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Cardiogenic Shock

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41. Protein-based cardiogenic shock patient classifier. Full Text available with Trip Pro

Protein-based cardiogenic shock patient classifier. Cardiogenic shock (CS) is associated with high short-term mortality and a precise CS risk stratification could guide interventions to improve patient outcome. Here, we developed a circulating protein-based score to predict short-term mortality risk among patients with CS.Mass spectrometry analysis of 2654 proteins was used for screening in the Barcelona discovery cohort (n = 48). Targeted quantitative proteomics analyses (n = 51 proteins) were (...) used in the independent CardShock cohort (n = 97) to derive and cross-validate the protein classifier. The combination of four circulating proteins (Cardiogenic Shock 4 proteins-CS4P), discriminated patients with low and high 90-day risk of mortality. CS4P comprises the abundances of liver-type fatty acid-binding protein, beta-2-microglobulin, fructose-bisphosphate aldolase B, and SerpinG1. Within the CardShock cohort used for internal validation, the C-statistic was 0.78 for the CardShock risk

2019 European Heart Journal

42. Cardiogenic shock during heart failure hospitalizations: Age-, sex-, and race-stratified trends in incidence and outcomes. (Abstract)

Cardiogenic shock during heart failure hospitalizations: Age-, sex-, and race-stratified trends in incidence and outcomes. The objectives were to study the overall and age-, sex-, and race-stratified incidence of cardiogenic shock (CS) during heart failure hospitalizations (HFHs) not complicated by acute coronary syndromes (ACS), utilization of short-term mechanical circulatory support (MCS) and in-hospital mortality with non-ACS-related CS, and respective temporal trends. Data are lacking

2019 American Heart Journal

43. Extracorporeal life support in myocardial infarction-induced cardiogenic shock: Weaning success. (Abstract)

Extracorporeal life support in myocardial infarction-induced cardiogenic shock: Weaning success. Outcome data of patients with acute myocardial infarction-induced (AMI) cardiogenic shock (CS) receiving extracorporeal life support (ECLS) are sparse.A consecutive series of 106 patients with AMI-induced CS receiving ECLS was evaluated regarding ECLS weaning success, hospital mortality, and long-term outcome. The IABP-SHOCK II risk score was applied and multivariable Cox regression analysis (...) was performed.Mean patient age was 58.2 ± 11.2 years and 78.3% were male gender. In 34 patients (32.1%) ECLS was implemented during ongoing CPR. De novo AMI was present in 58 patients (54.7%), PCI complications causative among 48 patients (45.3%). Multi-vessel coronary artery disease was diagnosed among 73.6% with mean SYNTAX scores of 30.8 ± 4.8. Actuarial 30-day survival was 54.4%, 42.2% at 1 year and 38.0% at 5 years and was significantly higher among patients with low and intermediate IABP-SHOCK II risk

2019 Annals of Thoracic Surgery

44. Utilization and Outcomes of Temporary Mechanical Circulatory Support Devices in Cardiogenic Shock. (Abstract)

Utilization and Outcomes of Temporary Mechanical Circulatory Support Devices in Cardiogenic Shock. Cardiogenic shock (CS) is associated with high morbidity and mortality despite recent advances in the temporary mechanical circulatory support (MCS) devices. The current utilization and outcomes of these MCS devices with or without vasopressors compared with conventional medical therapy (no-MCS) in CS remain poorly described. The study population was extracted from the 2014 Nationwide Readmissions

2019 American Journal of Cardiology

45. In-Hospital Outcomes of ST-Segment Elevation Myocardial Infarction Complicated With Cardiogenic Shock at Safety-Net Hospitals in the United States (from the Nationwide Inpatient Sample). (Abstract)

In-Hospital Outcomes of ST-Segment Elevation Myocardial Infarction Complicated With Cardiogenic Shock at Safety-Net Hospitals in the United States (from the Nationwide Inpatient Sample). Safety-net hospitals (SNHs) are hospitals that serve a higher proportion of patients insured by Medicaid or uninsured and have been reported to have poor outcomes compared with non-SNHs. Procedural and clinical outcomes of ST-segment elevation myocardial infarction complicated by cardiogenic shock (STEMI-CS

2019 American Journal of Cardiology

46. Hospital-Level Disparities in the Outcomes of Acute Myocardial Infarction With Cardiogenic Shock. (Abstract)

Hospital-Level Disparities in the Outcomes of Acute Myocardial Infarction With Cardiogenic Shock. There are limited data on hospital-level disparities in cardiogenic shock complicating acute myocardial infarction (AMI-CS). A retrospective cohort of adult admissions from the National Inpatient Sample database during 2000 to 2014, with primary diagnosis of AMI and concomitant CS were identified. Interhospital transfers were excluded. Hospitals were classified into rural, urban nonteaching

2019 American Journal of Cardiology

47. Predictors of Mortality and Outcomes of Acute Severe Cardiogenic Shock Treated with the Impella Device. Full Text available with Trip Pro

Predictors of Mortality and Outcomes of Acute Severe Cardiogenic Shock Treated with the Impella Device. The Impella (Abiomed, Danvers, Massachusetts) device is increasingly used for mechanical circulatory support (MCS) to treat acute severe cardiogenic shock (CS). Initial and continued determination of the appropriate degree of MCS is challenging. This study evaluates predictors of mortality in patients treated with the Impella for acute severe CS and outcomes associated with prolonged Impella

2019 American Journal of Cardiology

48. Prognostic value of endothelial biomarkers in refractory cardiogenic shock with ECLS: a prospective monocentric study. Full Text available with Trip Pro

Prognostic value of endothelial biomarkers in refractory cardiogenic shock with ECLS: a prospective monocentric study. Extracorporeal membrane oxygenation (ECMO) is often used in critical patients with severe myocardial failure. However, the mortality rate of patients on ECMO is often high. Recent studies have suggested that endothelial activation with subsequent vascular barrier breakdown is a critical pathogenic mechanism of organ damage and is related to the outcome of critical illness

2019 BMC Anesthesiology

49. Factors influencing the accuracy of non-invasive blood pressure measurements in patients admitted for cardiogenic shock. Full Text available with Trip Pro

Factors influencing the accuracy of non-invasive blood pressure measurements in patients admitted for cardiogenic shock. Although invasively measured blood pressure (invBP) is regarded as a "gold standard" in critically ill cardiac patients, the non-invasive BP is still widely used, at least at the initiation of medical care. The erroneous interpretation of BP can lead to clinical errors. We therefore investigated the agreement of both methods with respect to some common clinical situation.We (...) included 85 patients hospitalized for cardiogenic shock. We measured BP every 6 h for the first 72 h of hospitalization, in all patients. Each set of BP measurements included two invasive (invBP), two auscultatory (auscBP), and two oscillometric (oscBP) BP measurements. InvBP was considered as a gold standard. Mean non-invasive arterial pressure (MAP) was calculated as (diastolic pressure + (pulse pressure ÷ 3)). We used Bland-Altman analysis and we calculated concordance correlation coefficients

2019 BMC Cardiovascular Disorders

50. In-Hospital Outcomes After Percutaneous Coronary Intervention for Acute Coronary Syndrome With Cardiogenic Shock (from a Japanese Nationwide Registry [J-PCI Registry]). (Abstract)

In-Hospital Outcomes After Percutaneous Coronary Intervention for Acute Coronary Syndrome With Cardiogenic Shock (from a Japanese Nationwide Registry [J-PCI Registry]). In-hospital complications and their predictors in acute coronary syndrome (ACS) patients with cardiogenic shock (CS) have not been fully investigated, particularly in those who underwent invasive revascularization procedures. This study investigated the in-hospital outcomes, along with the volume-outcome relationship of ACS

2019 American Journal of Cardiology

51. Temporal trends and outcomes of prolonged invasive mechanical ventilation and tracheostomy use in acute myocardial infarction with cardiogenic shock in the United States. (Abstract)

Temporal trends and outcomes of prolonged invasive mechanical ventilation and tracheostomy use in acute myocardial infarction with cardiogenic shock in the United States. There are limited data on prolonged invasive mechanical ventilation (IMV) and tracheostomy use in intubated acute myocardial infarction with cardiogenic shock (AMI-CS) patients.Using the National Inpatient Sample, all admissions with AMI-CS requiring IMV between January 1, 2000, and December 31, 2014, were included. Prolonged

2019 International journal of cardiology

52. Procedural Success Rates and Mortality in Elderly Patients With Percutaneous Coronary Intervention for Cardiogenic Shock. (Abstract)

Procedural Success Rates and Mortality in Elderly Patients With Percutaneous Coronary Intervention for Cardiogenic Shock. The aim of this study was to determine the impact of age on procedural and clinical outcomes in patients with cardiogenic shock (CS).The use of early revascularization therapy with percutaneous coronary intervention (PCI) has been shown to improve outcome in patients with acute myocardial infarction (AMI) complicated by CS.Data from consecutive patients with AMI and CS

2019 JACC. Cardiovascular interventions

53. The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Postcardiotomy Patients with Cardiogenic Shock: A Pilot Randomized Controlled Trial. (Abstract)

The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Postcardiotomy Patients with Cardiogenic Shock: A Pilot Randomized Controlled Trial. The objectives of this study were to determine the feasibility and safety of simultaneous renal replacement therapy (RRT) during extracorporeal membrane oxygenation (ECMO) support for postcardiotomy patients with cardiogenic shock and whether simultaneous RRT with ECMO would improve survival and reduce (...) morbidity. The authors hypothesized that simultaneous RRT could facilitate effective fluid management and rapid metabolic control in postcardiotomy patients with cardiogenic shock who were undergoing ECMO support.A parallel, open-label, single-center pilot randomized trial.University-affiliated cardiac surgery intensive care unit.The study comprised 41 postcardiotomy patients with cardiogenic shock who received ECMO support.Participants were enrolled and randomly assigned via a 1:1 allocation

2019 Journal of cardiothoracic and vascular anesthesia Controlled trial quality: predicted high

54. A randomized controlled study comparing high-dose insulin to vasopressors or combination therapy in a porcine model of refractory propranolol-induced cardiogenic shock. (Abstract)

A randomized controlled study comparing high-dose insulin to vasopressors or combination therapy in a porcine model of refractory propranolol-induced cardiogenic shock. Context: Although cerebral perfusion (CP) is preserved across a wide range of mean arterial pressures (MAP) through cerebral-vascular autoregulation, the relationship between MAP and CP in refractory poison-induced cardiogenic shock (PICS) has never been studied. We compared the effects of therapies used in PICS: high-dose

2019 Clinical toxicology (Philadelphia, Pa.) Controlled trial quality: uncertain

55. Selenoprotein P in Myocardial Infarction with Cardiogenic Shock. (Abstract)

Selenoprotein P in Myocardial Infarction with Cardiogenic Shock. Reperfusion strategies in acute myocardial infarction (AMI) may result in ischemia reperfusion injury characterized by increased oxidative stress, inflammation and ultimately death of myocardial tissue which may be of particular importance in infarct-related cardiogenic shock (CS). Many anti-oxidative and immune regulatory processes depend on selenium which in large proportions is bound to circulating selenoprotein P (SelP (...) ). Individual SelP patterns may therefore be associated with inflammatory response and possibly mortality in patients with CS post AMI.In the randomized Intra-Aortic Balloon Pump in cardiogenic Shock II (IABP-SHOCK II)-trial, 600 patients with CS complicating AMI were assigned to therapy with or without IABP. In a predefined biomarker substudy of 147 patients, we analyzed SelP levels 1 and 3 days following randomization. Samples were compared to healthy controls and associations with the unspecific

2019 Shock (Augusta, Ga.) Controlled trial quality: uncertain

56. Fifteen years trends of cardiogenic shock and mortality in patients with diabetes and acute coronary syndromes. Full Text available with Trip Pro

Fifteen years trends of cardiogenic shock and mortality in patients with diabetes and acute coronary syndromes. To examine time trends of management and mortality of acute coronary syndrome patients with associated diabetes mellitus.We analyzed data from 5 nationwide registries established between 2001 and 2014, including consecutive acute coronary syndrome patients admitted to the Italian Intensive Cardiac Care Units.Out of 28,225 participants, 8521 (30.2%) had diabetes: as compared (...) to patients without diabetes, they were older and had significantly higher rates of prior myocardial infarction and comorbidities (all p<0.0001). Prevalence of diabetes and comorbidities increased over time (p for trend <0.0001). Cardiogenic shock rates were higher in patients with diabetes, as compared to those without diabetes (7.8% vs 2.8%, p<0.0001), and decreased significantly over time only in patients without diabetes (p=0.007). Revascularization rates increased over time both in patients

2019 American Journal of Medicine

57. Mechanical Circulatory Support for Cardiogenic Shock in the Critically Ill. (Abstract)

Mechanical Circulatory Support for Cardiogenic Shock in the Critically Ill. Patients requiring mechanical circulatory support (MCS) constitute a heterogeneous group whose needs have guided the development of a broad range of MCS devices. Appropriate patient and device selection are important for maximizing the potential benefit of these therapies. Currently available devices can be deployed percutaneously or surgically implanted. They can also be configured for left, right, or biventricular

2019 Chest

58. Application of pulse index continuous cardiac output system in elderly patients with acute myocardial infarction complicated by cardiogenic shock: A prospective randomized study. Full Text available with Trip Pro

Application of pulse index continuous cardiac output system in elderly patients with acute myocardial infarction complicated by cardiogenic shock: A prospective randomized study. Cardiogenic shock (CS) secondary to acute myocardial infarction (AMI) complicates management of the condition, and often leads to poor prognosis. Prompt and accurate monitoring of cardiovascular and accompanying hemodynamic changes is crucial in achieving adequate management of the condition. Advances in technology has

2019 World journal of clinical cases Controlled trial quality: uncertain

59. Management of cardiogenic shock complicating myocardial infarction: an update 2019. Full Text available with Trip Pro

Management of cardiogenic shock complicating myocardial infarction: an update 2019. Cardiogenic shock (CS) remains the most common cause of death in patients admitted with acute myocardial infarction (AMI) and mortality remained nearly unchanged in the range of 40-50% during the last two decades. Early revascularization, vasopressors and inotropes, fluids, mechanical circulatory support, and general intensive care measures are widely used for CS management. However, there is only limited

2019 European Heart Journal

60. Outcomes in Cardiogenic Shock from Acute Coronary Syndrome Depending on Severity of Obesity. (Abstract)

Outcomes in Cardiogenic Shock from Acute Coronary Syndrome Depending on Severity of Obesity. We reviewed 54,044 adult cases of cardiogenic shock (CS) accompanying acute coronary syndrome from the 2005 to 2014 Nationwide Inpatient Sample. We evaluated outcomes among patients who were nonobese, obese (body mass index 30.0 to 39.9 kg/m2) and extremely-obese (body mass index ≥40 kg/m2). A multivariate analysis was performed to assess their impact on in-hospital mortality. There were 3,602 (6.6

2019 American Journal of Cardiology

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