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1. Relative effectiveness assessment of Femtosecond laser-assisted cataract surgery (FLACS) compared to standard ultrasound phacoemulsification cataract surgery

Relative effectiveness assessment of Femtosecond laser-assisted cataract surgery (FLACS) compared to standard ultrasound phacoemulsification cataract surgery Dec2015 © EUnetHTA, 2015. Reproduction is authorised provided EUnetHTA is explicitly acknowledged 1 EUnetHTA Joint Action 3 WP4 Version 1.4 October 2018 Rapid assessment of other technologies using the HTA Core Model ® for Rapid Relative Effectiveness Assessment FEMTOSECOND LASER-ASSISTED CATARACT SURGERY (FLACS) FOR THE TREATMENT OF AGE (...) -RELATED CATARACT Project ID: OTCA07 Femtosecond Laser Assisted Surgery (FLACS) for age-related cataract Version 1.4. October 2018 EUnetHTA Joint Action 3 WP4 2 DOCUMENT HISTORY AND CONTRIBUTORS Version Date Description V1.0 07/05/2018 First draft. V1.1 04/06/2018 Input from co-author has been processed. V1.2 16/07/2018 Input from dedicated reviewers has been processed. V1.3 28/09/2018 Input from external experts and manufacturer(s) has been processed. V1.4 24/10/2018 Input from medical editor

2018 EUnetHTA

2. Laser-assisted cataract surgery versus standard ultrasound phacoemulsification cataract surgery. (PubMed)

Laser-assisted cataract surgery versus standard ultrasound phacoemulsification cataract surgery. Cataract is the leading cause of blindness in the world, and cataract surgery is one of the most commonly performed operations in the Western world. Preferred surgical techniques have changed dramatically over the past half century with associated improvements in outcomes and safety. Femtosecond laser platforms that can accurately and reproducibly perform key steps in cataract surgery, including (...) corneal incisions, capsulotomy and lens fragmentation, are now available. The potential advantages of laser-assisted surgery are broad, and include greater safety and better visual outcomes through greater precision and reproducibility.To compare the effectiveness of laser-assisted cataract surgery with standard ultrasound phacoemulsification cataract surgery by gathering evidence on safety from randomised controlled trials (RCTs).We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials

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2016 Cochrane

3. Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract. (PubMed)

Manual small incision cataract surgery (MSICS) with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract. Age-related cataract is the opacification of the lens, which occurs as a result of denaturation of lens proteins. Age-related cataract remains the leading cause of blindness globally, except in the most developed countries. A key question is what is the best way of removing the lens, especially (...) in lower income settings.To compare two different techniques of lens removal in cataract surgery: manual small incision surgery (MSICS) and extracapsular cataract extraction (ECCE).We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 8), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to September 2014), EMBASE (January 1980 to September 2014), Latin American and Caribbean Health

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2014 Cochrane

4. Routine preoperative medical testing for cataract surgery. (PubMed)

Routine preoperative medical testing for cataract surgery. Cataract surgery is practiced widely, and substantial resources are committed to an increasing cataract surgical rate in low- and middle-income countries. With the current volume of cataract surgery and future increases, it is critical to optimize the safety and cost-effectiveness of this procedure. Most cataracts are performed on older individuals with correspondingly high systemic and ocular comorbidities. It is likely that routine (...) preoperative medical testing will detect medical conditions, but it is questionable whether these conditions should preclude individuals from cataract surgery or change their perioperative management.1. To investigate the evidence for reductions in adverse events through preoperative medical testing2. To estimate the average cost of performing routine medical testing SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials

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2019 Cochrane

5. Cataracts in adults: management

Cataracts in adults: management Catar Cataracts in adults: management acts in adults: management NICE guideline Published: 26 October 2017 nice.org.uk/guidance/ng77 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement (...) . Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Cataracts in adults: management (NG77) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 23Contents Contents Overview 4 Who is it for? 4 Recommendations 5 1.1 Patient information 5 1.2 Referral

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

6. Systematic Review - Comparative Effectiveness of Multifocal, Accommodative, and Monofocal Intraocular Lenses for Cataract Surgery and Lens Replacement

Systematic Review - Comparative Effectiveness of Multifocal, Accommodative, and Monofocal Intraocular Lenses for Cataract Surgery and Lens Replacement 4 July 2019 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Center West Los Angeles VA Medical Center Los Angeles, CA Paul G. Shekelle, MD, PhD, Director Comparative Effectiveness of Multifocal (...) , Accommodative, and Monofocal Intraocular Lenses for Cataract Surgery and Lens Replacement 4 Authors: Principal Investigator: Paul Shekelle, MD, PhD Co-Investigators: Sumitra S. Khandelwal, MD Jason Jun, MD, MPP Research Associates: Selene Mak, PhDc Roberta Shanman, MLS Jessica M. Beroes, BS Marika Suttorp Booth, MS Evidence Synthesis Program Intraocular Lenses for Cataract Surgery and Lens Replacement Evidence Synthesis Program i PREFACE The VA Evidence Synthesis Program (ESP) was established in 2007

2019 Veterans Affairs Evidence-based Synthesis Program Reports

7. Combined surgery versus cataract surgery alone for eyes with cataract and glaucoma. (PubMed)

Combined surgery versus cataract surgery alone for eyes with cataract and glaucoma. Cataract and glaucoma are leading causes of blindness worldwide, and their co-existence is common in elderly people. Glaucoma surgery can accelerate cataract progression, and performing both surgeries may increase the rate of postoperative complications and compromise the success of either surgery. However, cataract surgery may independently lower intraocular pressure (IOP), which may allow for greater IOP (...) control among patients with co-existing cataract and glaucoma. The decision between undergoing combined glaucoma and cataract surgery versus cataract surgery alone is complex. Therefore, it is important to compare the effectiveness of these two interventions to aid clinicians and patients in choosing the better treatment approach.To assess the relative effectiveness and safety of combined surgery versus cataract surgery (phacoemulsification) alone for co-existing cataract and glaucoma. The secondary

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2015 Cochrane

8. Surgery for postvitrectomy cataract. (PubMed)

Surgery for postvitrectomy cataract. Cataract formation or acceleration can occur after intraocular surgery, especially following vitrectomy, a surgical technique for removing the vitreous that is used in the treatment of many disorders that affect the posterior segment of the eye. The underlying problem that led to vitrectomy may limit the benefit from removal of the cataractous lens.To evaluate the effectiveness and safety of surgery versus no surgery for postvitrectomy cataract with respect (...) , ClinicalTrials.gov (www.clinicaltrials.gov); searched 17 May 2017, and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en); searched 17 May 2017. We did not use any date or language restrictions in the electronic searches for trials.We planned to include randomized controlled trials (RCTs) and quasi-RCTs that had compared surgery versus no surgery to remove the lens from eyes of adults in which cataracts had developed following vitrectomy.Two

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2018 Cochrane

10. Cataracts

Cataracts Cataracts - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Cataracts Last reviewed: February 2019 Last updated: August 2018 Summary The most common cause of curable blindness in the world. Diagnosis is made by the detection of a decrease in visual acuity that cannot be corrected by refractive correction, and an eye examination that is otherwise normal apart from opacity in the crystalline lens. Treatment (...) is with surgery involving an incision into the eye and removal of the opacified crystalline lens. In most cases the cataract is replaced by an artificial lens made of polymethyl methacrylate, acrylic, or silicone. If an implant lens is not used, or there is remaining refractive error (e.g., astigmatism that is uncorrected by the implant lens), the patient may need to wear either a contact lens or spectacles to achieve good postoperative vision. Adjunctive procedures may be done at the time of surgery

2018 BMJ Best Practice

11. Phacoemulsification with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract. (PubMed)

Phacoemulsification with posterior chamber intraocular lens versus extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens for age-related cataract. Age-related cataract is one of the leading causes of blindness worldwide. Therefore, it is important to establish the most effective surgical technique for cataract surgery.The aim of this review is to examine the effects of two types of cataract surgery for age-related cataract: phacoemulsification and extracapsular (...) cataract extraction (ECCE).We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2013, Issue 4), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to May 2013), EMBASE (January 1980 to May 2013), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to May 2013), Web of Science Conference Proceedings Citation Index - Science (CPCI-S) (January 1970

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2014 Cochrane

12. Premium versus Standard Intraocular Lenses for Cataracts: A Review of Clinical Effectiveness and Cost-Effectiveness

Premium versus Standard Intraocular Lenses for Cataracts: A Review of Clinical Effectiveness and Cost-Effectiveness Premium versus Standard Intraocular Lenses for Cataracts: A Review of Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Premium versus Standard Intraocular Lenses for Cataracts: A Review of Clinical Effectiveness and Cost-Effectiveness Premium versus Standard Intraocular Lenses for Cataracts: A Review of Clinical Effectiveness and Cost (...) -Effectiveness Last updated: June 18, 2018 Project Number: RC0991-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative effectiveness of premium versus standard intraocular lenses for patients with cataracts? What is the comparative cost-effectiveness of premium versus standard intraocular lenses for patients with cataracts? Key Message Eight studies were identified within the current review: five systematic

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

13. Perioperative Ophthalmic Eye Drops for Cataract Surgery: Clinical and Cost-Effectiveness and Guidelines

Perioperative Ophthalmic Eye Drops for Cataract Surgery: Clinical and Cost-Effectiveness and Guidelines Perioperative Ophthalmic Eye Drops for Cataract Surgery: Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Perioperative Ophthalmic Eye Drops for Cataract Surgery: Clinical and Cost-Effectiveness and Guidelines Perioperative Ophthalmic Eye Drops for Cataract Surgery: Clinical and Cost-Effectiveness and Guidelines Last updated: November 26, 2018 Project (...) Number: RB1282-000 Product Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of perioperative ophthalmic eye drops for the prevention of infection and adverse events associated with cataract surgery? What is the cost-effectiveness of perioperative ophthalmic eye drops for the prevention of infection and adverse events associated with cataract surgery? What are the evidence-based guidelines regarding the use of perioperative

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

14. Different-sized incisions for phacoemulsification in age-related cataract. (PubMed)

Different-sized incisions for phacoemulsification in age-related cataract. Age-related cataract is the principal cause of blindness and visual impairment in the world. Phacoemulsification is the main surgical procedure used to treat cataract. The comparative effectiveness and safety of different-sized incisions for phacoemulsification has not been determined.The aim of this systematic review was to assess the effectiveness and safety of smaller versus larger incisions for phacoemulsification (...) in age-related cataract. The primary outcome of this review was surgically induced astigmatism at three months after surgery.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 10), MEDLINE Ovid (1946 to 28 October 2016), Embase Ovid (1947 to 28 October 2016), PubMed (1948 to 28 October 2016), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 28 October 2016

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2017 Cochrane

15. Interventions to improve access to cataract surgical services and their impact on equity in low- and middle-income countries. (PubMed)

Interventions to improve access to cataract surgical services and their impact on equity in low- and middle-income countries. Cataract is the leading cause of blindness in low- and middle-income countries (LMICs), and the prevalence is inequitably distributed between and within countries. Interventions have been undertaken to improve cataract surgical services, however, the effectiveness of these interventions on promoting equity is not known.To assess the effects on equity of interventions (...) to improve access to cataract services for populations with cataract blindness (and visual impairment) in LMICs.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 3), MEDLINE Ovid (1946 to 12 April 2017), Embase Ovid (1980 to 12 April 2017), LILACS (Latin American and Caribbean Health Sciences Literature Database) (1982 to 12 April 2017), the ISRCTN registry (www.isrctn.com/editAdvancedSearch); searched 12

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2017 Cochrane

16. Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery. (PubMed)

Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery. Cataract is a leading cause of blindness worldwide. Cataract surgery is commonly performed but can result in postoperative inflammation of the eye. Inadequately controlled inflammation increases the risk of complications. Non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are used to prevent and reduce inflammation following cataract surgery (...) , but these two drug classes work by different mechanisms. Corticosteroids are effective, but NSAIDs may provide an additional benefit to reduce inflammation when given in combination with corticosteroids. A comparison of NSAIDs to corticosteroids alone or combination therapy with these two anti-inflammatory agents will help to determine the role of NSAIDs in controlling inflammation after routine cataract surgery.To evaluate the comparative effectiveness of topical NSAIDs (alone or in combination

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2017 Cochrane

17. N-acetylcarnosine (NAC) drops for age-related cataract. (PubMed)

N-acetylcarnosine (NAC) drops for age-related cataract. Cataract is the leading cause of world blindness. The only available treatment for cataract is surgery. Surgery requires highly-trained individuals with expensive operating facilities. Where these are not available, patients go untreated. A form of treatment that did not involve surgery would be a useful alternative for people with symptomatic cataract who are unable or unwilling to undergo surgery. If an eye drop existed that could (...) reverse or even prevent progression of cataract, then this would be a useful additional treatment option.Cataract tends to result from oxidative stress. The protein, L-carnosine, is known to have an antioxidant effect on the cataractous lens, so biochemically there is sound logic for exploring L-carnosine as an agent to reverse or even prevent progression of cataract. When applied as an eye drop, L-carnosine cannot penetrate the eye. However, when applied to the surface of the eye, N-acetylcarnosine

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2017 Cochrane

18. Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. (PubMed)

Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery. Endophthalmitis is a severe inflammation of the anterior or posterior (or both) chambers of the eye that may be sterile or associated with infection. It is a potentially vision-threatening complication of cataract surgery. Prophylactic measures for endophthalmitis are targeted against various sources of infection.To evaluate the effects of perioperative antibiotic prophylaxis for endophthalmitis following (...) cataract surgery compared with no prophylaxis or other form of prophylaxis.We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 12), Ovid MEDLINE, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE Daily (January 1946 to December 2016), Embase (January 1980 to December 2016), Latin American and Caribbean Health Sciences Literature Database (LILACS) (1982 to December 2016),the ISRCTN registry (www.isrctn.com/editAdvancedSearch

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2017 Cochrane

19. Surgery for cataracts in people with age-related macular degeneration. (PubMed)

Surgery for cataracts in people with age-related macular degeneration. Cataract and age-related macular degeneration (AMD) are common causes of decreased vision that often occur simultaneously in people over age 50. Although cataract surgery is an effective treatment for cataract-induced visual loss, some clinicians suspect that such an intervention may increase the risk of worsening of underlying AMD and thus have deleterious effects on vision.The objective of this review was to evaluate (...) the effectiveness and safety of cataract surgery compared with no surgery in eyes with AMD.We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 11), Ovid MEDLINE, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE Daily (January 1946 to December 2016), Embase (January 1980 to December 2016), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to December 2016), the ISRCTN registry (www.isrctn.com/editAdvancedSearch

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2017 Cochrane

20. Distinct macular thickness changes after femtosecond laser–assisted cataract surgery of age-related cataract and myopia with cataract (PubMed)

Distinct macular thickness changes after femtosecond laser–assisted cataract surgery of age-related cataract and myopia with cataract Cataract surgery can cause macular thickness change. We used optical coherence tomography (OCT) to assess the macular thickness of different regions after femtosecond laser-assisted cataract surgery of age-related cataracts (ARC) and myopia cases with cataract (myopia group). Fifty eyes of 50 patients in ARC group and fifty eyes of 50 patients in myopia (...) with cataract group were included. All study underwent femtosecond laser-assisted cataract surgery and macular thickness of was measured at pre-operation and 1 week, 1 month after surgery. There are significant differences of foveal thickness (P = 0.02), foveal volume (P = 0.02) and average retinal thickness (P = 0.02) between two groups before operation. In the myopia group, statistically significant differences were not found in postoperative macular thickness as compared with ARC group

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2018 Scientific reports

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