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Cardiac CT Calcium Scoring

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1. Assessment of coronary artery calcium by chest CT compared with EKG-gated cardiac CT in the multicenter AIDS cohort study. (PubMed)

Assessment of coronary artery calcium by chest CT compared with EKG-gated cardiac CT in the multicenter AIDS cohort study. Individuals with HIV are at increased risk for coronary artery disease (CAD). Early detection of subclinical CAD by assessment of coronary artery calcium (CAC) may help risk stratify and prevent CAD events in these individuals. However, the current standard to quantify CAC i.e. Agatston scoring requires EKG-gated cardiac CT imaging.To determine if the assessment of CAC (...) where EKG-gated cardiac CT is not feasible for the assessment of coronary calcium, Weston scoring by using chest CT should be considered.

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2017 PLoS ONE

2. Coronary calcium scoring with partial volume correction in anthropomorphic thorax phantom and screening chest CT images. (PubMed)

Coronary calcium scoring with partial volume correction in anthropomorphic thorax phantom and screening chest CT images. The amount of coronary artery calcium determined in CT scans is a well established predictor of cardiovascular events. However, high interscan variability of coronary calcium quantification may lead to incorrect cardiovascular risk assignment. Partial volume effect contributes to high interscan variability. Hence, we propose a method for coronary calcium quantification (...) calcium scoring resulted in overestimation of calcium volume for medium and high density calcifications in the first phantom, and overestimation of calcium volume for high density and underestimation for low density calcifications in the second phantom. With induced motion these effects were further emphasized. The proposed quantification resulted in better accuracy and substantially lower over- and underestimation of calcium volume even in presence of motion. In chest CT, the agreement between

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2018 PLoS ONE

3. Iterative beam-hardening correction with advanced modeled iterative reconstruction in low voltage CT coronary calcium scoring with tin filtration: Impact on coronary artery calcium quantification and image quality. (PubMed)

Iterative beam-hardening correction with advanced modeled iterative reconstruction in low voltage CT coronary calcium scoring with tin filtration: Impact on coronary artery calcium quantification and image quality. We investigated the impact of iterative beam-hardening correction (IBHC) with advanced modeled iterative reconstruction (ADMIRE) of ultra-low radiation-dose tin filtered (Sn100 kVp) CACS acquisitions on image quality, calcium quantification, and risk classification.CT data of 60 (...) patients (55% male, age 62.3 ± 9.8years) who underwent a 3rd generation dual-source CACS scan using a prospectively ECG-triggered 100 kVp sequential acquisition protocol with tin filtration (Sn100 kVp) were reconstructed using IBHC with filtered back projection (FBP) and ADMIRE with strength levels of three and five. Image noise was calculated and Agatston scores were derived from all reconstructions. Image noise, Agatston score categories, and percentile-based cardiac risk categorization

2017 Journal of cardiovascular computed tomography

4. Cardiac CT Calcium Scoring

Cardiac CT Calcium Scoring Cardiac CT Calcium Scoring Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cardiac CT Calcium Scoring (...) Cardiac CT Calcium Scoring Aka: Cardiac CT Calcium Scoring , Coronary Calcium Score , CT Coronary Calcium II. Definition CT-based quantification of coronary calcium deposits Calcium deposits correlate with atherosclerotic III. Indications CAD Risk stratification of asymptomatic patients Intermediate risk patients who have not undergone stress testing Intermediate risk patients with equivocal stress testing IV. Efficacy Calcium scoring is an indepedent predictor of CAD event Calcium score does

2018 FP Notebook

5. Qualitative coronary artery calcium assessment on CT lung screening exam helps predict first cardiac events (PubMed)

Qualitative coronary artery calcium assessment on CT lung screening exam helps predict first cardiac events A total of 1,513 individuals underwent CTLS. Downstream data, pre-test cardiac risk factors and CAC scores were available for 88.3% (1,336/1,513). The average length of follow-up was 2.64 (SD ±0.72) years. There were a total of 43 events, occurring in 1.55% (6/386) of patients with mild CAC, 3.24% (11/339) of patients with moderate CAC, and 8.90% (26/292) of patients with marked CAC (...) . There were no events among patients with no reported CAC (0/319). Using multivariable logistic modeling, the increased odds of an initial cardiac event was 2.56 (95% CI, 1.76-3.92, P<0.001) for mild CAC, 6.57 (95% CI, 3.10-15.4, P<0.001) for moderate CAC, and 16.8 (95% CI, 5.46-60.3, P<0.001) for marked CAC, as compared to individuals with no CAC. Time to event analysis showed distinct differences among the four CAC categories (P<0.001).Qualitative coronary artery calcification scoring of CTLS exams may

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2018 Journal of thoracic disease

6. Computation of Calcium Score with Dual Energy CT: A Phantom Study (PubMed)

Computation of Calcium Score with Dual Energy CT: A Phantom Study Dual-energy computed tomography (DECT) improves material and tissue characterization compared with single-energy CT; we sought to validate coronary calcium quantification in advancing cardiovascular DECT. In an anthropomorphic phantom, agreement between measurements was excellent, and Bland-Altman analysis demonstrated minimal bias. Compared with the known calcium mass for each phantom, calcium mass by DECT was highly accurate (...) . Noncontrast DECT yields accurate calcium measures and warrants consideration in cardiac protocols for additional tissue characterizations.

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2017 Journal of computer assisted tomography

7. How useful is a cardiac calcium CT scan?

How useful is a cardiac calcium CT scan? How useful is a cardiac calcium CT scan? How useful is a cardiac calcium CT scan? | | April 19, 2017 129 Shares Being a radiologist, I rarely speak to patients, but I was asked to counsel Mrs. Patel (not her real name), who was worried about the risks of radiation from cardiac calcium CT scan. Because of her risk factors for atherosclerosis, her cardiologist wanted her to take statins for primary prevention, but she was reluctant to start statins (...) to keynote your next event "Kevin's keynote presentation was perfect. Extremely rich in content, and a delivery that is world class." Related Posts More in Conditions < Previous post Next post > Find jobs at Careers by KevinMD.com Search thousands of physician, PA, NP, and CRNA jobs now. × How useful is a cardiac calcium CT scan? 1 comments Comments are moderated before they are published. Please read the . Leave a Comment Name Email Website Comment Close X Most Popular Past Week | | | | | | Past 6

2017 KevinMD blog

8. Sex Differences in the Performance of Cardiac Computed Tomography Compared With Functional Testing in Evaluating Stable Chest Pain: Subanalysis of the Multicenter, Randomized CRESCENT Trial (Calcium Imaging and Selective CT Angiography in Comparison to Fu (PubMed)

and Selective CT Angiography in Comparison to Functional Testing for Suspected Coronary Artery Disease) prospectively randomized 350 patients with stable angina (55% women; aged 55±10 years), mostly with an intermediate coronary artery disease probability, between cardiac CT and functional testing. The tiered cardiac CT protocol included a calcium scan followed by CT angiography if the Agatston calcium score was between 1 and 400. Patients with test-specific contraindications were not excluded from study (...) Sex Differences in the Performance of Cardiac Computed Tomography Compared With Functional Testing in Evaluating Stable Chest Pain: Subanalysis of the Multicenter, Randomized CRESCENT Trial (Calcium Imaging and Selective CT Angiography in Comparison to Fu Cardiac computed tomography (CT) represents an alternative diagnostic strategy for women with suspected coronary artery disease, with potential benefits in terms of effectiveness and cost-efficiency.The CRESCENT trial (Calcium Imaging

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2017 Circulation. Cardiovascular imaging Controlled trial quality: uncertain

9. Aortic stenosis and CT calcium scoring: is it for everyone? (PubMed)

Aortic stenosis and CT calcium scoring: is it for everyone? 27647167 2018 01 29 2018 12 02 1468-201X 103 1 2017 01 01 Heart (British Cardiac Society) Heart Aortic stenosis and CT calcium scoring: is it for everyone? 8-9 10.1136/heartjnl-2016-310297 Cartlidge Timothy R G TR Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. Pawade Tania A TA Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. Dweck Marc R MR Centre for Cardiovascular Science (...) , University of Edinburgh, Edinburgh, UK. eng FS/13/77/30488 British Heart Foundation United Kingdom FS/14/78/31020 British Heart Foundation United Kingdom Editorial Research Support, Non-U.S. Gov't Comment 2016 09 19 England Heart 9602087 1355-6037 SY7Q814VUP Calcium AIM IM Heart. 2017 Jan 1;103(1):32-39 27504001 Aortic Valve Aortic Valve Stenosis Calcinosis Calcium Humans Tomography, X-Ray Computed Conflicts of Interest: None declared. 2016 9 21 6 0 2018 1 30 6 0 2016 9 21 6 0 ppublish 27647167 heartjnl

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2016 Heart

10. Focused Field of View Calcium Scoring Prior to Coronary CT Angiography

: through study completion, an average of three years ] The measurement of quality in comparison of the modified versus non-modified CCTA using a quantitative (CCTA signal, noise, contrast to noise ratio) score. Secondary Outcome Measures : Coronary CT parameter changes (mA by 50). [ Time Frame: through study completion, up to three years ] Any changes in the cardiac CT after evaluation of the modified or standard calcium scoring in a change in milliamps by 50. Coronary CT parameter changes (in kV (...) ). [ Time Frame: through study completion, up to three years ] Any changes in the cardiac CT after evaluation of the modified or standard calcium scoring in any change in killavolts. Coronary CT using high definition scanning. [ Time Frame: through study completion, up to three years ] Any changes in the cardiac CT after evaluation of the modified or standard calcium scoring in changing to high definition scanning. Coronary CT parameter changes (padding in milliseconds). [ Time Frame: through study

2016 Clinical Trials

11. Diagnostic Phase of Calcium Scoring Scan Applied as the Center of Acquisition Window of Coronary Computed Tomography Angiography Improves Image Quality in Minimal Acquisition Window Scan (Target CTA Mode) Using the Second Generation 320-Row CT (PubMed)

Diagnostic Phase of Calcium Scoring Scan Applied as the Center of Acquisition Window of Coronary Computed Tomography Angiography Improves Image Quality in Minimal Acquisition Window Scan (Target CTA Mode) Using the Second Generation 320-Row CT To compare the image quality of coronary computed tomography angiography (CCTA) acquired under two conditions: 75% fixed as the acquisition window center (Group 75%) and the diagnostic phase for calcium scoring scan as the center (CS; Group CS).320-row (...) cardiac CT with a minimal acquisition window (scanned using "Target CTA" mode) was performed on 81 patients. In Group 75% (n = 40), CS was obtained and reconstructed at 75% and the center of the CCTA acquisition window was set at 75%. In Group CS (n = 41), CS was obtained at 75% and the diagnostic phase showing minimal artifacts was applied as the center of the CCTA acquisition window. Image quality was evaluated using a four-point scale (4-excellent) and the mean scores were compared between

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2016 The Scientific World Journal

12. Iterative reconstruction can permit the use of lower X-ray tube current in CT coronary artery calcium scoring (PubMed)

Iterative reconstruction can permit the use of lower X-ray tube current in CT coronary artery calcium scoring CT coronary artery calcium scoring (CACS) is additive to traditional risk factors for predicting future cardiac events but is associated with relatively high radiation doses. We assessed the feasibility of CACS radiation dose reduction using a lower tube current and iterative reconstruction (IR).Artificial noise was added to the raw data from 27 CACS studies from patients who were (...) symptomatic to simulate lower tube current scanning (75, 50 and 25% original current). All studies were performed on the same CT scanner at 120 kVp. Data were reconstructed using filtered back projection [Quantum Denoising Software (QDS+)] and IR [adaptive iterative dose reduction three dimensional mild, standard and strong]. Agatston scores were independently measured by two readers. CACS percentile risk scores were calculated.At 75, 50 and 25% tube currents, all adaptive iterative dose reduction (AIDR

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2016 The British journal of radiology

13. Leveraging the coronary calcium scan beyond the coronary calcium score (PubMed)

and radiation exposure, it is important for radiologists, cardiologists and medical specialists in the field of preventive medicine to acknowledge that numerous additional markers of cardio-metabolic health and general health can be readily identified on a coronary calcium scan.• The coronary artery calcium score substantially increased the use of cardiac CT. • Cardio-metabolic and general health markers may be derived without changes to the scan protocol. • Those include epicardial fat, aortic valve (...) Leveraging the coronary calcium scan beyond the coronary calcium score Non-contrast cardiac computed tomography in order to obtain the coronary artery calcium score has become an established diagnostic procedure in the clinical setting, and is commonly employed in clinical and population-based research. This state-of-the-art review paper highlights the potential gain in information that can be obtained from the non-contrast coronary calcium scans without any necessary modifications to the scan

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2018 European radiology

14. Noncoronary Measures Enhance the Predictive Value of Cardiac CT Above Traditional Risk Factors and CAC Score in the General Population. (PubMed)

Noncoronary Measures Enhance the Predictive Value of Cardiac CT Above Traditional Risk Factors and CAC Score in the General Population. The aim of this study was to determine whether noncoronary measures from cardiac computed tomography (CT) may enhance the prognostic value of this imaging technology.When cardiac CT is performed for quantification of coronary artery calcium (CAC) score, information on other cardiac and thoracic structures is available.Participants without known cardiovascular (...) disease from the prospective population based Heinz Nixdorf Recall study underwent noncontrast cardiac CT for CAC score quantification. From CT, epicardial adipose tissue (EAT) volume, left ventricular and left atrial (LA) axial area index, ascending and descending aortic diameters, as well as aortic valve, mitral ring, and thoracic aortic calcification (TAC) were assessed. Incident cardiovascular events included myocardial infarction, stroke, and cardiovascular death. The prognostic value of CT

2016 JACC. Cardiovascular imaging

15. ASNC-SCCT-SNMMI Guideline for Cardiac SPECT/CT and PET/CT 1.0

coronary artery calcium scoring and coronary CT angiography (CTA). Hybrid SPECT/CT and PET/CT enable us to assess cardiac physiology along with cardiac and coronary anatomy (7–9). The use of CT-based transmission imaging and attenuation correction improvesthediagnosticaccuracyofmyocardialperfusionimaging (MPI),comparedwithnon–attenuation-correctedMPI(10).Atten- uation correction facilitates quantitative imaging of myocardial perfusion and metabolism. The assessment of anatomic coronary atherosclerotic (...) yttrium orthosilicate—can be used successfully for cardiac imaging (6). For hybrid imaging systems, the CT con?guration can below-resolutionCT(nondiagnosticCT)or2-sliceto$64- slice multidetector-row CT. Any of these systems can be used for attenuation correction of MPI. For coronary ar- tery calcium scoring, at least 4-slice CT is required ($6- slicerecommended).ForcoronaryCTA,atleasta16-slice scanner is required ($64-slice multidetector-row CT rec- ommended), with imaging capability for slice width

2015 Society of Nuclear Medicine and Molecular Imaging

16. One-stop-shop cardiac CT: Calcium score, angiography, and myocardial perfusion (PubMed)

One-stop-shop cardiac CT: Calcium score, angiography, and myocardial perfusion 26662557 2018 10 02 2018 11 13 1532-6551 23 5 2016 10 Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology J Nucl Cardiol One-stop-shop cardiac CT: Calcium score, angiography, and myocardial perfusion. 1176-1179 10.1007/s12350-015-0351-9 van Rosendael Alexander R AR Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. a.r.rosendael@lumc.nl (...) , The Netherlands. eng Case Reports Journal Article Research Support, Non-U.S. Gov't 2015 12 11 United States J Nucl Cardiol 9423534 1071-3581 SY7Q814VUP Calcium IM Calcium Coronary Angiography Humans Male Middle Aged Myocardial Perfusion Imaging Tomography, X-Ray Computed 2015 10 30 2015 11 06 2015 12 15 6 0 2015 12 15 6 0 2018 10 3 6 0 ppublish 26662557 PMC5033996 10.1007/s12350-015-0351-9 10.1007/s12350-015-0351-9 Atherosclerosis. 2009 Apr;203(2):533-7 18774135 Eur Heart J. 2011 Jun;32(11):1316-30 21367834

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2015 Journal of Nuclear Cardiology

17. 151 Prevalence of Coronary Artery Disease and Major Adverse Cardiovascular Events in Patients with A Zero Calcium Score: A Prospective Cardiac CT Study. (PubMed)

151 Prevalence of Coronary Artery Disease and Major Adverse Cardiovascular Events in Patients with A Zero Calcium Score: A Prospective Cardiac CT Study.

2014 Heart

18. Prognostic value of coronary artery calcium score in patients with symptoms suggestive of coronary artery disease. Results from the Silesian Calcium Score (SILICAS) study. (PubMed)

Prognostic value of coronary artery calcium score in patients with symptoms suggestive of coronary artery disease. Results from the Silesian Calcium Score (SILICAS) study. INTRODUCTION    The prognostic value of coronary artery calcium score (CACS) in symptomatic patients with a suspicion of coronary artery disease (CAD) has been poorly defined. OBJECTIVES    The aim of the study was to assess the predictive value of the CACS in the incidence of major adverse coronary events (MACEs) in patients (...) with an intermediate probability of CAD and establish its usefulness as the first-line risk assessment tool. PATIENTS AND METHODS    This single-center, observational, prospective study enrolled consecutive symptomatic patients without a previous diagnosis of CAD, referred to our center for CACS assessment with non-contrast-enhanced cardiac computed tomography (CT). CACS measurements were performed using an electrocardiogram-gated 64-row CT scanner. The CACS measurement was treated as the first‑line noninvasive

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2016 Polskie Archiwum Medycyny Wewnetrznej

19. Non-contrast cardiac CT-based quantitative evaluation of epicardial and intra-thoracic fat in healthy, recently menopausal women: Reproducibility data from the Kronos Early Estrogen Prevention Study. (PubMed)

intervals (0.22,1.7) and -1.8 cm3 for inter-observer, with 95% CI (-2.9, -0.69). Bland-Altman plots for intra-thoracic fat measurements were similarly impressive for both inter- and intra-observer reads.Our data showed that measuring epicardial and intra-thoracic fat volumes by CT using a semi-automated software has excellent intra-observer and inter-observer reliability. Cardiac fat volumes can be obtained easily and reproducibly from routine calcium scoring scans and may help in assessing (...) volumetric measurements using a semi-automated CT software.We used non-contrast coronary calcium CT scans to quantify epicardial and intra-thoracic fat volumes. Two expert readers analyzed baseline and follow up CT scans of 45 subjects by using a semi-automated CT software (QFAT 2.0, Cedars Sinai-Medical Center). Correlation and Bland-Altman analysis was performed for both intra- and inter-observer comparisons for each cardiac fat type.The intra-observer correlation coefficients ranged between 0.86

2019 Journal of cardiovascular computed tomography

20. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. (PubMed)

A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Coronary inflammation induces dynamic changes in the balance between water and lipid content in perivascular adipose tissue (PVAT), as captured by perivascular Fat Attenuation Index (FAI) in standard coronary CT angiography (CCTA). However, inflammation is not the only process involved in atherogenesis and we hypothesized that additional radiomic (...) with the radiomic features extracted from tissue CT images. Adipose tissue wavelet-transformed mean attenuation (captured by FAI) was the most sensitive radiomic feature in describing tissue inflammation (TNFA expression), while features of radiomic texture were related to adipose tissue fibrosis (COL1A1 expression) and vascularity (CD31 expression). In Study 2, we analysed 1391 coronary PVAT radiomic features in 101 patients who experienced major adverse cardiac events (MACE) within 5 years of having a CCTA

2019 European Heart Journal

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