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Cerebral Spinal Fluid

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81. Starling resistors, autoregulation of cerebral perfusion and the pathogenesis of Idiopathic Intracranial Hypertension. (PubMed)

Starling resistors, autoregulation of cerebral perfusion and the pathogenesis of Idiopathic Intracranial Hypertension. Two critical functions for the control of intracranial fluids dynamics are carried on the venous side of the perfusion circuit: the first is the avoidance of cortical veins collapse during the physiological increases of cerebrospinal fluid (CSF) pressure in which they are immersed. The second, is the generation of an abrupt venous pressure drop at the confluence of the cortical (...) requires that the walls of the dural sinuses are rigid enough to avoid the collapse under the external cerebrospinal fluid pressure, and predicts that in the presence of excessively flexible dural sinuses, the system admits a second point of balance between cerebral fluid pressure and dural sinus pressure, at higher values. The second balance state is due to the triggering of a self-limiting venous collapse feedback loop between the CSF pressure, that compresses the sinus, and the subsequent increase

2016 Panminerva medica

82. Imaging Features of the Brain, Cerebral Vessels and Spine in Pediatric Tuberculous Meningitis with Associated Hydrocephalus. (PubMed)

the difficulty of lumbar puncture and correlated with high cerebrospinal fluid protein content.TBM involves extensive pathology in the central nervous system. Severe infarction was predictive of poor outcome although this was not the case for angiographic abnormalities. Spinal disease occurs commonly and has important implications for diagnosis and treatment. Comprehensive imaging of the brain, spine and cerebral vessels adds insight into disease pathophysiology. (...) Imaging Features of the Brain, Cerebral Vessels and Spine in Pediatric Tuberculous Meningitis with Associated Hydrocephalus. Pediatric tuberculous meningitis (TBM) leads to high rates of mortality and morbidity. Prompt diagnosis and initiation of treatment are challenging; imaging findings play a key role in establishing the presumptive diagnosis. General brain imaging findings are well reported; however, specific data on cerebral vascular and spinal involvement in children are sparse.This

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2016 Pediatric Infectious Dsease Journal

83. A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations (PubMed)

task and hypercapnia using the measurement of baseline apparent R2' as a calibration technique. Further, in order to examine the effects of cerebral spinal fluid (CSF) signal contamination on the measurement of apparent R2', we examined the effects of measuring this parameter with and without CSF-nulling. We found that the two calibration techniques provided consistent estimates of the metabolic response on average, with a median R2'-based estimate of the metabolic response to CO2 of 1.4%, and R2 (...) A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations Calibrated blood oxygenation level dependent (BOLD) imaging is a multimodal functional MRI technique designed to estimate changes in cerebral oxygen metabolism from measured changes in cerebral blood flow and the BOLD signal. This technique addresses fundamental ambiguities associated with quantitative BOLD signal analysis; however, its dependence on biophysical modeling

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2016 NeuroImage

84. Cerebral Ventricle

: Cerebral Ventricle , Ventricular Anatomy , Third Ventricle , Fourth Ventricle , Lateral Ventricle , Cerebral Aqueduct , Cerebral Choroid Plexus , Aqueduct of Sylvius , Middle Foramen of Magendie , Lateral Foramena of Luschka , Cerebrospinal Flow II. Definitions Plexus Produces cerebrospinal fluid in the walls of the Cerebral Ventricles III. Pathophysiology Occurs when CSF flow is obstructed, leading to expansion of the Lateral Ventricles IV. Anatomy: Cerebrospinal spinal fluid pathway Lateral (...) ) The four connected cavities (hollow spaces) centrally located within the brain that connect posteriorly with the central canal of the spinal cord. Definition (MSH) Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE). Definition (CSP) cavities within the brain which are filled with cerebrospinal fluid, including the two lateral, the third, and linked

2018 FP Notebook

85. Paraplegia caused by cerebral contusions in the bilateral precentral gyri (PubMed)

testing of his legs revealed improvements. In the subacute phase, the precentral gyrus lesion disappeared on MRI.We must emphasize that cerebral contusion can be a differential diagnosis for paraplegia. In the acute phase, fluid-attenuated inversion recovery (FLAIR) MRI coronal and sagittal images are useful for identifying precentral gyri contusions. Paraplegia caused by a cerebral contusion may be misdiagnosed as a spinal concussion due to the disappearance of the precentral gyrus lesion on FLAIR (...) Paraplegia caused by cerebral contusions in the bilateral precentral gyri Paraplegia is mainly caused by spinal cord disease and rarely occurs due to head trauma. In this report, we describe a case of paraplegia caused by cerebral contusions in the bilateral precentral gyri.A 72-year-old man was admitted to our hospital with mildly impaired consciousness and severe pure motor paralysis in both legs. He was healthy until the morning of the day, but his wife found him injured in front of his

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2016 Surgical neurology international

86. Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery

Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02925611 Recruitment Status : Unknown Verified October 2016

2016 Clinical Trials

87. Epidural Volume Extension During Combined Spinal-Epidural Labor Analgesia Does Not Increase Sensory Block. (PubMed)

Epidural Volume Extension During Combined Spinal-Epidural Labor Analgesia Does Not Increase Sensory Block. Combined spinal-epidural (CSE) analgesia is widely used for delivering labor analgesia. Epidural volume extension (EVE) involves the injection of fluid into the epidural space compressing the dural sac, causing cephalad shift of the cerebral spinal fluid. Our hypothesis was that EVE with 10 mL normal saline during CSE would increase the sensory block height at 15 minutes after intrathecal

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2016 Anesthesia and Analgesia

88. Sudden Sensorineural Hearing Loss after Orthopedic Surgery under Combined Spinal and Epidural Anesthesia (PubMed)

Sudden Sensorineural Hearing Loss after Orthopedic Surgery under Combined Spinal and Epidural Anesthesia Postoperative hearing loss following nonotologic surgery is rare. For patients undergoing subarachnoid anesthesia, the loss of cerebral spinal fluid and hence the drop in intracranial pressure can result in hearing loss and cranial nerve palsy. We report a case in which a patient sustained orthopedic surgery under combined spinal and epidural anesthesia complicated by severe and persistent

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2016 Case reports in otolaryngology

89. Cognitive and structural cerebral changes in amnestic mild cognitive impairment due to Alzheimer's disease after multicomponent training (PubMed)

Cognitive and structural cerebral changes in amnestic mild cognitive impairment due to Alzheimer's disease after multicomponent training Information about how physical exercise affects patients with amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD) is still missing. This study evaluated the impact of multicomponent exercise training on cognition and brain structure in aMCI subjects with cerebral spinal fluid positive AD biomarkers.Forty aMCI subjects were divided

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2018 Alzheimer's & dementia : translational research & clinical interventions

90. Dynamics of the cerebrospinal fluid and the spinal dura mater (PubMed)

Dynamics of the cerebrospinal fluid and the spinal dura mater DURING MYELOGRAPHY WE OBSERVED THE CONTRAST MATERIAL IN THE SPINAL SUBARACHNOID SPACE WHILE WE CHANGED: (1) the intracranial blood volume by CO(2) inhalation, hyperventilation, and jugular vein compression; (2) the intra-abdominal and intrathoracic pressure by forced expiration with glottis closed; and (3) the CSF volume by withdrawals and reinjections of fluid. The spinal dural sac enlarges with increases in volume of both (...) in response to changes in cerebral blood flow. By its bladder-like ability to alter its capacity, the spinal dural sac provides the `elasticity' of the covering of the central nervous system.

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1972 Journal of neurology, neurosurgery, and psychiatry

91. Ventilatory Acclimatization to Moderate Hypoxemia in Man: THE ROLE OF SPINAL FLUID [H+] (PubMed)

Ventilatory Acclimatization to Moderate Hypoxemia in Man: THE ROLE OF SPINAL FLUID [H+] This study has assessed the regulation of arterial blood and cerebrospinal fluid (CSF) pH and thereby their contribution to the control of breathing in normal man during various stages of ventilatory acclimatization to 3,100 m altitude. CSF acid-base status was determined: (a) from measurements of lumbar spinal fluid during steady-state conditions of chronic normoxia (250 m altitude) and at + 8 h and + 3-4 (...) wk of hypobaric hypoxia; and (b) from changes in cerebral venous P(CO2) at + 1 h hypoxic exposure. After 3-4 wk at 3,100 m, CSF [H(+)] remained significantly alkaline to values obtained in either chronic normoxia or with 1 h hypoxic exposure and was compensated to the same extent ( approximately 66%) as was arterial blood [H(+)]. Ventilatory acclimatization to 3,100 m bore no positive relationship to accompanying changes in arterial P(O2) and pH and CSF pH: (a) CSF pH either increased or remained

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1974 Journal of Clinical Investigation

92. Role of cerebral spinal fluid (CSF) flow measured by magnetic resonance imaging (MRI) as a diagnostic biomarker of Normal Pressure Hydrocephalus (NPH)

Role of cerebral spinal fluid (CSF) flow measured by magnetic resonance imaging (MRI) as a diagnostic biomarker of Normal Pressure Hydrocephalus (NPH) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith

2015 PROSPERO

93. Goal-directed Intraoperative Fluid Therapy in High-risk Surgery

Goal-directed Intraoperative Fluid Therapy in High-risk Surgery Goal-directed Intraoperative Fluid Therapy in High-risk Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Goal-directed Intraoperative (...) Fluid Therapy in High-risk Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02470221 Recruitment Status : Unknown Verified June 2015 by Huang YuGuang, Peking Union Medical College Hospital. Recruitment status was: Not yet recruiting First Posted : June 12, 2015 Last Update Posted : June 12

2015 Clinical Trials

94. Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients

Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients (FRESEDICU) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02679625 Recruitment Status : Unknown Verified February 2016 by Alan Chiem, M.D., Olive View-UCLA Education & Research

2014 Clinical Trials

95. Restrictive Fluid Therapy in Severe Preeclampsia

spinal anesthesia for combat hypotension and hypovolemia manifested by oliguria. However, as water therapy have antagonistic effects on cardiopulmonary and renal systems is no doubt as to the benefits compared to conventional or restrictive pattern of fluid therapy on renal function. Objective: To compare the renal function of patients with severe preeclampsia who received restrictive fluid therapy during caesarean section, as well as evaluating the use of cystatin C and Neutrophil gelatinase (...) -associated lipocalin (NGAL) as a predictor of renal damage in this population. Hypothesis: Intraoperative fluid restriction did not influence renal function of patients with severe preeclampsia undergoing cesarean section under spinal anesthesia. Condition or disease Intervention/treatment Phase Pre-Eclampsia Other: Restrictive Fluid Therapy Not Applicable Detailed Description: Preeclampsia (PE) is the leading cause of morbidity and mortality worldwide during pregnancy. Fluid therapy for PE women during

2014 Clinical Trials

96. Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM)

: November 6, 2018 Sponsor: Dartmouth-Hitchcock Medical Center Information provided by (Responsible Party): Lara K. Ronan, Dartmouth-Hitchcock Medical Center Study Details Study Description Go to Brief Summary: The purpose of this study is to learn whether the DNA from cancer tumor cells can be found in the cerebral spinal fluid (CSF) that bathes the brain and spinal cord of patients before malignant the cancer cells themselves are able to be found in the CSF. The researchers doing this study hope (...) Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM) Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2014 Clinical Trials

97. Pulse Pressure in Relation to Tau-Mediated Neurodegeneration, Cerebral Amyloidosis, and Progression to Dementia in Very Old Adults. (PubMed)

Pulse Pressure in Relation to Tau-Mediated Neurodegeneration, Cerebral Amyloidosis, and Progression to Dementia in Very Old Adults. Increased pulse pressure associated with age-related arterial stiffening increases risk for Alzheimer dementia but the mechanism responsible for this association remains unclear.To determine the relationship between pulse pressure and cerebral spinal fluid biomarker profiles of preclinical Alzheimer disease, investigate whether observed relationships are stronger (...) in adults with more advanced arterial age (≥80 years of age), and examine the relationship between pulse pressure and progression to dementia.In this retrospective cohort study, 877 participants without dementia (55-91 years of age) from the Alzheimer's Disease Neuroimaging Initiative underwent baseline health assessment, including blood pressure assessment and lumbar puncture for determination of cerebral spinal fluid phosphorylated tau (P-tau) and β-amyloid 1-42. Participants have been followed up

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2015 JAMA neurology

98. Autologous Mesenchymal Stem Cells Transplantation for Spinal Cord Injury- A Phase I Clinical Study

types including neuronal lineage cells. Intravenous application or direct injection of MSCs into cerebrospinal fluid (CSF) via lumber puncture in animal models of SCI and brain trauma had shown that MSCs can migrate towards and integrate into injured spinal tissue and reduce cyst size and increase functional recovery. The literature indicates that acute, sub-acute and chronic injury can be a therapeutic target for MSC grafting. The mechanism of action may however vary among these conditions (...) Spinal Injury Association (ASIA) impairment scale "A" Confirmation by MRI of injury level Time between injury and enrollment greater than 2 weeks Ability to provide informed consent Exclusion Criteria: Axonic brain injury Inability to provide consent Open injuries Active infectious diseases Terminal patients Neurodegenerative diseases Evidence of meningitis Cerebral palsy Primary haematologic diseases Coagulopathies Pregnancy Other medical complications that contra-indicate surgery, including major

2015 Clinical Trials

99. Spinal segmental myoclonus as an unusual presentation of multiple sclerosis. (PubMed)

in cerebral spinal fluid confirmed the diagnosis of MS. Based on the history and progressive clinical features, a diagnosis of primary progressive MS was established.Spinal myoclonus can be the presenting manifestation of MS in association with demyelinating plaques in the root exit zones of the spinal cord. Spinal myoclonus may pose a diagnostic challenge when it presented at the disease onset and especially in patients with progressive course at onset. Our patient represents the first reported primary (...) Spinal segmental myoclonus as an unusual presentation of multiple sclerosis. Unusual presentations of multiple sclerosis (MS) at onset may post a diagnostic dilemma to the treating neurologists. Spinal myoclonus is rare in MS and may lead to perform extensive investigations to rule out other etiologies affecting the spinal cord.We described a 31-year-old male who presented with involuntary brief jerky movements of the left shoulder and arm with significant wasting of shoulder muscles

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2015 BMC Neurology

100. Cerebrospinal Fluid, Leak

use in CSF leaks, but they may show a relevant skull fracture or the presence of empty sella. Diagnostic ultrasound has not been useful in cranial CSF leak. Paraspinal fluid collections can be localized for needle aspiration with ultrasound guidance. Cerebral arteriography is not used in the diagnostic imaging workup to localize the site of a CSF leak. Arterial injury may occur with skull trauma that causes CSF leakage. CTA, MRA, or digital subtraction cerebral and cervical arteriography may (...) of the spinal canal (suitable for local treatment by extradural blood patch or alternate therapy) by routine postmyelogram CT spine scan. A high percentage of fast leaks have spinal extradural fluid collections on preliminary MRI spine scans. Dynamic CT myelography is recommended in these patients, with the injection of the iodinated contrast medium intrathecal on the CT scan table with immediate spine CT scan. [ ] CT cisternographic findings in CSF leak include the concentration of contrast medium

2014 eMedicine Radiology

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