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Cerebral Spinal Fluid

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181. Cerebral palsy

of cerebral palsy include: Brain tumour — suggested by acute presentation with headache, other signs and symptoms of raised intracranial pressure (such as early morning vomiting), seizures, and focal neurological deficits, following initially normal development. Dystonia — suggested by onset of muscular deformity after several years of normal development. Presents with sustained periods of muscle contraction and dystonia (movements can be abrupt and violent). Contractures are absent. There may (...) Cerebral palsy Cerebral palsy - NICE CKS Share Cerebral palsy: Summary Cerebral palsy (CP) is an umbrella term for a group of permanent movement and posture disorders that limit activity. The undelying cause is an acquired pathology within the developing brain during the prenatal, neonatal, or early infant period. The impaired movement associated with CP results from centrally-mediated abnormal muscle tone which leads (most commonly) to spasticity. CP can also incorporate disorders of sensation

2019 NICE Clinical Knowledge Summaries

182. Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease. Full Text available with Trip Pro

Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease. To investigate the cumulative effect of five consecutive nights of partial sleep deprivation (PSD) on a panel of cerebrospinal fluid (CSF) biomarkers in healthy adults.A randomized, cross-over study conducted at the University of Gothenburg. The participants (N = 13) were healthy adults (20-40 years of age) with a normal sleeping pattern. The participants underwent a baseline sleep period consisting of five nights (...) with 8 hr spent in bed. A subsequent period with PSD consisted of five nights of maximum 4 hr of sleep per night. Four participants were also subjected to a prolonged period of PSD consisting of eight nights with 4 hr of sleep per night. Sleep was monitored by means of observation, actigraphy, and continuous polysomnographic recordings. CSF samples were collected by routine lumbar puncture after each period. CSF biomarkers included the 38, 40, and 42 amino acid-long Aβ isoforms, total-τ, phospho-τ

2018 Sleep Controlled trial quality: uncertain

183. H NMR metabolic signature of cerebrospinal fluid following repetitive lower-limb remote ischemia preconditioning. (Abstract)

H NMR metabolic signature of cerebrospinal fluid following repetitive lower-limb remote ischemia preconditioning. Background OBJECTIVE: The cerebral ischemia/reperfusion greatly influences brain metabolism. Remote ischemia preconditioning (RIPC) is reported to confer neuroprotective effects against cerebral ischemia in animal models and human. This study aims to investigate the metabolomic profiles of cerebrospinal fluid (CSF) in patients treated with repetitive lower limb RIPC and provides (...) -acid metabolism in brain, which provides a potential mechanistic understanding of RIPC-induced tolerance to cerebral ischemia.Copyright © 2018 Elsevier Ltd. All rights reserved.

2018 Neurochemistry international Controlled trial quality: uncertain

184. Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease. Full Text available with Trip Pro

Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease. Neuropathological and in vivo brain imaging studies agree that the cornu ammonis 1 and subiculum subfields of the hippocampus are most vulnerable to atrophy in the prodromal phases of Alzheimer's disease (AD). However, there has been limited investigation of the structural integrity of the components of the hippocampal circuit, including subfields (...) and extra-hippocampal white matter structure, in relation to the progression of well-accepted cerebrospinal fluid (CSF) biomarkers of AD, amyloid-β 1-42 (Aβ) and total-tau (tau). We investigated these relationships in 88 aging asymptomatic individuals with a parental or multiple-sibling familial history of AD. Apolipoprotein (APOE) ɛ4 risk allele carriers were identified, and all participants underwent cognitive testing, structural magnetic resonance imaging, and lumbar puncture for CSF assays of tau

2018 Human brain mapping Controlled trial quality: uncertain

185. Two Fluid Strategies for Prevention of Post-dural Puncture Headache

Two Fluid Strategies for Prevention of Post-dural Puncture Headache Two Fluid Strategies for Prevention of Post-dural Puncture Headache - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Two Fluid Strategies (...) Information provided by (Responsible Party): Ahmed Hasanin, Cairo University Study Details Study Description Go to Brief Summary: Postdural puncture headache (PDPH) is a common complication after cesarean delivery (CD). The role of peri-operative fluid therapy in prophylaxis against PDPH is unclear. The aim of this work is to compare restrictive versus liberal fluid therapy in prophylaxis against PDPH after CD Condition or disease Intervention/treatment Phase Post-Dural Puncture Headache Drug: Restrictive

2018 Clinical Trials

186. Intraocular pressure during neurosurgical procedures in context of head position and loss of cerebrospinal fluid. (Abstract)

Intraocular pressure during neurosurgical procedures in context of head position and loss of cerebrospinal fluid. OBJECTIVEPerioperative visual loss (POVL) is a rare but serious complication in surgical disciplines, especially in spine surgery. The exact pathophysiology of POVL remains unclear, but elevated intraocular pressure (IOP) is known to be part of it. As POVL is rarely described in patients undergoing intracranial or intradural surgery, the aim of this study was to investigate (...) the course of IOP during neurosurgical procedures with opening of the dura mater and loss of CSF.METHODSIn this prospective, controlled trial, 64 patients fell into one of 4 groups of 16 patients each. Group A included patients undergoing spine surgery in the prone position, group B patients had intracranial procedures in the prone position, and group C patients were treated for intracranial pathologies in a modified lateral position with the head rotated. In groups A-C, the dura was opened during

2018 Journal of Neurosurgery

187. Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: A 25-Year Follow-Up Study. Full Text available with Trip Pro

Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: A 25-Year Follow-Up Study. Psychological stress has previously been associated with higher risk of developing late-life dementia, especially Alzheimer's disease (AD). This study tested whether longstanding midlife stress is related to cerebrospinal fluid (CSF) biomarkers of late-life AD, such as tau protein and amyloid beta (Aβ).The study included 79 nondemented females from the Prospective Population (...) Study of Women in Gothenburg, Sweden, who responded to a standardized stress question at baseline (mean age 49 years) and underwent a lumbar puncture at follow-up 25 years later. Multiple linear regression models analyzed the relationships between midlife psychological stress and late-life CSF measures of total tau (t-tau), phosphorylated tau (p-tau), Aβ40, and Aβ42.Longstanding stress in midlife was associated with higher levels of CSF t-tau (β = 0.64, p = 0.01) and Aβ40 (β = 0.60, p = 0.02

2018 Dementia and Geriatric Cognitive Disorders

188. Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus Full Text available with Trip Pro

Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus The aim of the present study was to examine cerebrospinal fluid (CSF) volumetric net flow rate and direction at the cranio-cervical junction (CCJ) and cerebral aqueduct in individuals with idiopathic normal pressure hydrocephalus (iNPH) using cardiac-gated phase-contrast magnetic resonance imaging (PC-MRI). An in-depth, pixel-by-pixel analysis of regions of interest from the CCJ and cerebral (...) aqueduct, respectively, was done in 26 iNPH individuals, and in 4 healthy subjects for validation purposes. Results from patients were compared with over-night measurements of static and pulsatile intracranial pressure (ICP). In iNPH, CSF net flow at CCJ was cranially directed in 17/22 as well as in 4/4 healthy subjects. Estimated daily CSF volumetric net flow rate at CCJ was 6.9 ± 9.9 L/24 h in iNPH patients and 4.5 ± 5.0 L/24 h in healthy individuals. Within the cerebral aqueduct, the CSF net flow

2018 NeuroImage : Clinical

189. Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Full Text available with Trip Pro

Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Traumatic brain injury (TBI) elevates Abeta (Aβ) peptides in the brain and cerebral spinal fluid. Aβ peptides are amphipathic molecules that can modulate membrane mechanics. Because the mechanosensitive cation channel PIEZO1 is gated by membrane tension and curvature, it prompted us to test the effects of Aβ on PIEZO1. Using precision fluid shear stress as a stimulus, we found that Aβ monomers inhibit PIEZO1

2018 Scientific reports

190. Morphogenesis of Canine Chiari Malformation and Secondary Syringomyelia: Disorders of Cerebrospinal Fluid Circulation Full Text available with Trip Pro

of the axis and atlas with increased odontoid angulation. The most shared manifestation of CM is the development of fluid-filled pockets (syrinx, syringes) in the spinal cord that can be readily quantified. Dogs with symptomatic CM without SM have a reduced basioccipital bone, compensatory increased cranial fossa height with displaced parenchyma whereby the cerebellum is invaginated beneath the occipital lobes but without compromising cerebrospinal fluid channels enough to cause SM. Thus, broadly defined (...) Morphogenesis of Canine Chiari Malformation and Secondary Syringomyelia: Disorders of Cerebrospinal Fluid Circulation Chiari-like Malformation (CM) and secondary syringomyelia (SM), as well as their analogous human conditions, is a complex developmental condition associated with pain and accompanying welfare concerns. CM/SM is diagnosed ever more frequently, thanks in part to the increased availability of magnetic resonance imaging in veterinary medicine. Research over the last two decades has

2018 Frontiers in veterinary science

191. Traumatic cerebrospinal fluid oculorrhea managed with an external ventricular drain Full Text available with Trip Pro

Traumatic cerebrospinal fluid oculorrhea managed with an external ventricular drain Cerebrospinal fluid (CSF) leaks following head injuries are rare complications with significant morbidity and mortality if left untreated. CSF oculorrhea secondary to a cranio-orbital fistula is a rare presentation of this complication. Standard treatment for a CSF leak involves management of intracranial pressure, CSF diversion and surgical repair of any dural defect. Lumbar drains have commonly been inserted

2018 Journal of surgical case reports

192. Low Diagnostic Yield of Routine Cerebrospinal Fluid Analysis in Juvenile Stroke Full Text available with Trip Pro

Low Diagnostic Yield of Routine Cerebrospinal Fluid Analysis in Juvenile Stroke Background: The diagnostic value of cerebrospinal fluid (CSF) analysis in juvenile stroke, i.e., stroke in young adult patients, is not well studied. We sought to determine the therapeutic impact of routine CSF-analysis in young adults with acute ischemic stroke or transient ischemic attack (TIA). Methods: We abstracted data from patients with acute cerebral ischemia aged 18-45 years who were consecutively admitted (...) %). Of these, 25 patients (12.4 %) had CSF pleocytosis (leucocyte cell count ≥ 5 Mpt/L), that was rated as non-specific (e.g., traumatic lumbar puncture, reactive pleocytosis) in 22 patients. Only 3 patients (1.5% of all patients who underwent CSF-analysis) with CSF-pleocytosis had specific CSF-findings that were related to stroke etiology and affected secondary stroke prevention therapy. Imaging findings had already suggested cerebral vasculitis in two of these patients. Conclusions: The diagnostic yield

2018 Frontiers in neurology

193. The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis Full Text available with Trip Pro

The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis Organ development depends on the integration of coordinated long-range communication between cells. The cerebrospinal fluid composition and flow properties regulate several aspects of central nervous system development, including progenitor proliferation, neurogenesis, and migration [1-3]. One understudied component of the cerebrospinal fluid, described over a century ago in vertebrates, is the Reissner fiber (...) . This extracellular thread forming early in development results from the assembly of the SCO-spondin protein in the third and fourth brain ventricles and central canal of the spinal cord [4]. Up to now, the function of the Reissner fiber has remained elusive, partly due to the lack of genetic invalidation models [4]. Here, by mutating the scospondin gene, we demonstrate that the Reissner fiber is critical for the morphogenesis of a straight posterior body axis. In zebrafish mutants where the Reissner fiber

2018 Current Biology

194. Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants Full Text available with Trip Pro

Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants Cerebral ischemia generates neuroinflammation that can induce neural cell death. This cohort study assessed whether Fas-ligand (FasL) and interleukin (IL)-6 levels in the cerebrospinal fluid (CSF) after hypoxic-ischemic encephalopathy (HIE) can serve as biomarkers of hypoxic brain injury in neonates.Term infants (> 37-week (...) gestational age) who were admitted to the neonatal intensive care unit of Karolinska University Hospital in years 2002 to 2004 with perinatal asphyxia were enrolled prospectively. Control infants without brain pathology underwent lumbar puncture for suspected infection. FasL and IL-6 levels were measured in the CSF, by enzyme-linked immunosorbent assays. All patients underwent neurological assessment at 18 months. HIE was classified as mild, moderate, or severe (HIE I-III). Adverse neurological outcome

2018 Journal of neuroinflammation

195. Low Cerebrospinal Fluid Aβ42 and Aβ40 are Related to White Matter Lesions in Cognitively Normal Elderly Full Text available with Trip Pro

of AD in the oldest old.To study CSF amyloid biomarkers in relation to brain atrophy and WMLs in 85-year-olds with and without dementia.53 octogenarians took part in neuropsychiatric examinations and underwent both a lumbar puncture and a brain CT scan. CSF levels of Aβ42 and Aβ40 were examined in relation to cerebral atrophy and WMLs. Dementia was diagnosed.In 85-year-olds without dementia, lower levels of both CSF Aβ42 and CSF Aβ40 were associated with WMLs. CSF Aβ42 also correlated with measures (...) Low Cerebrospinal Fluid Aβ42 and Aβ40 are Related to White Matter Lesions in Cognitively Normal Elderly Low cerebrospinal fluid (CSF) levels of Aβ42 may be the earliest manifestation of Alzheimer's disease (AD). Knowledge on how CSF Aβ interacts with different brain pathologies early in the disease process is limited. We examined how CSF Aβ markers relate to brain atrophy and white matter lesions (WMLs) in octogenarians with and without dementia to explore the earliest pathogenetic pathways

2018 Journal of Alzheimer's Disease

196. Cerebrospinal fluid B cells and disease progression in multiple sclerosis - A longitudinal prospective study. Full Text available with Trip Pro

Cerebrospinal fluid B cells and disease progression in multiple sclerosis - A longitudinal prospective study. There is evidence that B cells play an important role in disease pathology of multiple sclerosis (MS). The aim of this prospective observational study was to determine the predictive value of cerebrospinal fluid (CSF) B cell subtypes in disease evolution of patients with MS.128 patients were included between 2004 and 2012. Median follow up time was 7.9 years (range 3.3-10.8 years). 10 (...) patients were lost to follow-up. 32 clinically isolated syndrome- (CIS), 25 relapsing remitting MS- (RRMS), 2 secondary progressive MS- (SPMS) and 9 primary progressive MS- (PPMS) patients were included. The control group consisted of 40 patients with other neurological diseases (OND). CSF samples were analyzed for routine diagnostic parameters. B cell phenotypes were characterized by flow cytometry using CD19 and CD138 specific antibodies. Standardized baseline brain MRI was conducted at the time

2017 PLoS ONE

197. Cerebrospinal fluid markers of extracellular matrix remodeling, synaptic plasticity and neuroinflammation before and after cranial radiotherapy. Full Text available with Trip Pro

Cerebrospinal fluid markers of extracellular matrix remodeling, synaptic plasticity and neuroinflammation before and after cranial radiotherapy. Advances in the treatment of brain tumours have increased the number of long-term survivors, but at the cost of side effects following cranial radiotherapy ranging from neurocognitive deficits to outright tissue necrosis. At present, there are no tools reflecting the molecular mechanisms underlying such side effects, and thus no means to evaluate (...) interventional effects after cranial radiotherapy. Therefore, fluid biomarkers are of great clinical interest.Cerebrospinal fluid (CSF) levels of proteins involved in inflammatory signalling, synaptic plasticity and extracellular matrix (ECM) integrity were investigated following radiotherapy to the brain.Patients with small-cell lung cancer (SCLC) eligible for prophylactic cranial irradiation (PCI) were asked to participate in the study. PCI was prescribed either as 2 Gy/fraction to a total dose of 30 Gy

2018 Journal of internal medicine

198. Assessment of Cerebrospinal Fluid Flow Related Disorders Using a Phase-contrast Magnetic Resonance Imaging Technique.

. ClinicalTrials.gov Identifier: NCT03656016 Recruitment Status : Recruiting First Posted : September 3, 2018 Last Update Posted : January 10, 2019 See Sponsor: Assiut University Information provided by (Responsible Party): Shimaa Hassanien Hassanien Bakr, Assiut University Study Details Study Description Go to Brief Summary: Cerebrospinal fluid is a clear, colorless fluid that circulates in the cranial and spinal subarachnoid spaces, located between the pia and arachnoid matters. It is mainly produced (...) by the choroid plexus, while lesser amount produced by the ependymal cells lining the ventricles. Its function includes cushioning and lubrication of the central nervous system, circulation of nutrients and waste collection providing basic mechanical and immunological protection to the brain. Condition or disease Intervention/treatment Cerebrospinal Fluid Device: Magnetic Resonance Imaging Detailed Description: There are several disorders such as communicating and non- communicating hydrocephalus, normal

2018 Clinical Trials

199. Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease

Injury (e.g., CSF NfL and tau) at 3, 9, and 15 Months [ Time Frame: Baseline to 15 Months ] CSF = Cerebrospinal Fluid NfL = Neurofilament Light Chain Change from Baseline in Brain Atrophy Endpoints (e.g., Whole Brain Volume Decline, Caudate Volume Decline) as Determined by Brain MRI, at 3, 9, and 15 Months [ Time Frame: Baseline to 15 Months ] Secondary Outcome Measures : Within-Participant Change from Baseline in CSF mHTT Levels at 3, 9, and 15 Months [ Time Frame: Baseline to 15 Months ] mHTT (...) Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2018 Clinical Trials

200. Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study. Full Text available with Trip Pro

Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study. To compare the orbital cerebral spinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) determined noninvasively in ocular hypertensive (OH) subjects and controls.Cross-sectional observational study. Magnetic resonance imaging was used to measure orbital subarachnoid space width (OSASW). The CSFP (mm Hg) was estimated from a published formula as 17.54 × MRI derived

2018 Acta ophthalmologica

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