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Cerebral Aneurysm

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5341. Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications

, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Subjects with ischemic and non-ischemic cardiac disease referred for cardiac PET for viability imaging. Exclusion Criteria: Contraindications for MRI, including cardiac pacemaker, claustrophobia, retained metallic foreign body, cochlear implant, Aneurysm clip in the brain, pregnancy and eGFR less than 45%. Contacts and Locations Go to Information from the National Library of Medicine To learn more

2014 Clinical Trials

5342. Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease

Abdominal Aortic Aneurysm Other: No intervention Detailed Description: The linkage of Clinical Practice Research Datalink (CPRD) to the national registry of acute coronary syndromes (the Myocardial Ischaemia National Audit Project, MINAP), Hospital Episode Statistics (HES) and Office for National Statistics (ONS) available through CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records), offers an opportunity to investigate the association between autoimmune (...) : Followed for the duration of general practice registration between date of eligibility and date of administrative censoring, outcome occurrence or death (expected median of 5 years) ] Associated studies: overall, by sex, by age group Hazard ratios for the association between the presence of autoimmune disease and the initial presentation of abdominal aortic aneurysm [ Time Frame: Followed for the duration of general practice registration between date of eligibility and date of administrative censoring

2014 Clinical Trials

5343. Diffusion-weighted MRI for Individualized Radiation Therapy Planning of Lung Cancer

to receive external beam radiation therapy for at least 6 weeks Tumor visible on planning CT scan Negative pregnancy test for women of childbearing potential prior to study entry Exclusion Criteria: Patients requiring continuous supplemental oxygen Patients with metal implants including pace makers and defibrillators Patients with cerebral aneurysm clips or middle ear implant Patients with pain pump, a programmable shunt, or non-surgical metal (i.e. a foreign body) Claustrophobic patients Prior

2014 Clinical Trials

5344. Contrast- Enhanced Whole-Heart Coronary MRA at 3.0T (Tesla)

, such as cardiac pacemakers, neurostimulators, and infusion pumps. Persons with ferromagnetic implants and ferromagnetic foreign bodies, such as intracranial, aneurysm clips, shrapnel and intraocular metal chips as these could become dislodged. Patients who are pregnant, nursing are implanted with intrauterine devices (IUD's) Persons who are in atrial fibrillation at the time of the MR scan as this could result in poor image quality due to interference with electrocardiographic gating necessary for image

2014 Clinical Trials

5345. Subclavian Vein catheterization_Seldinger Vs Modified Seldinger

First Posted: March 18, 2014 Last Update Posted: May 13, 2014 Last Verified: March 2014 Additional relevant MeSH terms: Layout table for MeSH terms Aneurysm Intracranial Aneurysm Brain Neoplasms Moyamoya Disease Vascular Diseases Cardiovascular Diseases Intracranial Arterial Diseases Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Central Nervous System Neoplasms Nervous System Neoplasms Neoplasms by Site Neoplasms Carotid Artery Diseases Cerebral (...) . Both technique is widely used in central venous catheterization, however, few researches have been investigated to compare success rate or complications of both methods. Condition or disease Intervention/treatment Phase Brain Neoplasm Intracranial Aneurysm Cerebrovascular Moyamoya Disease Procedure: Seldinger technique Procedure: Modified Seldinger technique Not Applicable Detailed Description: The major complications of central venous catheterization through subclavian vein, are unintended

2014 Clinical Trials

5346. Clinical Evaluation of HW005 Ventricular Assist System for the Treatment of Advanced Heart Failure in Japan

of a LVAD is contraindicated due to an ongoing aortic/cardiac aneurysm, intraventricular septum rupture and/or use of a mechanical heart valve. Etiology of heart failure is due to, or associated with, uncorrected thyroid disease, obstructive cardiomyopathy, pericardial disease, amyloidosis, active myocarditis or restrictive cardiomyopathy. Patients with irreversible hepatic dysfunction. Patients with irreversible renal dysfunction. Pregnancy. Patients with serious COPD (FEV1 < 50%). Pulmonary vascular (...) of screening. Patients with severe central nervous system disorder or severe cerebral vascular disorder. Patients with a history of drug intoxication, alcohol dependence. Patients unwilling or unable to comply with study requirements. Patients who refuse transfusion. Patients who in the investigator judgement are deemed to be unsuitable as a subject. Patients who are participating in another clinical trial involving investigational drugs or devices. Contacts and Locations Go to Information from

2014 Clinical Trials

5347. Intensive Insulin Therapy With Tight Glycemic Control to Improve Outcomes After Endovascular Therapy for Acute Ischemic Stroke

improvement from baseline NIHSS , or increase to absolute NIHSS > 30 before randomization or treatment Major stroke symptoms- NIHSS >30 Seizure at the onset of stroke Stroke due to a neurointerventional procedure for treatment of a cerebral aneurysm and/or cerebral arteriovenous malformation (stroke due to diagnostic cerebral angiography or cardiac catheterization might be treated) Clinical presentation suggestive of subarachnoid hemorrhage, even when the initial CT scan is normal. Previous known ICH (...) stroke, including impairment of language, motor function, cognition and/or gaze, vision, or neglect. Ischemic stroke is defined as an event characterized by the sudden onset of a focal neurologic deficit presumed to be due to cerebral ischemia after exclusion of ICH with a baseline CT The signal stroke should be (a) acute, (b) the most recent significant, acute worsening of serial neurologic events, or (c) related to a diagnostic radiographic procedure but not an interventional procedure Minimum

2014 Clinical Trials

5348. Modulation of Muscle Protein Synthesis With Diet and Exercise in Old Aged Women

cardiovascular disease: uncontrolled high blood pressure, angina, heart failure (class III/IV), abnormal heart rhythm, right to left cardiac shunt or recent cardiac event. Taking statin-based medication above 60mg•day-1. Individuals taking beta-adrenergic blocking agents or Non-steroidal anti-inflammatory agents (NSAIDS) Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial). Respiratory disease including pulmonary hypertension, chronic obstructive pulmonary disease (COPD), asthma

2014 Clinical Trials

5349. Clinical Outcomes and Molecular Phenotypes in Smokers With Parenchymal Lung Disease

from the study if they meet one or more of the following criteria: Subjects who are under the age of 40 or over 80 years old Women who are pregnant or lactating Have known allergies to lidocaine or medications used for moderate sedation Active coronary artery disease Cerebral-vascular accident within the past 12 months Active anticoagulation Active infections Cancer, or a history of cancer within the previous 5 years of screening (other than adequately treated cutaneous basal cell, squamous cell (...) carcinoma, excised melanoma, or carcinoma in situ of the uterine cervix with no evidence of recurrence). Poorly controlled chronic diseases Unable to provide consent Impaired renal function (including dialysis) Contraindications to MRI scan including: electrical implants such as cardiac pacemakers or perfusion pumps ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants

2014 Clinical Trials

5350. FMISO PET Study of Glioblastoma

in promoting the growth or spreading of tumor blood vessels. Since anti-VEGF agents also affect normal blood vessels in the brain, they can inhibit the way other drugs used in combination with bevacizumab are delivered to the tumor. In PET scans, a radioactive substance is injected into the body. The scanning machine finds the radioactive substance, which tends to go to cancer cells. For the PET scans in this research study, the investigators are using an investigational radioactive substance called FMISO (...) will be intravenously injected at a dose of 3.7 MBq/kg (0.1 mCi/kg) (maximum 260 MBq, 7 mCi) in < 15 mL. The IV will remain in place for injection of the gadolinium for the MRI scan. There will be one injection of FMISO in the PET protocol. Approximately 90 minutes after the injection, the PET scan will begin. The PET scan will be approximately 60-75 minutes. MRI -- Each MRI will last 60-75 minutes versus 45 minutes for standard brain MRIs. Device: FMISO PET Device: MRI MR scans will be performed with the same

2014 Clinical Trials

5351. Systemic Normothermia in Intracerebral Hemorrhage (ICH)

terms: Layout table for MeSH terms Hemorrhage Cerebral Hemorrhage Pathologic Processes Intracranial Hemorrhages Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases (...) ) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with spontaneous supratentorial ICH >20 cc Age 18 to 85 years of age Consent from the patient or surrogate decision maker Within 24 hours of onset of ictus Exclusion Criteria: Hemorrhage secondary to trauma, Arterio-venous malformation (AVM), aneurysm or Arterio-venous dural fistula Moribund state and deemed unlikely to survive until study completion (5 days) Patients with a don-not-resuscitate (DNR

2014 Clinical Trials

5352. Whole Body Hyperthermia & Combat-Related Posttraumatic Stress Disorder (PTSD)

, for example peripheral vascular disease, deep vein thrombosis (DVT), or lymphedema. History of a cerebral vascular accident. History of stroke, epilepsy or cerebral aneurisms. Cancer in the last five years, except for fully resected non-melanoma skin cancer. Diabetes mellitus types I or II. Any clinically significant autoimmune disease (compensated hypothyroidism allowed). Active alcohol/drug abuse in 2 weeks prior to screening for those who have been dependent or have abused on drugs/alcohol in the last

2014 Clinical Trials

5353. Comparing the Nautilus NeuroWaveTM to TCD or DSA for the Detection of Vasospasm

are undergoing surveillance for vasospasm Criteria Inclusion Criteria: Male or female subjects 18 years of age or older. Subjects with subarachnoid hemorrhage who are receiving clinical and diagnostic surveillance for vasospasm. Signed informed consent from the patient or the patient's Legally Authorized Representative Exclusion Criteria: Unstable medical illness such that recordings might interfere with medical care. Presence of head bandages or brain monitors that might physically interfere with the NNW (...) . Identifier: Other Study ID Numbers: NMDCL100212-OCA First Posted: February 26, 2014 Last Update Posted: March 13, 2017 Last Verified: March 2017 Keywords provided by Jan Medical, Inc.: Vasospasm Aneurysm SAH Nautilus NeuroWave

2014 Clinical Trials

5354. Effects of Modafinil, Caffeine and Methylphenidate in Healthy Volunteers

of German Right-handedness Exclusion Criteria: Known hypersensitivity to the study medication All contraindications to the study medication: arrhythmia, hyperthyroidism , glaucoma , pheochromocytoma , congestive heart failure , diabetes mellitus, known liver and kidney dysfunction, vascular disease , angina, haemodynamically significant congenital heart disease , cardiomyopathy , myocardial infarction, channelopathies, arterial hypertension , cerebrovascular diseases , such as cerebral aneurysm (...) Foundation Information provided by (Responsible Party): Dimitris Repantis, Charite University, Berlin, Germany Study Details Study Description Go to Brief Summary: In this study the investigators compare three stimulants to each other. The effects of these agents on cognitive performance (eg, attention and memory) and on the brain are being measured. The hypothesis is that stimulants will have a positive effect on cognitive performance. Each study participant will receive once a placebo and once

2014 Clinical Trials

5355. Technology-Based Application To Improve The Triple Therapy Adherence Rate In Subjects With Hepatitis C Infection

with the subject's participation in and completion of the trial, including, but not limited to: Central nervous system (CNS) trauma requiring intubation, intracranial pressure monitoring, brain meningeal or skull surgery, or resulting in seizure, coma, permanent neurologic deficits, abnormal brain imaging, or cerebral spinal fluid (CSF) leak. Prior brain hemorrhage and/or intracranial aneurysms (whether adequately repaired or not). Current uncontrolled seizure disorder unless now controlled on stable medical

2014 Clinical Trials

5356. Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder

24, 2014 Last Update Posted : May 1, 2018 See Sponsor: Wayne State University Information provided by (Responsible Party): Christine A. Rabinak, Wayne State University Study Details Study Description Go to Brief Summary: The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these processes and how this relates to the development (...) (approximately 120 min prior to fMRI scanning in Visit 3) by the oral route and is placed in opaque capsules with dextrose filler. Half of the participants in each diagnostic group [HC = 20; PTSD = 20; TEC = 20] will receive dronabinol. Other Name: Marinol Outcome Measures Go to Primary Outcome Measures : Brain Measures [ Time Frame: 4 years ] functional magnetic resonance imaging (fMRI) BOLD percent signal change within region of interests [amygdala; ventromedial prefrontal cortex; hippocampus

2014 Clinical Trials

5357. Compare Ticagrelor vs Clopidogrel on the Reduction of Arterial Stiffness and Wave Reflectionsin Patients With Coronary Artery Disease . The NOVELTY Study

the previous 6 months. Other bleeding diathesis, or considered by Investigator to be at high risk for bleeding. Any previous history of ischemic or hemorrhagic stroke, intracranial hemorrhage or disease (neoplasm, arteriovenous malformation, aneurysm). International Normalized Ratio (INR) known to be >1.5 within 1 week of study entry. Poorly controlled blood pressure (>160/100 mmHg). Known platelet count of <100,000/mm3 within 1 week of study entry. Known anemia (hemoglobin [Hb] <10 gr/dL) within 1 week (...) method, are required). Treatment with other investigational agents (including placebo) or devices within 30 days prior to randomization or planned use of investigational agents or devices prior to the Day 30 visit. Life expectancy less than 1 year. Indication for major surgery (e.g. cancer treatment, carotid surgery, cerebral surgery, major vascular surgery). High likelihood of being unavailable for the Day 30 follow up. Contacts and Locations Go to Information from the National Library of Medicine

2014 Clinical Trials

5358. Study to Evaluate the Efficacy and Safety of Combined Administration of TAK-536CCB and Hydrochlorothiazide in Patients With Grade I or II Essential Hypertension.

. Cerebrovascular disease: cerebral infarction, cerebral hemorrhage (within 24 weeks before the placebo run-in period), or transient ischemic attack (within 24 weeks before the placebo run-in period). Vascular diseases: peripheral arterial disease with intermittent claudication, artery dissection, aneurysm Advanced hypertensive retinopathy: bleeding, exudation, or papilledema (within 24 weeks before the placebo run-in period). 7. Clinically significant hepatic disorder. 8. Clinically significant renal

2014 Clinical Trials

5359. Scrambler Therapy in the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy

pills, injections, intrauterine device [IUD], surgical sterilization, subcutaneous implants, abstinence, etc.). Use of an investigational agent for pain control concurrently or within the past 30 days History of an allergic reaction or previous intolerance to transcutaneous electronic nerve stimulation Patients with implantable drug delivery systems, e.g. Medtronic Synchromed Patients with heart stents or metal implants such as pacemakers, automatic defibrillators, cochlear implants, aneurysm clips (...) , vena cava clips and skull plates. (Metal implants for orthopedic repair, e.g. pins, clips, plates, cages, joint replacements are allowed) Patients with a history of myocardial infarction or ischemic heart disease within the past six months Patients with history of epilepsy, brain damage, or symptomatic brain metastases Prior celiac plexus block, or other neurolytic pain control treatment Other identified causes of painful parasthesias existing prior to chemotherapy (e.g., radiation or malignant

2014 Clinical Trials

5360. Characterization Imaging Instruments in Alcoholics and Non-Alcoholics

by the screening protocol 14-AA-0181. EXCLUSION CRITERIA: ADULT PARTICIPANTS Exclusion criteria for MR scan Presence of ferromagnetic objects in the body that are contraindicated for MRI of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments) or fear of enclosed spaces. Eligibility will be determined by a "MRI Safety Screening Questionnaire (...) : National Institute on Alcohol Abuse and Alcoholism (NIAAA) Information provided by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute on Alcohol Abuse and Alcoholism (NIAAA) ) Study Details Study Description Go to Brief Summary: Background: - People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks. Researchers want to find out more about

2014 Clinical Trials

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