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Cerebral Spinal Fluid

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141. Blood Brain Barrier Permeability Could Be a Biomarker to Predict Severity of Neuromyelitis Optica Spectrum Disorders: A Retrospective Analysis Full Text available with Trip Pro

scores, anti-aquporin-4 immunoglobulin G titers, more dense cerebrospinal fluid protein concentrations, white blood cell counts, myelin basic protein levels and more dense complement 3 concentrations than found in the comparative normal BBB permeability group. The albumin index was positively correlated to the length of lesions in spinal cord. Conclusions: BBB permeability was associated with clinical features, laboratory results and radiological data of NMOSD patients, and may be a potential (...) Blood Brain Barrier Permeability Could Be a Biomarker to Predict Severity of Neuromyelitis Optica Spectrum Disorders: A Retrospective Analysis Background: Blood-brain barrier (BBB) pathology exists in neuromyelitis optica spectrum disorders (NMOSD). However, the clinical use of BBB permeability, such as predicting disease severity of NMOSD, has rarely been studied in a large cohort of patients. Objectives: The current study explored the association between BBB permeability and clinical

2018 Frontiers in neurology

142. A consistency evaluation of signal-to-noise ratio in the quality assessment of human brain magnetic resonance images Full Text available with Trip Pro

, T2 and contrast-enhanced T1 (T1C) weighted MR imaging sequences, respectively. To each imaging protocol, the consistency of SNR measurement is verified between and within two observers, and white matter (WM) and cerebral spinal fluid (CSF) are alternately used as the tissue region of interest (TOI) for SNR measurement. The procedure is repeated on another day within 30 days. At first, overlapped voxels in TOIs are quantified with Dice index. Then, test-retest reliability is assessed in terms (...) A consistency evaluation of signal-to-noise ratio in the quality assessment of human brain magnetic resonance images Quality assessment of medical images is highly related to the quality assurance, image interpretation and decision making. As to magnetic resonance (MR) images, signal-to-noise ratio (SNR) is routinely used as a quality indicator, while little knowledge is known of its consistency regarding different observers.In total, 192, 88, 76 and 55 brain images are acquired using T2*, T1

2018 BMC Medical Imaging

143. Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress Full Text available with Trip Pro

show an increased association between brain NE and mental health symptoms commonly observed after trauma, as compared to Veterans who did not report a history of trauma exposure, consistent with the possibility of increased brain reactivity to NE after traumatic stress.Using a convenience sample of 69 male Veterans with a history of combat-theater deployment, we examined the relationship between trauma-related mental health symptoms and the concentration of NE in cerebrospinal fluid (CSF). CSF NE (...) Evidence for altered brain reactivity to norepinephrine in Veterans with a history of traumatic stress Increases in the quantity or impact of noradrenergic signaling have been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). This increased signaling may result from increased norepinephrine (NE) release, from altered brain responses to NE, or from a combination of both factors. Here, we tested the hypothesis that Veterans reporting a history of trauma exposure would

2018 Neurobiology of stress

144. ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease

to ultrasound contrast agent or PET amyloid tracer History of a bleeding disorder History of liver disease Known cerebral or systemic vasculopathy Significant depression and at potential risk of suicide Any contraindications to MRI scanning Any contraindication to lumbar puncture for collection of cerebral spinal fluid Untreated, uncontrolled sleep apnea History of seizure disorder or epilepsy Severely Impaired renal function Currently in a clinical trial involving an investigational product or non-approved (...) ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2018 Clinical Trials

145. HER2-CAR T Cells in Treating Participants With Brain or Leptomeningeal Metastases

) in participants with brain and/or leptomeningeal metastases from HER2 positive cancers. SECONDARY OBJECTIVES: I. Assess cerebrospinal fluid (CSF) and peripheral blood for HER2-CAR T cell persistence and endogenous immune system activation. II. Describe changes in cytokine levels in the CSF and peripheral blood. III. Describe changes in circulating tumor cells in the CSF. IV. In study participants who complete at least the first three cycles of HER2-CAR T cell infusions: describe the CNS clinical benefit (...) has recurrent leptomeningeal metastases after intrathecal chemotherapy SCREENING: Participant has untreated brain or leptomeningeal metastases and refuses to undergo radiation and/or intrathecal chemotherapy Note: Participants with leptomeningeal metastasis (diagnosed by positive CSF cytology or characteristic findings on brain or spine magnetic resonance imaging [MRI]) may have concomitant brain metastases, but having both is not required SCREENING: Participant must have a Karnofsky performance

2018 Clinical Trials

146. Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

[ Time Frame: Up to 3 years ] Radiomic texture features and changes in features at diagnosis with pathology and over time will be included in various classifiers for modeling including decision trees, discriminate analysis, and nearest neighbor classifiers using classification learner in Matlab. Circulating tumor cell analysis [ Time Frame: Up to 3 years ] Cerebral spinal fluid analysis [ Time Frame: Up to 3 years ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing (...) Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

147. ExAblate Blood-Brain Barrier Opening for Treatment of Alzheimer's Disease

or systemic vasculopathy Significant depression and at potential risk of suicide Any contraindications to MRI scanning Any contraindication to lumbar puncture for collection of cerebral spinal fluid Untreated, uncontrolled sleep apnea History of seizure disorder or epilepsy Severely Impaired renal function Currently in a clinical trial involving an investigational product or non-approved use of a drug or device or in any other type of medical research Chronic pulmonary disorders Positive human (...) ExAblate Blood-Brain Barrier Opening for Treatment of Alzheimer's Disease ExAblate Blood-Brain Barrier Opening for Treatment of Alzheimer's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. ExAblate

2018 Clinical Trials

148. Brain Penetrance of 2-HOBA in Humans

Technologies Inc. Study Details Study Description Go to Brief Summary: The purpose of this study is to confirm that 2-HOBA crosses the blood brain barrier and to compare blood and cerebrospinal fluid levels of 2-HOBA after a single oral dose. Condition or disease Intervention/treatment Phase Healthy Adults Dietary Supplement: 2-HOBA Not Applicable Detailed Description: Consenting volunteers between 40 and 70 years old with no morbidity, including males, and females who are not pregnant will be recruited (...) to obtain cerebrospinal fluid and a blood sample will be collected. 2-HOBA levels will be measured in cerebrospinal fluid and blood samples from this timepoint to assess the ability or orally ingested 2-HOBA to cross the blood brain barrier. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 3 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Masking Description: The dietary supplement will be delivered

2018 Clinical Trials

149. Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease

performed surgery with the painful condition for over months Behavioral: pain evaluation collect CSF during spinal anesthesia Outcome Measures Go to Primary Outcome Measures : cytokine measurement in cerebrospinal fluid [ Time Frame: through study completion, an average of 1 year ] cytokine measurement ( via ELISA) in cerebrospinal fluid cytokine measurement in blood [ Time Frame: through study completion, an average of 1 year ] cytokine measurement (via ELISA) in blood Biospecimen Retention: Samples (...) Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2018 Clinical Trials

150. Posterior Associative and Cingulate Cortex Involvement of Brain Single-Photon Emission Computed Tomography (SPECT) Imaging in Semantic Dementia with Probable Alzheimer Disease Pathology: A Case Report Full Text available with Trip Pro

Alzheimer disease (AD), clinical diagnostic clues are not readily available. We present a characteristic finding based on a single-photon emission computed tomography (SPECT)-based regional cerebral blood flow study and its statistical imaging analysis for a rare case of SD with AD-like pathology. CASE REPORT A 61-year-old male was referred to our hospital due to difficulties in self-management and impaired comprehension of word meaning suggestive of SD. Although his brain MRI revealed mild frontal lobe (...) Posterior Associative and Cingulate Cortex Involvement of Brain Single-Photon Emission Computed Tomography (SPECT) Imaging in Semantic Dementia with Probable Alzheimer Disease Pathology: A Case Report BACKGROUND Semantic dementia (SD) is a type of primary progressive aphasia with prominent language dysfunction, mostly within the spectrum of frontotemporal lobar degeneration (FTLD). Although there is an overlap in clinical manifestations of SD attributable to FTLD and neuropathologically proven

2018 The American journal of case reports

151. Deferiprone for Ruptured Brain Aneurysm

of Iowa Study Details Study Description Go to Brief Summary: Ruptured cerebral aneurysms lead to subarachnoid hemorrhage (SAH),that has a high morbidity and mortality rate, the severity of which is predicted by the "Hunt-Hess grade" (HHG). SAH leads to iron (Fe) and hemoglobin (Hb) accumulation in the brain, which is toxic for neurons. Ferritin (iron reported in the brian) and iron overload leads to brain atrophy, specifically in the mesial temporal lobe (hippocampus, impairing patients' cognition (...) . It is estimated that 50% of survivors have cognitive deficits. Most of the survivors of SAH could not return to work. Iron chelation therapy has been recently gaining ground as a therapeutic intervention in intraparenchymal hemorrhage and in SAH. However, there has not been any study that assess the iron deposition in the brain and the level of ferritin in the cerebrospinal fluid of SAH patients. The investigators propose to conduct a randomized trial using Deferiprone (oral chelating agent, "De") + stadndard

2018 Clinical Trials

152. Congenital Aqueduct Stenosis: Progressive Brain Findings In Utero to Birth in the Presence of Severe Hydrocephalus. (Abstract)

% with 6% meeting the criteria for Chiari I malformation.Hydrocephalus in the fetus results in enlarging ventricular rupture, loss of the septum pellucidum leaflets, volume reduction of brain parenchyma including corpus callosum, and risk for Chiari I anomaly. Given advances in fetal surgery and imaging in the last 3 decades, there may be cause to revisit the idea of in utero cerebral spinal fluid diversion as a means to potentially ameliorate progressive loss of the developing brain.© 2018 John Wiley (...) Congenital Aqueduct Stenosis: Progressive Brain Findings In Utero to Birth in the Presence of Severe Hydrocephalus. To evaluate the effects of progressive hydrocephalus on the developing brain in a cohort of fetuses diagnosed with congenital aqueduct stenosis by comparing prenatal magnetic resonance imaging and postnatal imaging.This IRB approved single center retrospective review of prenatally diagnosed children with congenital aqueduct stenosis interrogated changes in the brain between

2018 Prenatal diagnosis

153. Reduced brain amyloid burden in elderly patients with narcolepsy type 1. (Abstract)

Reduced brain amyloid burden in elderly patients with narcolepsy type 1. To determine whether brain amyloid burden in elderly patients with narcolepsy type 1 (NT1) is lower than in controls, and to assess in patients with NT1 the relationships between amyloid burden, cerebral spinal fluid (CSF) markers of Alzheimer disease (AD), CSF orexin-A, and cognitive profile.Cognitive and 18 F-florbetapir positron emission tomography (PET) data were compared in patients with NT1 aged ≥ 65 years (n = 23 (...) group. In the NT1 group, cortical or regional amyloid load was not associated with CSF orexin-A, CSF AD biomarkers, or neuropsychological profile.Lower brain amyloid burden, assessed by 18 F-florbetapir PET, in patients with NT1 suggests delayed appearance of amyloid plaques. ANN NEUROL 2019;85:74-83.© 2018 American Neurological Association.

2018 Annals of Neurology

154. Treating Brain Swelling in Pediatric Cerebral Malaria

Treating Brain Swelling in Pediatric Cerebral Malaria Treating Brain Swelling in Pediatric Cerebral Malaria - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treating Brain Swelling in Pediatric Cerebral (...) of diffuse cerebral swelling is rapid. Mechanical ventilation may help to preserve life while diffuse brain swelling diminishes. Intravenous hypertonic saline may work as an osmotic diuretic, directly decreasing brain swelling. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 261 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description: Participants will be randomly assigned to one

2017 Clinical Trials

155. Chiari Type 1 Malformation-induced Intracranial Hypertension with Diffuse Brain Edema Treated with Foramen Magnum Decompression: A Case Report Full Text available with Trip Pro

edema with a focus on venous sinus assessment, and discuss the surgical strategy. A 24-year-old woman presented to Nagoya University Hospital complaining of 4-year history of severe occipital headache and blurry vision with slowly progressive worsening. Head and whole spine MRI showed a CM1 with diffuse white matter hyperintensities (WMH) on T2-weighted imaging and narrowed brain sulci without hydrocephalus. Lumbar puncture revealed extremely high opening pressure. Detailed blood examination (...) Chiari Type 1 Malformation-induced Intracranial Hypertension with Diffuse Brain Edema Treated with Foramen Magnum Decompression: A Case Report Chiari type 1 malformation (CM1) rarely causes papilloedema, which is indicative of high intracranial pressure with or without ventricular dilatation. Furthermore, concomitant brain parenchymal abnormalities have not been reported to date. In this paper, the authors report on a young woman of CM1-induced intracranial hypertension (ICH) with diffuse brain

2017 NMC Case Report Journal

156. Cerebrospinal fluid profiles with increasing number of cerebral microbleeds in a continuum of cognitive impairment. Full Text available with Trip Pro

Cerebrospinal fluid profiles with increasing number of cerebral microbleeds in a continuum of cognitive impairment. Cerebral microbleeds (CMBs) are hypothesised to have an important yet unknown role in the dementia disease pathology. In this study we analysed increasing number of CMBs and their independent associations with routine cerebrospinal fluid (CSF) biomarkers in a continuum of cognitive impairment. A total of 1039 patients undergoing dementia investigation were analysed and underwent (...) lumbar puncture, and an MRI scan. CSF samples were analysed for amyloid β (Aβ) 42, total tau (T-tau), tau phosphorylated at threonine 18 (P-tau) and CSF/serum albumin ratios. Increasing number of CMBs were independently associated with low Aβ42 levels, in the whole cohort, Alzheimer's disease and mild cognitive impairment (p < 0.05). CSF/serum albumin ratios were high with multiple CMBs (p < 0.001), reflecting accompanying blood-brain barrier dysfunction. T-tau and P-tau levels were lower

2015 Journal of Cerebral Blood Flow and Metabolism

157. Low cerebrospinal fluid protein in prepubertal children with idiopathic intracranial hypertension. (Abstract)

Low cerebrospinal fluid protein in prepubertal children with idiopathic intracranial hypertension. To evaluate a clinical observation that prepubertal children with idiopathic intracranial hypertension (IIH) have low cerebrospinal fluid (CSF) protein levels compared to healthy children and pubertal patients with IIH.The medical records of prepubertal and pubertal IIH patients and controls seen in the pediatric neuro-ophthalmology clinic at Duke between 2003 and 2013 were retrospectively (...) reviewed. The control group consisted of children who had normal intracranial pressure on lumbar puncture performed to evaluate for headaches or anomalous-looking optic nerves. The records were analyzed with attention to demographic characteristics, clinical presentation, course, and lumbar puncture results.A total of 23 prepubertal children with IIH (age range, 0.75-13 years), 16 pubertal patients with IIH (age range, 13-21 years), and 12 controls (age range 3-14 years) were included. CSF analysis

2015 JAAPOS - Journal of the American Association for Pediatric Ophthalmology and Strabismus

158. Risk factors for incidental durotomy during posterior open spine surgery for degenerative diseases in adults: A multicenter observational study. Full Text available with Trip Pro

Risk factors for incidental durotomy during posterior open spine surgery for degenerative diseases in adults: A multicenter observational study. Incidental durotomy (ID) is a common intraoperative complication of spine surgery. It can lead to persistent cerebrospinal fluid leakage, which may cause serious complications, including severe headache, pseudomeningocele formation, nerve root entrapment, and intracranial hemorrhage. As a result, it contributes to higher healthcare costs and poor (...) patient outcomes. The purpose of this study was to clarify the independent risk factors that can cause ID during posterior open spine surgery for degenerative diseases in adults. We conducted a prospective multicenter study of adult patients who underwent posterior open spine surgery for degenerative diseases at 10 participating hospitals from July 2010 to June 2013. A total of 4,652 consecutive patients were enrolled. We evaluated potential risk factors, including age, sex, body mass index, American

2017 PLoS ONE

159. Whorling-Sclerosing Variant Meningioma of the Spine: Surgical Management and Outcome of an Extremely Rare Case. (Abstract)

Whorling-Sclerosing Variant Meningioma of the Spine: Surgical Management and Outcome of an Extremely Rare Case. Case report OBJECTIVE.: To report surgical resection of multiple ventral cervical and thoracic lesion being diagnosed as whorling-sclerosing variant meningioma (WSM) and subsequent stabilization of cervicothoracic spine.WSM is a rare histopathology variant of meningioma which is mostly reported in brain and only one case of cervical spine WSM has been reported. Because of the rarity (...) antigen, cytokeratin, Olig-2 and S-100 and immunoactivity for progesterone receptor (PR) and glial fibrillary acidic protein in the tumoral cells located at the periphery. Ki-67 indexing was low.The spine multiple WSM is an extremely rare condition, which has a malignant behavior and it seems that it is spread by cerebrospinal fluid seeding. Surgical removal is hard and requires experience and appropriate equipment.4.

2018 Spine

160. Simultaneous Spinal and Intracranial Chronic Subdural Hematoma Cured by Craniotomy and Laminectomy: A Video Case Report Full Text available with Trip Pro

craniotomy, he complained of sensory disturbance on his buttocks. Lumbar MRI showed a space-occupying lesion behind the thecal sac at L5. CT with myelography showed a subdural mass lesion; there was no communication with the subarachnoid space. Fourteen days after craniotomy, L5 laminectomy was performed and the dura mater was incised carefully. The video shows that a liquid hematoma similar to the intracranial CSDH flowed out, followed by cerebrospinal fluid. His symptoms improved after the operation (...) Simultaneous Spinal and Intracranial Chronic Subdural Hematoma Cured by Craniotomy and Laminectomy: A Video Case Report Simultaneous spinal and intracranial chronic subdural hematoma (CSDH) is a rare entity. A 67-year-old man visited our hospital due to headache after diving into a river 2 weeks before. Non-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) revealed bilateral intracranial CSDH. The bilateral CSDH was evacuated and his symptoms improved. Three days after

2016 Case reports in neurology

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