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Cerebral Aneurysm

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5441. A Pilot Study of Inosine in ALS

1 year prior to Screening. Symptomatic congestive heart failure with a documented ejection fraction below 45%. Poorly controlled arterial hypertension (SBP>160mmHg or DBP>100mmHg at Screening). Contraindications to undergo magnetic resonance spectroscopy (MRS) at Baseline and at Week 12 of the study such as history of claustrophobia, inability to lie flat for approximately one hour, or metal implants (metal pins or plates, extensive non-removable dental work, cerebral aneurysm clips, pacemaker

2014 Clinical Trials

5442. Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus

- Clinical and Translational Science Institute Information provided by (Responsible Party): University of Minnesota - Clinical and Translational Science Institute Study Details Study Description Go to Brief Summary: The purpose of the study is to investigate different stimulation parameters for a new noninvasive approach for modulating the brain that could potentially be beneficial for decreasing tinnitus perception. The new approach is called Multimodal Synchronization Therapy (mSync). mSync uses (...) a combination of acoustic stimulation played through headphones and low levels of electrical current delivered via electrodes placed on the surface of different body regions. The timing interval between the acoustic and body stimulation is varied in order to cause different types of changes in the brain. In addition to acoustic and body stimulation, noninvasive cortical stimulation will also be presented as part of mSync to attempt to further modulate or decrease the tinnitus percept. Cortical stimulation

2014 Clinical Trials

5443. Electrical Stimulation in Patients With Unipolar Major Depression

for treatment of MDD; Patients with exposure to ECT or rTMS or any investigational treatment (for any disorder) within the past 6 months; Prior VNS and/or DBS therapy (lifetime); Past history of skull fracture; cranial surgery entering the calvarium; space occupying intracranial lesion; stroke, CVA, or TIAs; cerebral aneurysm; Parkinson's or Huntington's disease; or Multiple Sclerosis. Current pregnancy, breast feeding, plans to become pregnant during the study, or not using a medically accepted means

2014 Clinical Trials

5444. Electrical Stimulation in Patients With Unipolar Major Depression

of depression) will be excluded. Patients currently receiving more than six medications for treatment of MDD; Patients with exposure to ECT or rTMS or any investigational treatment (for any disorder) within the past 6 months; Prior VNS and/or DBS therapy (lifetime); Past history of skull fracture; cranial surgery entering the calvarium; space occupying intracranial lesion; stroke, CVA, or TIAs; cerebral aneurysm; Parkinson's or Huntington's disease; or Multiple Sclerosis; Current pregnancy, breast feeding

2014 Clinical Trials

5445. PET Imaging in ALS Patients

: This is a pilot study to evaluate a potential imaging biomarker for aiding diagnosis and monitoring progression of ALS, based on a well established basic science pathway, published human autopsy data, preliminary data in ALS mutant mice, and our recently published data using brain PET scans to image the metabotropic glutamate receptor type 5 (mGluR5) in healthy human volunteers. Condition or disease Intervention/treatment Phase Amyotrophic Lateral Sclerosis (ALS) Other: PET Scanning Not Applicable Study (...) in at least two extremities. Forced vital capacity less than 80% and greater than 50%. Exclusion Criteria: Documented orthopnea or otherwise unable to lie flat in a PET scanner for 90 minutes. Presence of pacemakers, aneurysm clips, shrapnel, or other implanted metallic devices that would preclude an MRI scan. Absence of sufficient collateral arterial circulation for radial arterial line placement in both wrists. Significant abnormalities of hepatic or renal function, or illicit substance use. Positive

2014 Clinical Trials

5446. Effects of Chemoradiation and Surgery on Cardiopulmonary Fitness and Tumor Neoplastic Phenotype in Gastrointestinal Malignancies

mortality for patients with breast, prostate, brain or colorectal cancer. Nearly a 40-50% relative risk reduction in cancer specific death and 20-50% relative risk reduction in all cause mortality have been reported with exercise. At present it is unknown if preclinical pleiotropic effects on tumors through aerobic exercise are clinically relevant. Before launching into further studies of exercise training on changes in tumor hypoxia and response to CRT in rectal cancer patients, it is first important (...) as recommended by the American Thoracic Society: (a) acute myocardial infarction (3-5 days), (b) unstable angina, (c) uncontrolled arrhythmias causing symptoms or hemodynamic compromise, (d) syncope, (e) acute endocarditis, (f) acute myocarditis or pericarditis, (g) uncontrolled heart failure, (h) acute pulmonary embolus or pulmonary infarction, (i) thrombosis of lower extremities, (j) suspected dissecting aneurysm, (k) uncontrolled asthma, (l) pulmonary edema, (m) room air desaturation at rest ≤85%, (n

2014 Clinical Trials

5447. A Study of Pre-hospital Treatment of Acute Myocardial Infarction Based on Diagnosis by Interpretation of Remotely Acquired ECG and Thrombolysis With Accelerated Alteplase ( Actilyse®)

ischaemic attack, or central nervous system structural damage (e.g. neoplasm, aneurysm, intracranial surgery) Oral anticoagulation Recent (within 10 days) non - compressible vascular puncture Pregnancy (positive urine pregnancy test) or lactation, parturition within the previous 30 days, or female of childbearing potential not using adequate birth control (oral contraception) Severe liver disease, including hepatic failure, cirrhosis portal hypertension (oesophageal varices) and active hepatitis (...) Diabetes with definite history of retinopathy Other serious illness (e.g. malignancy, active infection) Bacterial endocarditis / pericarditis Acute pancreatitis Documented ulcerative gastrointestinal disease during last 3 month, arterial aneurysms, arterial / venous malformations Any other condition that the investigator feels would pose a significant hazard to the subject if the investigational therapy was to be initiated Patients who are not excluded from thrombolytic therapy by the criteria above

2014 Clinical Trials

5448. Efficacy and Safety of TC+AVASTIN Versus TC in Patients With Metastatic Nasopharyngeal Carcinoma

blood mixed with phlegm are not excluded Patients receiving other experimental therapeutic cancer treatment Severe, active co-morbidity, defined as follows: i.--Unstable angina and/or congestive heart failure or vascular (e.g. aortic aneurysm requiring surgical repair or peripheral thrombosis) disease requiring hospitalization within the last 12 months, or other cardiac compromise (e.g. an inadequately controlled cardiac arrhythmia) that in the judgment of the investigator will preclude the safe (...) administration of a study drug; Patient must not show sign of recent myocardial infarction or ischemia by the findings of S-T elevations of ≥ 2mm on an EKG ii.--History of arterial thromboembolic events, venous thromboembolism >NCI CTCAE Grade 3, transient ischemic attack (TIA), cerebral vascular accident (CVA), transmural myocardial infarction (MI), or hypertensive crisis or hypertensive encephalopathy iii.--History of ongoing bleeding diathesis, hemorrhagic disorder, or coagulopathy iv.--Chronic

2014 Clinical Trials

5449. AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)

of patients followed at the University Hospital of Strasbourg showed the presence of vascular lesions discovered incidentally during assessments performed for reasons other than cardiovascular screening: cystic lymphangioma, internal carotid aneurysm, agenesis of the inferior vena cava, early varicose veins, embryonic cerebral artery, etc ... None of these patients showed any dilatation of the ascending aorta or heart disease. Peripheral vascular abnormalities in this patient group are exclusive (...) and ovarian failure with infertility. Other anomalies are inconstant: morphological characteristics of varying intensity, associated malformations, and increased risk of acquired diseases ... The prognosis of patients reaching the Turner Syndrome is linked to cardiovascular complications (congenital heart disease, dilatation of the ascending aorta with risk of dissection or rupture of aneurysm), causing early mortality with reduction of life expectancy of at least 10 years. For these reasons, screening

2014 Clinical Trials

5450. Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 60732 in Healthy Male Volunteers

of arteriovenous malformation or aneurysm History of gastroduodenal ulcer disease or gastrointestinal haemorrhage History of intracranial, intraocular, spinal, retroperitoneal, or atraumatic intraarticular bleeding Use of drugs that may interfere with haemostasis during trial conduct (e.g. acetylsalicylic acid or other non-steroidal anti-inflammatory drugs) Thrombocytopenia (platelet count < 100/nL) Contacts and Locations Go to No Contacts or Locations Provided More Information Go to Additional Information

2014 Clinical Trials

5451. Thrombolysis in Ischemic Spinal Cord Stroke

: Ischemic stroke of the spinal cord is a rare disease accounting for about 1% of all ischemic events in the central nervous system (CNS). In most cases the consequences are catastrophic, with a high rate of severe functional disability and mortality rate up to 30%. Ischemic stroke of the spinal cord can arise from: Dissection of the aorta. Aneurism in the aorta. Atherosclerotic disease of the aorta or vertebral arteries. Spinal surgeries. Spinal AVM. Embolism from cardiac origin. Occlusion of radicular (...) or acute demyelinating polyneuropathy like Guillan Barree Syndrome (GBS). Therefore in order to reach the appropriate diagnosis in most cases an urgent MRI of the spinal cord is necessary upon arrival in the emergency department. One of the treatments to acute ischemic stroke is providing thrombolysis. As tested and validated in numerous studies for ischemic events in the brain, until today no validated study in ischemic spinal stroke using thrombolysis has been completed. Condition or disease

2014 Clinical Trials

5452. A Study of LY2157299 in Participants With Unresectable Hepatocellular Cancer (HCC)

disease. Myocardial infarction within 6 months prior to enrollment, unstable angina pectoris, New York Heart Association (NYHA) Class III/IV congestive heart failure, or uncontrolled hypertension. Documented major electrocardiogram (ECG) abnormalities at the investigator's discretion within 28 days prior to enrollment. Major abnormalities documented by echocardiography with Doppler at investigator's direction within 28 days prior to enrollment. Have persistently elevated brain natriuretic peptide (BNP (...) ) or elevated troponin I within 14 days prior to enrollment. Predisposing conditions that are consistent with development of aneurysms of the ascending aorta or aortic stress. Have a history of cardiac or aortic surgery. Have undergone liver transplant. Are pregnant or breastfeeding. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor

2014 Clinical Trials

5453. Ipilimumab and/or Nivolumab in Combination With Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

of stroke, cerebral vascular accident (CVA) or transient ischemic attack within 6 months prior to registration Serious and inadequately controlled cardiac arrhythmia Significant vascular disease (e.g., aortic aneurysm, history of aortic dissection) or clinically significant peripheral vascular disease Evidence of bleeding diathesis or coagulopathy Serious or non-healing wound, ulcer, or bone fracture or history of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess major surgical

2014 Clinical Trials

5454. Dietary Flavanols and Dentate Gyrus Function

days (28 occasions total) or if there are > 8 capsules left in the bottle after the two weeks will be excluded). Run-In Period. MRI RELATED Cardiac Pacemaker Interview Internal Pump Interview Insulin Pump Interview Tattoo eyeliner Interview Wire sutures Interview Internal Metal Objects Interview Metal Slivers in Eye Interview Prosthesis Interview Hearing Aid Implants Interview Neurostimulator Interview Metal Fragments Interview Brain Aneurysm Clips Interview Vascular Clips Interview Breast Expander (...) Active Comparator: F 650 mg daily consumption of capsules containing 650 mg cocoa flavanol for 12 weeks Dietary Supplement: Cocoa Flavanol 12 weeks administration of cocoa flavanol Outcome Measures Go to Primary Outcome Measures : dentate gyrus specific cognitive function [ Time Frame: 12 weeks ] measured by the modified Benton Recognition Task (ModBent) Secondary Outcome Measures : inflammatory markers [ Time Frame: 12 weeks ] IL6, CRP, CCL11, TNFa, HMGB1 dentate gyrus cerebral blood volume [ Time

2014 Clinical Trials

5455. Sudden death due to subarachnoid haemorrhage in an infant with autosomal dominant polycystic kidney disease. (Full text)

Sudden death due to subarachnoid haemorrhage in an infant with autosomal dominant polycystic kidney disease. Intracranial aneurysm rupture is the most serious and potentially lethal extra-renal manifestation of autosomal dominant polycystic kidney disease (ADPKD). Almost all cases of ruptured intracranial aneurysm occur in adult patients with a median age of rupture of 40 years. We report the occurrence of sudden death in a newborn infant born to a mother with typical ADPKD in the first week (...) of life. Post-mortem examination revealed the cause of death to be subarachnoid haemorrhage with focal glomerular and tubular cysts detected in the kidney. This is the earliest reported case of intracranial aneurysm rupture in ADPKD and should raise awareness of this rare but lethal complication in younger patients. © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

2014 Transplantation PubMed abstract

5456. Open aortic arch reconstruction after previous cardiac surgery: Outcomes of 168 consecutive operations. (Full text)

of reoperation were analyzed.The mean age was 61 ± 14 years, and 119 were men (70%). The indications for reoperation were aneurysm (57%), valvular disease (13%), impending rupture (12%), aortic dissection (9.0%), and endocarditis (7.7%). The median time from the previous operation to reoperation was 7 years. The mean aortic diameter was 55 mm. Total or partial arch replacement was performed in 38% and 62% of patients, respectively. Fifty-five patients (32.7%) had undergone previous ascending dissection (...) repair and 45 (26.8%) had previous coronary bypass surgery. Deep hypothermic circulatory arrest was used in all. Selective cerebral perfusion was used in 39% and retrograde cerebral perfusion in 14%. The incidence of permanent stroke was 5.4%. Operative mortality (30-day) was 8.3%. Older age (odds ratio, 1.05; 95% confidence interval, 1.00-1.10; P = .04), New York Heart Association class III/IV (odds ratio, 3.15; 95% confidence interval, 1.01-9.86; P = .04), and extracorporeal circulation time (odds

2014 Journal of Thoracic and Cardiovascular Surgery PubMed abstract

5457. Further delineation of Loeys-Dietz syndrome type 4 in a family with mild vascular involvement and a TGFB2 splicing mutation. (Full text)

, a 57-year-old woman, showed high palate, hypoplasic uvula, easy bruising, joint hypermobility, chronic pain, scoliosis, multiple relapsing hernias, dural ectasia, and mitral valve prolapse. Magnetic resonance angiography revealed tortuosity and ectasia of carotid, vertebral, cerebral, and segmental pulmonary arteries. Arterial aneurysm and dissection never occurred. Her 39- and 34-year-old daughters presented with a variable degree of musculoskeletal involvement. Molecular analysis disclosed (...) Further delineation of Loeys-Dietz syndrome type 4 in a family with mild vascular involvement and a TGFB2 splicing mutation. The Loeys-Dietz syndrome (LDS) is a rare autosomal dominant disorder characterized by thoracic aortic aneurysm and dissection and widespread systemic connective tissue involvement. LDS type 1 to 4 are caused by mutations in genes of the TGF-β signaling pathway: TGFBR1 and TGFBR2 encoding the TGF-β receptor (LDS1 and LDS2), SMAD3 encoding the TGF-β receptor cytoplasmic

2014 BMC Medical Genetics PubMed abstract

5458. Aortic arch replacement without circulatory arrest or deep hypothermia: The "branch-first" technique. (Full text)

Aortic arch replacement without circulatory arrest or deep hypothermia: The "branch-first" technique. Although current developments in aortic arch replacement have demonstrated progressively improving mortality, cerebral morbidity remains significant. We describe a "branch-first" technique that avoids circulatory arrest and profound hypothermia, yielding excellent survival and low cerebral morbidity.From September 2005 to February 2014, 64 patients underwent the "branch-first" technique (...) age was 65 (range, 17-85) years. Twenty-five cases (39.1%) were of urgent/emergency status. Thirty-one patients (48.4%) underwent operation for aortic dissection, and the remaining patients underwent operation for aneurysms. Sixteen patients (25.0%) had previously undergone a cardiac surgical procedure.There were 2 (3.1%) early mortalities, and 1 patient (1.6%) had a permanent stroke. One patient (1.6%) required mechanical support, and 4 patients (6.3%) required hemofiltration for renal support

2014 Journal of Thoracic and Cardiovascular Surgery PubMed abstract

5459. Frameless neuronavigation based only on 3D digital subtraction angiography using surface-based facial registration. (Full text)

on 3D DSA was then used to guide an open clipping procedure for a patient who presented with a ruptured distal lenticulostriate aneurysm.The accuracy of the measurements for the cadaver model was 0.71 ± 0.25 mm (mean ± SE), which is superior to the 1.8-5 mm reported for neuronavigation. The 3D DSA-based navigation-assisted surgery for the distal lenticulostriate aneurysm aided in localization, resulting in a small craniotomy and minimal brain dissection.This is the first example of frameless

2014 Journal of Neurosurgery PubMed abstract

5460. Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio). (Full text)

contributing to endothelial cell-cell adhesion is of clinical relevance, particularly in the treatment of aneurysms and cerebral cavernous malformations. The zebrafish (Danio rerio) have recently emerged as a powerful paradigm for studies geared toward elucidating the etiology of cerebrovascular disorders, principally in uncovering the genetic and mechanistic basis controlling endothelial adhesive barrier function.

2014 Journal of Cerebral Blood Flow and Metabolism PubMed abstract

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