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Cerebral Gigantism

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1. Cerebral Gigantism

Cerebral Gigantism Cerebral Gigantism Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cerebral Gigantism Cerebral Gigantism Aka (...) : Cerebral Gigantism , Soto Syndrome From Related Chapters II. Signs Prominent forehead High arched Large irregular head Antimongoloid slant of palpebral fissures Advanced III. Labs See Lab results are normal in this condition Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Cerebral Gigantism." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Sotos

2018 FP Notebook

2. Cerebral Gigantism

Cerebral Gigantism Cerebral Gigantism Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cerebral Gigantism Cerebral Gigantism Aka (...) : Cerebral Gigantism , Soto Syndrome From Related Chapters II. Signs Prominent forehead High arched Large irregular head Antimongoloid slant of palpebral fissures Advanced III. Labs See Lab results are normal in this condition Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Cerebral Gigantism." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Sotos

2015 FP Notebook

3. Letter: Cerebral gigantism. (PubMed)

Letter: Cerebral gigantism. 1271433 1976 08 02 2018 11 13 0022-2593 13 1 1976 Feb Journal of medical genetics J. Med. Genet. Letter: Cerebral gigantism. 80 Townes P L PL eng Journal Article England J Med Genet 2985087R 0022-2593 IM Genes, Recessive Gigantism genetics 1976 2 1 1976 2 1 0 1 1976 2 1 0 0 ppublish 1271433 PMC1013360 J Med Genet. 1974 Jun;11(2):158-65 4841084

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1976 Journal of Medical Genetics

4. Letter: Diagnositc problems in cerebral gigantism. (PubMed)

Letter: Diagnositc problems in cerebral gigantism. 1271434 1976 08 02 2018 11 13 0022-2593 13 1 1976 Feb Journal of medical genetics J. Med. Genet. Letter: Diagnositc problems in cerebral gigantism. 80 Cohen M M MM eng Journal Article England J Med Genet 2985087R 0022-2593 IM Genes, Recessive Gigantism diagnosis Phenotype 1976 2 1 1976 2 1 0 1 1976 2 1 0 0 ppublish 1271434 PMC1013361 J Med Genet. 1974 Jun;11(2):158-65 4841084

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1976 Journal of Medical Genetics

5. Autonomic failure with persistent fever in cerebral gigantism. (PubMed)

Autonomic failure with persistent fever in cerebral gigantism. 5783288 1969 07 25 2018 11 13 0022-3050 32 2 1969 Apr Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Autonomic failure with persistent fever in cerebral gigantism. 123-8 Appenzeller O O Snyder R D RD eng Journal Article England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Autonomic Nervous System physiopathology Body Temperature Regulation Dysautonomia, Familial complications Female Fever (...) etiology Gigantism complications physiopathology Humans Hypothalamus physiopathology Infant 1969 4 1 1969 4 1 0 1 1969 4 1 0 0 ppublish 5783288 PMC496453 Clin Sci (Lond). 1957 Feb;16(1):67-74 13414140 Clin Sci. 1964 Dec;27:345-56 14236770 Pediatrics. 1968 Jan;41(1):130-8 4169648 N Engl J Med. 1964 Jul 16;271:109-16 14148233 Pediatrics. 1967 Sep;40(3):395-402 5298529 J Appl Physiol. 1965 Sep;20(5):984-90 5837627 Physiol Rev. 1953 Oct;33(4):566-92 13100071 Radiology. 1967 Mar;88(3):446-56 4289663 N Engl

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1969 Journal of neurology, neurosurgery, and psychiatry

6. Atypical cerebral gigantism. A case report. (PubMed)

Atypical cerebral gigantism. A case report. 5763313 1969 03 06 2018 11 13 0027-9684 61 1 1969 Jan Journal of the National Medical Association J Natl Med Assoc Atypical cerebral gigantism. A case report. 44-6 Jung J S JS Martin B F BF eng Journal Article United States J Natl Med Assoc 7503090 0027-9684 IM Birth Injuries complications Brain Diseases etiology Child Female Gigantism etiology Humans Hydrocephalus surgery Intellectual Disability etiology Intelligence Tests Intracranial Pressure

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1969 Journal of the National Medical Association

7. Sotos' syndrome of cerebral gigantism. (PubMed)

Sotos' syndrome of cerebral gigantism. 5779431 1969 06 02 2018 11 13 1468-2044 44 234 1969 Apr Archives of disease in childhood Arch. Dis. Child. Sotos' syndrome of cerebral gigantism. 203-10 Abraham J M JM Snodgrass G J GJ eng Journal Article England Arch Dis Child 0372434 0003-9888 IM Acromegaly enzymology Birth Weight Brain Diseases enzymology genetics Female Gigantism enzymology genetics Growth Disorders enzymology Humans Infant Infant, Newborn Infant, Newborn, Diseases Intellectual

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1969 Archives of Disease in Childhood

8. Sotos' Syndrome (Cerebral Gigantism) with Peripheral Dysostosis (PubMed)

Sotos' Syndrome (Cerebral Gigantism) with Peripheral Dysostosis 5089596 1971 08 12 2018 11 13 1468-2044 46 246 1971 Apr Archives of disease in childhood Arch. Dis. Child. Sotos' syndrome (cerebral gigantism) with peripheral dysostosis. 199-202 Evans P R PR eng Journal Article England Arch Dis Child 0372434 0003-9888 IM Abnormalities, Multiple complications Acromegaly complications Adolescent Body Height Body Weight Bone Diseases, Developmental complications Brain Diseases complications Child (...) Child, Preschool Epiphyses Female Foot Diseases complications Gigantism complications Hand Humans Intellectual Disability complications Menarche 1971 4 1 1971 4 1 0 1 1971 4 1 0 0 ppublish 5089596 PMC1647461 J Pediatr. 1969 May;74(5):730-7 4305182 Arch Dis Child. 1969 Apr;44(234):203-10 5779431 N Engl J Med. 1964 Jul 16;271:109-16 14148233

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1971 Archives of Disease in Childhood

9. Evidence for autosomal recessive inheritance in cerebral gigantism (PubMed)

Evidence for autosomal recessive inheritance in cerebral gigantism 4841084 1974 09 17 2018 11 13 0022-2593 11 2 1974 Jun Journal of medical genetics J. Med. Genet. Evidence for autosomal recessive inheritance in cerebral gigantism. 158-65 Nevo S S Zeltzer M M Benderly A A Levy J J eng Journal Article England J Med Genet 2985087R 0022-2593 IM Abnormalities, Multiple genetics Acromegaly genetics Brain Diseases genetics Child Contracture genetics Dermatoglyphics Edema genetics Female Genes (...) , Recessive Gigantism genetics Humans Inbreeding Infant, Newborn Intellectual Disability genetics Israel Male Pedigree Syndrome 1974 6 1 1974 6 1 0 1 1974 6 1 0 0 ppublish 4841084 PMC1013112 Ann Pediatr (Paris). 1965 Nov 2;12(11):682-91 5851848 Radiology. 1967 Mar;88(3):446-56 4289663 J Pediatr. 1967 Jun;70(6):900-14 4290694 Pediatrics. 1967 Sep;40(3):395-402 5298529 Arch Fr Pediatr. 1968 Feb;25(2):151-61 5686253 Am J Dis Child. 1969 Mar;117(3):357-68 4304366 J Pediatr. 1970 Jan;76(1):105-11 4312004 Lille

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1974 Journal of Medical Genetics

10. Gigantism and Acromegaly (Diagnosis)

Gigantism and Acromegaly (Diagnosis) Gigantism and Acromegaly: Practice Essentials, Background, Pathophysiology and Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTI1NDQ2LW92ZXJ2aWV3 processing (...) > Gigantism and Acromegaly Updated: Sep 05, 2017 Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Sasigarn A Bowden, MD Share Email Print Feedback Close Sections Sections Gigantism and Acromegaly Overview Practice Essentials Gigantism refers to abnormally high linear growth (see the image below) due to excessive action of (IGF-I) while the epiphyseal growth plates are open during childhood. Acromegaly is the same disorder of IGF-I excess but occurs after the growth plate cartilage fuses in adulthood

2014 eMedicine Pediatrics

11. Gigantism and Acromegaly (Treatment)

Gigantism and Acromegaly (Treatment) Gigantism and Acromegaly Treatment & Management: Approach Considerations, Pharmacologic Therapy, Transsphenoidal Surgery Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTI1NDQ2LXRyZWF0bWVudA== processing > Gigantism and Acromegaly Treatment & Management Updated: Sep 05, 2017 Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Sasigarn A Bowden, MD Share Email Print Feedback Close Sections Sections Gigantism and Acromegaly Treatment Approach Considerations Most experts define cure, or adequate control, of growth hormone (GH) excess as a glucose-suppressed GH concentration of less than 2 ng/mL, as determined by radioimmunoassay (1 mcg/L by IRMA), and normalization of the serum

2014 eMedicine Pediatrics

12. Gigantism and Acromegaly (Overview)

Gigantism and Acromegaly (Overview) Gigantism and Acromegaly: Practice Essentials, Background, Pathophysiology and Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTI1NDQ2LW92ZXJ2aWV3 processing (...) > Gigantism and Acromegaly Updated: Sep 05, 2017 Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Sasigarn A Bowden, MD Share Email Print Feedback Close Sections Sections Gigantism and Acromegaly Overview Practice Essentials Gigantism refers to abnormally high linear growth (see the image below) due to excessive action of (IGF-I) while the epiphyseal growth plates are open during childhood. Acromegaly is the same disorder of IGF-I excess but occurs after the growth plate cartilage fuses in adulthood

2014 eMedicine Pediatrics

13. Gigantism and Acromegaly (Follow-up)

Gigantism and Acromegaly (Follow-up) Gigantism and Acromegaly Treatment & Management: Approach Considerations, Pharmacologic Therapy, Transsphenoidal Surgery Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTI1NDQ2LXRyZWF0bWVudA== processing > Gigantism and Acromegaly Treatment & Management Updated: Sep 05, 2017 Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: Sasigarn A Bowden, MD Share Email Print Feedback Close Sections Sections Gigantism and Acromegaly Treatment Approach Considerations Most experts define cure, or adequate control, of growth hormone (GH) excess as a glucose-suppressed GH concentration of less than 2 ng/mL, as determined by radioimmunoassay (1 mcg/L by IRMA), and normalization of the serum

2014 eMedicine Pediatrics

14. Birmingham Mid-Head Resection Hip Arthroplasty in a Young Man with Gigantism. (PubMed)

Birmingham Mid-Head Resection Hip Arthroplasty in a Young Man with Gigantism. The Birmingham Mid-Head Resection (Smith & Nephew Ltd, Warwick, United Kingdom) arthroplasty is a new bone-conserving procedure that, like hip resurfacing, is used in younger, active patients. We present the case of a young man with Sotos syndrome (cerebral gigantism) with associated extraordinary stature (height, 2.16 m; weight, 157 kg) who underwent Birmingham Mid-Head Resection arthroplasty. The large stature

2011 Journal of Arthroplasty

15. Cerebral dysfunction and physical growth: the overgrown child. (PubMed)

Cerebral dysfunction and physical growth: the overgrown child. 5114289 1972 01 05 2018 11 13 0035-9157 64 9 1971 Sep Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Cerebral dysfunction and physical growth: the overgrown child. 915-8 Salmon M M Bernstein L H LH Taylor D D eng Journal Article England Proc R Soc Med 7505890 0035-9157 IM Atrophy Body Height Body Weight Brain Diseases diagnosis Cerebral Ventricles Child, Preschool Dermatoglyphics Electroencephalography Female (...) Gigantism diagnosis Growth Disorders diagnosis genetics Humans Karyotyping Male Pneumoencephalography 1971 9 1 1971 9 1 0 1 1971 9 1 0 0 ppublish 5114289 PMC1812880 Radiology. 1967 Mar;88(3):446-56 4289663 J Pediatr. 1967 Jun;70(6):900-14 4290694 Pediatrics. 1967 Sep;40(3):395-402 5298529 Arch Dis Child. 1969 Apr;44(234):203-10 5779431 N Engl J Med. 1964 Jul 16;271:109-16 14148233

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1971 Proceedings of the Royal Society of Medicine

17. Diagnosis and Treatment of Peripheral Arterial Diseases

, demonstrated that DAPT vs. aspirin reduced silent cerebral micro-emboli by 37% after 7 days. No life-threatening intracranial or major bleeding was observed, but the sample size was small. For these reasons, DAPT may be considered within 24 h of a minor ischaemic stroke or transient ischaemic attack (TIA) and may be continued for 1 month in patients treated conservatively. DAPT is recommended in patients undergoing CAS. Two small RCTs comparing aspirin alone with DAPT for CAS were terminated prematurely

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2017 European Society of Cardiology

20. Celebrating unglamorous medical jobs…and understanding what matters in the end

, or cerebral. Instead, it was colorectal. In plain language it was about diseases of the backside, and the profound effect that they have upon quality of life. The point is that we need to focus on what truly matters, even if — perhaps especially if — it fails to get attention or adulation. Thirty years on, these lectures still remind me that what truly matters for our patients rarely makes the nightly news. These lecture were not only necessary, regardless of one’s chosen specialty, but they were also (...) stuff right, and being silently proud to have played a small unheralded part. This same lecturer was also pretty adept with the maxims. He taught our class that the top third of the medical school class makes the best professors, the middle third makes the best doctors, and the bottom third makes the most money. Thirty years on his comments are still spot on. Regardless, let’s review what we ought to mean when we say the “best doctors”. Firstly, it has less to do with a gigantic brain and more about

2018 The BMJ Blog

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