How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

213 results for

Cafe-Au-Lait Macule

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

181. Dermatological Manifestations of Inherited Cancer Syndromes in Children. (PubMed)

Dermatological Manifestations of Inherited Cancer Syndromes in Children. Various cutaneous signs presenting in childhood, for example café-au-lait macules, may have systemic cancer associations. Indeed, this may be the first manifestation of the underlying cancer predisposition. The syndromes covered in this review fall into four main categories: (i) DNA damage processing defects including Fanconi anaemia, ataxia telangiectasia, Bloom syndrome, Rothmund-Thomson syndrome, constitutional mismatch

2010 British Journal of Dermatology

182. Laser treatment of dark skin: an updated review. (PubMed)

tones. This review provides an updated discussion of the range of laser treatments available for pigmented skin and sets the stage for further advancements. Pigment-specific laser technology with green, red, or near-infrared light targets a variety of pigmented lesions such as lentigines, ephelides, café-au-lait macules, and melanocytic nevi as well as tattoos and unwanted hair. Short-pulsed alexandrite, ruby, and neodymium:yttrium-aluminum-garnet (Nd:YAG) lasers are used for pigmented lesions

2010 American journal of clinical dermatology

183. Pathogenesis of vestibular schwannoma in ring chromosome 22. (PubMed)

Pathogenesis of vestibular schwannoma in ring chromosome 22. Ring chromosome 22 is a rare human constitutional cytogenetic abnormality. Clinical features of neurofibromatosis type 1 and 2 as well as different tumour types have been reported in patients with ring chromosome 22. The pathogenesis of these tumours is not always clear yet.We report on a female patient with a ring chromosome 22 presenting with severe mental retardation, autistic behaviour, café-au-lait macules and facial dysmorphism

Full Text available with Trip Pro

2009 BMC Medical Genetics

184. Phenotypic and Genotypic Analyses of Genetic Skin Disease through the Online Mendelian Inheritance in Man (OMIM) Database. (PubMed)

-encoding genes. The most common elemental skin features included [corrected] hair/nail phenotypes, while [corrected] the most common systemic features included those associated with developmental, musculoskeletal, and neurological systems. As a proof of principle, we focused on a single skin feature- café-au-lait macules-and partitioned the disease space into hierarchical groupings on the basis of this finding. Finally, functional analyses among GSD loci were mapped back to skin features, providing

Full Text available with Trip Pro

2009 Journal of Investigative Dermatology

185. Topical Imiquimod 5% Cream for Treatment of Cutaneous Neurofibromas in Adults With Neurofibromatosis 1

or more of the following characteristics: six or more cafe-au-lait macules (1.5cm or greater in size) skin fold freckling in the axilla or groin optic pathway glioma two or more Lisch nodules of the iris distinctive bony lesions such as dysplasia of the sphenoid wing or of a long bone such as the tibia two or more neurofibromas of any type of 1 or more plexiform neurofibroma first degree relative with NF1 Participants must have at least four cutaneous neurofibromas on skin exam with the following

2009 Clinical Trials

186. Natural History Study of Patients With Neurofibromatosis Type I

evaluations or MRI scans requested for research purposes, or other studies which might negatively impact on the pregnancy. ELIGIBILITY CRITERIA PATIENT FOR OPTIONAL TUMOR / TISSUE BIOPSY FOR RESEARCH INCLUSION CRITERIA: Age greater than 12 years, and neurofibroma, cafe-au-lait macule, xanthogranuloma, or other skin area, which is easily accessible, and sufficiently distant from vital structures to allow for biopsy. Platelet count has to be greater than or equal to 100,000/microL, and PT and PTT have (...) exams, MRI scans and PET scans to evaluate optic pathway gliomas (tumors arising from the vision nerves or the brain areas for vision) and the chemicals within the tumor and brain. Eye exams and photographs to evaluate the development of Lisch nodules (non-cancerous tumors on the eye). Photographs of dermal neurofibromas (tumors of the skin), cafe-au-lait spots (dark or pigmented areas on the skin that are often the first signs of NF1) and other skin problems. Pain evaluations to monitor

2009 Clinical Trials

187. Melanoma arising in segmental nevus spilus: Detection by sequential digital dermatoscopy. (PubMed)

Melanoma arising in segmental nevus spilus: Detection by sequential digital dermatoscopy. Nevus spilus (NS) defines a café-au-lait macule with superimposed maculopapular speckles. Although the café-au-lait macule often presents at birth, the darker pigmented speckles increase in number and size during a period of several years. The need for close follow-up of patients with NS is underlined by reports of several cases of cutaneous melanoma developing within such lesions.We followed up 4 adult

2009 Journal of American Academy of Dermatology

188. Poliosis circumscripta associated with neurofibromatosis 1. (PubMed)

Poliosis circumscripta associated with neurofibromatosis 1. A 38-year-old man presented with axillary freckling, multiple café au lait macules and neurofibromas on the scalp, trunk and extremities. In addition, he had a patch of white hair on the right parieto-occipital area overlying a scalp neurofibroma. He was diagnosed with poliosis circumscripta associated with neurofibromatosis 1.

2008 Australasian Journal of Dermatology

189. Giant café-au-lait macule in neurofibromatosis 1: a type 2 segmental manifestation of neurofibromatosis 1? (PubMed)

Giant café-au-lait macule in neurofibromatosis 1: a type 2 segmental manifestation of neurofibromatosis 1? Type 2 segmental manifestation of autosomal dominant dermatoses refers to pronounced segmental lesions superimposed on the ordinary nonsegmental phenotype, indicating loss of heterozygosity occurring at an early stage of embryogenesis. We describe a 20-year-old Taiwanese woman with typical lesions of neurofibromatosis type 1 (NF1) in the form of characteristic café-au-lait spots (...) , neurofibromas, axillary freckling and Lisch nodules. In addition, a giant garment-like or "bathing-trunk" café-au-lait macule involved the lower half of the trunk, the buttocks, and parts of the thighs, being superimposed on the ordinary smaller spots of NF1. This large café-au-lait macule may be best explained as an example of type 2 segmental NF1. A novel mutation (3009delG) in exon 23 was also identified in this patient, which has not yet been described in sporadic and familial NF1.

2008 Journal of American Academy of Dermatology

190. Ipsilateral café-au-lait macules, deafness, and pituitary microadenoma in a 35-year-old woman. (PubMed)

Ipsilateral café-au-lait macules, deafness, and pituitary microadenoma in a 35-year-old woman. The association between ipsilateral café-au-lait macules, deafness, and pituitary adenoma has not been described previously.A 35-year-old woman affected since birth with two café-au-lait macules, one measuring 15 x 20 cm, with an irregular shape, covering almost all of the left buttock, and the other measuring 6 x 13 cm on the front side of the left thigh, is described. For as long as the patient can

2008 International Journal of Dermatology

191. Ranibizumab for Neurofibromas Associated With Neurofibromatosis 1

of the following characteristics: a) Six or more cafe-au-lait macules b) Skin fold freckling in the axilla or groin c) Optic pathway glioma d) Two or more Lisch nodules of the iris e) Distinctive bony lesions such as dysplasia of the sphenoid wing or of a long bone such as the tibia f) Two or more neurofibromas of any type or 1 or more plexiform neurofibroma g) First degree relative with NF1 At least four cutaneous neurofibromas on skin exam with the following qualities: a) the lesion must be discrete

2008 Clinical Trials

192. Transsphenoidal surgery in a patient with acromegaly and McCune-Albright syndrome: application of neuronavigation. (PubMed)

Transsphenoidal surgery in a patient with acromegaly and McCune-Albright syndrome: application of neuronavigation. The McCune-Albright syndrome (MAS) is characterized by a clinical triad of polyostotic fibrous dysplasia, café-au-lait hyperpigmented macules, and hypersecretory endocrinopathies. Acromegaly is an uncommon manifestation of the endocrine disturbance associated with MAS, and the role of surgery in managing these cases has been a topic of debate. The authors present the case of a 35 (...) -year-old man with MAS who was also diagnosed with acromegaly, hyperprolactinemia, and pituitary macroadenoma. The patient had an 18-year history of fibrous dysplasia involving the right frontal bone and ribs as well as multiple endocrinopathies, but no cutaneous hyperpigmented macules. An oral glucose tolerance test demonstrated partial suppression of plasma levels of growth hormone (GH). The patient underwent transsphenoidal resection of the pituitary tumor, performed with assistance

Full Text available with Trip Pro

2008 Journal of Neurosurgery

193. Congenital atresia of portal vein with portocaval shunt associated with cardiac defects, skeletal deformities, and skin lesions in a boy. (PubMed)

and generally limited to females. We describe a rare case of aberrant portal vein development with congenital portocaval shunt (end-to-side) in a 3.5-year male child associated with cardiac defects (atrial and ventricular septal defects), skeletal deformities (flexion deformity and clinodactyly of digits and toes), and lichen planus with café au lait macules of skin.

2008 Journal of Pediatric Surgery

194. Health-Related Quality of Life in Patients with Neurofibromatosis Type 1. A Survey of 129 Italian Patients. (PubMed)

Health-Related Quality of Life in Patients with Neurofibromatosis Type 1. A Survey of 129 Italian Patients. Neurofibromatosis type 1 (NF1), a genetic condition most commonly characterized by the presence of dermal neurofibromas and café au lait macules, has a significant impact upon quality of life (QoL). The study aimed to assess the impact of NF1 on QoL.A total of 129 patients with NF1 completed the study questionnaires in an Italian academic dermatological centre and a neurofibromatosis

2008 Dermatology

195. coast of Maine spots

coast of Maine spots coast of Maine spots - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search coast of Maine spots Cafe au lait spots are brown cutaneous macules which may be present at birth and, if numerous, are strongly suggestive of the diagnosis of neurofibromatosis or Albright's syndrome. The incidence of single lesions is high and of no significance - a patient is allowed up to four patches of less than 0.5cm diameter

2010 GP Notebook

196. Neurofibromatosis

. The schwannomatosis phenotype is limited to multiple schwannomas, and usually presents with pain. Diagnostic criteria for NF1 There are diagnostic criteria for NF1 that require at least two of seven criteria. Some of these do not appear until later childhood or adolescence, and so confirmation of the diagnosis may be delayed and children should be followed up. At least six café-au-lait spots or hyperpigmented macules. They must be at least 5 mm wide in children younger than 10 years and 15 mm in adults. Axillary (...) have mosaic NF1 or NF2. Axillary or inguinal freckles are rare at birth but appear throughout childhood and adolescence. Café-au-lait patches and skin-fold freckling do not usually cause complications; however, some patients are distressed by the appearance of this pigmentation and may be helped by skin camouflage advice. There is no evidence to support the routine use of laser treatment for café-au-lait patches. Hypopigmented macules may co-exist with café-au-lait spots in NF1 and are found

2008 Mentor

197. Tuberous Sclerosis

tags can occur in the axillae, groins, and around the head and neck. Confetti lesions are a cluster of hypomelanotic lesions that have a reticulated appearance. They can develop anywhere on the skin. NB : café-au-lait spots are not a diagnostic sign. Renal involvement Renal angiomyolipoma may be multiple. They are benign hamartomas of the kidney. Usually, they are asymptomatic in childhood. In adults, they can rupture leading to intraperitoneal or intrarenal/ureteric haemorrhage. This can present (...) and do not cause hydrocephalus. Skin and teeth involvement Most patients have skin changes. Pictures of the lesions are available in 'Further reading & references', below. All patients should undergo a detailed skin and teeth examamination at time of diagnosis to evaluate for facial angiofibromas, fibrous cephalic plaques, hypomelanotic macules or confetti lesions, ungual fibromas, shagreen patch, defects in tooth enamel, and intraoral fibroma. A skin survey should be performed annually, with focus

2008 Mentor

198. Junctional Naevus

the level of the skin, to confirm as a junctional naevus. Distinguish from other similar pigmented macules that affect the skin: Freckles (ephelides) are usually multiple, small and darken after sunlight exposure. Café-au-lait spots are usually larger, lighter in pigmentation and have very distinct borders. Lentigines are small, sharply circumscribed and pigmented, surrounded by normal-appearing skin and tend to be multiple, lighter brown and more irregular in shape. Melanoma tends to be darker, have

2008 Mentor

199. cafe au lait spots

cafe au lait spots cafe au lait spots - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search cafe au lait spots Cafe au lait spots are brown cutaneous macules which may be present at birth and, if numerous, are strongly suggestive of the diagnosis of neurofibromatosis or Albright's syndrome. The incidence of single lesions is high and of no significance - a patient is allowed up to four patches of less than 0.5cm diameter

2010 GP Notebook

200. Neurofibromatosis type 1

the same family. Multiple caf�-au-lait macules are found in almost all patients (some at birth and most before the first year). Intertriginous freckling develops starting at 5 years of age. Multiple cutaneous and subcutaneous neurofibromas develop in adults. In older patients, they continue to increase in number and size. Cutaneous neurofibromas do not become malignant. Plexiform neurofibromas (growing along the nerve and its branches) may cause disfigurement, pain, and functional problems (...) . Neurofibromatosis-Noonan syndrome is a variant of NF1 in 99% of cases (see these terms). Etiology NF1 is caused by mutations in the tumor suppressor neurofibromin 1 NF1 gene (17q11.2) and rarely by 17q11 microdeletion (only 5%). Diagnostic methods Formal diagnostic criteria have been established. 2 or more of the following are diagnostic: more than 5 caf�-au-lait macules, 2 or more neurofibromas or one plexiform neurofibroma, optic glioma, freckling, 2 or more Lisch nodules, specific bone dysplasias, first

2005 Orphanet

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>