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Cerebral Spinal Fluid

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141. Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative update (PubMed)

Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative update Human cerebral spinal fluid (CSF) is known to be a rich source of small molecule biomarkers for neurological and neurodegenerative diseases. In 2007, we conducted a comprehensive metabolomic study and performed a detailed literature review on metabolites that could be detected (via metabolomics or other techniques) in CSF. A total of 308 detectable metabolites were identified

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2012 Genome medicine

142. The Rilpivirine Cerebrospinal-fluid (CSF) Study

Levels [ Time Frame: Day 60 ] The levels of rilpivirine will be measured in the cerebral spinal fluid and plasma after 60 days of exposure Secondary Outcome Measures : Number of Subjects With HIV Viral Load Above 50 Copies Per mL [ Time Frame: Day 3,14, 28, 60, 80-100 ] Plasma viral load will be measured at all study visits to assess if viral load is above the lower limit of detection (50 copies mL) Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate (...) The Rilpivirine Cerebrospinal-fluid (CSF) Study The Rilpivirine Cerebrospinal-fluid (CSF) Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Rilpivirine Cerebrospinal-fluid (CSF) Study The safety

2012 Clinical Trials

143. Cerebrospinal Fluid (CSF) Biomarkers Alzheimer's Disease (AD) and Non-AD Dementias

Those with non-Alzheimer's disease dementia Healthy elderly volunteers Outcome Measures Go to Primary Outcome Measures : Ratio of CSF tau to Aβ42 (tau/Aβ42) [ Time Frame: CSF will be collected at Visit 1 (up to 30 days after the screening visit) ] CSF will be collected in clinic and shipped frozen to Merck's Clinical Development Lab for testing. Any remaining samples will be kept up to 20 years. Biospecimen Retention: Samples With DNA Blood, urine and cerebral spinal fluid. Eligibility Criteria Go (...) Cerebrospinal Fluid (CSF) Biomarkers Alzheimer's Disease (AD) and Non-AD Dementias Cerebrospinal Fluid (CSF) Biomarkers Alzheimer's Disease (AD) and Non-AD Dementias - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2012 Clinical Trials

144. Adult-Onset Cerebral Folate Deficiency. (PubMed)

Adult-Onset Cerebral Folate Deficiency. To report new manifestations of cerebral folate deficiency, a rare metabolic autoimmune syndrome,in an adult.Case report.University teaching hospital.A 58-year-old woman with progressive memory loss and myoclonus presented for medical attention. Results of cerebral spinal fluid analysis showed low levels of tetrahydrobiopterin and 5-methyltetrahydrofolate. The patient's serum folate level was normal. Serum contained folate receptor 1 blocking and binding (...) antibodies.The patient was treated successfully with folinic acid supplementation, and after 6 months of treatment,clinical symptoms had resolved.To our knowledge, we report the first case of adult-onset cerebral folate deficiency. Furthermore, this condition could represent a treatable form of early-onset dementia.

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2012 Archives of Neurology

145. Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury

: Massachusetts General Hospital Information provided by (Responsible Party): Brian P. Walcott, Massachusetts General Hospital Study Details Study Description Go to Brief Summary: Cerebral edema is seen heterogenous group of neurological disease states that mainly fall under the categories of metabolic, infectious, neoplasia, cerebrovascular, and traumatic brain injury disease states. Regardless of the driving force, cerebral edema is defined as the accumulation of fluid in the brain's intracellular (...) Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2012 Clinical Trials

146. Cerebral Ventricle

: Cerebral Ventricle , Ventricular Anatomy , Third Ventricle , Fourth Ventricle , Lateral Ventricle , Cerebral Aqueduct , Cerebral Choroid Plexus , Aqueduct of Sylvius , Middle Foramen of Magendie , Lateral Foramena of Luschka , Cerebrospinal Flow II. Definitions Plexus Produces cerebrospinal fluid in the walls of the Cerebral Ventricles III. Pathophysiology Occurs when CSF flow is obstructed, leading to expansion of the Lateral Ventricles IV. Anatomy: Cerebrospinal spinal fluid pathway Lateral (...) ) The four connected cavities (hollow spaces) centrally located within the brain that connect posteriorly with the central canal of the spinal cord. Definition (MSH) Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE). Definition (CSP) cavities within the brain which are filled with cerebrospinal fluid, including the two lateral, the third, and linked

2015 FP Notebook

147. Does Ultrasound Guidance Improve Time to Perform a Spinal or Number of Attempts in Obese Patients?

the spinal [ Time Frame: From the beginning of palpation or ultrasound to free flow of Cerebral Spinal Fluid (CSF), up to 1 hour. ] Secondary Outcome Measures : Time from administration of the local anesthetic needle until free flow CSF [ Time Frame: Up to 1 hour ] Number of needle redirections [ Time Frame: At time of spinal anesthetic administration ] Number of attempts to complete the spinal [ Time Frame: At time of spinal anesthetic administration ] As measured by new needle puncture sites, according (...) Does Ultrasound Guidance Improve Time to Perform a Spinal or Number of Attempts in Obese Patients? Does Ultrasound Guidance Improve Time to Perform a Spinal or Number of Attempts in Obese Patients? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2012 Clinical Trials

148. High Thoracic/Cervical Epidural Blood Patch for Spontaneous Cerebrospinal Fluid Leak: A New Challenge for Anesthesiologists. (PubMed)

High Thoracic/Cervical Epidural Blood Patch for Spontaneous Cerebrospinal Fluid Leak: A New Challenge for Anesthesiologists. Spontaneous cerebral spinal fluid leakage is increasingly recognized as a cause of headache due to low intracranial pressure. The site of leakage can be identified with radionuclide cisternography, and anesthesiologists are increasingly requested to provide epidural blood patch for their management. This series of case reports demonstrates some of the issues relating

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2011 Anesthesia and Analgesia

149. Constitution of Cerebrospinal Fluid and Blood Database/Specimen in Acute Stage of Subarachnoid Hemorrhage (aSAH) Patients

Constitution of Cerebrospinal Fluid and Blood Database/Specimen in Acute Stage of Subarachnoid Hemorrhage (aSAH) Patients Constitution of Cerebrospinal Fluid and Blood Database/Specimen in Acute Stage of Subarachnoid Hemorrhage (aSAH) Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Constitution of Cerebrospinal Fluid and Blood Database/Specimen in Acute Stage of Subarachnoid Hemorrhage (aSAH) Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01292278 Recruitment Status : Unknown Verified

2011 Clinical Trials

150. A Pharmacokinetic Study to Characterize JNJ-39393406 in the Cerebrospinal Fluid of Healthy Volunteers

. Placebo Comparator: Placebo Drug: Placebo Form= oral suspension, Route= oral administration. Oral suspension to be taken once with 240 mL (8 ounces of water) between 8:00 AM and 10:30 AM. Outcome Measures Go to Primary Outcome Measures : Plasma concentration of JNJ39393406 [ Time Frame: At 0:30, 1, 1:30, 2, 2:30, 3, 3:30, 4, 6, 8, 10, 12, 16, 20 and 24 hours post dose ] Cerebral spinal fluid (CSF) concentration of JNJ39393406 [ Time Frame: At 0:30, 1, 1:30, 2, 2:30, 3, 3:30, 4, 6, 8, 10, 12, 16, 20 (...) ( EudraCT Number ) First Posted: March 16, 2012 Last Update Posted: July 24, 2013 Last Verified: July 2013 Keywords provided by Johnson & Johnson Pharmaceutical Research & Development, L.L.C.: Healthy volunteers JNJ-39393406-aaa Pharmacokinetics Central brain penetrance Cerebral spinal fluid

2011 Clinical Trials

151. Measuring Signatures in the Fluid Surrounding the Spinal Cord in Patients Who Have Problems With Intrathecal Drug Delivery

First Posted : May 5, 2010 Results First Posted : November 18, 2013 Last Update Posted : May 30, 2017 Sponsor: MedtronicNeuro Information provided by (Responsible Party): MedtronicNeuro Study Details Study Description Go to Brief Summary: The purpose of this study is to record signatures from the fluid surrounding the spinal cord from people who have an implanted drug infusion system. Condition or disease Cerebral Palsy Multiple Sclerosis Traumatic Brain Injury Spinal Cord Injury Detailed (...) Measuring Signatures in the Fluid Surrounding the Spinal Cord in Patients Who Have Problems With Intrathecal Drug Delivery Measuring Signatures in the Fluid Surrounding the Spinal Cord in Patients Who Have Problems With Intrathecal Drug Delivery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2010 Clinical Trials

152. Association of Brain Damage with Therapeutic Abortion Induced by Amniotic-fluid Replacement: Report of Two Cases (PubMed)

effects Adult Amniotic Fluid Blood-Brain Barrier Brain Edema etiology Cerebral Arteries Cerebral Hemorrhage etiology pathology Cerebrospinal Fluid Dehydration etiology Drainage adverse effects Female Humans Hypertonic Solutions adverse effects Intracranial Embolism and Thrombosis etiology Pregnancy Sodium Chloride adverse effects Spinal Cord pathology 1966 4 23 1966 4 23 0 1 1966 4 23 0 0 ppublish 5909844 PMC1844440 J Neurosurg. 1962 Oct;19:859-64 13975061 AMA J Dis Child. 1956 Dec;92(6):562-75 (...) Association of Brain Damage with Therapeutic Abortion Induced by Amniotic-fluid Replacement: Report of Two Cases 5909844 1966 06 26 2018 11 13 0007-1447 1 5494 1966 Apr 23 British medical journal Br Med J Association of brain damage with therapeutic abortion induced by amniotic-fluid replacement: report of two cases. 1010-3 Cameron J M JM Dayan A D AD eng Journal Article England Br Med J 0372673 0007-1447 0 Hypertonic Solutions 451W47IQ8X Sodium Chloride AIM IM Abortion, Therapeutic adverse

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1966 British medical journal

153. The development of the human cerebrospinal fluid pathway with particular reference to the roof of the fourth ventricle. (PubMed)

The development of the human cerebrospinal fluid pathway with particular reference to the roof of the fourth ventricle. 4187088 1970 01 02 2018 11 13 0021-8782 105 Pt 3 1969 Nov Journal of anatomy J. Anat. The development of the human cerebrospinal fluid pathway with particular reference to the roof of the fourth ventricle. 467-75 Brocklehurst G G eng Journal Article England J Anat 0137162 0021-8782 IM Brain Stem anatomy & histology embryology Cerebellum anatomy & histology embryology Cerebral (...) Ventricles anatomy & histology embryology Cerebrospinal Fluid Choroid Plexus anatomy & histology Female Gestational Age Humans Pregnancy Spinal Dysraphism etiology Staining and Labeling 1969 11 1 1969 11 1 0 1 1969 11 1 0 0 ppublish 4187088 PMC1232183 Acta Radiol Diagn (Stockh). 1966;5:1013-23 5333987 Anat Rec. 1965 May;152:9-16 14316824 Am J Anat. 1953 Nov;93(3):365-95 13104337 J Anat. 1938 Jan;72(Pt 2):181-215 17104684 J Anat. 1937 Oct;72(Pt 1):23-53 17104678 Brain. 1961 Sep;84:514-20 14473930 J Anat

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1969 Journal of anatomy

154. Spontaneous canine hydrocephalus: cerebrospinal fluid dynamics (PubMed)

of the choroid villi. The formation and absorption of CSF were studied by perfusion of the cerebral ventricles. The rate of formation of CSF was found to decrease with perfusion pressure by V(f) = 0·02595-0·00022 P ml./min (P = pressure in cm H(2)O). The absorption of spinal fluid was found to increase linearly with pressure by V(a) = 0·0165 + 0·00050 P. The various factors influencing the formation and absorption of the spinal fluid are discussed. The meaning and attainment of `arrest' of the hydrocephalic (...) Spontaneous canine hydrocephalus: cerebrospinal fluid dynamics Cerebrospinal fluid dynamics were studied in 14 dogs with spontaneous hydrocephalus. In nine of the dogs aqueductal obstruction was observed and the remainder had a `communicating type' hydrocephalus. The major histological findings consisted of severe ependymal destruction, spongy changes in the periventricular white matter, increased density of capillaries in this area, and varying degrees of thickening, fibrosis, and fusion

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1971 Journal of neurology, neurosurgery, and psychiatry

155. Alpha-amino nitrogen in cerebrospinal fluid and its alterations in meningitis, multiple sclerosis, and some other neurological disorders (PubMed)

in lumbar cerebrospinal fluid and in plasma.Alpha-amino nitrogen was also estimated in 79 samples of fluid from patients with meningitis, cerebral tumour, multiple sclerosis, and other neurological disorders. High concentrations were found in meningitis, spinal block, and xanthochromic fluids. In cerebral tumours, the concentrations were mostly normal. Low concentrations were found in children, in many cases of multiple sclerosis, and in benign intracranial hypertension. In some cases, the changes (...) Alpha-amino nitrogen in cerebrospinal fluid and its alterations in meningitis, multiple sclerosis, and some other neurological disorders The concentration of alpha-amino nitrogen (a measure of total amino-acids) was estimated in 58 samples of cerebrospinal fluid in which other findings were normal. Values for lumbar and ventricular cerebrospinal fluid in adults, and lumbar cerebrospinal fluid in children, are reported. A relationship was found between the concentrations of alpha-amino nitrogen

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1965 Journal of Clinical Pathology

156. Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy (PubMed)

in cerebral ALD (C-ALD) if performed early. In contrast, for advanced patients the risk of morbidity and mortality is increased with transplantation. To date there is no means of quantitating neuroinflammation in C-ALD, nor is there an accepted measure to determine prognosis for more advanced patients.As cellular infiltration has been observed in C-ALD, including activation of monocytes and macrophages, we evaluated the activity of chitotriosidase in the plasma and spinal fluid of boys with active C-ALD (...) Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder characterized by the abnormal beta-oxidation of very long chain fatty acids (VLCFA). In 35-40% of children with ALD, an acute inflammatory process occurs in the central nervous system (CNS) leading to demyelination that is rapidly progressive, debilitating and ultimately fatal. Allogeneic hematopoietic stem cell transplantation (HSCT) can halt disease progression

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2011 Journal of neuroinflammation

157. Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors

: Baseline and 6 months ] Cerebrospinal fluid (CSF) routine parameters will be analyzed by the Central Laboratory. Results will then be provided to the investigator. For determination of τ, phospho-τ, β−amyloid 1 40 and β−amyloid 1 42, 5 ml of cerebral-spinal-fluid will be analyzed at the laboratories of the German Center for Neurodegenerative Diseases (DZNE), Biomarker Dementia Working Group, Sigmund-Freud-Str. 25, 53105 Bonn Eligibility Criteria Go to Information from the National Library of Medicine (...) Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors Long-term Cognitive and Cerebral Changes in Sepsis Survivors and Their Predictors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2011 Clinical Trials

158. Changes in Cerebral Function in Treatment Naive HIV-1 Infected Subjects Commencing Either Boosted Atazanavir With Truvada or Boosted Darunavir With Maraviroc and Kivexa

with the evolution of NC function impairment is the direct effect of cART on the central-nervous-system (CNS). Certain antiretroviral drugs such as zidovudine, lamivudine, abacavir, nevirapine, efavirenz and indinavir are known to achieve optimal exposure in the cerebro-spinal-fluid (CSF) whereas other drugs, such as the majority of the HIV-1 protease inhibitors penetrate less effectively. Studies to date suggest different cART regimens may have differing effects on NC performance. In the EuroSIDA study, the use (...) Changes in Cerebral Function in Treatment Naive HIV-1 Infected Subjects Commencing Either Boosted Atazanavir With Truvada or Boosted Darunavir With Maraviroc and Kivexa Changes in Cerebral Function in Treatment Naive HIV-1 Infected Subjects Commencing Either Boosted Atazanavir With Truvada or Boosted Darunavir With Maraviroc and Kivexa - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search

2011 Clinical Trials

159. Evaluation of Ultrasound (US) Assistance for Anesthesia Trainees for Caesarean Section Spinal Placement

Name: M-turbo No Intervention: Control Control group. (Standard practice) Trainees will NOT receive pre-procedure U/S guided examination. Outcome Measures Go to Primary Outcome Measures : Number of attempts at intrathecal needle tip placement during spinal anesthesia. [ Time Frame: Day 1 ] Secondary Outcome Measures : 1. Time to place spinal anesthetic (seconds), measured from introducer placement to confirmation of cerebral spinal fluid (CSF). [ Time Frame: Day 1 ] Space used for 1st attempt (...) Evaluation of Ultrasound (US) Assistance for Anesthesia Trainees for Caesarean Section Spinal Placement Evaluation of Ultrasound (US) Assistance for Anesthesia Trainees for Caesarean Section Spinal Placement - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2011 Clinical Trials

160. INDUCED RESISTANCE OF THE CENTRAL NERVOUS SYSTEM TO EXPERIMENTAL INFECTION WITH EQUINE ENCEPHALOMYELITIS VIRUS : I. NEUTRALIZING ANTIBODY IN THE CENTRAL NERVOUS SYSTEM IN RELATION TO CEREBRAL RESISTANCE (PubMed)

INDUCED RESISTANCE OF THE CENTRAL NERVOUS SYSTEM TO EXPERIMENTAL INFECTION WITH EQUINE ENCEPHALOMYELITIS VIRUS : I. NEUTRALIZING ANTIBODY IN THE CENTRAL NERVOUS SYSTEM IN RELATION TO CEREBRAL RESISTANCE 1. Neutralizing antibody to equine encephalomyelitis virus was found in the spinal fluid of rabbits sufficiently vaccinated with active or formalin-inactivated virus. Antibody was specific for the Western or for the Eastern virus. 2. Neutralizing capacity of spinal fluid was equivalent (...) to that of a 1/300 dilution of serum of the same animal, and was of the same order of magnitude as that of perfused brain of a vaccinated animal. 3. Vaccinated rabbits which showed antibody in the spinal fluid resisted intracerebral or intracisternal injection of active virus. This immunity was specific, i.e., there was no cross-reaction between the Eastern and Western virus after vaccination with formalin-inactivated virus. On the other hand, lack of antibody in the spinal fluid, even when antibody

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1942 The Journal of experimental medicine

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