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Cerebral Aneurysm

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5281. Impaired progression of cerebral aneurysms in interleukin-1beta-deficient mice. Full Text available with Trip Pro

Impaired progression of cerebral aneurysms in interleukin-1beta-deficient mice. Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats, monkeys, and mice. Interleukin-1beta (IL-1beta) is a key inflammatory mediator, and it is thought to be a promising (...) target for the treatment of inflammatory diseases. In the present study, we examined the role of IL-1beta in cerebral aneurysm development.Cerebral aneurysms were experimentally induced in 5-week-old male C57BL/6 mice, IL-1beta gene-deficient (IL-1beta-/-) mice, and age-matched control B10 mice (wild-type). Their cerebral arteries were dissected and examined histologically and immunohistochemically.IL-1beta was expressed in vascular media in mice at an early stage of aneurysmal models' cerebral

2006 Stroke

5282. Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Full Text available with Trip Pro

Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Arterial bifurcation apices are common sites for cerebral aneurysms, raising the possibility that the unique hemodynamic conditions associated with flow dividers predispose the apical vessel wall to aneurysm formation. This study sought to identify the specific hemodynamic insults that lead to maladaptive vascular remodeling associated with aneurysm development (...) at the bifurcation apex and (2) destructive remodeling in the adjacent region of flow acceleration that resembled the initiation of an intracranial aneurysm, characterized by disruption of the internal elastic lamina, loss of medial smooth muscle cells, reduced proliferation of smooth muscle cells, and loss of fibronectin.Strong localization of aneurysm-type remodeling to the region of accelerating flow suggests that a combination of high wall shear stress and a high gradient in wall shear stress represents

2007 Stroke

5283. Impairment of cerebral perfusion and infarct patterns attributable to vasospasm after aneurysmal subarachnoid hemorrhage: a prospective MRI and DSA study. Full Text available with Trip Pro

Impairment of cerebral perfusion and infarct patterns attributable to vasospasm after aneurysmal subarachnoid hemorrhage: a prospective MRI and DSA study. The objective of this study was to investigate disturbance of perfusion and infarct patterns attributable to cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH).One hundred seventeen patients with aneurysmal SAH specifically selected at high risk for CVS were enrolled in this prospective study. One hundred twelve patients underwent (...) surgical (n=63) or endovascular (n=59) therapy. For assessment of CVS, relative diameter changes of proximal and distal vessel segments on follow-up angiography at day 7+/-3 after SAH were analyzed in relation to baseline measurements, and cerebral circulation times were measured. Postprocedure MRI was undertaken selectively at four time points: within 3 days, between days 4 and 6, day 7 to 14, and day 15 to 28 from onset of SAH, including perfusion- and diffusion-weighted images. Procedure-related

2007 Stroke

5284. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Full Text available with Trip Pro

Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. The degradation of extracellular matrix (ECM) is a hallmark of a cerebral aneurysm; however, little is known regarding the molecular mechanism leading to this change. Tissue inhibitor of matrix metalloproteinase (TIMP) regulates the ECM degradation in vascular walls by inhibiting the activity of matrix metalloproteinases (MMPs). We investigated the role of TIMPs in the progression of cerebral aneurysms in the present study.TIMP (...) -1 and TIMP-2 expression was examined by immunohistochemistry and quantitative RT-PCR in experimentally-induced cerebral aneurysms in rats. The incidence of aneurysmal changes in TIMP-1(-/-) and TIMP-2(-/-) mice was compared with that in the wild-type mice.TIMP-1 and TIMP-2 were expressed mainly by smooth muscle cells in aneurysmal walls. Quantitative PCR showed an increase of TIMP-1 and TIMP-2 mRNA in the early stage of aneurysm progression (form 0 to 1 month) but not in the late stage (form 1

2007 Stroke

5285. Anaesthesia for endovascular management of cerebral aneurysms. Full Text available with Trip Pro

Anaesthesia for endovascular management of cerebral aneurysms. Subarachnoid haemorrhage due to rupture of cerebral aneurysms is a multisystem disease. Treatment of the condition in the past has relied on craniotomy and clipping of the aneurysm to prevent a recurrent haemorrhage. There is now emerging evidence to suggest that endovascular treatment of cerebral aneurysms may reduce the morbidity associated with open surgery. The anaesthetic management of interventional neuroradiology also creates

2006 European Journal of Anaesthesiology

5286. Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00243893 Recruitment Status : Completed First Posted : October 25, 2005 Last Update Posted : October 9, 2013 Sponsor: University

2005 Clinical Trials

5287. Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH)

Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH) Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH) (CONSCIOUS-1) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00111085 Recruitment Status : Completed First

2005 Clinical Trials

5288. Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage Full Text available with Trip Pro

Insulin-related decrease in cerebral glucose despite normoglycemia in aneurysmal subarachnoid hemorrhage Hyperglycaemia following aneurysmal subarachnoid hemorrhage (SAH) is associated with complications and impaired neurological recovery. The aim of this study was to determine the effect of insulin treatment for glucose control on cerebral metabolism in SAH patients.This prospective, nonrandomized study was conducted in 31 SAH patients in an intensive care unit (age 52 +/- 10 years, World (...) Federation of Neurological Surgeons grade 2.9 +/- 1.6). A microdialysis catheter was inserted into the vascular territory of the aneurysm after clipping. Blood glucose levels above 140 mg/dl were treated with intravenous insulin and the microdialysates were analyzed hourly for the first 12 hours of infusion.No hypoglycaemia occurred. Twenty-four patients were treated with insulin for glucose control. Higher age and World Federation of Neurological Surgeons score were risk factors for need for insulin

2008 Critical Care

5289. Multiple Cerebral Aneurysms Caused by Cardiac Myxoma: A Case Report and Present State of Knowledge Full Text available with Trip Pro

Multiple Cerebral Aneurysms Caused by Cardiac Myxoma: A Case Report and Present State of Knowledge A case of multiple cerebral aneurysms caused by left atrial myxoma is reported.We present the details of this case and discuss the hypothetical pathogenesis, radiological aspects and treatment of these neoplastic aneurysms.

2007 Interventional Neuroradiology

5290. Traumatic Cerebral Aneurysm Associated with a Contralateral Traumatic Carotid Cavernous Fistula: A Case Report Full Text available with Trip Pro

Traumatic Cerebral Aneurysm Associated with a Contralateral Traumatic Carotid Cavernous Fistula: A Case Report This report documents the management of a traumatic carotid aneurysm (TCA) with a traumatic carotid-cavernous fistula (T-CCF) of the contralateral internal carotid artery (ICA) following a closed head injury. A 38-year-old man presented with severe traumatic subarachnoid hemorrhage and pneumocephalus due to a severe head injury. Four months after the accident, the patient presented (...) with clinical symptoms of exophthalmos and retroorbital bruit. Cerebral angiography showed a TCA of the IC-PC region, which coexisted with a contralateral T-CCF. Both lesions were successfully managed with an endovascular treatment using coils to isolate a fistula from the ICA, and direct surgical trapping of the intracranial ICA to eliminate a TCA. Post-operative angiography revealed a good cross-flow through the anterior communicating artery from the contralateral ICA, which was completely obliterated

2007 Interventional Neuroradiology

5291. Radiation Exposure during Cerebral Artery Aneurysm Coil Embolization: the Current Situation and Measures to Prevent Radiation Injury Full Text available with Trip Pro

Radiation Exposure during Cerebral Artery Aneurysm Coil Embolization: the Current Situation and Measures to Prevent Radiation Injury Coil embolization is the treatment of choice for cerebral artery aneurysms at our institution. The duration of a fluoroscopic study and frequency of radiation exposure are varied, and the safety measures against radiation injury have not yet been established. Guidelines about radiation injury prevention with IVR have been published. However, there is not yet

2007 Interventional Neuroradiology

5292. Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms

Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00615381 Recruitment Status : Withdrawn (Study was not initiated and has been withdrawn due to lack

2008 Clinical Trials

5293. Cerebral Aneurysm Perforations during Treatment with Detachable Coils: Use of Remodelling Balloon Inflation to Achieve Hemostasis Full Text available with Trip Pro

Cerebral Aneurysm Perforations during Treatment with Detachable Coils: Use of Remodelling Balloon Inflation to Achieve Hemostasis Perforation of intracranial aneurysms during endovascular treatment with platinum microcoils is a well-known and serious complication reported to occur in 2-4% of patients. Inflation of a remodelling balloon across the aneurysm neck or within the proximal parent vessel is an additional technique that theoretically might be useful to reduce flow within the aneurysm (...) and achieve hemostasis. In the case reports that follow, we present our experience using this technique for managing intraprocedural aneurysm rupture.

2006 Interventional Neuroradiology

5294. A Double Catheter Technique for Elongated Middle Cerebral Artery Bifurcation Aneurysm: A Case Report Full Text available with Trip Pro

A Double Catheter Technique for Elongated Middle Cerebral Artery Bifurcation Aneurysm: A Case Report We report a case of an elongated middle cerebral artery bifurcation aneurysm which was managed using an endovascular double catheter technique. After positioning two microcatheters, one at the distal dome and the other at the proximal dome, two coils were subsequently deployed through each microcatheter.We created a proximal supporting coil frame using one microcatheter and preserved the parent (...) middle cerebral artery bifurcation aneurysm.

2006 Interventional Neuroradiology

5295. Parent Artery Occlusion for Posterior Cerebral Artery Aneurysms Full Text available with Trip Pro

Parent Artery Occlusion for Posterior Cerebral Artery Aneurysms We review four cases of posterior cerebral artery (PCA) aneurysm, of which three showed intolerance of parent artery occlusion. In two, balloon test occlusion (BTO) indicated poor opacification of the PCA branches from the anastomoses, and therefore, permanent occlusion was not attempted.

2006 Interventional Neuroradiology

5296. Thromboembolic Events during Endovascular Coil Embolization of Cerebral Aneurysms Full Text available with Trip Pro

Thromboembolic Events during Endovascular Coil Embolization of Cerebral Aneurysms Thromboembolic events was most important adverse event for coil embolization for intracerebral aneurysm. The present study investigated possible risk factors for thromboembolic events during coil embolization using diffusion-weighted imaging (DWI), comparing unruptured and ruptured lesions.

2006 Interventional Neuroradiology

5297. Endovascular Treatment of Experimental Cerebral Aneurysms Using Thermoreversible Liquid Embolic Agents Full Text available with Trip Pro

Endovascular Treatment of Experimental Cerebral Aneurysms Using Thermoreversible Liquid Embolic Agents We have developed a new embolic agent, thermoreversible gelation polymer (TGP). This polymer is unique in that solidification occurs at body temperature. The utility of this new liquid embolic agent for the treatment of large experimental aneurysms was evaluated angiographically. TGP remains liquid at temperatures below the sol-gel transition temperature (TT) and becomes gelatinous above (...) the TT. TGP can also be used to slowly deliver biologically active substances such as growth factors or engineered cells. In this study, TGP was mixed with radiopaque material without solvent. Bilateral common carotid arteries of swine (n=5) were used for surgical creation of lateral aneurysms, then 1 aneurysm in each animal was embolized using TGP without any protection device. The remaining untreated aneurysm in each animal was used as a control. All aneurysms were successfully embolized using TGP

2006 Interventional Neuroradiology

5298. Efficacy of 3-D Reconstructed Time of Flight MRA Follow-up of the Embolized Cerebral Aneurysms Full Text available with Trip Pro

Efficacy of 3-D Reconstructed Time of Flight MRA Follow-up of the Embolized Cerebral Aneurysms A follow-up of the embolized cerebral aneurysm with Guglielmi Detachable Coils (GDC) were performed mainly using craniograms and digital subtraction angiograms (DSA) so far.Recently, several authors have reported about efficacy of the time of flight (TOF) magnetic resonance angiogram (MRA) as a follow-up for the embolized cerebral aneurysms. In our institution, 3-D reconstructed TOF MRAs have been (...) performed as a follow-up of the embolized cerebral aneurysms.We examined efficacy of 3-D reconstructed TOF MRA. 3-D TOF MRA was performed for a followup of the embolized cerebral aneurysms at our outpatient clinic in 35 patients. Morphological examination of the 3-D images between 3-D TOF MRA and 3-D DSA was performed. Almost similar images of 3-D MRA were obtained after 3-D reconstruction as compared with those of 3-D DSA. In three cases, recanalization was suspected in the 3-D TOF MRA

2006 Interventional Neuroradiology

5299. Applications and Roles of Coil Embolization and/or Clipping in the Treatment of Cerebral Aneurysm Full Text available with Trip Pro

Applications and Roles of Coil Embolization and/or Clipping in the Treatment of Cerebral Aneurysm We retrospectively analysed to demonstrate the selection of the treatment modality and its efficacy in our department. Subjects of the present study comprised patients in whom coil embolization was abandoned due to such reasons as broad neck, whom coil embolization was performed for residual aneurysm following incomplete clipping or recurrent cerebral aneurysm, whom coil embolization was performed (...) after coil compaction, whom coil embolization and clipping were performed for the treatment of multiple cerebral aneurysms. In the treatment of cerebral aneurysm, selecting proper techniques by considering the characteristics of clipping and coil embolization is desirable. In other words, strategizing therapy by taking advantages of the merits of clipping and coil embolization is important.

2006 Interventional Neuroradiology

5300. Coil Embolization for Ruptured Cerebral Aneurysms of 2×3 mm Diameter Full Text available with Trip Pro

Coil Embolization for Ruptured Cerebral Aneurysms of 2×3 mm Diameter Small ruptured cerebral aneurysms, such as those of 2x3 mm diameter, are considered to be difficult to embolize by detachable coils because of the risk of procedural perforation of the aneurysms. We have treated these small aneurysms and report the techniques and pitfalls of these embolizations. Twenty-four patients with ruptured cerebral aneurysms of 2x3 mm diameter were intended for treatment by coil embolization. Before (...) coil embolization, three-dimensional digital subtraction angiography was performed, and the simulation of the volume embolization ratio (VER) was performed in all patients, except for the first basilar artery aneurysm patient. The tip of the microcatheter was steam-shaped several times and was placed on the neck of the aneurysm. A balloon neck remodeling technique was used for two aneurysms. GDC 10 softs and soft SRs were used for the first ten aneurysms, and Ultrasofts were used for the last

2006 Interventional Neuroradiology

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