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Cardiovascular Manifestations of HIV

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1. Cardiovascular Manifestations of HIV

Cardiovascular Manifestations of HIV Cardiovascular Manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Cardiovascular Manifestations of HIV Cardiovascular Manifestations of HIV Aka: Cardiovascular Manifestations of HIV , HIV related Cardiovascular Complications , HIV Cardiomyopathy II. Causes: Infection Cryptococcus neoformans (CMV) (EBV) III. Causes: Medication adverse effects Direct cardiotoxicity ( ) ( ) Dyslipidemia or s (especially boosted s) Elvitegravir/cobicistat IV. Findings Common Longstanding HIV carries a coronary disease equivalent risk similar to <500 is associated with an increased risk

2018 FP Notebook

2. HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation (PubMed)

of cardiovascular diseases. The purpose of this review is to examine existing evidence regarding the role of innate and cellular components of the oral cavity in HIV infection and how HIV infection may drive systemic hyper-immune activation in these patients. We will also discuss current knowledge on HIV oral transmission, HIV immunosenescence in relation to the oral mucosal alterations during the course of HIV infection and periodontal disease. Finally, we discuss oral manifestations associated with HIV (...) HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation Mucosal surfaces account for the vast majority of HIV transmission. In adults, HIV transmission occurs mainly by vaginal and rectal routes but rarely via oral route. By contrast, pediatric HIV infections could be as the result of oral route by breastfeeding. As such mucosal surfaces play a crucial role in HIV acquisition, and spread of the virus depends on its ability to cross a mucosal barrier. HIV

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2017 Frontiers in immunology

3. Head and neck manifestations of HIV

Head and neck manifestations of HIV Head and neck manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Head and neck (...) manifestations of HIV Head and neck manifestations of HIV Aka: Head and neck manifestations of HIV , HIV related head and neck complications II. Associated Conditions ( ) May progress to esophageal s May occur with normal s May occur in early HIV with normal s Consider Differential Diagnosis Oral and Primary HSV gingivostomatitis Most common oral Lesions on Similar lesions in B-Cell Same l pathogens as in non-HIV patients Pseudomonas aeruginosa amy be seen in advanced HIV See Viral Presents with gradual, non

2018 FP Notebook

4. Endocrine Manifestations of HIV

Endocrine Manifestations of HIV Endocrine Manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Endocrine (...) Manifestations of HIV Endocrine Manifestations of HIV Aka: Endocrine Manifestations of HIV , HIV related endocrine complications II. Manifestations or Most common endocrine disease in HIV patients Characterized by low (and dyslipidemia) See Obtain lipid profile and at HIV diagnosis and then at intervals after More common with highly active s Also associated with low s III. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term

2018 FP Notebook

5. Dermatologic Manifestations of HIV

Dermatologic Manifestations of HIV Dermatologic Manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Dermatologic (...) Manifestations of HIV Dermatologic Manifestations of HIV Aka: Dermatologic Manifestations of HIV , HIV Related Rash , HIV Related Dermatologic Complications , Pruritus in HIV II. Symptoms: Pruritus May be presentation without associated rash or Other causes of Pruritus in HIV failure with cholestasis III. Signs Early, Acute HIV (prior to Seroconversion) Transient, r, r rash on trunk Late HIV (40 to 80% of HIV patients) (40 to 80% of HIV patients) and infectious ( ) IV. Reference Images: Related links

2018 FP Notebook

6. Renal Manifestations of HIV

Renal Manifestations of HIV Renal Manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Renal Manifestations of HIV (...) Renal Manifestations of HIV Aka: Renal Manifestations of HIV , HIV related renal complications II. Associated Conditions: Renal dysfunction ( ) Fluid and electrolyte abnormalities and common due to occult infection Drug induced Renal toxicity See Amphotericin B Foscarnet s fumarate (TDF) Causes proximal tubule dysfunction (e.g. ) and decreased Avoid if GFR <60 ml/min and discontinue if GFR falls more than 25% or <60 ml/min May safely use as alternative (less nephrotoxic) III. References Images

2018 FP Notebook

7. Neurologic Manifestations of HIV

Neurologic Manifestations of HIV Neurologic Manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Neurologic (...) Manifestations of HIV Neurologic Manifestations of HIV Aka: Neurologic Manifestations of HIV , HIV Related Neurologic Complications , HIV Infection with Neurologic Disease II. Epidemiology HIV patients with neurologic complications: 39-70% III. Symptoms: Common presentations s Focal neurological deficits See at time of seroconversion See CSF shows lymphocytic and high protein IV. Associated Conditions: Neurologic Primary Central Nervous System Presents with , blurred vision, s, personality or cognitive

2018 FP Notebook

8. Pulmonary manifestations of HIV

Pulmonary manifestations of HIV Pulmonary manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pulmonary (...) manifestations of HIV Pulmonary manifestations of HIV Aka: Pulmonary manifestations of HIV , HIV related pulmonary complications II. Epidemiology HIV and abuse both play major roles in the increased risk of and Lung patients III. Causes: General causes lung infection in HIV Typical occurs in HIV patients e occurs in advanced HIV with CD4 < 500 Pneumocystis occurs in advanced HIV with CD4 < 200 IV. Causes: Cavitary Lesions Pneumococcus Cryptococcus neoformans Rhodococcus equi (especially Pseudomonas) V

2018 FP Notebook

9. Gynecologic Manifestations of HIV

Gynecologic Manifestations of HIV Gynecologic Manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Gynecologic (...) Manifestations of HIV Gynecologic Manifestations of HIV Aka: Gynecologic Manifestations of HIV , HIV related Gynecologic Complications II. Associated Conditions: Invasive Cervical Cancer (AIDS defining disease) Progressive enhances HPV replication HPV infection is very common in HIV HPV Implicated in and anal carcinoma Monitor high risk patient with every 6 months Women with <200 III. Associated Conditions: Infectious Vaginitis Occurs in 20-30% HIV infected women if >500 Recurrent in young women suggests HIV

2018 FP Notebook

10. Gastrointestinal Manifestations of HIV

Gastrointestinal Manifestations of HIV Gastrointestinal Manifestations of HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 (...) Gastrointestinal Manifestations of HIV Gastrointestinal Manifestations of HIV Aka: Gastrointestinal Manifestations of HIV , HIV-related Gastrointestinal Conditions II. Differential Diagnosis Infectious esophagitis, and colitis (or ) (or ) Infiltrative hepatobiliary infections Infiltrative pancreatic infections Rectal lesions s (especially anorectal warts) Anorectal lesions (consider ) Medication adverse effects: therapy , and Common adverse effects (esp. s) Inquire about side effects at each visit to prevent

2018 FP Notebook

11. Statins for the primary prevention of cardiovascular events

Statins for the primary prevention of cardiovascular events 2019 www.kce.fgov.be KCE REPORT 306 STATINS FOR THE PRIMARY PREVENTION OF CARDIOVASCULAR EVENTS 2019 www.kce.fgov.be KCE REPORT 306 HEALTH TECHNOLOGY ASSESSMENT STATINS FOR THE PRIMARY PREVENTION OF CARDIOVASCULAR EVENTS AUDREY CORDON, CHRISTOPHE DE MEESTER, SOPHIE GERKENS, DOMINIQUE ROBERFROID, CHRIS DE LAET COLOPHON Title: Statins for the primary prevention of cardiovascular events Authors: Audrey Cordon (KCE), Christophe De Meester (...) the full responsibility of the KCE. Publication date: 15 January 2019 Domain: Health Technology Assessment (HTA) MeSH: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Cardiovascular Diseases; Primary prevention; Costs and Cost Analysis. NLM Classification: WG 120 Language: English Format: Adobe® PDF™ (A4) Legal depot: D/2019/10.273/07 ISSN: 2466-6459 Copyright: KCE reports are published under a “by/nc/nd” Creative Commons Licence http://kce.fgov.be/content/about-copyrights-for-kce-publications. How

2019 Belgian Health Care Knowledge Centre

12. The Society of Invasive Cardiovascular Professionals New 2015 Educational Guidelines for Invasive Cardiovascular Technology Personnel in the Cardiovascular Catheterization Laboratory

and Treatments A. Identification of Pathologies and Complications B. Evaluation of Statistical Data for Cardiovascular Diseases C. Etiology, Pathophysiology, Clinical Manifestations, and Treatment of: 1. Coronary Artery Disease – Atherosclerosis 2. Angina a. Stable, Unstable Variants (Printzmetal’s) 3. Acute Coronary Syndromes – Myocardial Infarction (STEMI, UA/NSTEMI) a. No-Reflow, Microvascular Obstruction 4. Heart Failure (Left Heart, Right Heart, Biventricular) 5. Shock (Cardiogenic, Hypovolemic, Septic (...) The Society of Invasive Cardiovascular Professionals New 2015 Educational Guidelines for Invasive Cardiovascular Technology Personnel in the Cardiovascular Catheterization Laboratory The Society of Invasive Cardiovascular Professionals New 2015 Educational Guidelines for Invasive Cardiovascular Technology Personnel in the Cardiovascular Catheterization Laboratory | Cath Lab Digest SICP The Society of Invasive Cardiovascular Professionals New 2015 Educational Guidelines for Invasive

2015 Society for Cardiovascular Angiography and Interventions

13. Cardiovascular Disease: Secondary Prevention

Cardiovascular Disease: Secondary Prevention © 1996 Kaiser Foundation Health Plan of Washington. All rights reserved. 1 0 Atherosclerotic Cardiovascular Disease (ASCVD) Secondary Prevention Guideline Major Changes as of April 2018 2 Definitions 2 Target Population 2 Goals 2 Lifestyle Modifications 3 Dietary Supplements 4 Influenza Vaccination 4 Statin Therapy 4 ACE Inhibitor or ARB Therapy 9 Antiplatelet Therapy 9 Lowering Triglycerides to Prevent Pancreatitis 10 Beta-blocker Therapy for Post (...) , ischemic stroke, and carotid artery stenosis > 50%. • Peripheral artery disease, such as claudication. • Aortic atherosclerotic disease, such as abdominal aortic aneurysm and descending thoracic aneurysm. Primary prevention refers to the effort to prevent or delay the onset of ASCVD. Secondary prevention refers to the effort to treat known, clinically significant ASCVD, and to prevent or delay the onset of disease manifestations. Target Population The target population for secondary prevention of ASCVD

2018 Kaiser Permanente Clinical Guidelines

14. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease Arnett et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease Page 1 of 98 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Geriatrics Society, the American (...) Society of Preventive Cardiology, and the Preventive Cardiovascular Nurses Association WRITING COMMITTEE MEMBERS Donna K. Arnett, PhD, MSPH, FAHA, Co-Chair Roger S. Blumenthal, MD, FACC, FAHA, Co-Chair Michelle A. Albert, MD, MPH, FAHA* Erin D. Michos, MD, MHS, FACC, FAHA* Andrew B. Buroker, Esq† Michael D. Miedema, MD, MPH* Zachary D. Goldberger, MD, MS, FACC, FAHA‡ Daniel Muñoz, MD, MPA, FACC* Ellen J. Hahn, PhD, RN* Sidney C. Smith, Jr, MD, MACC, FAHA* Cheryl D. Himmelfarb, PhD, RN, ANP, FAHA

2019 American Heart Association

15. Pro-Inflammatory Markers in Relation to Cardiovascular Disease in HIV Infection. A Systematic Review. (PubMed)

Pro-Inflammatory Markers in Relation to Cardiovascular Disease in HIV Infection. A Systematic Review. In the past years many inflammatory markers have been studied in association with clinically manifest cardiovascular disease (CVD) and carotid intima-media thickness (CIMT) in HIV-infected patients, to obtain insights in the increased cardiovascular risk observed in HIV infection. This systematic review provides an oversight of the current knowledge.A search was performed in PubMed, Embase (...) and Cochrane in July 2014, identifying all articles from 1996 onwards addressing the relation between inflammatory markers and CVD or CIMT in HIV-positive adults. Two authors, using predefined criteria, independently conducted the selection of articles, critical appraisal and extraction of the data. Analysis was focused on the immune markers that were most frequently assessed. The review protocol was registered in the PROSPERO database at 11 July 2014 (registration number CRD42014010516). This review

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2016 PloS one

16. The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association

, the ability to measure RNA levels in a commercial diagnostic testing laboratory has been well established. For example, measuring RNA levels of hepatitis C virus or HIV viral loads has been standard diagnostic testing available to physicians for decades. Thus, a multitude of reasons have motivated investigators to use gene expression profiling as the starting point for biomarker discovery and identification of novel disease mechanisms in the cardiovascular system. The focus of this section is the analysis (...) The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association | Circulation: Cardiovascular Genetics Search Hello Guest! Login to your account Email Password Keep me logged in Search February 2019 January 2019 This site uses cookies

2017 American Heart Association

17. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease

= cerebrovascu- lar; CVA = cerebrovascular accident; EL = evidence level; FH = familial hypercholesterolemia; FIELD = Secondary Endpoints from the Fenofibrate Intervention and Event Lowering in Diabetes trial; FOURIER = Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects With Elevated Risk trial; HATS = HDL-Atherosclerosis Treatment Study; HDL-C = high- density lipoprotein cholesterol; HeFH = heterozygous familial hypercholesterolemia; HHS = Helsinki Heart Study; HIV = human (...) American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease ENDOCRINE PRACTICE Vol 23 (Suppl 2) April 2017 1 Copyright © 2017 AACE AACE 2017 Guidelines AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE Paul S. Jellinger, MD, MACE, Chair 1 ; Yehuda Handelsman MD, FACP

2017 American Association of Clinical Endocrinologists

18. Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association (PubMed)

to influence health behavior change, as described in the AHA Community Guide for Prevention, may have greater potential to reach both African American women and men and to shift the health behaviors and consequent cardiovascular risk of the entire population. Comorbidities Certain health conditions that predispose to CVDs are more common among African Americans than whites. Below, we highlight chronic kidney disease, sickle cell disease/sickle cell trait, and HIV, given their relatively higher prevalence (...) Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 February 2019 January 2019 January 2019 January 2019 January 2019 January 2019 This site uses

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2017 American Heart Association

19. Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association

Biology; and Stroke Council Originally published 26 Jun 2017 Circulation Research. 2017;121:e2–e8 You are viewing the most recent version of this article. Previous versions: Abstract Recent decades have witnessed robust successes in conquering the acutely lethal manifestations of heart and vascular diseases. Many patients who previously would have died now survive. Lifesaving successes like these provide a tremendous and easily recognized benefit to individuals and society. Although cardiovascular (...) Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association | Circulation Research Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 February 2019 February 2019 January 2019 January 2019 This site uses cookies. By continuing to browse this site you

2017 American Heart Association

20. Human immunodeficiency virus‐associated heart failure in sub‐Saharan Africa: evolution in the epidemiology, pathophysiology, and clinical manifestations in the antiretroviral era (PubMed)

Human immunodeficiency virus‐associated heart failure in sub‐Saharan Africa: evolution in the epidemiology, pathophysiology, and clinical manifestations in the antiretroviral era The survival of patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) who have access to highly active antiretroviral therapy (ART) has dramatically increased in recent times. This review focuses on HIV-associated heart failure in sub-Saharan Africa (SSA). In HIV infected (...) persons, heart failure may be related to pathology of the pericardium, the myocardium, the valves, the conduction system, or the coronary and pulmonary vasculature. HIV-associated heart failure can be because of direct consequences of HIV infection, autoimmune reactions, pro-inflammatory cytokines, opportunistic infections (OIs) or neoplasms, use of ART or therapy for OIs and presence of traditional cardiovascular risk factors. Myocardial involvement includes diastolic dysfunction, asymptomatic left

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2016 ESC heart failure

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