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Cancer Prevention

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161. Prevention and Treatment of Anticipatory Nausea and Vomiting due to Chemotherapy in Pediatric Cancer Patients

Prevention and Treatment of Anticipatory Nausea and Vomiting due to Chemotherapy in Pediatric Cancer Patients 1 Version Date: April 23, 2014 Recommended citation: Dupuis LL, Robinson PD, Boodhan S, Holdsworth M, Portwine C, Gibson P, Phillips R, Maan C, Stefin N and Sung L. Guideline for the Prevention and Treatment of Anticipatory Nausea and Vomiting due to Chemotherapy in Pediatric Cancer Patients. Pediatric Oncology Group of Ontario; Toronto. 2014. Guideline for the Prevention and Treatment (...) of Anticipatory Nausea and Vomiting due to Chemotherapy in Pediatric Cancer Patients 2 Version Date: April 23, 2014 The Pediatric Oncology Group of Ontario (POGO) Guideline for the Prevention and Treatment of Anticipatory Nausea and Vomiting due to Chemotherapy in Pediatric Cancer Patients was developed by health care professionals using evidence-based or best practice references available at the time of its creation. The content of the guideline will change since it will be reviewed and revised on a periodic

2014 SickKids Supportive Care Guidelines

162. Cervical cancer prevention in El Salvador (CAPE)—An HPV testing-based demonstration project: Changing the secondary prevention paradigm in a lower middle-income country (PubMed)

Cervical cancer prevention in El Salvador (CAPE)—An HPV testing-based demonstration project: Changing the secondary prevention paradigm in a lower middle-income country •CareHPV tests were used to compare screen-and-treat and colposcopy management.•Screen-and-treat strategy with HPV testing was found to be very cost-effective.•CAPE has screened > 25,000 women in the Paracentral region.•Over 70% of screen-positive women received recommended treatment within six months.•CAPE is an example

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2017 Gynecologic Oncology Reports

163. Public health approach to prevent cervical cancer in HIV-infected women in Kenya: Issues to consider in the design of prevention programs (PubMed)

Public health approach to prevent cervical cancer in HIV-infected women in Kenya: Issues to consider in the design of prevention programs Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings (...) is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya. This review article is based on our prior research on the epidemiology of pHR/HR-HPV genotypes in HIV-infected women and CIN 2 + in Kenya and other sub-Saharan contexts. In order to contextualize the findings

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2017 Gynecologic Oncology Reports

164. Endometrial cancer and venous thromboembolism in women under age 50 who take tamoxifen for prevention of breast cancer: a systematic review

Endometrial cancer and venous thromboembolism in women under age 50 who take tamoxifen for prevention of breast cancer: a systematic review Endometrial cancer and venous thromboembolism in women under age 50 who take tamoxifen for prevention of breast cancer: a systematic review Endometrial cancer and venous thromboembolism in women under age 50 who take tamoxifen for prevention of breast cancer: a systematic review Iqbal J, Ginsburg OM, Wijeratne TD, Howell A, Evans G, Sestak I, Narod SA CRD (...) , Narod SA. Endometrial cancer and venous thromboembolism in women under age 50 who take tamoxifen for prevention of breast cancer: a systematic review. Cancer Treatment Reviews 2012; 38(4): 318-328 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Adult; Antineoplastic Agents, Hormonal /administration & Breast Neoplasms /prevention & Endometrial Neoplasms /chemically induced; Female; Humans; Middle Aged; Randomized Controlled Trials as Topic; Selective Estrogen

2012 DARE.

165. Targeting autophagy using natural compounds for cancer prevention and therapy. (PubMed)

Targeting autophagy using natural compounds for cancer prevention and therapy. Autophagy, also known as macroautophagy, is a tightly regulated process involved in the stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation of damaged proteins and organelles in eukaryotic cells. Autophagy also plays a key role in various tissue processes and immune responses and in the regulation of inflammation. Over the past decade, three levels of autophagy regulation (...) synthetic autophagy modulators have been identified as promising candidates for cancer therapy. In addition, diverse phytochemicals derived from natural sources, such as curcumin, ursolic acid, resveratrol, thymoquinone, and γ-tocotrienol, also have attracted attention as promising autophagy modulators with minimal side effects. In this review, the authors discuss the importance of autophagy regulators and various natural compounds that induce and/or inhibit autophagy in the prevention and therapy

2019 Cancer

166. Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary. (PubMed)

Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary. Ovarian cancer (OC) is the leading cause of death from gynaecological malignancies in the UK. Despite considerable funding to develop new treatments, 10-year survival remains poor at ~30%. This translates into 4,271 deaths annually in the UK, 42,700 in Europe and 152,000 deaths annually worldwide. High (e.g.-BRCA1/BRCA2

2019 BJOG

167. Efficacy and safety of RGB-02, a pegfilgrastim biosimilar to prevent chemotherapy-induced neutropenia: results of a randomized, double-blind phase III clinical study vs. reference pegfilgrastim in patients with breast cancer receiving chemotherapy. (PubMed)

Efficacy and safety of RGB-02, a pegfilgrastim biosimilar to prevent chemotherapy-induced neutropenia: results of a randomized, double-blind phase III clinical study vs. reference pegfilgrastim in patients with breast cancer receiving chemotherapy. Treatment with recombinant human granulocyte-colony stimulating factor (G-CSF) is accepted standard for prevention of chemotherapy-induced neutropenia. RGB-02 (Gedeon Richter) is a proposed biosimilar to pegylated G-CSF (Neulasta®, Amgen (...) ) with sustained release properties. This is a randomized, comparative, double-blind, multicenter study to evaluate efficacy and safety of RGB-02 in breast cancer patients receiving cytotoxic regimen.Two hundred thirty-nine women presenting with breast cancer were randomized to RGB-02 (n = 121) and the reference product (n = 118). All patients received up to 6 cycles of docetaxel/doxorubicin chemotherapy combination and a once-per-cycle injection of a fixed 6 mg dose of pegfilgrastim. Primary endpoint

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2019 BMC Cancer

168. Adherence to preventive swallowing exercises for head and neck cancer patients undergoing (chemo)radiotherapy treatment. (PubMed)

Adherence to preventive swallowing exercises for head and neck cancer patients undergoing (chemo)radiotherapy treatment. In recent years, preventive swallowing exercises have been investigated as a means to limit dysphagia in head and neck cancer patients. However, adherence to exercise regimes has been poorly documented limiting the conclusions drawn on the effects of the interventions. We investigated adherence to a preventive swallowing exercise program and identified possible associations (...) and adherence.The study found a high adherence to preventive swallowing exercises in HNC patients undergoing (chemo)radiotherapy, both in home-based exercises and in supervised sessions, when compared to other studies, although median adherence to home-based exercises was below the defined 80% threshold. We acknowledge, that adherence in an RCT may be higher than in the everyday clinical situation due to surveillance bias. However, we find it reassuring that HNC patients comply with a preventive swallowing

2019 Acta Oncologica

169. Multicomponent non-pharmacological intervention to prevent delirium for hospitalised people with advanced cancer: study protocol for a phase II cluster randomised controlled trial. (PubMed)

Multicomponent non-pharmacological intervention to prevent delirium for hospitalised people with advanced cancer: study protocol for a phase II cluster randomised controlled trial. Delirium is a significant medical complication for hospitalised patients. Up to one-third of delirium episodes are preventable in older inpatients through non-pharmacological strategies that support essential human needs, such as physical and cognitive activity, sleep, hydration, vision and hearing. We hypothesised (...) that a multicomponent intervention similarly may decrease delirium incidence, and/or its duration and severity, in inpatients with advanced cancer. Prior to a phase III trial, we aimed to determine if a multicomponent non-pharmacological delirium prevention intervention is feasible and acceptable for this specific inpatient group.The study is a phase II cluster randomised wait-listed controlled trial involving inpatients with advanced cancer at four Australian palliative care inpatient units. Intervention sites

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2019 BMJ open

170. Case-Control Studies of the Efficacy of Screening Tests That Seek to Prevent Cancer Incidence: Results of an Approach That Utilizes Administrative Claims Data That Do Not Provide Information Regarding Test Indication. (PubMed)

Case-Control Studies of the Efficacy of Screening Tests That Seek to Prevent Cancer Incidence: Results of an Approach That Utilizes Administrative Claims Data That Do Not Provide Information Regarding Test Indication. Case-control studies evaluating a screening test's efficacy in reducing cancer mortality require accurate classification of test indication to obtain a valid result. However, for analogous studies of cancer incidence, determination of test indication is not as critical because (...) , to define exposure, we need consider only tests that can identify precursor lesions whose treatment might prevent cancer, not tests leading to cancer diagnosis. This study utilizes US Surveillance, Epidemiology, and End Results (SEER)-Medicare data, which do not include information about colonoscopy indication, to evaluate the efficacy of colonoscopy in preventing colorectal cancer (CRC) incidence. Cases were Medicare enrollees diagnosed with CRC between 1996 and 2013; up to 3 controls were matched

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2019 American Journal of Epidemiology

171. New Year’s Resolution: Prevent Cervical Cancer

New Year’s Resolution: Prevent Cervical Cancer New Year’s Resolution: Prevent Cervical Cancer | | Blogs | CDC Search Form Controls TOPIC ONLY Search The CDC cancel submit Search Form Controls TOPIC ONLY Search The CDC cancel submit Note: Javascript is disabled or is not supported by your browser. For this reason, some items on this page will be unavailable. For more information about this message, please visit this page: . New Year’s Resolution: Prevent Cervical Cancer Posted on Wednesday (...) , January 30, 2019 by DCPC Every year, people resolve to get into better shape or better health. This year take steps to prevent more women from getting cervical cancer. Each year, approximately 12,000 women in the United States get cervical cancer. Although all women are at risk for cervical cancer, all women do not have to get this cancer. Cervical cancer can be prevented or treated, if found early. The keys to prevention and control are Education, Vaccination, and Screening. CDC (NCCCP) programs

2019 CDC The Topic Is Cancer blog

172. We have a shot at preventing cervical cancer

We have a shot at preventing cervical cancer We have a shot at preventing cervical cancer We have a shot at preventing cervical cancer | | January 25, 2019 21 Shares Many people think eradicating cancer is unattainable. But for cervical cancer, we are well on our way to doing just that. Cervical cancer was once the leading cause of death in women in the U.S. But we are on the cusp of vanquishing this disease thanks to regular pap screening and a vaccine that protects women and men from (...) developing the human papilloma virus (HPV), the cause of nearly all cervical cancers. In fact, over the last 40 years, the number of new cases and deaths from cervical cancers has plummeted. We are in the midst of Cervical Health Awareness Month, and you’ll likely be reading and hearing many news reports about how the disease that once claimed the lives of more women than any other disease is now largely preventable. But an important element to the story of cervical cancer is that it is up to all of us

2019 KevinMD blog

173. Aspirin does not prevent pancreatic cancer in a large Asian cohort. (PubMed)

Aspirin does not prevent pancreatic cancer in a large Asian cohort. Evidence has suggested that aspirin reduces the incidence of several cancers, but these benefits may not occur with pancreatic cancer.A 12-year nationwide longitudinal cohort merged with health checkup data were divided into "exposure ascertainment period" and "outcome ascertainment period" to avoid immortal time bias. The Daily Defined Dose system was used to indicate the drug exposure.We found no significant association (...) between aspirin use and incident pancreatic cancer based on hazard ratio.Aspirin dose not prevent pancreatic cancer.A large Asian cohort study with reliable medication information affirm no impact of aspirin on pancreatic cancer development.Copyright ©2019, American Association for Cancer Research.

2019 Cancer Epidemiology & Biomarkers and Prevention

174. The HPV Vaccine Should Be Preventing Cervical Cancer: Can We Tell Whether It Actually Is?

The HPV Vaccine Should Be Preventing Cervical Cancer: Can We Tell Whether It Actually Is? The HPV Vaccine Should Be Preventing Cervical Cancer: Can We Tell Whether It Actually Is? | Absolutely Maybe PLOS Blogs Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental Sciences Multi-disciplinary Sciences Medicine & Health Research Analysis & Scientific Policy Diverse perspectives on science and medicine Staff Blogs Blogs by Topic Biology & Life Sciences Earth & Environmental (...) years old. So their risk of having cervical cancer is still very low. Even if a large proportion of them were vaccinated – and very few were back then – we wouldn’t see a big difference for years yet. Per the US Preventive Services Taskforce ( ): The incidence of invasive cervical cancer peaks among U.S. women aged 40 to 44 years and few cases of cervical cancer are detected in women younger than age 20. Age-adjusted incidence and death rates of invasive cervical cancer in the United States in 5

2018 Absolutely Maybe

175. Progressive resistance training to prevent arm lymphedema in the first year after breast cancer surgery: Results of a randomized controlled trial. (PubMed)

Progressive resistance training to prevent arm lymphedema in the first year after breast cancer surgery: Results of a randomized controlled trial. Existing research suggests that progressive resistance training (PRT) after breast cancer (BC) surgery is safe, but the preventive effect on arm lymphedema has yet to be determined.Women aged 18 to 75 years who were undergoing BC surgery with axillary lymph node dissection were eligible for the study. Recruited on the day of surgery, participants (...) of effects included t tests and regression models; missing data were addressed by multiple imputation.Among the 158 randomized women, no mean group difference was found in arm volume (0.3%; 95% confidence interval, -1.7% to 2.3%) or lymphedema incidence (adjusted odds ratio, 1.2; 95% confidence interval, 0.5-2.8). None of the participants exited the program because of adverse events.This study provides no evidence that PRT can prevent arm lymphedema in the first year after BC, but the results corroborate

2019 Cancer

176. COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials. (PubMed)

COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials. Vitamins are among the most frequently used supplements (48% of US adults). However, little is known about contributions of genetic variation to their efficacy and safety. Multiple pathways link catechol-O-methyltransferase (COMT) to the vitamin E supplement, alpha-tocopherol, and cancer.Here we determined if COMT exerted pharmacogenetic effects on cancer prevention in two (...) Prevention Study (ATBC, N = 29 133). The primary outcome was total cancers. Rates of cancer types prevalent in women (colorectal, breast, lung, uterine, and lymphoma/leukemia) were also examined. All statistical tests were two-sided.Random-effects meta-analysis of rs4680 genotype strata, in WGHS and ATBC overall periods, revealed differential alpha-tocopherol effects compared with placebo: met/met (hazard ratio [HR] = 0.88; 95% confidence interval [CI] = 0.80 to 0.97; P = .01), val/met (HR = 0.99; 95% CI

2019 Journal of the National Cancer Institute

177. Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial. (PubMed)

Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial. The aim of this phase II, multicentre, randomized controlled trial was to evaluate the effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients with oral cancer receiving radiotherapy alone (...) or chemoradiotherapy. In total, 124 patients with oral cancer were enrolled from five institutions. Of these, 37 patients undergoing radiotherapy were randomly divided into an intervention group (n=18) and a control group (n=19). The remaining 87 patients, who were undergoing chemoradiotherapy, were also randomized into an intervention group (n=42) and a control group (n=45). During radiotherapy, patients in the control group received only oral care, while those in the intervention group additionally received

2019 International Journal of Oral and Maxillofacial Surgery

178. Randomized Double-blind Placebo-controlled Trial of Celecoxib for the Prevention of Skin Toxicity in Patients Receiving Radiation Therapy for Breast Cancer. (PubMed)

Randomized Double-blind Placebo-controlled Trial of Celecoxib for the Prevention of Skin Toxicity in Patients Receiving Radiation Therapy for Breast Cancer. The skin toxicity-induced by ionizing radiation may limit the duration of treatment and may lead to discomfort in quality of life of patients during radiotherapy.The purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of oral administration of celecoxib (CLX) on the acute radiation (...) - induced skin toxicity in patients with breast cancer.Sixty breast cancer patients were randomly assigned to use CLX (400 mg per day) or placebo capsules during radiotherapy. Radiation-induced dermatitis was classified according to the radiation therapy oncology group (RTOG) criteria, as well as pain and itching were scored according to the VAS (Visual Analogue Scale) for six weeks of treatment. Breast swelling was evaluated through increase in the size of the breast during radiotherapy.Oral

2019 Anti-inflammatory & anti-allergy agents in medicinal chemistry

179. Prophylactic use of carvedilol to prevent ventricular dysfunction in patients with cancer treated with doxorubicin. (PubMed)

Prophylactic use of carvedilol to prevent ventricular dysfunction in patients with cancer treated with doxorubicin. Deterioration in ventricular function is often observed in patients treated with anthracyclines for cancer. There is a paucity of evidence on interventions that might provide cardio-protection. We investigated whether prophylactic use of carvedilol can prevent doxorubicin-induced cardiotoxicity and whether any observed effect is dose related.A prospective, randomized, double-blind (...) one of 116 patients (1%) assigned to carvedilol had an LVEF < 50% compared to four of the 38 assigned to placebo (11%), (p = 0.013). No significant differences were noted between carvedilol and placebo in terms of the development of diastolic dysfunction, clinically overt heart failure or death.Carvedilol might prevent deterioration in LVEF in cancer patients treated with doxorubicin. This effect may not be dose related within the studied range.Copyright © 2018. Published by Elsevier B.V.

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2019 Indian heart journal

180. Impact of an Educational Intervention Based on the BASNEF Model on Skin Cancer Preventive Behavior of College Students (PubMed)

Impact of an Educational Intervention Based on the BASNEF Model on Skin Cancer Preventive Behavior of College Students Background: Skin cancer is one of the most common cancers in the world but is largely preventable through protective behavior. The aim of this study was to evaluate the impact of an educational intervention based on the BASNEF model on skin cancer prevention and protective behavior in midwifery students in Urmia. Methods: In this quasi-experimental study, the subject population (...) and three months thereafter and analyzed using paired t-test and independent t-test statistics. Results: The results showed that after intervention, mean score of knowledge was significantly higher in the study group compared to the control group. Significant improvement in mean scores for attitude, enabling factors, mental norms, and intent of behavior was limited to the study group Also, behavior for prevention of skin cancer was significantly better in the intervention group. Conclusions: The results

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2019 Asian Pacific journal of cancer prevention : APJCP

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