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Cerebral Aneurysm

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5321. Development of Clinical Methods to Evaluate Neural Function in Aging

Lying on the floor and rising to a standing position Kneeling on the floor and rising to standing position Climbing a flight of stairs Lift a weighted laundry basket and placing it on a shelf Muscle strength tests will be performed on the legs and arms. Questionnaires that address physical function. Muscle and nerve testing will be done. During the above testing, sensors will be worn on the forehead that use invisible light to indirectly measure blood flow and blood oxygen content of the brain (...) exposure to very small amounts of radiation. Images of the brain will be taken using magnetic resonance imaging (MRI). Magnetic resonance imaging (MRI) is a procedure that allows doctors to look inside the body by using a scanner that sends out a strong magnetic field and radio waves. All of these test are done for this study and will not be used to diagnose or treat any medical problems. The expected length of participation is approximately six hours total, over the course of 4 separate visits. Study

2014 Clinical Trials

5322. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

-2 would be compromised with regard to follow-up assessment of outcomes or continuation in CREST-2. Inability to understand and cooperate with study procedures or provide informed consent. Non-atherosclerotic carotid stenosis (dissection, fibromuscular dysplasia, or stenosis following radiation therapy). Previous ipsilateral CEA or CAS. Ipsilateral internal or common carotid artery occlusion. Intra-carotid floating thrombus. Ipsilateral intracranial aneurysm > 5 mm. Extreme morbid obesity (...) Stenting (CAS) Other: Intensive Medical Management - no CEA Other: Intensive Medical Management - no CAS Not Applicable Detailed Description: Prevention of stroke involves managing and treating risk factors. Most strokes are caused when blood flow to a portion of the brain is blocked. One place this often happens is in the carotid artery. This blockage is called atherosclerosis or hardening of the arteries. The purpose of this trial is to determine the best way to prevent strokes in people who have

2014 Clinical Trials

5323. Orthotic Use for Chronic Low Back Pain

medications or daily at-home exercises for general well-being). Current or future litigation for any healthcare concern Not fluent or literate in the English language. We will not be able to provide multiple translators within this study Brain disorders (e.g., dementia, Alzheimers Disease , etc.) that would lead to difficulty in questionnaire completion Chronic pain other than low back pain, such as fibromyalgia or multiple sclerosis Clinically significant chronic inflammatory spinal arthritis Spinal (...) pathology or fracture Progressive neurologic deficits due to nerve root or spinal cord compression, including symptoms/signs of cauda equina syndrome History of bleeding disorder Known arterial aneurysm Previous lumbar spine surgery Severe skeletal deformity of the foot Peripheral neuropathy due to disorders such as diabetes Low back pain that is not reproducible Current pregnancy Other conditions that may affect the subjects' ability to participate throughout the duration of the study or exclude

2014 Clinical Trials

5324. Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias

, brain aneurysm clips, pacemakers, and metallic foreign bodies in the eye or other body areas that would prevent use of MRI imaging Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT02041299 Contacts Layout table for location contacts Contact: Caroline

2014 Clinical Trials

5325. Preconditioning Shields Against Vascular Events in Surgery

surgical revascularisation Major lower limb amputation Additional relevant MeSH terms: Layout table for MeSH terms Ischemia Aneurysm Atherosclerosis Aortic Aneurysm Aortic Aneurysm, Abdominal Carotid Artery Diseases Pathologic Processes Vascular Diseases Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Aortic Diseases Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases (...) . It is then restored for a further five minutes. This cycle is repeated three more times. The blood supply is interrupted simply by inflating a blood pressure cuff to maximum pressure. This repeated brief interruption of the muscular blood supply sends signals to critical organs such as the brain and heart, which are rendered temporarily resistant to damage from reduced blood supply. Several small randomized clinical trials in patients undergoing different types of major vascular surgery have demonstrated

2014 Clinical Trials

5326. Endovascular Carotid Body Ablation in Patients With Treatment- Resistant Hypertension: A Safety and Feasibility Study

or the investigational system, and the delivery of RF energy. Carotid body is not within reach of the investigational system due to position within the carotid bifurcation or distance of the CB (carotid body) from the femoral access point. Other abnormal angiographic findings that indicate the patient is at risk of a stroke, such as carotid or intracranial aneurysm, arteriovenous malformation (AVM), other developmental or traumatic vascular lesion or tumor. Dementia or confusion precluding the patient's full (...) of spontaneous intracranial hemorrhage within past 12 months. Unable to tolerate exposure to the radiopaque contrast agent. Unable to tolerate aspirin and/or other anti-coagulation; anti-platelet medication. Femoral arterial access is not possible. Presence of carotid artery dissection prior to the index procedure. Atherosclerotic disease involving vessels adjoining the carotid body, marked vessel tortuosity or other anatomical findings that preclude safe placement of the guiding catheter

2014 Clinical Trials

5327. A Closed Loop Neural Activity Triggered Stroke Rehabilitation Device

Description: There is no plan to share data with participants. Keywords provided by University of Wisconsin, Madison: aneurysm transient ischemic attack Additional relevant MeSH terms: Layout table for MeSH terms Stroke Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases (...) Institute of Neurological Disorders and Stroke (NINDS) Information provided by (Responsible Party): University of Wisconsin, Madison Study Details Study Description Go to Brief Summary: The purpose of this research is to determine if functional muscle stimulation, directed by electroencephalogram (EEG) output, can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic resonance imaging (fMRI). Condition or disease Intervention

2014 Clinical Trials

5328. Advanced Analysis of the Carotid Phonoangiography and Diseases

for angiography study and intervention (n=300) with different disease entity such as atherosclerosis, tumor, aneurysm, arteriovenous malformation or fistula, and other vascular disorders. A period of about 20 seconds of the carotid phonoangiography was recorded. Standard for comparison: catheter angiography, CTA, MRI/MRA. The degree of stenosis, the wall thickness, SI and density change was clustered and compared. The clinical and laboratory data will be reviewed and the vascular risk factors (...) Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Non-Probability Sample Study Population the patients who is going to have carotid angiography study and with informed consent signed. Criteria Inclusion Criteria: Age: 20 years old to 99 years old Gender: Unlimited Because different types of brain diseases, those who received conventional catheter vascular examination. Exclusion Criteria: Neck inflammation locally who can not admit the sound. Due to inability to cooperate to accept

2014 Clinical Trials

5329. Co-LEsions in Alzheimer Disease and Related Disorders

with progressive and unstable pathologies which could interfere with the variables under consideration Deafness or blindness which could compromise evaluation of the patient Patients being not able to undergo DaTscan®: with moderate or severe hepatic or renal impairment, a known hypersensitivity to ioflupane or any of the excipients Patient living in an institution Patient meeting brain MRI exclusion criteria (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects (...) to their clinical, pathological heterogeneity and the multiple pathological subtypes. We do not know the precise role and weight of each brain lesion type in the disability progression in elderly. To target the actual pathological process, we need to disclose the functional weight of AD, Lewy body and vascular lesion types in elderly. Most of the studies report on functional and clinical abnormalities in patients with pure pathologies. Thus, co-morbid processes involved in the transition from an independent

2014 Clinical Trials

5330. 3-Tesla MRI Response to TACE in HCC (Liver Cancer)

(prior surgical procedures not related to HCC are allowed) Subjects who have undergone prior radioembolization Subjects with a central venous line Subjects who have any type of biomedical implant, device and/or ferromagnetic material that can be displaced, perturbed, or otherwise malfunction due to mechanical, electronic, or magnetic means; these items may include: Metallic fragments or shrapnel (such as from war wounds) Cerebral aneurysm clips, biopsy marker clips Vascular access ports (as are used

2014 Clinical Trials

5331. A Pilot Study to Evaluate Image-guided Breast Conserving Surgery in the Advanced Multimodality Image Guided Operating Suite (AMIGO)

therapy post-operatively). Participants must have measurable disease, defined as one lesion that can be accurately measured by MRI. (More than one lesion will be an exclusion criteria for BCS; lesions not identified by MRI will also be an exclusion criteria). Age ≥ 18 years and < 75. Completion of the magnetic resonance (MR) procedure screening form and clearance by the MR technologist that the patient does not have a pacemaker, brain aneurysm clip, inner ear implant, neurostimulator or metal

2014 Clinical Trials

5332. CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage

will enable us to predict which patients will go on to develop vasospasm. Condition or disease Intervention/treatment Phase Subarachnoid Hemorrhage Delayed Cerebral Ischemia Cerebral Vasospasm CT Perfusion Radiation: CT Perfusion Not Applicable Detailed Description: Rupture of a brain aneurysm results in a type of bleeding into the brain called subarachnoid hemorrhage (SAH). This is a substantial cause of morbidity and mortality world-wide: even with the best possible care, up to half of patients die (...) Identifier: Other Study ID Numbers: CT-PIPS First Posted: February 6, 2014 Last Update Posted: February 19, 2019 Last Verified: February 2019 Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Ischemia Subarachnoid Hemorrhage Brain Ischemia Cerebral Infarction Vasospasm, Intracranial Pathologic Processes Intracranial Hemorrhages Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain

2014 Clinical Trials

5333. Study to Determine the Efficacy and Safety of ELS-M11 in Acute Migraine

artery bypass surgery, abdominal aortic aneurysm repair, etc.) Current life-threatening condition Significant hypersensitivity to NSAIDs (e.g., difficulty swallowing or breathing, tachycardia, anaphylaxis, angioedema or skin reaction) Pregnancy (defined by positive urine pregnancy test) or lactation at Visit 1, or planning to become pregnant prior to completion of the study History or suspicion of alcohol or substance abuse (current or past 6 months). Participation in any clinical trial within 30 (...) : Layout table for MeSH terms Migraine Disorders Headache Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Pain Neurologic Manifestations Signs and Symptoms

2014 Clinical Trials

5334. Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke

Exclusion Criteria: Patients who have suffered a prior ischemic stroke within 30 days of the presenting event or who have any history of intracranial hemorrhage will be excluded. Patients with a known secured or unsecured cerebral aneurysm or vascular malformation will be ineligible. An inability to control systolic BP > 180 mmHg, or diastolic BP > 105 mmHg with IV anti-hypertensive medications will result in exclusion. Patients with a known coagulopathy or evidence of active bleeding will be excluded (...) superior thrombolytic agents. Condition or disease Intervention/treatment Phase Cerebral Infarction Brain Ischemia Stroke Drug: Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 20 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke

2014 Clinical Trials

5335. Assessment of Emphysema Using 1.5T MRI With UTE Pulse Sequences

, neurostimulators, cochlear implants), metal inside the eye or the brain (aneurysm clip, ocular foreign body), cardiac valvular prosthesis (Starr-Edwards pre-6000), subject with claustrophobia. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT02100800 Contacts

2014 Clinical Trials

5336. Amlodipine for Myocardial Iron in Thalassemia

. Patients with known signs and symptoms of heart failure. Patients with a T2* value of < 4 ms on cardiac MRI. Patients with systolic blood pressures ≤ 2 SD for age (systemic hypotension) at the time of enrolment. Patients with previously diagnosed significant congenital heart diseases or acquired heart diseases other than thalassemia (as defined earlier). Patients with known contraindications to MRI (pacemakers, cerebral aneurysm metal clips, etc.) Patient with a known history of developing tetany after

2014 Clinical Trials

5337. Effects of a Home Based Walking Program Using Rhythmic Auditory Stimulation in Patients With Multiple Sclerosis

based walking program (HBWP) with Rhythmic Auditory Stimulation (RAS), to that of a HBWP without RAS, or to RAS without walking exercise. A second part of this study will assess the effects of Rhythmic Auditory Stimulation (RAS) on brain activity in patients with Multiple Sclerosis while performing mental imagery of walking. Condition or disease Intervention/treatment Phase Multiple Sclerosis Ambulation Difficulty Other: Rhythmic Auditory Stimulation (RAS) Not Applicable Study Design Go to Layout (...) , aneurysm clips etc. pregnancy. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT02065284 Locations Layout table for location information United States, Ohio Cleveland Clinic Neurological Institute Mellen Center Cleveland, Ohio, United States, 44195

2014 Clinical Trials

5338. Genetically Engineered HSV-1 Phase 1 Study

the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 19 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria Patients must have histologically or cytologically confirmed glioblastoma multiforme, anaplastic astrocytoma, or gliosarcoma. Prior therapy: Patients must have failed external beam radiotherapy >5,000 cGy (centrigray)to the brain, and if eligible and tolerated (...) contrast material that is not amenable to pre-treatment by University of Alabama at Birmingham protocol. Patients with pacemakers, ferro-magnetic aneurysm clips, metal infusion pumps, metal or shrapnel fragments or certain types of stents. Receipt of Gliadel Therapy. (Receipt of Bevacizumab (Avastin) therapy within 4 weeks of scheduled M032 administration. (Receipt of Bevacizumab (Avastin) greater than 4 weeks of scheduled M032 administration does not exclude patient.) Contacts and Locations Go

2014 Clinical Trials

5339. The Mortality and Changes in Quality of Life of Patients Suffering From SAH With Different Hydration Strategies

: Subarachnoid hemorrhage vasospasm Lactated Ringer's solution Hydroxyethyl starch solution Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Subarachnoid Hemorrhage Pathologic Processes Intracranial Hemorrhages Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Pharmaceutical Solutions Hydroxyethyl Starch Derivatives Plasma Substitutes Blood Substitutes (...) : Lactated Ringer's solution Drug: Hydroxyethyl starch Phase 4 Detailed Description: Study protocol: Upon arrival Computed Tomography Angiography (CTA), or if necessary, a four-vessel cerebral angiography is carried out in case of each patient. Previous medical history is obtained with particular regard to the onset of the symptoms and the premorbid blood pressure values. Afterwards the Hunt-Hess classification of the patients take place. The neurological condition is recorded with the help of the NIH

2014 Clinical Trials

5340. Safety Study of Regorafenib With PF-03446962 to Treat Colorectal Cancer

brain or leptomeningeal metastases, including patients who continue to require glucocorticoids for brain or leptomeningeal metastases. Treated, asymptomatic metastases are permitted provided the patient has been off steroids for at least 1 month prior to day 1 of study drug. Severe chronic obstructive or other pulmonary disease with hypoxemia (requires supplementary oxygen, symptoms due to hypoxemia or O2 saturation <90% by pulse oximetry after a 2 minute walk or in the opinion of the investigator (...) . The mean SBP/DBP ratio must be <140/90 mmHg in order for a subject to be eligible for the study. Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of oral medications (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection). Significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent peripheral arterial thrombosis) within 6 months prior to day 1 of study

2014 Clinical Trials

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