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Cerebral Aneurysm

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5261. Update on Varicella Zoster Virus Vasculopathy Full Text available with Trip Pro

vasculopathy due to productive virus infection of the cerebral arteries. In recent decades, the clinical spectrum of VZV vasculopathy has expanded to include not only transient ischemic attacks and ischemic and hemorrhagic stroke, but also multifocal VZV vasculopathy, with temporal artery infection mimicking giant cell arteritis, extracranial vasculopathy, aneurysm with and without subarachnoid hemorrhage, arterial dissection and dolichoectasia, ischemic cranial neuropathies, cerebral venous sinus

2014 Current infectious disease reports

5262. A novel application of CT angiography to detect extracoronary vascular abnormalities in patients with spontaneous coronary artery dissection. (Abstract)

A novel application of CT angiography to detect extracoronary vascular abnormalities in patients with spontaneous coronary artery dissection. Spontaneous coronary artery dissection (SCAD) is associated with extracoronary vascular abnormalities, which depending on type and location may warrant treatment or provide additional diagnostic or prognostic information about this uncommon entity. Fibromuscular dysplasia (FMD), aneurysms, and dissections have been detected in multiple vascular (...) in 1 patient, a vascular bed not included in the SCAD CTA protocol. Extracoronary vascular abnormalities were common, including FMD, aneurysms, dissection, and aortic tortuosity, and were seen in the iliac (36%), carotid and/or vertebral (31%), splanchnic (10%), and renal (26%) arteries and in the thoracic and/or abdominal aorta (10%).The frequency of extracoronary vascular abnormalities and extent of territories identified the CTA protocol in our cohort are high. A tailored CTA may be the optimal

2014 Journal of cardiovascular computed tomography

5263. Genetically Engineered HSV-1 Phase 1 Study

the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 19 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria Patients must have histologically or cytologically confirmed glioblastoma multiforme, anaplastic astrocytoma, or gliosarcoma. Prior therapy: Patients must have failed external beam radiotherapy >5,000 cGy (centrigray)to the brain, and if eligible and tolerated (...) contrast material that is not amenable to pre-treatment by University of Alabama at Birmingham protocol. Patients with pacemakers, ferro-magnetic aneurysm clips, metal infusion pumps, metal or shrapnel fragments or certain types of stents. Receipt of Gliadel Therapy. (Receipt of Bevacizumab (Avastin) therapy within 4 weeks of scheduled M032 administration. (Receipt of Bevacizumab (Avastin) greater than 4 weeks of scheduled M032 administration does not exclude patient.) Contacts and Locations Go

2014 Clinical Trials

5264. 3-Tesla MRI Response to TACE in HCC (Liver Cancer)

(prior surgical procedures not related to HCC are allowed) Subjects who have undergone prior radioembolization Subjects with a central venous line Subjects who have any type of biomedical implant, device and/or ferromagnetic material that can be displaced, perturbed, or otherwise malfunction due to mechanical, electronic, or magnetic means; these items may include: Metallic fragments or shrapnel (such as from war wounds) Cerebral aneurysm clips, biopsy marker clips Vascular access ports (as are used

2014 Clinical Trials

5265. A Pilot Study to Evaluate Image-guided Breast Conserving Surgery in the Advanced Multimodality Image Guided Operating Suite (AMIGO)

therapy post-operatively). Participants must have measurable disease, defined as one lesion that can be accurately measured by MRI. (More than one lesion will be an exclusion criteria for BCS; lesions not identified by MRI will also be an exclusion criteria). Age ≥ 18 years and < 75. Completion of the magnetic resonance (MR) procedure screening form and clearance by the MR technologist that the patient does not have a pacemaker, brain aneurysm clip, inner ear implant, neurostimulator or metal

2014 Clinical Trials

5266. Study to Determine the Efficacy and Safety of ELS-M11 in Acute Migraine

artery bypass surgery, abdominal aortic aneurysm repair, etc.) Current life-threatening condition Significant hypersensitivity to NSAIDs (e.g., difficulty swallowing or breathing, tachycardia, anaphylaxis, angioedema or skin reaction) Pregnancy (defined by positive urine pregnancy test) or lactation at Visit 1, or planning to become pregnant prior to completion of the study History or suspicion of alcohol or substance abuse (current or past 6 months). Participation in any clinical trial within 30 (...) : Layout table for MeSH terms Migraine Disorders Headache Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Pain Neurologic Manifestations Signs and Symptoms

2014 Clinical Trials

5267. CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage

will enable us to predict which patients will go on to develop vasospasm. Condition or disease Intervention/treatment Phase Subarachnoid Hemorrhage Delayed Cerebral Ischemia Cerebral Vasospasm CT Perfusion Radiation: CT Perfusion Not Applicable Detailed Description: Rupture of a brain aneurysm results in a type of bleeding into the brain called subarachnoid hemorrhage (SAH). This is a substantial cause of morbidity and mortality world-wide: even with the best possible care, up to half of patients die (...) ClinicalTrials.gov Identifier: Other Study ID Numbers: CT-PIPS First Posted: February 6, 2014 Last Update Posted: February 19, 2019 Last Verified: February 2019 Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Ischemia Subarachnoid Hemorrhage Brain Ischemia Cerebral Infarction Vasospasm, Intracranial Pathologic Processes Intracranial Hemorrhages Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain

2014 Clinical Trials

5268. Safety & Efficacy Study of TPI 287 + Avastin in Adults With Glioblastoma That Progressed Following Prior Avastin Therapy

or infratentorial tumor Evidence or suspicion of disease metastatic to sites remote from supratentorial brain Prior treatment with anti-vascular endothelial growth factor (VEGF) drugs other than bevacizumab Prior treatment with tyrosine-kinase inhibitors targeting VEGF, platelet-derived growth factor, fibroblast growth factor, tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 2 (TIE-2), or angiopoietin (or their receptors) Prior treatment with histone deacetylase inhibitors (...) (e.g., aortic aneurysm, requiring surgical repair or recent peripheral arterial thrombosis) within 6 months prior to Day 1 History of hemoptysis (≥ 1/2 teaspoon of bright red blood per episode) within 1 month prior to Day 1 Evidence of bleeding diathesis or significant coagulopathy (in absence of therapeutic anticoagulation) Grade 2 or higher peripheral neuropathy per NCI CTCAE History of abdominal fistula or gastrointestinal perforation within 6 months prior to Day 1 Serious, non-healing wound

2014 Clinical Trials

5269. Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection

participants will undergo a standardized routine MRI scan of brain and neck before study entry. 14 +/- 7 days after treatment onset a second MRI of brain and neck will be performed. The following MRI sequences will be performed on a 3 Tesla scanner (1) spin echo (SE) T1w, turbo spin-echo (TSE) T2w, FLAIR to detect chronic ischemic brain lesions. (2) Diffusion weighted imaging (DWI) including apparent diffusion coefficient (ADC) maps to detect acute ischemic brain lesions. (3) susceptibility-weighted (...) imaging (SWI) sequences or T2*w gradient echo (GRE) to detect hemorrhagic brain lesions (4) contrast-enhanced magnetic resonance angiography (CE-MRA) to improve delineation of the wall hematoma against the perfused vessel lumen, and to assess the degree of obstruction of the affected artery. MRI scans will be centrally analysed at the University Hospital Basel, and independently assessed by two observers who are blinded to the type of treatment and clinical outcome. Clinical examination: Patients

2014 Clinical Trials

5270. Systemic Normothermia in Intracerebral Hemorrhage (ICH)

terms: Layout table for MeSH terms Hemorrhage Cerebral Hemorrhage Pathologic Processes Intracranial Hemorrhages Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases (...) ) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with spontaneous supratentorial ICH >20 cc Age 18 to 85 years of age Consent from the patient or surrogate decision maker Within 24 hours of onset of ictus Exclusion Criteria: Hemorrhage secondary to trauma, Arterio-venous malformation (AVM), aneurysm or Arterio-venous dural fistula Moribund state and deemed unlikely to survive until study completion (5 days) Patients with a don-not-resuscitate (DNR

2014 Clinical Trials

5271. Whole Body Hyperthermia & Combat-Related Posttraumatic Stress Disorder (PTSD)

, for example peripheral vascular disease, deep vein thrombosis (DVT), or lymphedema. History of a cerebral vascular accident. History of stroke, epilepsy or cerebral aneurisms. Cancer in the last five years, except for fully resected non-melanoma skin cancer. Diabetes mellitus types I or II. Any clinically significant autoimmune disease (compensated hypothyroidism allowed). Active alcohol/drug abuse in 2 weeks prior to screening for those who have been dependent or have abused on drugs/alcohol in the last

2014 Clinical Trials

5272. FMISO PET Study of Glioblastoma

in promoting the growth or spreading of tumor blood vessels. Since anti-VEGF agents also affect normal blood vessels in the brain, they can inhibit the way other drugs used in combination with bevacizumab are delivered to the tumor. In PET scans, a radioactive substance is injected into the body. The scanning machine finds the radioactive substance, which tends to go to cancer cells. For the PET scans in this research study, the investigators are using an investigational radioactive substance called FMISO (...) will be intravenously injected at a dose of 3.7 MBq/kg (0.1 mCi/kg) (maximum 260 MBq, 7 mCi) in < 15 mL. The IV will remain in place for injection of the gadolinium for the MRI scan. There will be one injection of FMISO in the PET protocol. Approximately 90 minutes after the injection, the PET scan will begin. The PET scan will be approximately 60-75 minutes. MRI -- Each MRI will last 60-75 minutes versus 45 minutes for standard brain MRIs. Device: FMISO PET Device: MRI MR scans will be performed with the same

2014 Clinical Trials

5273. Development of Clinical Methods to Evaluate Neural Function in Aging

Lying on the floor and rising to a standing position Kneeling on the floor and rising to standing position Climbing a flight of stairs Lift a weighted laundry basket and placing it on a shelf Muscle strength tests will be performed on the legs and arms. Questionnaires that address physical function. Muscle and nerve testing will be done. During the above testing, sensors will be worn on the forehead that use invisible light to indirectly measure blood flow and blood oxygen content of the brain (...) exposure to very small amounts of radiation. Images of the brain will be taken using magnetic resonance imaging (MRI). Magnetic resonance imaging (MRI) is a procedure that allows doctors to look inside the body by using a scanner that sends out a strong magnetic field and radio waves. All of these test are done for this study and will not be used to diagnose or treat any medical problems. The expected length of participation is approximately six hours total, over the course of 4 separate visits. Study

2014 Clinical Trials

5274. The Neurophysiological Effects of Intravenous Alcohol as Potential Biomarkers of Ketamine's Rapid Antidepressant Effects in Major Depressive Disorder

stimulation (TMS) and vagal nerve stimulation (VNS), within 4 weeks of study phase II. Lifetime history of deep brain stimulation. Treatment with any disallowed concomitant medications. Positive HIV test Presence of ferromagnetic implants, e.g, heart pacemaker or aneurysm clip, or other contraindications to magnetic resonance imaging (MRI), e.g. claustrophobia or hearing loss. Clinically-significant anatomical brain abnormalities detected on routine brain MRI. Subjects who, in the investigator s judgment (...) : The primary hypothesis/outcome measure will be change in mean Montgomery-Asberg Depression Rating Scale (MADRS) total score from the pre-ketamine infusion baseline-to-7 days post-infusion between the FHP and FHN groups. Other exploratory measures include neurophysiological responses to intravenous alcohol infusion, brain neurochemical alterations during intravenous alcohol infusion, brain neurochemical alterations during intravenous ketamine infusion and resting state (task-free) functional magnetic

2014 Clinical Trials

5275. The Use of Cardiovascular Biomarkers in Abdominal Aortic Surgery

, 2014 Sponsor: Prim PD Dr Afshin Assadian Collaborator: Wilhelminenspital Vienna Information provided by (Responsible Party): Prim PD Dr Afshin Assadian, Wilhelminenspital Vienna Study Details Study Description Go to Brief Summary: The aim of the present study is the evaluation of cardiovascular biomarkers in patients with abdominal aortic aneurysms (AAA) or abdominal aortic occlusive disease AOD) undergoing open (OR) or endovascular aortic repair (EVAR) with regards to short- and long-term outcome (...) . By blood collection and measurement of the serum biomarkers Copeptin, N-terminal- pro Brain Natriuretic Peptide (NT-proBNP), cardiac Troponin I (cTnI), high sensitive Troponin T (hs-cTnT) and C-reactive Protein (CRP) we expect an improvement of patients stratification by assessment of cardiac stress tolerance. Data gathered may help to simplify the decision whether an open or endovascular approach for abdominal aortic repair (OR and EVAR) should be performed. Study Hypothesis: The evaluation

2014 Clinical Trials

5276. Resveratrol and First-degree Relatives of Type 2 Diabetic Patients

or abnormal laboratory test result that, in the opinion of the Investigator, would interfere with the study outcome, affect trial participation or put the subject at undue risk Any contra-indication to MRI scanning. These contra-indications include patients with following devices: Central nervous system aneurysm clip Implanted neural stimulator Implanted cardiac pacemaker of defibrillator Cochlear implant Insulin pump Metal containing corpora aliena in the eye or brains Contacts and Locations Go

2014 Clinical Trials

5277. Positioning of Surgical Patients With Sleep Apnea

Undergoing nasal, eye, head/neck surgery, intracranial or cardiac/thoracic surgery Currently undergoing treatment for sleep apnea including CPAP Requiring prolonged postoperative ventilation NYHA functional class III and IV Valvular heart disease, dilated cardiomyopathy, implanted cardiac pacemaker, or unstable angina Myocardial infarction or cardiac surgery within 3 months Chronic obstructive pulmonary disease, or asthma Presence of tracheostomy, facial, neck, or chest wall abnormalities Abdominal (...) aortic aneurysm surgery, chemotherapy, or immunosuppressive therapy within 3 months Visiting preoperative clinic less than 3 days before surgery Requiring postoperative nasogastric tube Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02123238

2014 Clinical Trials

5278. An MRI Study of Post-op Cognitive Deficit in Patients Undergoing Major Surgery

bears fruit. At the least, further elucidation into POD for major surgery is expected with this study. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 20 participants Observational Model: Case-Only Time Perspective: Prospective Official Title: "Blue" Cerebrovascular Reactivity (CVR) Maps as a Marker for Post-operative Delirium (POD) in Patients Undergoing Abdominal Aortic Aneurysm (AAA) Surgery: A Pilot Study: Addition of Other Patients Being (...) Outcome Measures Go to Primary Outcome Measures : Blue voxel count/whole brain voxel count [ Time Frame: Baseline ] the number and distribution of 'blue' voxels - those with reversed CO2 responsiveness to a controlled CO2 change with blood oxygen level dependent (BOLD) MRI. Incidence of post-op delirium [ Time Frame: Post-op out to discharge or maximum of 2 weeks post-surgery ] the incidence and severity of post-op delirium using the cognitive assessment method - intensive care unit (CAM-ICU) scoring

2014 Clinical Trials

5279. Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation.

, intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or implanted medical pumps. Individuals with a significant neurological disorder or insult including, but not limited to: Any condition likely to be associated with increased intracranial pressure Space occupying brain lesion History of cerebrovascular accident Transient ischemic attack within two years Cerebral aneurysm Dementia Mini Mental State Exam score of less than or equal to 24 Parkinson's disease (...) of deeper neuronal pathways than the standard TMS. The Brainsway Coil is a novel dTMS coil desigend to allow deeper brain stimulation without significant increase of electric fields induced in superficial cortical regions. Other Name: Brainsway Deep TMS Treatment Sham Comparator: Sham Treatment Brainsway Sham Treatment Device: Sham Treatment In the sham treatment, the electrical field induced by the sham coil cannot invoke any action potentials and if no action potentials are induced, then the electric

2014 Clinical Trials

5280. CARE: A Prospective Multicenter Case Study to Assess Radiation Exposure in Patients Treated With the Penumbra Coil 400

relevant MeSH terms: Layout table for MeSH terms Aneurysm Intracranial Aneurysm Vascular Diseases Cardiovascular Diseases Intracranial Arterial Diseases Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases (...) review study of patients presenting with intracranial aneurysms who are treated with coil embolization therapy using the PC 400 or conventional coils. Data for each patient are collected acutely.Up to 90 patients treated with the PC 400 or conventional coils (2:1) at up to 15 centers in the USA will be enrolled. Condition or disease Intervention/treatment Intracranial Aneurysms Device: PC 400 Study Design Go to Layout table for study information Study Type : Observational [Patient Registry] Actual

2014 Clinical Trials

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