How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

5,399 results for

Cerebral Spinal Fluid

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Childhood Brain Stem Glioma Treatment (PDQ®): Health Professional Version

frequently.[ ] Anatomy Anatomy of the inside of the brain, showing the pineal and pituitary glands, optic nerve, ventricles (with cerebrospinal fluid shown in blue), and other parts of the brain. The posterior fossa is the region below the tentorium, which separates the cortex from the cerebellum and essentially denotes the region containing the brain stem, cerebellum, and fourth ventricle. Clinical Features Children with DIPG may present with the following classic triad of symptoms; however, children (...) intracranial pressure with associated hydrocephalus. Unilateral hemiparesis. Unilateral cranial neuropathies. Ataxia. Diagnosis Primary tumors of the brain stem are most often diagnosed on the basis of clinical findings and on neuroimaging studies using magnetic resonance imaging (MRI), as follows:[ ] DIPG. A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained

2017 PDQ - NCI's Comprehensive Cancer Database

122. Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease

Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary (...) Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease

2012 Clinical Trials

123. Influence of incidental dural tears and their primary microendoscopic repairs on surgical outcomes in patients undergoing microendoscopic lumbar surgery. (Abstract)

Influence of incidental dural tears and their primary microendoscopic repairs on surgical outcomes in patients undergoing microendoscopic lumbar surgery. Dural tear represents a common complication of microendoscopic spine surgery that may lead to postoperative sequelae including insufficient decompression, cerebrospinal fluid fistula, intracranial hypotension and subdural/intraparenchymal bleeding. The gold standard to manage intraoperative dural tears is primary repair. However, the downside (...) of prospectively enrolled patients using a propensity-matched analysis.A total of 922 consecutive patients underwent microendoscopic surgery of the lumbar spine between February and December 2012 in the three institutions belonging to our study group.Outcome measures included the Numeric Rating Scale for back and leg pain, Oswestry Disability Index, Japanese Orthopaedic Association score, Short Form-36 and a patients' satisfaction scale.All incidental dural tears were repaired by microendoscopic suture

2019 The Spine Journal

124. Posterior reversible encephalopathy syndrome with lumbar drainage and surgery: coincidence or correlation? A case report. Full Text available with Trip Pro

Posterior reversible encephalopathy syndrome with lumbar drainage and surgery: coincidence or correlation? A case report. Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disorder usually associated with specific medical conditions that cause a disturbance of the CNS homeostasis. It has seldom been reported to be a consequence of an iatrogenic intervention causing intracranial hypotension.We report the case of an individual 69-year-old male presenting with headache (...) and blurred vision following cerebrospinal fluid (CSF) leak from resection of a sellar mass. The patient developed the condition following removal of the lumbar drain post-operatively. Magnetic Resonance Imaging showed bilateral occipital, parieto-occipital, and cerebellar T2 FLAIR hyper-intensities, suggesting a radiological diagnosis of posterior reversible encephalopathy syndrome (PRES). The patient's symptoms started to improve shortly afterwards and had completely resolved at 3 months follow-up.The

2019 BMC Neurology

125. Cerebral microbleeds topography and cerebrospinal fluid biomarkers in cognitive impairment. Full Text available with Trip Pro

Cerebral microbleeds topography and cerebrospinal fluid biomarkers in cognitive impairment. Cerebral microbleeds, a marker of small vessel disease, are thought to be of importance in cognitive impairment. We aimed to study topographical distribution of cerebral microbleeds, and their involvement in disease pathophysiology, reflected by cerebrospinal fluid biomarkers; 1039 patients undergoing memory investigation underwent lumbar puncture and a brain magnetic resonance imaging scan (...) . Cerebrospinal fluid samples were analyzed for amyloid β(Aβ)42, total tau(T-tau), tau phosphorylated at threonine 18(P-tau) and cerebrospinal fluid/serum albumin ratios. Magnetic resonance imaging sequences were evaluated for small vessel disease markers, including cerebral microbleeds, white matter hyperintensities and lacunes. Low Aβ42 levels were associated with lobar cerebral microbleeds in the whole cohort and Alzheimer's disease ( P < 0.001). High cerebrospinal fluid/serum albumin ratios were seen

2016 Journal of Cerebral Blood Flow and Metabolism

126. Neonatal Enterovirus Infection: Case Series of Clinical Sepsis and Positive Cerebrospinal Fluid Polymerase Chain Reaction Test with Myocarditis and Cerebral White Matter Injury Complications Full Text available with Trip Pro

neonatal intensive care unit (NICU) by cerebral spinal fluid (CSF) reverse transcriptase polymerase chain reaction (PCR) testing for EV in neonates suspected to have sepsis, but with sterile bacterial cultures. Results Cases were identified in each of three sequential years in a NICU with 800 to 900 admissions/year. Two cases were likely acquired perinatally; all were symptomatic with lethargy and poor feeding by age 5 to 10 days. All had signs of sepsis and/or meningitis; one progressed (...) Neonatal Enterovirus Infection: Case Series of Clinical Sepsis and Positive Cerebrospinal Fluid Polymerase Chain Reaction Test with Myocarditis and Cerebral White Matter Injury Complications Objective We describe five neonates with enteroviral (EV) infection to demonstrate central nervous system (CNS) and cardiac complications and report successful treatment of myocarditis with immunoglobulin intravenous (IVIG) in two. Study Design Case series identified during three enteroviral seasons in one

2016 AJP Reports

127. Osmolality of Cerebrospinal Fluid from Patients with Idiopathic Intracranial Hypertension (IIH) Full Text available with Trip Pro

Osmolality of Cerebrospinal Fluid from Patients with Idiopathic Intracranial Hypertension (IIH) Idiopathic intracranial hypertension (IIH) is a disorder of increased intracranial fluid pressure (ICP) of unknown etiology. This study aims to investigate osmolality of cerebrospinal fluid (CSF) from patients with IIH.We prospectively collected CSF from individuals referred on suspicion of IIH from 2011-2013. Subjects included as patients fulfilled Friedman and Jacobson's diagnostic criteria for IIH (...) . Individuals in whom intracranial hypertension was refuted were included as controls. Lumbar puncture with ICP measurement was performed at inclusion and repeated for patients after three months of treatment. Osmolality was measured with a Vapor Pressure Osmometer.We collected 90 CSF samples from 38 newly diagnosed patients and 28 controls. At baseline 27 IIH-samples and at 3 months follow-up 35 IIH-samples were collected from patients. We found no significant differences in osmolality between 1) patients

2016 PloS one

128. Application of time-spatial labeling inversion pulse magnetic resonance imaging in the diagnosis of spontaneous intracranial hypotension due to high-flow cerebrospinal fluid leakage at C1-2 Full Text available with Trip Pro

Application of time-spatial labeling inversion pulse magnetic resonance imaging in the diagnosis of spontaneous intracranial hypotension due to high-flow cerebrospinal fluid leakage at C1-2 Spontaneous intracranial hypotension (SIH) due to cerebrospinal fluid (CSF) leakage at C1-2 poses diagnostic and therapeutic challenges to spine surgeons. Although computed tomography (CT) myelography has been the diagnostic imaging modality of choice for identifying the CSF leakage point, extradural CSF

2016 Surgical neurology international

129. Diagnosis and treatment of spontaneous intracranial hypotension due to cerebrospinal fluid leakage Full Text available with Trip Pro

Diagnosis and treatment of spontaneous intracranial hypotension due to cerebrospinal fluid leakage Spontaneous intracranial hypotension is one of the causes of a postural headache in young people. In this study, the diagnosis and treatment results of a case of intracranial hypotension headache due to spinal cerebrospinal fluid leakage were reported. Up to now, there is not absolutely effective treatment for intracranial hypotension headache.A 32-year-old woman complained, a headache after (...) such as infection etc. were observed. A small dose of intrathecal gadolthis is the first reported case ofinium during CEMRM allows for improved detection of CSF leakage.Leakage of spinal CSF is a major cause of spontaneous intracranial hypotension. In order to improve clinical diagnosis and provide effective treatment, the precise etiology of spontaneous intracranial hypotension should be investigated in each patient.

2016 SpringerPlus

130. Real-time optic nerve sheath diameter reduction measured with bedside ultrasound after therapeutic lumbar puncture in a patient with idiopathic intracranial hypertension. (Abstract)

Real-time optic nerve sheath diameter reduction measured with bedside ultrasound after therapeutic lumbar puncture in a patient with idiopathic intracranial hypertension. Idiopathic intracranial hypertension (IIH), also referred to as pseudotumor cerebri, is a condition of raised intracranial pressure (ICP) with unknown etiology. Sonographic measurement of optic nerve sheath diameter (ONSD) has been shown to be a reliable, noninvasive method to characterize elevated ICP in a variety of settings (...) . However, little is known about the immediate response of ONSD to an acute reduction in ICP after lumbar puncture. We describe a case of an emergency department patient with IIH in whom we identified real-time change in ONSD correlated with a decrease in cerebrospinal fluid pressure after a therapeutic lumbar puncture. Ocular ultrasound and ONSD measurements were performed by a trained provider using a 9- to 13-MHz linear transducer and an ultrasound machine with ocular software package and low

2015 American Journal of Emergency Medicine

131. Effects of Opioid Antagonism on Cerebrospinal Fluid Melanocortin Peptides and Cortisol Levels in Humans Full Text available with Trip Pro

by POMC neurons. The opioid antagonist naltrexone (NTX) stimulates POMC neurons in rodents and decreases food intake.The effect of NTX on brain POMC in humans was assessed by measuring POMC peptide concentrations in lumbar cerebrospinal fluid (CSF). AgRP and cortisol levels were also measured because both are inhibited by opioids. In a double-blinded crossover study, 14 healthy subjects were given NTX (50 mg daily) or placebo for either 2 or 7 days.CSF β-EP levels increased after 2 and 7 days of NTX (...) Effects of Opioid Antagonism on Cerebrospinal Fluid Melanocortin Peptides and Cortisol Levels in Humans Hypothalamic proopiomelanocortin (POMC) is processed to α-melanocyte-stimulating hormone, which interacts with the melanocortin antagonist agouti-related protein (AgRP), to regulate energy balance. The POMC-derived opioid peptide β-endorphin (β-EP) also affects feeding behavior via interactions with brain µ-opioid receptors (MORs), including autoinhibitory interactions with MOR expressed

2017 Journal of the Endocrine Society Controlled trial quality: uncertain

132. THE CEREBRO-SPINAL FLUID IN INTRACRANIAL INFLAMMATION Full Text available with Trip Pro

THE CEREBRO-SPINAL FLUID IN INTRACRANIAL INFLAMMATION 20775045 2011 03 31 2011 03 31 0007-1447 2 3592 1929 Nov 09 British medical journal Br Med J THE CEREBRO-SPINAL FLUID IN INTRACRANIAL INFLAMMATION. 841-2 Greenfield J G JG eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1929 11 9 0 0 1929 11 9 0 1 ppublish 20775045 PMC2452476

1929 British medical journal

133. Estimation of 5-hydroxytryptamine (5-HT) level in cerebrospinal fluid of patients with intracranial or spinal lesions. Full Text available with Trip Pro

Estimation of 5-hydroxytryptamine (5-HT) level in cerebrospinal fluid of patients with intracranial or spinal lesions. 6034108 1967 10 12 2019 02 06 0022-3050 30 2 1967 Apr Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Estimation of 5-hydroxytryptamine (5-HT) level in cerebrospinal fluid of patients with intracranial or spinal lesions. 163-5 Misra S S SS Singh K S KS Bhargava K P KP eng Journal Article England J Neurol Neurosurg Psychiatry 2985191R 0022 (...) -3050 0 Tryptamines 333DO1RDJY Serotonin 54-16-0 Hydroxyindoleacetic Acid 8DUH1N11BX Tryptophan IM Cerebrovascular Disorders cerebrospinal fluid Chromatography, Paper Humans Hydroxyindoleacetic Acid cerebrospinal fluid Paraplegia cerebrospinal fluid Quadriplegia cerebrospinal fluid Serotonin cerebrospinal fluid Tryptamines cerebrospinal fluid Tryptophan cerebrospinal fluid 1967 4 1 1967 4 1 0 1 1967 4 1 0 0 ppublish 6034108 PMC496156 Nature. 1960 Jul 23;187:324 13792237 J Neurosurg. 1957 Jan;14(1

1967 Journal of neurology, neurosurgery, and psychiatry

134. A Case of Traumatic Cerebral Abscess: Trephining: Free: Discharge of Cerebro-Spinal Fluid: Recovery Full Text available with Trip Pro

A Case of Traumatic Cerebral Abscess: Trephining: Free: Discharge of Cerebro-Spinal Fluid: Recovery 20753318 2011 03 29 2011 03 29 0007-1447 1 1584 1891 May 09 British medical journal Br Med J A Case of Traumatic Cerebral Abscess: Trephining: Free: Discharge of Cerebro-Spinal Fluid: Recovery. 1015-6 Southam F A FA eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1891 5 9 0 0 1891 5 9 0 1 ppublish 20753318 PMC2273029

1891 British medical journal

135. Brain Energy for Amyloid Transformation in Alzheimer's Disease Study

interventions induce changes in cognitive function, cerebral blood flow, and levels of certain proteins and hormones in body fluids. The study will include volunteers who have mild cognitive impairment, who will be randomly assigned to receive either a ketogenic low-carbohydrate diet or a low-fat diet for 16-weeks, with follow-up assessment 8 weeks after diet completion. Study measures, clinic visits and phone sessions will occur at baseline and throughout the 24-week study. Group 2 will include volunteers (...) : low fat/high carbohydrate diet American Heart Association Diet is a low fat/high carbohydrate diet. Outcome Measures Go to Primary Outcome Measures : Cerebrospinal Fluid (CSF) Abeta42 [ Time Frame: 16 Weeks ] CSF Aβ42 is a a key AD biomarker that reflects pathological aggregation of amyloid in the brain. Secondary Outcome Measures : CSF abeta42/ptau ratio [ Time Frame: 16 Weeks ] The ratio of CSF Aβ42 to tau is a key AD biomarker that reflects an integrated value of amyloid and tau pathology

2018 Clinical Trials

136. Evaluation of Safety and Efficacy of Patients With Four and More Symptomatic Brain Metastases of Melanoma

Metastatic histologically confirmed melanoma that is unresectable Presence of > 3 active brain metastases confirmed/evaluated by MRI Measurable disease by MRI per iRANO and RECIST 1.1 criteria The time between the baseline MRI and the date of registration should not exceed 28 days. Steroid treatment is permissible before brain MRI evaluation but the dose should have been stable for at least 7 days and should be carefully documented Patient must agree to the cerebro-spinal fluid (CSF) collections (...) Control Rate after 6 months of treatment [ Time Frame: 6 months ] Proportion of patients with complete intracranial responses (CR), partial intracranial responses (PR) or stable intracranial disease (SD) after 6 months of treatment. Secondary Outcome Measures : Overall survival [ Time Frame: 2 years ] Number of patients who stay alive after 2 years. Progression-free survival [ Time Frame: 2 years ] Number of patients without progression after 2 years. Stereotactic irradiation or surgery of brain

2018 Clinical Trials

137. Sex-specific alterations in preterm brain. Full Text available with Trip Pro

. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures.There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical (...) Sex-specific alterations in preterm brain. The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age.The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants

2018 Pediatric Research

138. A Case of Diffuse Leptomeningeal Glioneuronal Tumor Misdiagnosed as Chronic Tuberculous Meningitis without Brain Biopsy Full Text available with Trip Pro

of tuberculosis in our country, similarity in MRI finding of prominent leptomeningeal enhancement in the basal cisterns, and extreme rarity of DLGNT in the elderly. DLGLT should be considered in differential diagnosis of medical conditions presenting as communicating hydrocephalus with prominent leptomeningeal enhancement. A timely histologic diagnosis through a leptomeningeal biopsy of the brain and spinal cord in case of unusual leptomeningeal enhancement with uncertain laboratory findings is essential (...) A Case of Diffuse Leptomeningeal Glioneuronal Tumor Misdiagnosed as Chronic Tuberculous Meningitis without Brain Biopsy Here we report a rare case of diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 62-year-old male patient misdiagnosed as having tuberculous meningitis. Due to its rarity and radiologic findings of leptomeningeal enhancement in the basal cisterns on magnetic resonance imaging (MRI) similar to tuberculous meningitis, DLGNT in this patient was initially diagnosed

2018 Case reports in neurological medicine

139. Polymorphonuclear (PMN) elastase in patients after severe traumatic brain injury Full Text available with Trip Pro

Polymorphonuclear (PMN) elastase in patients after severe traumatic brain injury Data on PNM elastase levels in cerebrospinal fluid following traumatic brain injury (TBI) in humans are not available in the literature. Therefore, the aim of this prospective study was to evaluate the dynamics of PMN elastase in the cerebrospinal fluid (CSF) of patients after TBI.Patients suffering from isolated, closed TBI, presenting with an initial Glasgow coma score ≤ 8 and with intracerebral hemorrhage (...) on the initial cranial computed tomography scan (performed within 90 min after TBI) were enrolled. CSF and blood samples were obtained immediately, 12 h, 24 h, 48 h, and 72 h after admission. ELISA testing was used to quantify the PMN elastase levels in CSF. In addition, the ratio of CSF albumin to serum albumin was calculated to evaluate the role of the blood-cerebrospinal fluid barrier (BCSFB). As controls, CSF samples were taken from patients receiving spinal anesthesia for elective orthopedic surgery

2018 European Journal Of Medical Research

140. Salivary MicroRNAs: Diagnostic Markers of Mild Traumatic Brain Injury in Contact-Sport Full Text available with Trip Pro

Salivary MicroRNAs: Diagnostic Markers of Mild Traumatic Brain Injury in Contact-Sport Concussion is difficult to diagnose, particularly when symptoms are atypical or late in presenting. An accurate and timely initial assessment is crucial for clinical management. Cerebral spinal fluid (CSF) and blood markers of traumatic brain injury show promising results but their clinical applicability in concussion has significant limitations. In the study, we explored saliva as a new source of biomarkers

2018 Frontiers in molecular neuroscience

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>