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Cerebral Aneurysm

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5381. Positive Emotional Processing: Exploring Novel Treatment Targets in Social Phobia

but not limited to: unstable hypertension, unstable angina, unstable diabetes mellitus, unstable cardiac arrhythmias, transient ischemic attacks, severe coronary artery disease, severe peripheral vascular disease, severe hepato-gastro-intestinal disease, severe infectious disease (e.g. HIV), recurrent severe headache or migraine, fainting spells, seizures, and history of traumatic brain injury with loss of consciousness >30 minutes Current use of the following medications: antidepressants, benzodiazepines (...) , antipsychotics, mood stabilizers, or other drugs that can acutely affect the hemodynamic response (methylphenidate and acetazolamide) Caffeine intake >10 cups/day or recent significant changes in consumption MRI exclusions, including claustrophobia, cardiac pacemaker, metal fragments in eyes/skin/body (shrapnel), aortic/aneurysm clips, prosthesis, by-pass surgery/coronary artery clips, hearing aid, heart valve replacement, shunt (ventricular or spinal), electrodes, metal plates/pins/screws/wires, or neuro

2014 Clinical Trials

5382. The ISLAND Study: InSuLa Assessed Needs for Depression

: National Institute of Mental Health (NIMH) Information provided by (Responsible Party): Boadie W. Dunlop, Emory University Study Details Study Description Go to Brief Summary: While there are many effective options for treating a major depressive episode, there are no clinical markers that predict the likelihood of remission with an initial trial of either an antidepressant medication or psychotherapy. The goal of this study is to test how brain function changes in depress patients treated (...) by the investigator. Received electroconvulsive therapy in the past 6 months or during the current depressive episode. Currently responding to medication treatment, without clinical reasons to change. Current treatment with weekly individual or group psychotherapy of any type targeted at depressive symptoms. QTc >500 milliseconds on EKG at screening. Contraindications for MRI, including, but not limited to pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, intra-uterine

2014 Clinical Trials

5383. Clinical Outcomes and Molecular Phenotypes in Smokers With Parenchymal Lung Disease

from the study if they meet one or more of the following criteria: Subjects who are under the age of 40 or over 80 years old Women who are pregnant or lactating Have known allergies to lidocaine or medications used for moderate sedation Active coronary artery disease Cerebral-vascular accident within the past 12 months Active anticoagulation Active infections Cancer, or a history of cancer within the previous 5 years of screening (other than adequately treated cutaneous basal cell, squamous cell (...) carcinoma, excised melanoma, or carcinoma in situ of the uterine cervix with no evidence of recurrence). Poorly controlled chronic diseases Unable to provide consent Impaired renal function (including dialysis) Contraindications to MRI scan including: electrical implants such as cardiac pacemakers or perfusion pumps ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants

2014 Clinical Trials

5384. Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications

, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Subjects with ischemic and non-ischemic cardiac disease referred for cardiac PET for viability imaging. Exclusion Criteria: Contraindications for MRI, including cardiac pacemaker, claustrophobia, retained metallic foreign body, cochlear implant, Aneurysm clip in the brain, pregnancy and eGFR less than 45%. Contacts and Locations Go to Information from the National Library of Medicine To learn more

2014 Clinical Trials

5385. Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease

Abdominal Aortic Aneurysm Other: No intervention Detailed Description: The linkage of Clinical Practice Research Datalink (CPRD) to the national registry of acute coronary syndromes (the Myocardial Ischaemia National Audit Project, MINAP), Hospital Episode Statistics (HES) and Office for National Statistics (ONS) available through CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records), offers an opportunity to investigate the association between autoimmune (...) : Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) ] Associated studies: overall, by sex, by age group Hazard ratios for the association between the presence of autoimmune disease and the initial presentation of abdominal aortic aneurysm [ Time Frame: Followed for the duration of general practice registration between date of eligibility and date of administrative censoring

2014 Clinical Trials

5386. Modulation of Muscle Protein Synthesis With Diet and Exercise in Old Aged Women

cardiovascular disease: uncontrolled high blood pressure, angina, heart failure (class III/IV), abnormal heart rhythm, right to left cardiac shunt or recent cardiac event. Taking statin-based medication above 60mg•day-1. Individuals taking beta-adrenergic blocking agents or Non-steroidal anti-inflammatory agents (NSAIDS) Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial). Respiratory disease including pulmonary hypertension, chronic obstructive pulmonary disease (COPD), asthma

2014 Clinical Trials

5387. Co-LEsions in Alzheimer Disease and Related Disorders

with progressive and unstable pathologies which could interfere with the variables under consideration Deafness or blindness which could compromise evaluation of the patient Patients being not able to undergo DaTscan®: with moderate or severe hepatic or renal impairment, a known hypersensitivity to ioflupane or any of the excipients Patient living in an institution Patient meeting brain MRI exclusion criteria (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects (...) to their clinical, pathological heterogeneity and the multiple pathological subtypes. We do not know the precise role and weight of each brain lesion type in the disability progression in elderly. To target the actual pathological process, we need to disclose the functional weight of AD, Lewy body and vascular lesion types in elderly. Most of the studies report on functional and clinical abnormalities in patients with pure pathologies. Thus, co-morbid processes involved in the transition from an independent

2014 Clinical Trials

5388. Relative Bioavailability of Dabigatran Capsules, Pellets and Oral Solution in Healthy Volunteers

in the investigator's judgement are perceived as having an increased risk of bleeding, for example because of: Hemorrhagic disorders or bleeding diathesis Occult blood in faeces or haematuria Trauma or surgery within the last month or as long as an excessive risk of bleeding persists after these events, or planned surgery during trial participation History of arteriovenous malformation or aneurysm History of gastroduodenal ulcer disease or gastrointestinal haemorrhage History of intracranial, intraocular, spinal

2014 Clinical Trials

5389. MR Imaging Biomarkers of Disease Response to ECT (Electroconvulsive Therapy) in Depression

of Arkansas Information provided by (Responsible Party): University of Arkansas Study Details Study Description Go to Brief Summary: The purpose of this study is to (a) measure how brain structure, metabolism (how the brain uses energy), and function predict response to electroconvulsive therapy (ECT) for treatment of depression; and (b) measure how ECT changes brain metabolism and function. We will ask you to undergo magnetic resonance imaging (MRI) at three sessions: (1) prior to your first ECT therapy (...) ) Exclusion Criteria: Claustrophobia, or the inability to lie still in a confined space Magnetic metallic implants (such as screws, pins, shrapnel remnants, aneurysm clips, artificial heart valves, inner ear (cochlear) implants, artificial joints, and vascular stents), as these may heat, pull, or twist in the strong magnetic field of the MRI scanner Electronic or magnetic implants, such as pacemakers, as these may stop working Non-removable dental implants, such as braces or permanent retainers

2014 Clinical Trials

5390. Microvascular Disease Exercise Trial

: Prior CABG (due to limitations of CMR quantitative perfusion in this population) Prior myocardial infarction (due to its effects on myocardial flow reserve) Hypertrophic or restrictive cardiomyopathy Coronary vasospasm Acute coronary syndrome unless concurrent coronary angiography reveals no epicardial stenoses of >50% Contraindications to CMR including - intracranial aneurysm clips, implantable pacemaker or defibrillator, metal cochlear/intraocular implants, any metallic implant not listed

2014 Clinical Trials

5391. A Study to Assess the Effect of a Single Infusion of VAY736 on Disease Activity in Patients With Relapsing-remitting Multiple Sclerosis

of chronic disease of the immune system other than MS, or a known immunodeficiency syndrome Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing and for 4 months following completion of the study. Unable to undergo MRI scans due to inter-alia, claustrophobia, incompatible cardiac pacemakers, ferromagnetic intracranial aneurysm clips, certain cochlear implants, and certain other (...) , Partially Blind, Placebo-controlled, Proof-of-concept Study to Assess the Effect of a Single Infusion of VAY736 on Disease Activity as Measured by Brain MRI Scans in Patients With Relapsing-remitting Multiple Sclerosis Actual Study Start Date : December 20, 2013 Actual Primary Completion Date : May 15, 2018 Actual Study Completion Date : September 13, 2018 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment

2014 Clinical Trials

5392. Diffusion-weighted MRI for Individualized Radiation Therapy Planning of Lung Cancer

to receive external beam radiation therapy for at least 6 weeks Tumor visible on planning CT scan Negative pregnancy test for women of childbearing potential prior to study entry Exclusion Criteria: Patients requiring continuous supplemental oxygen Patients with metal implants including pace makers and defibrillators Patients with cerebral aneurysm clips or middle ear implant Patients with pain pump, a programmable shunt, or non-surgical metal (i.e. a foreign body) Claustrophobic patients Prior

2014 Clinical Trials

5393. Advanced Analysis of the Carotid Phonoangiography and Diseases

for angiography study and intervention (n=300) with different disease entity such as atherosclerosis, tumor, aneurysm, arteriovenous malformation or fistula, and other vascular disorders. A period of about 20 seconds of the carotid phonoangiography was recorded. Standard for comparison: catheter angiography, CTA, MRI/MRA. The degree of stenosis, the wall thickness, SI and density change was clustered and compared. The clinical and laboratory data will be reviewed and the vascular risk factors (...) Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Non-Probability Sample Study Population the patients who is going to have carotid angiography study and with informed consent signed. Criteria Inclusion Criteria: Age: 20 years old to 99 years old Gender: Unlimited Because different types of brain diseases, those who received conventional catheter vascular examination. Exclusion Criteria: Neck inflammation locally who can not admit the sound. Due to inability to cooperate to accept

2014 Clinical Trials

5394. Intensive Insulin Therapy With Tight Glycemic Control to Improve Outcomes After Endovascular Therapy for Acute Ischemic Stroke

improvement from baseline NIHSS , or increase to absolute NIHSS > 30 before randomization or treatment Major stroke symptoms- NIHSS >30 Seizure at the onset of stroke Stroke due to a neurointerventional procedure for treatment of a cerebral aneurysm and/or cerebral arteriovenous malformation (stroke due to diagnostic cerebral angiography or cardiac catheterization might be treated) Clinical presentation suggestive of subarachnoid hemorrhage, even when the initial CT scan is normal. Previous known ICH (...) stroke, including impairment of language, motor function, cognition and/or gaze, vision, or neglect. Ischemic stroke is defined as an event characterized by the sudden onset of a focal neurologic deficit presumed to be due to cerebral ischemia after exclusion of ICH with a baseline CT The signal stroke should be (a) acute, (b) the most recent significant, acute worsening of serial neurologic events, or (c) related to a diagnostic radiographic procedure but not an interventional procedure Minimum

2014 Clinical Trials

5395. Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias

, brain aneurysm clips, pacemakers, and metallic foreign bodies in the eye or other body areas that would prevent use of MRI imaging Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02041299 Contacts Layout table for location contacts Contact: Caroline

2014 Clinical Trials

5396. Antiplatelet Strategy for Peripheral Arterial Interventions for Revascularization of Lower Extremities

of AT (history of intra-cerebral bleed, presence of intra-cerebral mass, recent or <6 weeks gastrointestinal bleed, blood transfusion within the last 6 weeks, any trauma requiring surgery or blood transfusion within the last 4 weeks or any surgical procedure within the last 4 weeks. Angiographic: Endovascular intervention to iliac, femoropopliteal or BTK artery bypass graft Persistent, intraluminal thrombus of the proposed target lesion at the completion of the index procedure Perforated vessel as evidenced (...) by extravasation of contrast media Vascular graft, aneurysm or postsurgical stenosis of the target vessel Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02217501 Contacts Layout table for location contacts Contact: Ishita Tejani, BDS,MS, MSPH 2148573048

2014 Clinical Trials

5397. Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease

or interpretation of the results or who in the opinion of the investigator are not suitable to participate. Subjects with Alpha-1 antitrypsin deficiency (an inherited disorder that can cause lung disease and liver disease). Unwilling and/or not able to give written consent Patient is positive for hepatitis (past history of Hepatitis A is allowed) Any medical condition, which in the opinion of the clinical investigator, would interfere with the treatment or outcome of the patient Cerebral aneurysm clips Contacts

2014 Clinical Trials

5398. Anesthesia and Functional Connectivity: An Analysis of fMRI Changes

provided by (Responsible Party): Scott Peltier, University of Michigan Study Details Study Description Go to Brief Summary: Functional connectivity is defined as a correlation in neural activity between distinct regions of the brain. Several recent studies have demonstrated areas of low-frequency functional connectivity inherent to brain tissue at rest. These oscillations can be measured using functional magnetic resonance imaging (fMRI) and appear to be synchronized between related areas of the brain (...) . To date, no investigators have examined the effects of low-dose anesthesia on functional connectivity. This study will image the human brain under conditions of rest, and low-dose anesthetic induced sedation. Quality of the acquired signals will be evaluated and functional networks in the brain will be examined. Of interest is whether administration of a low-dose anesthetic disrupts functional connectivity in the brain, and whether a disruption of functional connectivity is responsible

2014 Clinical Trials

5399. Tesamorelin Effects on Liver Fat and Histology in HIV

such as the presence of a pacemaker or cerebral aneurysm clip Previous weight loss surgery For women, positive pregnancy test performed in a CLIA certified laboratory using a test with a sensitivity of at least 25mIU/mL, or breastfeeding. Known hypersensitivity to tesamorelin or mannitol Unwillingness to abstain from the conception process during the study (i.e., must agree not to participate in an active attempt to become pregnant or impregnate, donate sperm, or participate in in vitro fertilization

2014 Clinical Trials

5400. Decompressive Hemicraniectomy in Intracerebral Hemorrhage

Keywords provided by University Hospital Inselspital, Berne: Intracerebral hemorrhage Decompressive craniectomy Randomized controlled trial Acute stroke Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Cerebral Hemorrhage Pathologic Processes Intracranial Hemorrhages Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases (...) history and imaging Age: ≥18 to ≤75 years Glasgow coma scale (GCS) <14 and >7 Neurological deficit with a NIHSS score of ≥10 and ≤30 Able to be randomly assigned to surgical treatment within 66 hours after ictus Surgery performed not later than 6 hours after randomization Volume of hematoma ≥30 ml and ≤100 ml Stable clot volume International normalized ratio (INR) <1.5, thrombocytes >100 T/ml Exclusion Criteria ICH due to known or suspected structural abnormality in the brain (e.g., intracranial

2014 Clinical Trials

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