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1. Laxatives

Laxatives Laxativ Laxatives es Key therapeutic topic Published: 15 January 2015 nice.org.uk/guidance/ktt1 pathways Options for local implementation Options for local implementation Review and, if appropriate, revise prescribing of laxatives for adults to ensure that they are prescribed routinely only for the short-term treatment of constipation when dietary and lifestyle measures have proven unsuccessful or if there is an immediate clinical need. For children and young people, laxatives should (...) be prescribed in line with the NICE guideline on constipation in children and young people. The NICE guideline on the use of strong opioids in palliative care in adults advises that laxatives should be prescribed for everyone starting strong opioids. Evidence conte Evidence context xt As discussed in the MeReC Bulletin on managing constipation, most cases of mild or acute functional (idiopathic) constipation in adults can be managed by dietary and lifestyle changes. In adults, laxatives should be reserved

2015 National Institute for Health and Clinical Excellence - Advice

2. Laxatives for the management of constipation in people receiving palliative care. Full Text available with Trip Pro

Laxatives for the management of constipation in people receiving palliative care. This article describes the second update of a Cochrane review on the effectiveness of laxatives for the management of constipation in people receiving palliative care. Previous versions were published in 2006 and 2010 where we also evaluated trials of methylnaltrexone; these trials have been removed as they are included in another review in press. In these earlier versions, we drew no conclusions on individual (...) effectiveness of different laxatives because of the limited number of evaluations. This is despite constipation being common in palliative care, generating considerable suffering due to the unpleasant physical symptoms and the availability of a wide range of laxatives with known differences in effect in other populations.To determine the effectiveness and differential efficacy of laxatives used to manage constipation in people receiving palliative care.We searched the Cochrane Central Register of Controlled

2015 Cochrane

3. Oral Laxative Use Pre- and Post-Hip Fracture or Other Emergency Orthopedic Surgery

Oral Laxative Use Pre- and Post-Hip Fracture or Other Emergency Orthopedic Surgery Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should (...) study only. It may not be copied, posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Oral Laxative Use Pre- and Post-Hip Fracture

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Correction: The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. Full Text available with Trip Pro

Correction: The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. [This corrects the article DOI: 10.1371/journal.pone.0195624.].

2018 PLoS ONE

5. The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. Full Text available with Trip Pro

The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats. Chronic constipation is a functional gastrointestinal disease that is detrimental to the quality of patient life. Cassia obtusifolia L. (CO) and Foeniculum vulgare M. (FV) are commonly used as medicinal foods in many countries. We aimed to examine the laxative effect and their underlying mechanism of CO and FV mixture on loperamide (lop)-induced constipated (...) rats. To determine the laxative effects of these compounds, Sprague-Dawley rats were divided into six groups: the control, lop-induced constipated (2mg/kg), and three doses (100, 300, and 500mg/kg) of CO and FV mixture-, and Bisacodyl (bis, 3.3mg/kg)-treated groups. The mixture of CO and FV and bis were orally administered once a day for 4 weeks. For induction of constipation, the lop were treated with a dose of 2 mg/kg twice a day on the 3rd week after treatments of CO and FV extracts and bis

2018 PLoS ONE

6. Automated C. elegans embryo alignments reveal brain neuropil position invariance despite lax cell body placement. Full Text available with Trip Pro

Automated C. elegans embryo alignments reveal brain neuropil position invariance despite lax cell body placement. The Caenorhabditis elegans cell lineage is nearly invariant. Whether this stereotyped cell-division pattern promotes reproducibility in cell shapes/positions is not generally known, as manual spatiotemporal cell-shape/position alignments are labor-intensive, and fully-automated methods are not described. Here, we report automated algorithms for spatiotemporal alignments of C

2018 PLoS ONE

7. Randomised controlled trial: Naloxegol increases frequency of bowel movements and combats inadequate response to laxatives Full Text available with Trip Pro

Randomised controlled trial: Naloxegol increases frequency of bowel movements and combats inadequate response to laxatives Naloxegol increases frequency of bowel movements and combats inadequate response to laxatives | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Naloxegol increases frequency of bowel movements and combats inadequate response to laxatives Article Text Therapeutics/Prevention Randomised controlled trial Naloxegol increases

2015 Evidence-Based Medicine

8. Is Laxative Misuse Associated with Binge Eating? Examination of Laxative Misuse among Individuals Seeking Treatment for Eating Disorders Full Text available with Trip Pro

Is Laxative Misuse Associated with Binge Eating? Examination of Laxative Misuse among Individuals Seeking Treatment for Eating Disorders Our research focuses on laxative misuse, which has been understudied in previous eating disorders (ED) research, to understand its prevalence and correlates among individuals seeking ED treatment. We also test the association between laxative misuse and binge eating to examine the assumption that laxative misuse is intended to compensate for binge (...) eating.Participants were 2,295 ED treatment-seeking adults (29.5 ± 10.5) who self-reported their disordered eating behaviors on the Eating Disorder Questionnaire. Participants met DSM-5 diagnostic criteria for anorexia nervosa (AN: 11.5%, n = 264), bulimia nervosa (BN: 39.0%, n = 896), binge-eating disorder (14.9%, n = 343), or other specified feeding or eating disorder (34.5%, n = 792).Nearly 25% of participants (n = 571) reported misusing laxatives during the last month. Laxative misusers with AN reported

2017 The International journal of eating disorders

9. A novel volume-reduced CT colonography regimen using hypertonic laxative (polyethylene glycol with ascorbic acid): randomized controlled trial. (Abstract)

A novel volume-reduced CT colonography regimen using hypertonic laxative (polyethylene glycol with ascorbic acid): randomized controlled trial. The aim of this study is to investigate the feasibility of bowel preparation using a hypertonic laxative (polyethylene glycol with ascorbic acid, PEG + Asc) for CT colonography (CTC) and to examine the volume limit of laxative.In one institution, patients who met the indications for CTC were enrolled and randomly assigned to CTC with regimen A (800 ml (...) -inferiority margin. No adverse events occurred.A novel CTC regimen using hypertonic laxative demonstrated optimal colon cleansing effectiveness even with the lowest volume of laxative (UMIN000022851).• A novel CTC regimen using a hypertonic laxative is feasible. • The lowest volume of laxative provides excellent colon imaging. • However, the lowest volume of laxative did not improve patient acceptance.

2019 European radiology Controlled trial quality: predicted high

10. The hospital-based evaluation of laxative prophylaxis in ICU (HELP-ICU): A pilot cluster-crossover randomized clinical trial. (Abstract)

The hospital-based evaluation of laxative prophylaxis in ICU (HELP-ICU): A pilot cluster-crossover randomized clinical trial. Prophylactic laxative regimens may prevent constipation but may increase diarrhea and subsequent rectal tube insertion. Our aim was to compare three prophylactic laxative regimens on the rate of rectal tube insertion (primary outcome) and major constipation- or diarrhea-associated complications.We conducted a cluster-crossover trial. Three pods in a single ICU were each (...) was not statistically different between the three regimens (A = 12.9%, B = 7.8%, C = 7.7%; p = 0.15). The proportions of patients with other major constipation- or diarrhea-associated complications were similar, as were major patient-centred outcomes.Earlier commencement of a prophylactic coloxyl-based laxative regimen (day 1 or 3) did not affect the rates of complications associated with constipation or diarrhea when compared to delayed introduction (day 6).Copyright © 2019. Published by Elsevier Inc.

2019 Journal of critical care Controlled trial quality: uncertain

11. There might be a distinctive clinical phenotype of constipation with non-cardiac chest pain which responds to combination laxatives: A retrospective, longitudinal symptom analysis. Full Text available with Trip Pro

There might be a distinctive clinical phenotype of constipation with non-cardiac chest pain which responds to combination laxatives: A retrospective, longitudinal symptom analysis. Proton pump inhibitor (PPI)-refractory non-cardiac chest pain (NCCP) is often resolved when constipation was relieved. This study aimed to investigate the clinical features of patients with both NCCP and constipated functional bowel disorders (FBD).Among 692 consecutive patients diagnosed with functional constipation (...) (16.2% vs 6.9%, P = .036) and squeezing pressure (62.2% vs 50.7%, P = .049) of the anal sphincter, increased urgency volume (40.5% vs 23.2%, P = .004), and maximal volume (25.7% vs 15.0%, P = .032) for rectal sensation were more frequently observed in the NCCP group. After taking laxatives for 1 to 3 months, 81.1% of patients with NCCP reported improvement.Subjects with NCCP showed decreased rectal sensation more frequently at anorectal manometry. Majority of patients with NCCP reported improvement

2019 Medicine

12. Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats. Full Text available with Trip Pro

model of spastic constipation.Spastic constipation was induced via oral treatment with LP (3 mg/kg) for 6 days 1 h before the administration of each test compound. Similarly, FBe (100, 200 and 300 mg/kg) was orally administered to rats once a day for 6 days. The changes in number, weight, and water content of fecal, motility ratio, colonic mucosa histology, and fecal mucous contents were recorded. The laxative properties of FBe were compared with those of a cathartic stimulant, sodium picosulfate (...) Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats. Constipation, a common health problem, causes discomfort and affects the quality of life. This study intended to evaluate the potential laxative effect of triple fermented barley (Hordeum vulgare L.) extract (FBe), produced by saccharification, Saccharomyces cerevisiae, and Weissella cibaria, on loperamide (LP)-induced constipation in Sprague-Dawley (SD) rats, a well-established animal

2019 BMC Complementary and Alternative Medicine

13. Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats. (Abstract)

Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats. As a traditional Chinese herbal medicine, Anemarrhena asphodeloides Bge. possesses the effects of nourishing yin, moistening dryness, clearing lungs and relieving fire. Simultaneously, it has been used to treat constipation for more than one thousand years in China. However, modern medical studies are limited and lacking on its therapeutic mechanism.This current (...) study was aimed to investigate the laxative activities and explore the potential mechanism of Anemarrhena asphodeloides Bge. polysaccharides (AABP) in loperamide-induced constipation rats.The structure of AABP was determined by using infrared spectrum, high performance gel permeation chromatography (HPGPC), and high performance liquid chromatography (HPLC). Real-time quantitative polymerase chain reaction (PCR), multitudinous methods were adopted to explore the underlining therapeutic mechanism

2019 Journal of Ethnopharmacology

14. Computed tomography colonography: Retrospective comparison of laxative plus barium tagging versus iodinated contrast only for bowel preparation and faecal tagging. (Abstract)

Computed tomography colonography: Retrospective comparison of laxative plus barium tagging versus iodinated contrast only for bowel preparation and faecal tagging. There is no consensus as to the most optimal bowel preparation regime for Computed Tomographic Colonography (CTC). Concerns regarding laxative bowel preparation (LBP) include tolerability, adverse effects and complexity of regimen. Two hospitals in Auckland changed CTC bowel preparation from standard LBP to Gastrografin (GG) in 2015

2019 Journal of medical imaging and radiation oncology Controlled trial quality: uncertain

15. Laxative use does not preclude diagnosis or reduce disease severity in Clostridiodes difficile infection. Full Text available with Trip Pro

Laxative use does not preclude diagnosis or reduce disease severity in Clostridiodes difficile infection. To optimize utility of laboratory testing for Clostridiodes difficile infection (CDI), the 2017 Infectious Diseases Society of America-Society for Healthcare Epidemiology of America (IDSA-SHEA) clinical practice guidelines recommend excluding patients from stool testing for C. difficile if they have received laxatives within the preceding 48 hours. Sparse data support (...) this recommendation.Patients with new-onset diarrhea (≥3 bowel movements in any 24 hour period in the 48 hours before stool collection) and a positive stool C. difficile nucleic acid amplification test (NAAT) were enrolled. Laxative use within 48 hours prior to stool testing, severity of illness (defined by four distinct scoring methods), and clinical outcomes were recorded.209 patients with CDI were studied, 65 of whom had received laxatives. There were no significant differences in the proportion of patients meeting

2019 Clinical Infectious Diseases

16. Appropriate Use of Laxatives in the Older Person. (Abstract)

Appropriate Use of Laxatives in the Older Person. Constipation is a common condition, affecting up to half of all older adults during their lifetime. Untreated constipation has significant impacts, decreasing quality of life and potentially leading to urinary and/or faecal incontinence, faecal impaction and, in severe cases, hospitalisation. The increased constipation prevalence among older populations is multifactorial, with a number of age-related factors contributing to the rise (...) in prevalence with aging. Laxatives are the mainstay of constipation management and are commonly used among older populations for both treatment and prevention of constipation. A range of laxative types including bulk forming agents, softeners and emollients, osmotic agents, stimulants, and the newer prokinetic and secretory agents are available. Despite laxatives being freely available without prescription in many countries and commonly used by older individuals, evidence regarding the effectiveness

2019 Drugs & Aging

17. Constipation and laxative use among people living in nursing homes in 2007 and 2013. Full Text available with Trip Pro

Constipation and laxative use among people living in nursing homes in 2007 and 2013. Constipation is a common condition among older people, particularly among people living in nursing homes, and the use of drugs such as opioids is one of many factors that contribute to its high prevalence. The aim of this study was to compare the prevalence of constipation and the use of laxatives between 2007 and 2013, to analyze constipation and laxative use among people who are prescribed opioids (...) , and to identify factors associated with constipation.In 2007 and 2013, two surveys were performed in the county of Västerbotten in Northern Sweden, comprising all those living in nursing homes. The Multi-Dimensional Dementia Assessment Scale was used to collect data regarding laxative, opioid and anticholinergic drug use, functioning in activities of daily living (ADL), cognition and symptoms of constipation. A comparison was made between 2820 people from 2007 and 1902 people from 2013.The prevalence

2019 BMC Geriatrics

18. Downregulation of Aquaporin 3 Mediated the Laxative Effect in the Rat Colon by a Purified Resin Glycoside Fraction from Pharbitis Semen. Full Text available with Trip Pro

Downregulation of Aquaporin 3 Mediated the Laxative Effect in the Rat Colon by a Purified Resin Glycoside Fraction from Pharbitis Semen. Pharbitis Semen, the seeds of Pharbitis nil, is widely used as a traditional purgative medicine in China, Korea, and Japan. This study investigated the laxative effects of a purified resin glycoside fraction obtained in our previous study from Pharbitis Semen in vivo and in vitro.After orally administering a purified resin glycoside fraction from Pharbitis (...) in the rat colons and in HT-29 cells, while the NF-κB pathway-mediated PGE2 production was activated. Interestingly, pretreating rats with BAY-11-7082 (NF-κB inhibitor) or indomethacin (COX-2 inhibitor) and RFP neither induced diarrhea nor decreased the AQP3 expression in the colon.The purgative property of the purified resin glycoside fraction was attributed to NF-κB activation in the colon, which increased the COX-2-mediated secretion of PGE2. PGE2 decreased AQP3 expression which inhibits water

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

19. Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study. Full Text available with Trip Pro

Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study. Evaluate the effect of combinations of green banana biomass and laxatives in children and adolescents with chronic constipation.This was a randomized study of 80 children and adolescents with functional constipation according to the Rome IV Criteria, who were divided into five groups: (1) green banana biomass alone; (2) green banana biomass plus PEG (...) laxative doses.On consumption of green banana biomass alone, a statistically significant reduction was observed in the proportion of children with Bristol Stool Form Scale rating 1 or 2, straining on defecation, painful defecation, and abdominal pain. Conversely, no reduction was observed in fecal incontinence episodes/week, blood in stool, and no increase was observed in the proportion of children with >3 bowel movements/week. The percentage of children who required decreased laxative dose was high

2019 Jornal de pediatria Controlled trial quality: uncertain

20. A load-measuring device can achieve fine-tuning of mediolateral load at knee arthroplasty but may lead to a more lax knee state. Full Text available with Trip Pro

A load-measuring device can achieve fine-tuning of mediolateral load at knee arthroplasty but may lead to a more lax knee state. A balanced knee arthroplasty should optimise survivorship and performance. Equilibration of medial and lateral femorotibial load requires guided judicious pericapsular ligament release. The null hypothesis was that there would be no difference between use of a tensiometer device and a remote load sensor final load transfer across the joint through functional arc

2018 Knee Surgery, Sports Traumatology, Arthroscopy

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