How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

5,399 results for

Cerebral Spinal Fluid

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

41. A Study of the Gene Mutation Status in Cerebrospinal Fluid, Blood and Tumor Tissue of Non-small Cell Lung Cancer Patients With Brain Metastases

%, and the prognosis is poor——the natural median survival period is about 1-2 months. Because of the impractical intracranial tumor biopsy and very low level of DNA in peripheral blood, cerebrospinal fluid, which makes close contact with brain tumors, becomes potential available samples. Several studies have shown that genetic testing of cerebrospinal fluid is feasible. Therefore, this study aims to test the cerebrospinal fluid, blood and tissue by the latest second-generation sequencing technology at different (...) A Study of the Gene Mutation Status in Cerebrospinal Fluid, Blood and Tumor Tissue of Non-small Cell Lung Cancer Patients With Brain Metastases A Study of the Gene Mutation Status in Cerebrospinal Fluid, Blood and Tumor Tissue of Non-small Cell Lung Cancer Patients With Brain Metastases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2017 Clinical Trials

42. Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain

confirmation, which is potentially problematic at upper lumbar vertebrae. For example, a study performed in the thoracic spine found that misidentifica- tion of the targeted spinal level occurred between 16% and 43% of the time depending on the scanning technique, with IA at 6 weeks and 3 months Differences favoring MBB non- significant at 6 months. Cohen et al 134 Case- control 511 who under MBB (n=212), IA (n=212) or MBB and IA (n=87) before RFA MBB with 0.5–0.75 mL LA or IA with 0.5–1 mL LA+steroid MBB (...) of the seven Revel’s criteria (above) including pain reduction by recumbency resulted in 92% sensitivity and 80% specificity. Manchikanti et al 50 Prospective n=120 =75% pain reduction MBB (double comparative diagnostic blocks) The prevalence of clinical findings (pain better by sitting/lying, pain worsened by sitting/standing/walking/coughing/lumbar spine range of motion, positive straight leg raising test and pain referral pattern) were similar between positive and negative block groups. Back pain

2020 American Academy of Pain Medicine

43. Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain from a Multispecialty, International Working Group Full Text available with Trip Pro

of treatment is a source of contention and scientific debate. Regarding prevalence, the cited frequency of lumbar facet joint pain ranges from as low as 4.8% in the multicenter National Low Back Pain Survey evaluating final diagnoses of 2374 patients with low back pain (LBP) referred to an orthopedic or neurosurgical spine surgeon, to over 50% in systematic reviews on prevalence studies using varying criteria for diagnostic blocks performed by interventional pain physicians. The wide disparity in reported (...) regulatory agencies and payers. The Spine Intervention Society (SIS; formerly the International Spine Intervention Society) has published guidelines on the performance of lumbar facet blocks and radiofrequency (RF) neurotomy, but these rigorous criteria have not been followed in recent randomized controlled trials (RCTs), and are not adhered to in domestic and international guidelines. Whereas stringent selection criteria have been anecdotally associated with high RFA success rates, the increased false

2020 American Society of Regional Anesthesia and Pain Medicine

44. Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma Full Text available with Trip Pro

Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma PurposeTo investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG).Patients and methodsRetrospective analysis of medical records of patients with open-angle glaucoma in the period from 2005 to 2015 from the Ophthalmology Department (...) demonstrates enlarged ONSDs and normal lumbar CSF-p in 38 Caucasian NTG patients. As enlarged ONSDs generally are associated with increased intracranial CSF-p, these results can be explained by a disturbed communication of CSF-p between the intracranial and intraorbital subarachnoid spaces.

2017 Eye

45. Management of a Ventral Cerebrospinal Fluid Leak With a Lumbar Transforaminal Epidural Blood Patch in a Child With Persistent Postdural Puncture Headache: A Case Report. (Abstract)

the physician both to question the diagnosis of PDPH by pursuing radiographic confirmation of a cerebral spinal fluid leak and, furthermore, identification of its location to best direct further therapy. (...) Management of a Ventral Cerebrospinal Fluid Leak With a Lumbar Transforaminal Epidural Blood Patch in a Child With Persistent Postdural Puncture Headache: A Case Report. Postdural puncture headache (PDPH) is an uncommon sequel of lumbar puncture in children. When conservative treatment with bed rest, hydration, and caffeine are ineffective, epidural blood patches are recommended and are generally effective. The purpose of this report was to highlight that when lumbar epidural blood patches fail

2017 Regional Anesthesia and Pain Medicine

46. Cryptogenic Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension: Role of Dynamic CT Myelography. Full Text available with Trip Pro

]). All patients had previously undergone spine MRI, conventional dynamic myelography, and CT myelography. Subsequent dynamic CT myelography covered a mean range of seven vertebral levels. The leak was caused by a calcified microspur in 10 patients and by a dural tear at the axilla of a spinal nerve root in the remaining four. The mean volume CT dose index of dynamic CT myelography was 107 mGy (range, 12-246 mGy), and the mean dose-length product was 1347 mGy·cm (range, 550-3750 mGy·cm). Conclusion (...) Cryptogenic Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension: Role of Dynamic CT Myelography. Purpose To propose a modified dynamic CT myelographic technique to locate cerebrospinal fluid (CSF) leaks, also known as cryptogenic leaks, in patients with spontaneous intracranial hypotension (SIH) in whom previous imaging did not show the dural breach. Materials and Methods This retrospective analysis included 74 consecutive patients with SIH and a myelographically proven CSF leak

2018 Radiology

47. Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects Full Text available with Trip Pro

Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH.Eighteen (...) subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also

2018 Fluids and barriers of the CNS

48. Iatrogenic Development of Cerebrospinal Fluid Leakage in Diagnosing Spontaneous Intracranial Hypotension Full Text available with Trip Pro

Iatrogenic Development of Cerebrospinal Fluid Leakage in Diagnosing Spontaneous Intracranial Hypotension A 34-year-old woman came to the emergency room complaining of a severe orthostatic headache. Results of a cerebrospinal fluid tap and brain computed tomography were normal. Based on her history and symptoms, she was found to have spontaneous intracranial hypotension. She was hospitalized and her symptoms improved with conservative treatment. On the next day, her headache suddenly worsened (...) . Cisternography was performed to confirm the diagnosis and determine the spinal level of her cerebrospinal fluid leak. It revealed multiple cerebrospinal fluid leaks in the lumbar and upper thoracic regions. It was strongly believed that she had an iatrogenic cerebrospinal fluid leak in the lumbar region. An epidural blood patch was performed level by level on the lumbar and upper thoracic regions. Her symptoms resolved after the epidural blood patch and she was later discharged without any complications

2018 Korean journal of family medicine

49. ACR–ASNR–SPR Practice Parameter for the Performance and Interpretation of Magnetic Resonance Imaging (MRI) of the Brain

.) Additional techniques that may be useful under the appropriate clinical circumstances include 3-dimensional imaging techniques [202-205], neuronavigation and intraoperative MRI [64,96,105,206], magnetization transfer imaging [207-211], cerebral spinal fluid (CSF) flow study using phase-contrast pulse sequences [212], and variations of single shot fast-spin- echo or turbo spin-echo imaging. It is the responsibility of the supervising physician to determine whether additional pulse sequences (...) accepted basic imaging protocols for MRI of the brain currently include a T1-weighted sequence in the sagittal plane (or a T1-weighted volumetric acquisition), and T2- weighted fluid-attenuated inversion recovery (FLAIR) and fast spin-echo or turbo-spin-echo (or equivalent) sequences in the axial plane. If FLAIR is not available or in children under the age of 2 years, proton density weighted sequences may be helpful. Under certain clinical circumstances, very rapid acquisitions such as echo planar

2019 American Society of Neuroradiology

50. ACR–ASNR Practice Parameter for the Performance of Computed Tomography (CT) of the Brain

. Neurology. 2010;74(2):150-156. 76. Nair PP, Kalita J, Misra UK. Role of cranial imaging in epileptic status. Eur J Radiol. 2009;70(3):475-480. 77. Sonnesen L, Jensen KE, Petersson AR, Petri N, Berg S, Svanholt P. Cervical vertebral column morphology in patients with obstructive sleep apnoea assessed using lateral cephalograms and cone beam CT. A comparative study. Dentomaxillofac Radiol. 2013;42(6):20130060. 78. Al-Nsoor NM, Mhearat AS. Brain computed tomography in patients with syncope. Neurosciences (...) possible. CT of the brain is superior to magnetic resonance imaging (MRI) for the evaluation of osseous structures, acute intracranial hemorrhage, and the detection of calcification, which can be important for the identification of an abnormality or for refinement of a differential diagnosis. CT of the brain is sufficient and diagnostic in many clinical circumstances such as in acute trauma, nontraumatic intracranial hemorrhage, evaluation of shunt malfunction, and selected postoperative follow-up

2019 American Society of Neuroradiology

51. Appropriate Use Criteria: Imaging of the Brain

-to-peer conversation include: ? CT brain and CT sinus for headache ? MRI brain and MRA brain for headache ? MRI cervical spine and MRI shoulder for pain indications ? MRI lumbar spine and MRI hip for pain indications ? MRI or CT of multiple spine levels for pain or radicular indications ? MRI foot and MRI ankle for pain indications ? Bilateral exams, particularly comparison studies There are certain clinical scenarios where simultaneous ordering of multiple imaging studies is consistent with current (...) of the Guidelines 4 Administrative Guidelines 5 Ordering of Multiple Studies 5 Simultaneous Ordering of Multiple Studies 5 Repeated Imaging 5 Pre-Test Requirements 6 History 6 Imaging of the Brain 7 General Information/Overview 7 Scope 7 Technology Considerations 7 Definitions 8 Clinical Indications 9 Congenital and Developmental Conditions 9 Ataxia, congenital or hereditary 9 Developmental delay (Pediatric only) 9 Congenital cerebral anomalies 10 Infection 10 Infection 10 Inflammatory Conditions 11 Multiple

2019 AIM Specialty Health

52. CRACKCast E198 – Brain Resuscitation

ICP that is not responding to hyperosmolar therapies. [3] What is the Monro-Kellie hypothesis? The Monro-Kellie hypothesis states that the skull is a rigid container with three non-compressible elements: brain, blood, and cerebrospinal fluid. Increases in one substance will cause displacement of others from the box or increases in ICP. The first vault content to be displaced is CSF. CSF is shunted from the intracranial compartment to the spinal subarachnoid space. Next to be displaced is blood (...) ] What is cerebral autoregulation? Cerebral autoregulation is the process by which the brain controls the amount of perfusing blood flow it receives. Under optimal conditions, the brain is able to accommodate changes in intracranial pressure and mean arterial pressure by altering cerebral vascular resistance. ICP is typically low, so cerebral perfusion is largely dependant in MAP. As MAP increases, cerebral blood vessels vasoconstrict to prevent vasogenic edema and increasing ICP. Conversely, if MAP

2019 CandiEM

53. The effects of lumboperitoneal and ventriculoperitoneal shunts on the cranial and spinal cerebrospinal fluid volume in a patient with idiopathic intracranial hypertension Full Text available with Trip Pro

The effects of lumboperitoneal and ventriculoperitoneal shunts on the cranial and spinal cerebrospinal fluid volume in a patient with idiopathic intracranial hypertension Lumboperitoneal (LP) and ventriculoperitoneal (VP) shunts are a frequent treatment modality for idiopathic intracranial hypertension (IIH). Although these shunts have been used for a long time, it is still not clear how they change the total craniospinal CSF volume and what portions of cranial and spinal CSF are affected (...) . This report for the first time presents the results of a volumetric analysis of the total cranial and spinal CSF space in a patient with IIH. We performed an automated segmentation of the cranial and a manual segmentation of the spinal CSF space first with an LP shunt installed and again after the LP shunt was replaced by a VP shunt. When the LP shunt was in place, the total CSF volume was smaller than when the VP shunt was in place (222.4 cm(3) vs 279.2 cm(3)). The difference was almost completely

2016 Croatian medical journal

54. Elevated cerebral spinal fluid biomarkers in children with mucopolysaccharidosis I-H Full Text available with Trip Pro

Elevated cerebral spinal fluid biomarkers in children with mucopolysaccharidosis I-H Mucopolysaccharidosis (MPS) type-IH is a lysosomal storage disease that results from mutations in the IDUA gene causing the accumulation of glycosaminoglycans (GAGs). Historically, children with the severe phenotype, MPS-IH (Hurler syndrome) develop progressive neurodegeneration with death in the first decade due to cardio-pulmonary complications. New data suggest that inflammation may play a role in MPS (...) pathophysiology. To date there is almost no information on the pathophysiologic changes within the cerebral spinal fluid (CSF) of these patients. We evaluated the CSF of 25 consecutive patients with MPS-IH. While CSF glucose and total protein were within the normal range, we found a significantly mean elevated CSF opening pressure at 24 cm H2O (range 14-37 cm H2O). We observed a 3-fold elevation in CSF heparan sulfate and a 3-8 fold increase in MPS-IH specific non-reducing ends, I0S0 and I0S6. Cytokine

2016 Scientific reports

55. Cerebral Spinal Fluid levels of Cytokines are elevated in Patients with Metachromatic Leukodystrophy Full Text available with Trip Pro

Cerebral Spinal Fluid levels of Cytokines are elevated in Patients with Metachromatic Leukodystrophy Metachromatic leukodystrophy (MLD) is a lysosomal storage disease resulting from a deficiency of arylsulfatase A causing an accumulation of cerebroside sulfate, a lipid normally abundant in myelin. Sulfatide accumulation is associated with progressive demyelination and a clinical presentation in severe disease forms that is dominated by motor manifestations. Cerebral inflammation may contribute (...) to the pathophysiology of MLD. To date, cytokine levels in the cerebral spinal fluid of MLD patients have not previously been reported. The objective of this study was to evaluate the concentration of inflammatory cytokines in the CSF of patients with MLD and to compare these levels to unaffected controls. Of 22 cytokines evaluated, we documented significant elevations of MCP-1, IL-1Ra, IL-8, MIP-1b and VEGF in the MLD patients compared to unaffected controls. The elevated cytokines identified in this study may play

2016 Scientific reports

56. Continuous cerebral spinal fluid drainage associated with complications in patients admitted with subarachnoid hemorrhage Full Text available with Trip Pro

Continuous cerebral spinal fluid drainage associated with complications in patients admitted with subarachnoid hemorrhage Cerebral artery vasospasm is a major cause of death and disability in patients recovering from subarachnoid hemorrhage (SAH). Although the exact cause of vasospasm is unknown, one body of research suggests that clearing blood products by CSF drainage is associated with a lower frequency and severity of vasospasm. There are multiple approaches to facilitating CSF drainage (...) , but there is inadequate evidence to determine the best practice. The purpose of this study was to explore whether continuous or intermittent CSF drainage was superior for reducing vasospasm.The authors performed a randomized clinical trial. Within 72 hours of admission for SAH, patients with an external ventricular drain (EVD) were randomized to undergo continuous CSF drainage with intermittent intracranial pressure (ICP) monitoring (open-EVD group) or continuous ICP monitoring with intermittent CSF drainage (monitor

2013 EvidenceUpdates Controlled trial quality: uncertain

57. A Rare Complication of Lumbar Spinal Surgery: Pneumocephalus Full Text available with Trip Pro

A Rare Complication of Lumbar Spinal Surgery: Pneumocephalus A 25-year-old male patient with severe thigh and right side pain was presented. In the lumbar magnetic resonance images, there was a contrasting spinal cord tumor image with 1 cm in diameter at the level of the L3 vertebra. The patient was operated and the tumor was totally removed. All the pain of the patient recovered. The patient's postoperative two days were very comfortable and the patient was early mobilized. On the third (...) postoperative day, the patient complained of severe headache, nausea and vomiting. Immediate cranial computed tomography (CT) images was performed. Cerebral pneumocephalus was present in CT. The patient was treated with definite bed rest and plenty of fluid replacement. After three days, the patient's complaints were completely improved. This improvement was confirmed by performing a cerebral CT scan. In the formation of pneumocephalus, air is compressed into the intradural space during operation

2017 Korean Journal of Neurotrauma

58. ACR–ASNR–SCBT-MR Practice Parameter for the Performance of Magnetic Resonance Imaging (MRI) of the Adult Spine

, such as meningiomas, and gliomas of the cord. Again, MRI can portray the association of the neoplasm with the classic changes of prior radiation in the vertebral column. I. Vascular Lesions of the Spine Multiple vascular lesions can affect the spine. There are two general categories, spinal cord ischemia and vascular malformations. MRI is the most sensitive method of verifying the presence of abnormalities of the cord that may represent ischemia and infarction [47-49]. As in the brain, diffusion-weighted imaging (...) atrophy, amyotrophic lateral sclerosis d. Spinal Stenosis 6. Trauma Nature and extent of injury to spinal cord, vertebral column, ribs, and skull base; ligaments, thecal sac, and paraspinal soft tissues following trauma (CT is considered the Gold Standard primary tool for the initial evaluation of the traumatized spine, with MRI often performed to provide complementary data, particularly when the patients' clinical findings are discrepant with the initial CT findings.) 7. Neoplastic abnormalities

2019 American Society of Neuroradiology

59. Practice Advisory for Perioperative Visual Loss Associated with Spine Surgery 2019 Full Text available with Trip Pro

artery occlusion, cerebral visual loss, and posterior reversible encephalopathy syndrome. Anterior ischemic optic neuropathy damages the front of the optic nerve (the optic nerve head or optic disc), whereas posterior ischemic optic neuropathy injures the portion of the optic nerve behind the eye. “High-risk patients” are defined for this Advisory as those who undergo spine procedures while positioned prone and who have prolonged procedures, experience substantial blood loss, or both. Purpose (...) was associated with a reduced risk of developing ischemic optic neuropathy (Category B2-E evidence). Case reports indicate that visual loss may still occur when these fluids are used (Category B4-E evidence). , , , , , , , , , , , , , , , Survey Findings. The consultants and members of ASA, SNACC, and AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves strongly agree and members of NANOS agree with the recommendation to periodically monitor hemoglobin or hematocrit values during surgery

2019 American Society of Anesthesiologists

60. Spine imaging

5 Ordering of Multiple Studies 5 Simultaneous Ordering of Multiple Studies 5 Repeated Imaging 5 Pre-Test Requirements 6 History 6 Imaging of the Spine 7 General Information/Overview 7 Scope 7 Technology Considerations 7 Definitions 7 Clinical Indications 9 Congenital and Developmental Conditions 9 Chiari malformation 9 Congenital spinal cord anomalies not listed 9 Congenital vertebral defects 10 Craniocervical junction abnormalities 10 Scoliosis 10 Spinal dysraphism 11 Tethered cord 11 (...) Infectious and Inflammatory Conditions 12 Juvenile idiopathic arthritis (Pediatric only) 12 Multiple sclerosis or other white matter disease 12 Rheumatoid arthritis (Adult only) 12 Spinal infection 13 Spondyloarthropathy 13 Trauma 14 Cervical injury 14 Thoracic or lumbar injury 14 Tumor 15 Tumor 15 Miscellaneous Conditions of the Spine 15 Osteoporosis and osteopenia 15 Spinal cord infarction 16 Spondylolysis and spondylolisthesis 16 Syringomyelia 16 Signs and Symptoms 16 Cauda equina syndrome 16

2019 AIM Specialty Health

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>