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Cerebral Spinal Fluid

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41. Lipiodol ultra-fluide (Fatty acid ethyl esters) - radiology

Lipiodol ultra-fluide (Fatty acid ethyl esters) - radiology HAS - Medical, Economic and Public Health Assessment Division 1/20 The legally binding text is the original French version TRANSPARENCY COMMITTEE Opinion 18 December 2013 LIPIODOL ULTRA-FLUIDE 480 mg/ml, solution for injection 1 10 ml glass ampoule (CIP: 34009 306 216 0 8) Applicant: GUERBET INN Fatty acid ethyl esters ATC Code (2013) V08AD01 (iodinated contrast medium) Reasons for the review - Re-assesement of the actual benefit (...) the indications for LIPIODOL ULTRA-FLUIDE correspond to procedures listed in the CCAM (French Joint Classification Of Medical Procedures). 03 INDICATIONS "In diagnostic radiology: • Lymphography • Diagnosis of liver lesions: diagnosis of the spread of malignant lesions, whether hepatic or not, by selective hepatic arterial injection. In interventional radiology: • Embolisation with surgical glues In association with surgical glues during vascular embolisations. In endocrinology: • Prevention of iodine

2014 Haute Autorite de sante

42. H NMR metabolic signature of cerebrospinal fluid following repetitive lower-limb remote ischemia preconditioning. (PubMed)

H NMR metabolic signature of cerebrospinal fluid following repetitive lower-limb remote ischemia preconditioning. Background OBJECTIVE: The cerebral ischemia/reperfusion greatly influences brain metabolism. Remote ischemia preconditioning (RIPC) is reported to confer neuroprotective effects against cerebral ischemia in animal models and human. This study aims to investigate the metabolomic profiles of cerebrospinal fluid (CSF) in patients treated with repetitive lower limb RIPC and provides (...) an insight into possible mechanism underlying RIPC-induced neuroprotection.Fifty healthy patients undergoing minor surgery under spinal anesthesia were randomly allocated to 2 groups: control group (Group C, n = 25) and RIPC treatment group (Group T,n = 25). Repetitive limb RIPC were performed 3 sessions, consisting of three 5-min cycles per session from the day before surgery to the morning on the surgery day. The CSF samples were collected from 48 patients before intrathecal injection of local

2018 Neurochemistry international

43. Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study. (PubMed)

Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study. To compare the orbital cerebral spinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) determined noninvasively in ocular hypertensive (OH) subjects and controls.Cross-sectional observational study. Magnetic resonance imaging was used to measure orbital subarachnoid space width (OSASW). The CSFP (mm Hg) was estimated from a published formula as 17.54 × MRI derived

2018 Acta ophthalmologica

44. Cerebrospinal Fluid Biomarkers Are Associated With Glial Fibrillary Acidic Protein and αII-spectrin Breakdown Products in Brain Tissues Following Penetrating Ballistic-Like Brain Injury in Rats (PubMed)

(GFAP), αII-spectrin, and their breakdown products (BDPs) have been well established, but little is known about the subacute-chronic post-injury profiles of these biomarkers. Thus, the current study was designed to determine the extended profile of these TBI-specific biomarkers both in brain tissue and cerebral spinal fluid (CSF). Protein abundance was evaluated in brain tissue samples taken from regions of interest and in CSF at 24 h, 3 days, 7 days, 1 month, and 3 months following severe TBI (...) Cerebrospinal Fluid Biomarkers Are Associated With Glial Fibrillary Acidic Protein and αII-spectrin Breakdown Products in Brain Tissues Following Penetrating Ballistic-Like Brain Injury in Rats Treatments to improve outcomes following severe traumatic brain injury (TBI) are limited but may benefit from understanding subacute-chronic brain protein profiles and identifying biomarkers suitable for use in this time. Acute alterations in the well-known TBI biomarkers glial fibrillary acidic protein

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2018 Frontiers in neurology

45. Fluids Affecting Bladder Urgency and Lower Urinary Symptoms

-day diary, urinating routinely more than two times at night, answering "yes" to experiencing frequent, strong feelings of urgency to empty the bladder. Exclusion Criteria: Men History of diabetes, spinal cord injury, multiple sclerosis, muscular dystrophy, cerebral palsy, dementia or Alzheimer's or stroke Currently pregnant or within one year of delivery Currently report symptoms of pain with urination or frequent urinary tract infections Uses diuretic medications, currently taking medication (...) Fluids Affecting Bladder Urgency and Lower Urinary Symptoms Fluids Affecting Bladder Urgency and Lower Urinary Symptoms - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Fluids Affecting Bladder Urgency

2018 Clinical Trials

46. Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus (PubMed)

Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus The aim of the present study was to examine cerebrospinal fluid (CSF) volumetric net flow rate and direction at the cranio-cervical junction (CCJ) and cerebral aqueduct in individuals with idiopathic normal pressure hydrocephalus (iNPH) using cardiac-gated phase-contrast magnetic resonance imaging (PC-MRI). An in-depth, pixel-by-pixel analysis of regions of interest from the CCJ and cerebral (...) aqueduct, respectively, was done in 26 iNPH individuals, and in 4 healthy subjects for validation purposes. Results from patients were compared with over-night measurements of static and pulsatile intracranial pressure (ICP). In iNPH, CSF net flow at CCJ was cranially directed in 17/22 as well as in 4/4 healthy subjects. Estimated daily CSF volumetric net flow rate at CCJ was 6.9 ± 9.9 L/24 h in iNPH patients and 4.5 ± 5.0 L/24 h in healthy individuals. Within the cerebral aqueduct, the CSF net flow

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2018 NeuroImage : Clinical

47. Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 (PubMed)

Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Traumatic brain injury (TBI) elevates Abeta (Aβ) peptides in the brain and cerebral spinal fluid. Aβ peptides are amphipathic molecules that can modulate membrane mechanics. Because the mechanosensitive cation channel PIEZO1 is gated by membrane tension and curvature, it prompted us to test the effects of Aβ on PIEZO1. Using precision fluid shear stress as a stimulus, we found that Aβ monomers inhibit PIEZO1

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2018 Scientific reports

48. Nusinersen sodium (Spinraza) - Spinal Muscular Atrophy

to function. This interpretation, based on the microscopic severity, was supported by the lack of effects on neurobehavioral assessments in these animals. The 53-week monkey study was designed to achieve an intermediate level of exposure compared to the 14-week study and determine if there was any progression or additional toxicities seen with chronic exposure. The total dose in the first 3 months of this study was 24 mg, which produced lumbar spinal cord and cerebral cortex concentrations of 106 and 71 (...) repeat-dose (14-weeks and 53-weeks) studies were conducted in a single species, cynomolgus monkeys. In the non-human primate studies transient deficits in lower spinal cord reflexes were noted. In the 14 week study these effects were seen at 3 mg and 4mg in the 53 week study. In the 14 week study, these effects consisted of negative responses for cutaneous (left and right sides), sensory foot (left and right), and/or tail reflexes. There were no effects on cerebral reflexes, general sensory or motor

2017 European Medicines Agency - EPARs

49. Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of haemorrhagic shock. (PubMed)

Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of haemorrhagic shock. During early treatment of haemorrhagic shock, cerebral perfusion pressure can be restored by small-volume resuscitation with vasopressors. Whether this therapy is improved with additional fluid remains unknown. We assessed the value of terlipressin and lactated Ringer's solution (LR) on early recovery (...) to recover these measures, but terlipressin plus 3LR or 3LR alone were not as effective. Spinal cord dorsum potential was preserved in all groups, but no therapy protected electromyographic function.Resuscitation from haemorrhagic shock using terlipressin with small-volume LR was superior to high-volume LR, with regard to cerebral microcirculation, and mitochondrial and electrophysiological functions.Copyright © 2018 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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2018 British Journal of Anaesthesia

50. Bilirubin Oxidation Products and Cerebral Vasoconstriction (PubMed)

Bilirubin Oxidation Products and Cerebral Vasoconstriction Key evidence in support of the hypothesis that bilirubin oxidation products (BOXes) contribute to the vasoconstriction associated with subarachnoid hemorrhage (SAH) are the (1) presence of BOXes in cerebral spinal fluid from SAH patients and (2) ability of one or more BOXes to elicit vasoconstriction. We critically evaluate this key evidence, detail where gaps remain, and describe recent approaches that will address these gaps.

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2018 Frontiers in pharmacology

51. Primary CNS Burkitt Lymphoma: A Case Report of a 55-Year-Old Cerebral Palsy Patient (PubMed)

of increased intracranial pressure. Four abnormal enhancing masses were detected on MRI with biopsy results consistent with Burkitt lymphoma. Complete staging workup was completed with no evidence of extra-CNS disease noted on PET/CT, bone marrow biopsy, or cerebral spinal fluid analysis. The patient was treated with intravenous as well as intrathecal chemotherapy and found to be in a complete remission at six months. Recurrence in the CNS was observed four months later with treatment consisting of whole (...) Primary CNS Burkitt Lymphoma: A Case Report of a 55-Year-Old Cerebral Palsy Patient With primary central nervous system lymphoma (PCNSL) being a rare disease, the subtype of Burkitt lymphoma (BL) presenting as a sole CNS lesion is an even more exceptional diagnosis. A case of coexistent primary CNS Burkitt lymphoma (PCNSBL) with cerebral palsy (CP) is presented. A 55-year-old Caucasian male presented with increasing bilateral lower extremity weakness above his baseline in addition to signs

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2018 Case reports in oncological medicine

52. Intrathoracic pressure regulation therapy applied to ventilated patients for treatment of compromised cerebral perfusion from brain injury (PubMed)

of venous blood and cerebral spinal fluid in the skull, and enhances cerebral blood flow. We examined the feasibility of active intrathoracic pressure regulation therapy in patients with brain injury. We hypothesized that active intrathoracic pressure regulation therapy would be associated with lowered intracranial pressure and increased cerebral perfusion pressure in these patients.At three institutions, active intrathoracic pressure regulation therapy (CirQlator™, ZOLL) was utilized for 2 consecutive (...) Intrathoracic pressure regulation therapy applied to ventilated patients for treatment of compromised cerebral perfusion from brain injury Reducing intrathoracic pressure in the setting of compromised cerebral perfusion due to acute brain injury has been associated with reduced intracranial pressure and enhanced cerebral perfusion pressure and blood flow in animals. Noninvasive active intrathoracic pressure regulation lowers intrathoracic pressure, increases preload, reduces the volume

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2018 Journal of medical case reports

53. Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study

Comprehension, Visual Spatial, Fluid Reasoning, Working Memory, and Processing Speed. A full scale IQ composite score is derived from these subtests. Other Outcome Measures: Changes in the tissue structure cortical-spinal tract and other relevant white matter tracts as measured by Diffusion Kurtosis Imaging (DKI). [ Time Frame: Change in the tissue structure of cortical-spinal tract and other relevant white matter tracts from baseline to 40 weeks ] DKI is a magnetic resonance imaging (MRI) modality (...) Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2018 Clinical Trials

54. Cerebral and occipito-atlanto-axial involvement in mucopolysaccharidosis patients: clinical, radiological, and neurosurgical features (PubMed)

Cerebral and occipito-atlanto-axial involvement in mucopolysaccharidosis patients: clinical, radiological, and neurosurgical features Neurosurgical features of mucopolysaccharidosis (MPS) patients mainly involve the presence of cranio-vertebral junction (CVJ) abnormalities and the development of communicating hydrocephalus. CVJ pathology is a critical aspect that severely influences the morbidity and mortality of MPS patients. Hydrocephalus is slowly progressing; it must be differentiated from (...) cerebral atrophy, and rarely requires treatment. The aim of this paper was to review the literature concerning these conditions, highlighting their clinical, radiological, and surgical aspects to provide a practical point of view for clinicians.CVJ involvement may present with cervical pain, unsteady gait, frequent falls, and progressive impairment of autonomous ambulation, an acute tetraplegia even after minor trauma. Magnetic resonance imaging (MRI) of the cervical spine, including active dynamic

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2018 Italian journal of pediatrics

55. Pseudohypoxic Brain Swelling After Elective Lumbar Spinal Surgery: Case Report (PubMed)

Pseudohypoxic Brain Swelling After Elective Lumbar Spinal Surgery: Case Report Pseudohypoxic brain swelling (or the more recent term, postoperative intracranial hypotension-associated venous congestion) is a rare and potentially deadly complication that can occur after routine spine or brain surgery. The mechanism of this injury has been described as a rapid cerebral spinal fluid drainage leading to venous cerebral congestion. The clinical and radiographic findings mimic those found (...) in a patient who has suffered an anoxic brain injury. We present the third reported case of postoperative intracranial hypotension-associated venous congestion following spinal surgery.

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2018 Cureus

56. Spinraza in Adult Spinal Muscular Atrophy

: Samples With DNA 5cc of Cerebral Spinal Fluid (CSF) is collected and typically discarded as part of the typical clinical encounter when SPINRAZA® (nusinersen) is administered. This 5cc of CSF will be collected for research purposes at each dosing visit. Blood samples, including whole blood, serum, and plasma (3 teaspoons total) will be collected within seven days of standard of care SPINRAZA® (nusinersen) administration at dose #1, 2, 4, 5, 7, 9 and 11. Eligibility Criteria Go to Information from (...) Spinraza in Adult Spinal Muscular Atrophy Spinraza in Adult Spinal Muscular Atrophy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Spinraza in Adult Spinal Muscular Atrophy (SAS) The safety and scientific

2018 Clinical Trials

57. Remote Cerebellar Haemorrhage: A Potential Iatrogenic Complication of Spinal Surgery (PubMed)

surgery, due to dural tearing and rapid cerebral spinal fluid (CSF) leakage, resulting in intracranial hypotension and cerebellar haemorrhage. This complication may result in severe permanent neurologic sequelae; hence, it is of pertinence to diagnose and manage it rapidly in order to optimise patient outcome. (...) Remote Cerebellar Haemorrhage: A Potential Iatrogenic Complication of Spinal Surgery We report the case of a 51-year-old man with no significant past medical history, who underwent elective revision spinal surgery and subsequently developed intracranial hypotension, remote cerebellar haemorrhage (RCH), and mild hydrocephalus on the fourth postoperative day. Remote cerebellar haemorrhage is a known complication of supratentorial surgery. This iatrogenic phenomenon may also occur following spinal

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2018 Case reports in neurological medicine

58. Nusinersen (Spinraza) - for the treatment of 5q spinal muscular atrophy (SMA)

Scottish Medicines Consortium 2 Indication For the treatment of 5q spinal muscular atrophy (SMA). 1 Dosing Information The recommended dosage is 12mg administered by intrathecal injection over one to three minutes. New treatment should be initiated as early as possible after diagnosis with four loading doses on days 0, 14, 28, and 63, followed by maintenance doses administered every four months thereafter. It is recommended that the volume of cerebral spinal fluid, equivalent to the volume (...) Nusinersen (Spinraza) - for the treatment of 5q spinal muscular atrophy (SMA) Published 7 May 2018 1 nusinersen 12mg solution for injection (Spinraza ® ) SMC No 1318/18 Biogen Idec Ltd 6 April 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHS Scotland. The advice is summarised as follows: ADVICE: following a full submission considered under the ultra-orphan

2018 Scottish Medicines Consortium

59. Role of Cerebrospinal Fluid in Spaceflight-induced Ocular Changes and Visual Impairment in Astronauts. (PubMed)

Role of Cerebrospinal Fluid in Spaceflight-induced Ocular Changes and Visual Impairment in Astronauts. Notice of retraction: the article "Role of Cerebral Spinal Fluid in Space Flight Induced Ocular Changes and Visual Impairment in Astronauts" by Alperin et al This article has been retracted due to security concerns raised by NASA, the sponsoring agency. © RSNA, 2017.

2017 Radiology

60. Management of a Ventral Cerebrospinal Fluid Leak With a Lumbar Transforaminal Epidural Blood Patch in a Child With Persistent Postdural Puncture Headache: A Case Report. (PubMed)

the physician both to question the diagnosis of PDPH by pursuing radiographic confirmation of a cerebral spinal fluid leak and, furthermore, identification of its location to best direct further therapy. (...) Management of a Ventral Cerebrospinal Fluid Leak With a Lumbar Transforaminal Epidural Blood Patch in a Child With Persistent Postdural Puncture Headache: A Case Report. Postdural puncture headache (PDPH) is an uncommon sequel of lumbar puncture in children. When conservative treatment with bed rest, hydration, and caffeine are ineffective, epidural blood patches are recommended and are generally effective. The purpose of this report was to highlight that when lumbar epidural blood patches fail

2017 Regional Anesthesia and Pain Medicine

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