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Cerebral Spinal Fluid

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101. The Passage of Penicillins into the Cerebro-Spinal Fluid and Brain in Experimental Meningitis: Experimental Investigations on Rabbits Full Text available with Trip Pro

The Passage of Penicillins into the Cerebro-Spinal Fluid and Brain in Experimental Meningitis: Experimental Investigations on Rabbits 14252871 1996 12 01 2018 12 01 0032-5473 40 1964 Dec Postgraduate medical journal Postgrad Med J THE PASSAGE OF PENICILLINS INTO THE CEREBRO-SPINAL FLUID AND BRAIN IN EXPERIMENTAL MENINGITIS--EXPERIMENTAL INVESTIGATIONS ON RABBITS. SUPPL:112-9 LITHANDER A A eng Journal Article England Postgrad Med J 0234135 0032-5473 0 Penicillins OM Animals Brain Cerebrospinal (...) Fluid Humans Meningitis Metabolism Penicillins Pharmacology Rabbits Research BRAIN CEREBROSPINAL FLUID EXPERIMENTAL LAB STUDY MENINGITIS METABOLISM PENICILLIN PHARMACOLOGY RABBITS 1964 12 1 1964 12 1 0 1 1964 12 1 0 0 ppublish 14252871 PMC2483085

1964 Postgraduate medical journal

102. Brain Stem and Entire Spinal Leptomeningeal Dissemination of Supratentorial Glioblastoma Multiforme in a Patient during Postoperative Radiochemotherapy: Case Report and Review of the Literatures. Full Text available with Trip Pro

seeding, although the exact incidence is not known as postmortem examination of the spine is not routinely performed. Herein, we present a rare case of symptomatic brain stem and entire spinal dissemination of GBM in a 36-year-old patient during postoperative adjuvant radiochemotherapy with temozolomide and cisplatin. Visual deterioration, intractable stomachache, and limb paralysis were the main clinical features. The results of cytological and immunohistochemical tests on the cerebrospinal fluid (...) Brain Stem and Entire Spinal Leptomeningeal Dissemination of Supratentorial Glioblastoma Multiforme in a Patient during Postoperative Radiochemotherapy: Case Report and Review of the Literatures. Glioblastoma multiforme (GBM) is the most common primary malignancy of the central nervous system in adults. Macroscopically evident and symptomatic spinal metastases occur rarely. Autopsy series suggest that approximately 25% of patients with intracranial GBM have evidence of spinal subarachnoid

2015 Medicine

103. Clinically Achievable Voriconazole, Posaconazole, and Itraconazole Concentrations within the Bloodstream and Cerebral Spinal Fluid: A Reference Laboratory Experience. Full Text available with Trip Pro

Clinically Achievable Voriconazole, Posaconazole, and Itraconazole Concentrations within the Bloodstream and Cerebral Spinal Fluid: A Reference Laboratory Experience. Interest in antifungal therapeutic-drug monitoring has increased due to studies demonstrating associations between concentrations and outcomes. We reviewed the antifungal drug concentration database at our institution to gain a better understanding of achievable triazole drug levels. Antifungal concentrations were measured by high (...) -performance liquid chromatography (HPLC), ultraperformance liquid chromatography and single-quadrupole mass spectrometry (UPLC/MS), or a bioassay. For this study, only confirmed human bloodstream (serum or plasma) and cerebral spinal fluid (CSF) concentrations of voriconazole, posaconazole, and itraconazole were analyzed. The largest numbers of bloodstream and CSF samples were found for voriconazole (14,370 and 173, respectively). Voriconazole bloodstream concentrations within the range of 1 to 5.5 μg/ml

2013 Antimicrobial Agents and Chemotherapy

104. AIUM Practice Parameter for the Performance of an Ultrasound Examination of the Neonatal and Infant Spine

. Detection of sequelae, such as: a. Hematoma following injury, such as birth injury; b. Infection or hemorrhage secondary to prior instrumentation, such as lumbar puncture; and c. Posttraumatic leakage of cerebrospinal fluid (CSF); 5. Visualization of blood products within the spinal canal in patients with intracranial hem- orrhage; 6. Guidance for lumbar puncture 11 ; and 7. Postoperative assessment for cord retethering. 12 Dimples associated with a high risk of occult spinal dysraphism include those (...) Page 4Upright positioning can be used for image guidance of lumbar puncture or to depict meningo- celes or pseudomeningoceles. Anterior meningoceles or presacral masses can also be scanned from an anterior position, usually through a fluid-filled bladder. The vertebral bodies and posterior elements can be evaluated for deformities. Open posterior elements in skin-covered dysraphic defects can be documented on transverse views. VI. Documentation Adequate documentation is essential for high-quality

2016 American Institute of Ultrasound in Medicine

105. Subarachnoid Hemorrhage Presenting with Seizure due to Cerebrospinal Fluid Leakage after Spinal Surgery Full Text available with Trip Pro

Subarachnoid Hemorrhage Presenting with Seizure due to Cerebrospinal Fluid Leakage after Spinal Surgery Cerebrospinal fluid leakage may commonly occur during spinal surgeries and it may cause dural tears. These tears may result in hemorrhage in the entire compartments of the brain. Most common site of such hemorrhages are the veins in the cerebellar region. We report a case of hemorrhage, mimicking aneurysmal subarachnoid hemorrhage due to a cerebrospinal fluid leakage following lumbar spinal

2016 Journal of Korean Neurosurgical Society

106. The Relief of Unilateral Painful Thoracic Radiculopathy without Headache from Remote Spontaneous Spinal Cerebrospinal Fluid Leak Full Text available with Trip Pro

The Relief of Unilateral Painful Thoracic Radiculopathy without Headache from Remote Spontaneous Spinal Cerebrospinal Fluid Leak Spontaneous intracranial hypotension (SIH) caused by spontaneous spinal cerebrospinal fluid (CSF) leaks produces orthostatic headaches. Although upper arm pain or paresthesia is reportedly associated with SIH from spontaneous spinal CSF leak in the presence of orthostatic headache, low thoracic radicular pain due to spontaneous spinal CSF leak unassociated (...) with postural headache is extremely rare. We report a 67-year-old female who presented with chronic, positional radicular right T11 pain. Computed tomography myelography showed a spontaneous lumbar spinal CSF leak at L2-3 and repeated lumbar epidural blood patches significantly alleviated chronic, positional, and lower thoracic radiculopathic pain. The authors speculate that a chronic spontaneous spinal CSF leak not severe enough to cause typical orthostatic headache or epidural CSF collection may cause

2016 Pain research & management

107. Management of Traumatic Brain Injury

with orthopedic procedures. Timing of spine fracture- dislocation surgery should depend on spine stability and the need for emergent spinal decompression in patients with spinal cord injury. In patients with intractable intracranial hypertension, consideration should be given to delaying trips to the operating room unless life-saving procedures are required. Open laparotomy or open thoracotomy should be performed when needed, with adherence to the same general principles of avoiding secondary brain injury (...) it is both diagnostic (measures ICP) and therapeutic (allows for drainage of cerebrospinal fluid (CSF) Elevated ICP is predictive of poor outcome. Furthermore, cerebral perfusion pressure (CPP), a parameter derived from ICP (Mean Arterial Pressure – ICP), is an important marker of cerebral blood flow; augmenting CPP can help to restore cerebral perfusion and oxygenation. In addition to enabling CPP measurement, ICP monitoring can provide advanced warning of impending structural brain derangements

2015 American College of Surgeons

108. Intrathecal cytotoxic chemotherapy: administration via a lumbar puncture or Ommaya reservoir

chemotherapy): nausea and vomiting altered neurological status infection arachnoiditis (inflammation of arachnoid lining caused by infection) ( ). The arachnoid layer is one of the three layers of the brain and spinal cord headache reduced white and red cell blood count medication formulary treatment protocol patient's medical notes with current dated treatment protocol manufacturer's drug information (if required) intrathecal medication and prescription sterile dressing pack alcohol-based antiseptic (...) ChloraPrep®, 2% chlorhexidine in 70% isopropyl alcohol Or alternative (see ). Allow to dry ( ). Insert a lumbar puncture needle and collect 20 drops of cerebrospinal fluid (CSF) ( ). Connect syringe containing chemotherapy to lumbar puncture needle, and inject slowly. Repeat process for double and triple injections. No flush is required between these medicines ( ). Remove the needle and syringe when the administration is complete. Apply pressure with gauze pad when CSF has stopped leaking. Spray with Op

2015 Publication 1593

109. Assessment of blood-brain barrier integrity and neuroinflammation in preeclampsia. (Abstract)

, in women with preeclampsia.We performed an observational case-control study in pregnant women >24 weeks gestation, undergoing spinal anesthesia for elective cesarean delivery or combined spinal epidural analgesia for labor. Cases were women with preeclampsia and controls were women with either healthy pregnancy, chronic hypertension, or gestational hypertension. Paired samples of blood, urine and cerebrospinal fluid were collected from each subject before delivery. We measured albumin, C5a, C5b-9, TNF (...) -α, and IL-6 concentrations in plasma and cerebrospinal fluid, and albumin, C5a, and C5b-9 concentrations in urine, using colorimetric or enzyme linked immunosorbent assays. The ratio of albumin in cerebrospinal fluid to plasma (Qalb) was used as a surrogate for maternal blood-brain barrier integrity. Cerebrospinal fluid concentrations of C5a, C5b-9, TNF-α, and IL-6 were used as surrogate markers of neuroinflammation. Differences in Qalb and cerebrospinal fluid protein concentrations between

2019 American Journal of Obstetrics and Gynecology

110. Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer's disease. (Abstract)

Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer's disease. Alzheimer's disease (AD) is the most common age-associated dementia. Many studies have sought to predict cerebral amyloid deposition, the major pathological hallmark of AD, using body fluids such as blood or cerebral spinal fluid (CSF). The use of blood in diagnostic procedures is widespread in medicine; however, existing blood biomarkers for AD remain unreliable. We sought to discover blood biomarkers (...) that discriminate Aβ deposition status in the brain. This study used 107 individuals who were cognitively normal (CN), 107 patients with mild cognitive impairment (MCI), and 40 AD patients with Pittsburg compound B positron emission tomography (PiB-PET) amyloid imaging data available. We found five plasma biomarker candidates via mass spectrometry (MS) based-proteomic analysis and validated these proteins using enzyme-linked immunosorbent assay (ELISA). Our integrated models were highly predictive of brain

2019 Progress in Neurobiology

111. Bihemispheric Cerebral Oximetry Monitoring's Functionality in Suspected Cerebral Edema Diabetic Ketoacidosis With Therapeutic 3% Hyperosmolar Therapy in a Pediatric Emergency Department. (Abstract)

). In pediatrics, rcSO2 of less than 60% or rcSO2 of greater than 85% reflects increased ICP and cerebral edema (Crit Care Med 2006;34:2217-2223, J Pediatr 2013;163: 1111-1116, Curr Med Chem 2009;16:94-112, Diabetologia 1985;28:739-742, Pediatr Crit Care Med 2013;14:694-700). Cerebral oximetry can detect increased ICP-induced altered bihemispheric cerebral physiology (rcSO2, CBVI) and cerebral physiological changes (rcSO2, CBVI changes) during therapeutic mechanical cerebral spinal fluid removal to decrease (...) ketoacidosis has been associated with initial diabetic ketoacidosis (DKA) presentation and at start of DKA therapy.Cerebral oximetry (bihemispheric regional cerebral oxygen saturation [rcSO2] and cerebral blood volume index [CBVI]) can detect increased intracranial pressure (ICP)-induced altered bihemispheric cerebral physiology (rcSO2) (Crit Care Med 2006;34:2217-2223, J Pediatr 2013;163: 1111-1116, Curr Med Chem 2009;16:94-112, Diabetologia 1985;28:739-742, Pediatr Crit Care Med 2013;14:694-700

2019 Pediatric Emergency Care

112. Validation of a Physiological Based Pharmacokinetic Model by the Study of Paracetamol Distribution in the Brain Compartments in Brain Injured Patients

drugs in cerebro spinal fluid (CSF) and in extracellular fluid (ECF) of brain tissue, making the development and optimization of dosing regimen of new drugs difficult. Most dosing regimen are determined from the plasma concentration because target site concentrations are difficult to obtain in the brain, hence making the prediction of the therapeutic effect, the adverse effect and the toxicity of a brain- diffused drug difficult. Although quantitative and qualitative differences exist (...) in tissue in both animal and human including cerebral tissue in rat and human. Recommendation from the scholar society suggests that brain injured patients should benefit from a multimodal monitoring to optimize their care and brain perfusion. This invasive multimodal monitoring consists of measuring the intracranial pressure, the oxygen tissue-pressure, the estimation of the cerebral blood flow-rate by cranial Doppler as well as the monitoring of cerebral ischemic parameters by microdialysis. We also

2017 Clinical Trials

113. The frequency and severity of intracranial hypotension post-intraoperative lumbar drainage using a Tuohy needle and the traditional needle. (Abstract)

The frequency and severity of intracranial hypotension post-intraoperative lumbar drainage using a Tuohy needle and the traditional needle. Background Intraoperative lumbar cerebrospinal fluid (CSF) drainage is a well-recognised technique in cranial and vascular surgery. The goal of the study was to assess the frequency and severity of intracranial hypotension post-intraoperative lumbar drainage performed using two different techniques, a 14G Tuohy needle versus an 18G traditional needle (...) . Methods The medical records and imaging studies of 94 patients who had undergone open cranial operation were retrospectively studied: 47 patients had intraoperative lumbar drainage and 47 patients did not. A 14G Tuohy needle was employed in 27 (57.4%) patients and an 18G traditional needle was employed in 20 (42.6%) patients. Results There were signs of intracranial hypotension on MR images in nine (19.1%) patients who had intraoperative lumbar CSF drainage; none of the patients in the control group

2016 British Journal of Neurosurgery

114. Intracranial subdural empyema after surgery for lumbar lipomyelomeningocele: A rare complication Full Text available with Trip Pro

Intracranial subdural empyema after surgery for lumbar lipomyelomeningocele: A rare complication Surgery is routinely recommended for lumbar lipomyelomeningocele, especially in the setting of tethered cord syndrome. The most common complications are wound infections and cerebrospinal fluid (CSF) leak, which remain confined to the surgical site. To the best of our knowledge, there have been no prior reports relating an intracranial subdural empyema following detethering surgery. Prompt diagnosis (...) of an external ventricular drain (EVD) secondary to persistent wound leakage. A subsequent magnetic resonance imaging (MRI) brain was carried out due to protracted irritability, which revealed extensive left subdural empyema along the parietooccipital region and the inferior and anterior temporal lobe. He underwent evacuation of the subdural empyema where cultures exhibited no growth. Subsequently, he progressed well. His lumbar incision continued to heal. Serial MRI brains and inflammatory markers were

2016 Surgical neurology international

115. A Possible Role for Temporary Lumbar Drainage in the Management of Idiopathic Intracranial Hypertension Full Text available with Trip Pro

A Possible Role for Temporary Lumbar Drainage in the Management of Idiopathic Intracranial Hypertension This paper reports 14 patients with idiopathic intracranial hypertension (IIH) who experienced immediate and sustained resolution of their IIH; 13 in the setting of a low-pressure headache and 1 who underwent lumbar drainage for 4 days draining the cerebrospinal fluid (CSF) at a rate of 5-15 mL/h. These observations, if confirmed, suggest that draining CSF using a temporary lumbar drain

2016 Neuro-Ophthalmology

116. Role of cerebral spinal fluid (CSF) flow measured by magnetic resonance imaging (MRI) as a diagnostic biomarker of Normal Pressure Hydrocephalus (NPH)

Role of cerebral spinal fluid (CSF) flow measured by magnetic resonance imaging (MRI) as a diagnostic biomarker of Normal Pressure Hydrocephalus (NPH) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2015 PROSPERO

117. Cerebral Spinal Fluid

Cerebral Spinal Fluid Cerebral Spinal Fluid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cerebral Spinal Fluid Cerebral Spinal (...) Fluid Aka: Cerebral Spinal Fluid , CSF II. Definitions Cerebrospinal Fluid Clear, colorless fluid produced in the plexus within the walls of the s Flows through the s within the subarachnoid space Surrounds and protects the brain and spinal cord III. Physiology Plexus: Formation of CSF Tufts of capillaries in s Produces CSF at 20 ml/hour (up to 500 ml/day) Pathway See for CSF flows down Magendie and Luschka canals and via subarachnoid space around the brain and spinal cord CSF Reabsorption CSF

2015 FP Notebook

118. Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury

increase in cell death and more significant neurological disability. Limiting tissue hypoperfusion post-injury can decrease the amount of cell death and axonal damage. Lumbar cerebrospinal fluid drainage (CSFD) together with increased mean arterial blood pressure (MAP) in the immediate post-injury period can reduce spinal cord tissue hypoperfusion. By reducing spinal cord hypoperfusion through elevation of MAP, less cell death and axonal damage will occur, leading to an improvement in neurological (...) Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cerebrospinal Fluid Drainage

2015 Clinical Trials

119. Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen Full Text available with Trip Pro

Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen 58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed antifungal therapy. Serum Cryptococcus antigen titer decreased. He had a full

2015 Case reports in infectious diseases

120. Childhood Brain Stem Glioma Treatment (PDQ®): Health Professional Version

frequently.[ ] Anatomy Anatomy of the inside of the brain, showing the pineal and pituitary glands, optic nerve, ventricles (with cerebrospinal fluid shown in blue), and other parts of the brain. The posterior fossa is the region below the tentorium, which separates the cortex from the cerebellum and essentially denotes the region containing the brain stem, cerebellum, and fourth ventricle. Clinical Features Children with DIPG may present with the following classic triad of symptoms; however, children (...) intracranial pressure with associated hydrocephalus. Unilateral hemiparesis. Unilateral cranial neuropathies. Ataxia. Diagnosis Primary tumors of the brain stem are most often diagnosed on the basis of clinical findings and on neuroimaging studies using magnetic resonance imaging (MRI), as follows:[ ] DIPG. A presumptive diagnosis of DIPG based on classic imaging features, in the absence of a histologic diagnosis, has been routinely employed. Increasingly however, histologic confirmation is obtained

2017 PDQ - NCI's Comprehensive Cancer Database

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