risk for cardiovascular disease early and late after a diagnosis of giant-cell arteritis: a cohort study. Full Text available with Trip Pro

Risk for cardiovascular disease early and late after a diagnosis of giant-cell arteritis: a cohort study. Involvement of large arteries is well-documented in giant-cell arteritis (GCA), but the risk for cardiovascular events is not well-understood.To evaluate the risks for incident myocardial infarction (MI), cerebrovascular accident (CVA), and peripheral vascular disease (PVD) in individuals with incident GCA in a general population context.Observational cohort study.U.K. primary care database (...) .3408 patients with incident GCA and 17 027 age- and sex-matched reference participants without baseline cardiovascular disease (MI, CVA, or PVD).Diagnoses of GCA, outcomes, and cardiovascular risk factors were identified from electronic medical records. One combined and 3 separate cohort analyses were conducted for the outcomes of MI, CVA, and PVD. The association of GCA with study outcomes is expressed with hazard ratios (HRs) with 95% CIs after adjustment for potential cardiovascular risk

2014 Annals of Internal Medicine

58. Cardiovascular Risk Prediction Models for People With Severe Mental Illness: Results From the Prediction and Management of Cardiovascular Risk in People With Severe Mental Illnesses (PRIMROSE) Research Program. Full Text available with Trip Pro

psychosis) aged 30 to 90 years. During a median follow-up of 5.6 years, 2324 CVD events (6.0%) occurred.Ten-year risk of the first cardiovascular event (myocardial infarction, angina pectoris, cerebrovascular accidents, or major coronary surgery). Predictors included age, sex, height, weight, systolic blood pressure, diabetes mellitus, smoking, body mass index (BMI), lipid profile, social deprivation, SMI diagnosis, prescriptions for antidepressants and antipsychotics, and reports of heavy alcohol (...) use.We developed 2 CVD risk prediction models for people with SMI: the PRIMROSE BMI model and the PRIMROSE lipid model. These models mutually excluded lipids and BMI. In terms of discrimination, from cross-validations for men, the PRIMROSE lipid model D statistic was 1.92 (95% CI, 1.80-2.03) and C statistic was 0.80 (95% CI, 0.76-0.83) compared with 1.74 (95% CI, 1.63-1.86) and 0.78 (95% CI, 0.75-0.82) for published Cox Framingham risk scores. The corresponding results in women were 1.87 (95% CI

2014 JAMA psychiatry (Chicago, Ill.)

59. Effect of Gender on the Risk of Neurologic Events and Subsequent Outcomes in Patients With Left Ventricular Assist Devices. (Abstract)

neurologic event on all-cause mortality by gender. Our study included 34 women and 157 men who received a HeartMate II LVAD at the University of Rochester Medical Center, Rochester, New York, from May 5, 2008, to June 5, 2014. Neurologic event was defined as a transient ischemic attack or cerebrovascular accident (hemorrhagic or ischemic). During a median follow-up of 25 months, 16 women (47%) and 20 men (13%) had neurologic events. Among patients with neurologic events, 7 women (44%) and 9 men (45 (...) Effect of Gender on the Risk of Neurologic Events and Subsequent Outcomes in Patients With Left Ventricular Assist Devices. Previous studies have shown that women with continuous-flow left ventricular assist devices (LVADs) are at greater risk of neurologic events. However, the relation between neurologic events and subsequent outcomes by gender is not well understood. We aimed to identify gender differences in the risk of neurologic events in patients with LVAD and the impact of time-dependent

2016 American Journal of Cardiology

60. CD4 Count in HIV- Brain Dead Donors: Insight into Donor Risk Assessment for HIV+ donors. (Abstract)

200 cells/μL; however, the numbers of circulating CD4+ cells in the HIV-negative (HIV-) brain-dead donor (BDD) is not known.Circulating T-lymphocyte subset profiles in conventional HIV- BDD were measured in 20 BDD in a clinical laboratory.The mean age of the BDD cohort was 48.7 years, 95% were white and 45% were women. The average body mass index was 29.2 kg/m. Cerebrovascular accident (40%) was the most prevalent cause of death. Sixteen (80%) subjects had a CD4 count ≤441 cells/μL (lower limit (...) CD4 Count in HIV- Brain Dead Donors: Insight into Donor Risk Assessment for HIV+ donors. The Human Immunodeficiency Virus (HIV) Organ Policy Equity Act allows for transplantation of organs from HIV-infected individuals (HIV+), provided it is performed under a research protocol. The safety assessment of an organ for transplantation is an essential element of the donation process. The risk for HIV-associated opportunistic infections increases as circulating CD4+ lymphocytes decrease to less than

2016 Transplantation

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