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CSF Gamma Globulin

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1. CSF Gamma Globulin

CSF Gamma Globulin CSF Gamma Globulin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 CSF Gamma Globulin CSF Gamma Globulin Aka: CSF (...) Gamma Globulin II. Background Represents 13-15% of III. Indications diagnosis IV. Differential Diagnosis: Elevated CSF Gamma Globulin Subacute Sclerosing Panencephalitis ral paresis Herpes Carcinomatous cerebellar degeneration V. Preparations: Other Similar Tests IgG albumin ratio IgG synthesis rate Oligoclonal bands Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "CSF Gamma Globulin." Click on the image (or right click) to open

2018 FP Notebook

2. CSF Gamma Globulin

CSF Gamma Globulin CSF Gamma Globulin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 CSF Gamma Globulin CSF Gamma Globulin Aka: CSF (...) Gamma Globulin II. Background Represents 13-15% of III. Indications diagnosis IV. Differential Diagnosis: Elevated CSF Gamma Globulin Subacute Sclerosing Panencephalitis ral paresis Herpes Carcinomatous cerebellar degeneration V. Preparations: Other Similar Tests IgG albumin ratio IgG synthesis rate Oligoclonal bands Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "CSF Gamma Globulin." Click on the image (or right click) to open

2015 FP Notebook

3. Gemtuzumab ozogamicin (Mylotarg) - Leukemia, Myeloid, Acute

gene G-CSF granulocyte colony-stimulating factor GMP Good Manufacturing Practice GO gemtuzumab ozogamicin (Mylotarg) GOELAMS Groupe Ouest Est d'Etude des Leucémies aiguës et Autres Maladies du Sang HC Heavy chain HiDAC high-dose AraC HL-60 CD33-positive human leukaemia cell line HMBC heteronuclear multiple-bond correlation spectroscopy HPLC High-Performance Liquid Chromatography HR hazard ratio HSCT haematopoietic stem cell transplant ICD Informed Consent Document ICH International Conference (...) class G subtype 4 (IgG4) antibody which specifically recognises human CD33. The antibody portion binds specifically to the CD33 antigen, a sialic acid-dependent adhesion protein found on the surface of myeloid leukaemic blasts and immature normal cells of myelomonocytic lineage, but not on normal haematopoietic stem cells. The small molecule, N acetyl gamma calicheamicin, is a cytotoxic semisynthetic natural product. N acetyl gamma calicheamicin is covalently attached to the antibody via an AcBut (4

2018 European Medicines Agency - EPARs

4. The role of immunotherapy in IVF: a guideline

to improved live-birth outcome. While some of these medica- tions (e.g., aspirin and corticosteroids) have been used for many years and are relatively low cost, others (e.g., intravenous fat emulsions and granu- locyte colony–stimulating factor [G- CSF]) are newer, of higher cost, and with risks that have been poorly char- acterized. It is imperative that physi- cians providing ART treatments have a full understanding of the potential risks and bene?ts associated with adjuvant immunotherapy in order (...) -CSF; glucocorticoid/s; GM-CSF; granulocyte colony-stimulating factor; harm; HLA; HLA antigens; hu- man leukocyte antigen; Humira; ICSI; IL-10; IL-17; IL-27; immune modulatory; immune therapy; immunoglobulins, intravenous; immunoglobulins/therapeutic use; immu- nologic tests; immunomodulation; immunomodulatory; immunosuppression;immunotherapy;invitrofertilisation; in vitro fertilization; interleukin-10; interleukin-17; interleukin-27; intracytoplasmic sperm injection; intrali- pid; intralipid

2018 Society for Assisted Reproductive Technology

5. Niraparib (Zejula) - Fallopian Tube Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms

and the cerebrospinal fluid (CSF) of monkeys. Brain-to-plasma C max ratios in rats were 0.77 and 0.64 following PO doses of 10 and 30 mg/kg, respectively. In monkeys, CSF-to-plasma C max and AUC 0-inf ratios were approximately 0.31 and 0.19, respectively, after a PO dose of 10 mg/kg. Metabolism All metabolites formed by human hepatocytes have been detected in the species used in the toxicity studies, with M1, a carboxylic acid metabolite formed by the carboxylesterases (CEs), being the major primary metabolite (...) ). evaluatio n platelets (F), ? red cell distribution width (RDW). ? neutrophils, lymphocytes and/or monocytes. ? total protein (albumin and globulins), triglycerides, sodium, chloride, and calcium and increases in albumin to globulin ratio and potassium. Bone marrow depletion (minimal to marked). Testicular germ cell depletion with ? sperm and cell debris in the epididymis, ? testicular weights. Lymphoid depletion (minimal to moderate) in the spleen. Recovery: Partially or complete recovery

2017 European Medicines Agency - EPARs

6. Comprehensive Systematic Review Summary: Disease-modifying Therapies for Adults with Multiple Sclerosis

protein, myelin oligodendrocyte glycoprotein, and proteolipid protein). e9 Analysis of oligoclonal bands has also failed to reveal a consistent antibody pattern across people with MS. e10 Cloned antibodies from CSF oligoclonal bands have not revealed a common antigenic target. e11 Thus, intrathecal synthesis of gamma globulins, the immunochemical hallmark of MS, does not appear to be associated with specific CNS targets. e12,e13 Despite an inability to conclusively determine an autoimmune target

2018 American Academy of Neurology

7. ASCIA Clinical Update - Primary Immunodeficiencies (PID)

associated with autoantibodies e.g. chronic mucocutaneous candidiasis due to IL-17 autoantibody, adult-onset immunodeficiency due to INF-gamma autoantibody, pulmonary alveolar proteinosis due to Granulocyte-macrophage colony- stimulating factor (GM-CSF) autoantibody ASCIA INFORMATION FOR HEALTH PROFESSIONALS 4 2. Recognition, diagnosis and management of PIDs There are 7 early warning signs of PIDs 1. An unusually large number of infections requiring treatment including: ? Frequent middle ear infections (...) : www.immunise.health.gov.au/internet/immunise/publishing.nsf/Content/Handbook10-home Vaccination information for patients on immunoglobulin repacement therapy (IRT): www.immunise.health.gov.au/internet/immunise/publishing.nsf/Content/Handbook10- home~handbook10part3~handbook10-3-3#3-3-4 ASCIA INFORMATION FOR HEALTH PROFESSIONALS 10 3. Immunoglobulin replacement therapy in PIDs Immunoglobulin replacement therapy (IRT) Replacement of serum immunoglobulin with human gamma globulin fraction is the standard treatment for most

2017 Australasian Society of Clinical Immunology and Allergy

8. Oncaspar - pegaspargase

, methotrexate, etoposide, decadron CML Chronic Myelogenous Leukemia CNS Central Nervous System CON Consolidation CR Complete remission CSF Cerebrospinal Fluid CT Computed chromography CTC Common Toxicity Criteria CTD Common Technical Document CTEP Cancer Therapy Evaluation Program d Day DDP Cisplatin DI Delayed Intensification DIC Disseminated Intravascular Coagulation E. coli Escherichia Coli EEG Electroencephalogram EFS Event Free Survival ELISA Enzyme-Linked Immunosorbent Assay EU European Unit F Female (...) F Absolute Bioavailability FAB French–American–British classification Assessment Report EMA/826135/2016 Page 4/122 FDA Food and Drug Administration FL Fluorescent (detection) FSR Final Study Report GGT Gamma Glutamyl Transferase GI Gastrointestinal GLP Good Laboratory Practice GOT see AST h Hour Hb Haemoglobin HD High Dose HI Haematologic Improvement HLA Human Leukocyte Antigen HPLC High Performance Liquid Chromatography HR High Risk i.m. Intramuscular i.p. Intraperitoneal i.v. Intravenous IC50

2016 European Medicines Agency - EPARs

9. National minimum retesting intervals in pathology: A final report detailing consensus recommendations for minimum retesting intervals for use in pathology

Implementation Network GGT Gamma-glutamyltransferase GPC Gastric parietal cell antibody Hb Haemoglobin HBV Hepatitis B virus HCV Hepatitis C virus CEff 161215 8 V7 Final HIV Human immunodeficiency virus HSV Herpes simplex virus HVS High vaginal swab Ig Immunoglobulin IGF-1 Insulin-like Growth Factor 1 IHD Ischaemic heart disease INR International normalised ratio ITT Immune tolerance therapy ITU Intensive treatment unit IUCD Intrauterine contraceptive device IV Intravenous IVF In vitro fertilisation LCMS (...) fracture or pain located in bone, suppression of other immune- globulin classes, renal impairment) and a band of 3 days for hCG) is a reliable indicator of residual tumour and a sig-nificant predictor of survival B- TM13 Serum ß-HCG (tumour marker) If rate of change in tumour marker concentration changes velocity, an urgent repeat to confirm the result is reasonable Sturgeon CM, Hoffman BR, Chan DW, Ch'ng SL, Hammond E, Hayes DF et al. National Academy of Clinical Biochemistry Laboratory Medicine

2016 Royal College of Pathologists

10. Farydak - panobinostat

. panleukopenia & thrombocytopenia, ? RBC (f), Hbg, HCT, Reticulocytes (severity increases with dose), ? ALP (m), ? phosphorus, ? triglyc. (f), ? thymic and spleen weight, lymphoid necrosis and atrophy thymus, =2.5 d6-8 all euthanized due to adverse clinical signs, BW loss, red. FC, dec. loc. Activity, chromorhinorrhea, ? FC d4 ( m,) d8 (all) ? ALT, ALP, ? total protein ((f), ? albumin, ? globulin, ? triglyc. , No organ weights collected, erythropoiesis (f), BMW depletion and heamorhage (including sparseness (...) estimated from data from 2 studies with iv dosing and 8 studies with oral dosing *Adjusted geometric mean AUCinf/dose i.v. (n=69) from two i.v. studies: 22.699 CSF: clinical service form; FMI: final market image; GMR: geometric mean ratio Overall panobinostat exposure and inter-patient variability remained unchanged with or without food, whereas C max was reduced by 500 ms), continues to be uncommon at (about 1% overall) with the highest frequency of 75 years of age, depending on the patient’s general

2015 European Medicines Agency - EPARs

11. Childhood Hematopoietic Cell Transplantation (PDQ®): Health Professional Version

factor (G-CSF) are used to increase the number of circulating stem and progenitor cells (CD34+ cells). Collection centers monitor the CD34-positive number in the patient and product each day to determine the best time to begin collection and when collection is complete. Patients with poorly mobilized CD34-positive cells can often have their cells successfully collected using alternative mobilization approaches (e.g., plerixafor).[ ] The collected PBSCs are cryopreserved for later use. After (...) types has been the contamination of the collected stem cell product by persistent tumor cells. Although many techniques have been developed to remove or purge tumor cells from products, most studies have shown no benefit to tumor purging.[ ] References Patel B, Pearson H, Zacharoulis S: Mobilisation of haematopoietic stem cells in paediatric patients, prior to autologous transplantation following administration of plerixafor and G-CSF. Pediatr Blood Cancer 62 (8): 1477-80, 2015. [ ] Kreissman SG

2018 PDQ - NCI's Comprehensive Cancer Database

12. Neuroblastoma Treatment (PDQ®): Health Professional Version

hormones or corticosteroids can be effective for acute symptoms, but some patients do not respond to corticosteroids.[ , ] Other therapy with various immunomodulatory drugs, plasmapheresis, intravenous gamma globulin, and rituximab have been reported to be effective in select cases.[ , - ] Combination immunosuppressive therapy has been explored, with improved short-term results.[ ] The short-term neurologic outcomes may be superior in patients treated with chemotherapy, possibly because of its

2018 PDQ - NCI's Comprehensive Cancer Database

14. Management of Dengue Infection in Adults

If patient had encephalitis, CSF should also be included as samples for investigation. The liver should be placed in sterile containers and moistened with viral transport media or sterile normal saline. CSF should be submitted in sterile bijou bottle. Both should be refrigerated if there is delay in transportation. Specimen for viral investigation should be transported in ice to IMR and National Public Health Laboratory. Recommendation 2 Dengue rapid combo test or non-structural protein 1 antigen (NS1 Ag

2015 Ministry of Health, Malaysia

15. Diagnosis and Management of Aplastic Anaemia

. Grade 2C Routine prophylactic platelet transfusions are not recommended for stable AA patients not on active treatment. Grade 2B Patients with chronic bleeding of World Health Organization grade 2 or above require individual management according to the severity of their symptoms and signs. Grade 2C Prior to administration of antithymocyte globulin (ATG), a daily threshold (pre‐transfusion) platelet count of 20 × 10 9 /l should be used for the duration of the ATG course. Grade 2C Only one adult (...) globulin (ATG). Key recommendations for inherited AA Chromosomal breakage analysis of peripheral blood lymphocytes following exposure to diepoxybutane to test for FA should be performed. Grade 1B Comprehensive assessment should be performed, including family history, abdominal ultrasound, echocardiogram, high resolution computerized tomography scan of the chest and pulmonary function tests, and evaluation for other extra‐haematopoietic abnormalities (such as cirrhosis, pulmonary fibrosis or renal

2015 British Committee for Standards in Haematology

16. Brain astrocytoma misdiagnosed as anti-NMDAR encephalitis: a case report. Full Text available with Trip Pro

were positive in CSF and serum. The patient was diagnosed as anti-NMDAR encephalitis and then was treated repeatedly with large dose of intravenous corticosteroids and gamma globulin. Accordingly, the refractory nature of seizures in this case may be attributed to NMDAR autoantibodies. When the patient presented at the hospital for the third time, the brain MRI revealed an increase in the size of the frontal parietal lesion and one new lesion in the left basal ganglia. The patient underwent (...) , and central hypoventilation or autonomic dysfunction.A 67-year-old man presented with new-onset focal seizures. The brain magnetic resonance imaging (MRI) plain scan and enhanced scan showed abnormal signal on the proximal midline frontoparietal junction region. Anti-NMDAR antibody was detected in cerebrospinal fluid (CSF) and serum using a commercial kit (Euroimmune, Germany) by indirect immunofluorescence testing (IIFT) according to the manufacturer's instructions for twice. Both of the test results

2019 BMC Neurology

17. Xeljanz - tofacitinib citrate

-reactive protein CsA Cyclosporine A CSF Cerebrospinal fluid CSR Clinical study report CT Computed tomography CTA Clinical Trial Application CTD Common Technical Document CV Cardiovascular CV-SEAC Cardiovascular Safety Endpoint Adjudication Committee CYP3A4 Cytochrome P450 enzyme 3A4 CYP2C19 Cytochrome P450 enzyme 2C19 CYP450 Cytochrome P450 DAS28-4(ESR) Disease activity score defined using 28 joint counts and erythrocyte sedimentation rate DB Double-blind DDI Drug-drug interaction DILI Drug-induced (...) sedimentation rate EU European Union FDA Food and Drug Administration GBM Glomerular basement membrane GCP Good clinical practice Assessment report EMA/CHMP/425279/2013 Page 5/197 GFR Glomerular filtration rate GGT Gamma-glutamyl transferase GI Gastrointestinal HDL High density lipoprotein HLGT High level group term HLT High level term hOCT2 Human organic cationic transporter 2 HR Hazard ratio IC 50 Concentration producing 50% of inhibitory effect ICH International Committee on Harmonisation ID

2013 European Medicines Agency - EPARs

18. Stivarga - regorafenib

weeks N.D Major findings =1: Shaking of body, scratching, thinning of fur, scab formation, wounds, papules, itching, ? hematomas, ? diarrhoea and vomiting, ? Relative beta-globulin (F), ? pancreas weight (F), inspissation in gal bladder, hyaline casts, alveolar/foamy macrophages, vacuolar degener in adrenal cortex (F), spermat. giant cells, hair growth arrest, hyperkeratosis, ? number of myeloid cells in sternum =4: ? monocytes (M), ? glu, , ? Relative beta-globulin (M), ? Relative gamma-globulin (...) Cochran-Mantel-Haenszel CRC colorectal cancer CYP cytochrome P450 DCE-MRI Dynamic contrast enhanced MRI (magnetic resonance imaging) DILI drug-induced liver injury DPD dihydro-pyrimidine dehydrogenase ECG electrocardiogram ECOG Eastern Cooperative Oncology Group EGFR epidermal growth factor receptor FACS fluorescence activated cell sorter FOLFIRI folinic acid (leucovorin), 5-fluorouracil, irinotecan FOLFOX folinic acid (leucovorin), 5-fluorouracil, oxaliplatin GGT gamma glutamyl transferase HB

2013 European Medicines Agency - EPARs

19. Lonquex - lipegfilgrastim

Electrochemiluminescence E. Coli Escherichia coli ELISA Enzyme-linked immunosorbent assay EMA European Medicines Agency EMEA European Medicines Agency EORTC European Organisation for Research and Treatment of Cancer EU European Union FDA Food and Drug Administration FN Febrile neutropenia GCP Good clinical practice GGT Gamma-glutamyltransferase G-CSF Granulocyte colony stimulating factor GLP Good laboratory practice GM-CSF Granulocyte-Macrophage colony-stimulating factor hG-CSF human Granulocyte colony-stimulating (...) plan PT Preferred Term Pts Patients QoL Quality of life RBC Red blood cell RH Relative Humidity r-metHuG- CSF Recombinant N-methionyl granulocyte-colony stimulating factor SAE Serious adverse event SAP Statistical analysis plan s.c./SC Subcutaneous SD Standard deviation SmPC Summary of product characteristics SOC System organ class (MedDRA) SOC Standard of care SPC Summary of product characteristics TBSA Total body surface area TEADR Treatment-emergent adverse drug reaction TEAE Treatment emergent

2013 European Medicines Agency - EPARs

20. Provenge - autologous peripheral-blood mononuclear cells activated with prostatic acid phosphatase granulocyte-macrophage colony-stimulating factor (sipuleucel-T)

: Autologous peripheral blood mononuclear cells activated with PAP-GM-CSF (sipuleucel-T) Procedure No. EMEA/H/C/002513/0000 Note Assessment report as adopted by the CHMP with all information of a commercially confidential nature deleted. Medicinal product no longer authorised Assessment report EMA/349312/2013 Page 2/135 Table of contents 1. Background information on the procedure 6 1.1. Submission of the dossier 6 1.2. Manufacturers 7 1.3. Steps taken for the assessment of the product 7 2. Scientific (...) Deoxyribonucleic acid cDNA coding DNA DOR Duration of Response EC European Commission ECOG Eastern Cooperative Oncology Group ED50 Effective Dose 50 EDQM European Department for the Quality of Medicines ELISA Enzyme-linked immunosorbent assay ELISPOT Enzyme-linked immunosorbent spot EMA European Medicines Agency EU European Union FBS Fetal Bovine Serum FDA Food and Drug Administration FP Final product FPRC Final Product Reference Control GC Gas Chromatography GCP Good clinical practices GM-CSF Granulocyte

2013 European Medicines Agency - EPARs

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