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CNS Infection

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161. Assessment of the HIV CNS Reservoir, Neurological and Neuro-cognitive Effects, and Source of Rebound HIV in CNS

may consent to study SEARCH 026 participation and hence a maximum of 15 subjects may enroll. As this is a sub-study, data will be shared from study SEARCH 019 and no interventions (venipunctures) will be repeated unnecessarily. Condition or disease Acute HIV Infection HIV CNS Involvement Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 9 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Study SEARCH (...) Assessment of the HIV CNS Reservoir, Neurological and Neuro-cognitive Effects, and Source of Rebound HIV in CNS Assessment of the HIV CNS Reservoir, Neurological and Neuro-cognitive Effects, and Source of Rebound HIV in CNS - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2015 Clinical Trials

162. Venezuelan equine encephalitis virus infection

, headache, malaise, nausea). CNS infection can lead to long-term neurological sequelae and death, particularly in children. Occurs mainly in Central and South America, but cases have been reported in North America. Large human outbreaks have been linked to epizootic infection, in which equine species are a major amplifying host for the virus. Enzootic infection, which likely utilises rodents as amplifying hosts, may be the cause of up to 10% of cases that are clinically misdiagnosed as dengue fever (...) Venezuelan equine encephalitis virus infection Venezuelan equine encephalitis virus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Venezuelan equine encephalitis virus infection Last reviewed: February 2019 Last updated: November 2017 Summary A mosquito-borne virus that usually causes mild and self-limiting disease in humans, characterised by symptoms that resemble influenza or dengue fever (e.g., fever

2017 BMJ Best Practice

163. Surveillance of healthcare-associated infections and prevention indicators in European intensive care units: HAI-Net ICU protocol, version 2.2

Surveillance of healthcare-associated infections and prevention indicators in European intensive care units: HAI-Net ICU protocol, version 2.2 TECHNICAL DOCUMENT www.ecdc.europa.eu Surveillance of healthcare-associated infections and prevention indicators in European intensive care units HAI-Net ICU protocol, version 2.2ECDC TECHNICAL DOCUMENT Surveillance of healthcare-associated infections and prevention indicators in European intensive care units HAI-Net ICU protocol, version 2.2 ii (...) members shall not, in the performance of their duties, deal with a matter in which, directly or indirectly, they have any personal interest such as to impair their independence. Acknowledgements ECDC would like to thank the HAI-Net ICU operational contact points and Member States experts for providing input during meetings (October 2013, February 2014, February 2015), as well as the European Society of Intensive Care Medicine (Infection Section) for reviewing and commenting on the structure

2017 European Centre for Disease Prevention and Control - Technical Guidance

164. Surveillance of surgical site infections and prevention indicators in European hospitals - HAISSI protocol

Surveillance of surgical site infections and prevention indicators in European hospitals - HAISSI protocol TECHNICAL DOCUMENT www.ecdc.europa.eu Surveillance of surgical site infections and prevention indicators in European hospitals HAI-Net SSI protocol, version 2.2ECDC TECHNICAL DOCUMENT Surveillance of surgical site infections and prevention indicators in European hospitals HAI-Net SSI protocol, version 2.2 ii This report of the European Centre for Disease Prevention and Control (ECDC (...) the pilot version 2.0 in the autumn of 2016. Suggested citation: European Centre for Disease Prevention and Control. Surveillance of surgical site infections and prevention indicators in European hospitals - HAI-Net SSI protocol, version 2.2. Stockholm: ECDC; 2017. Stockholm, May 2017 PDF ISBN 978-92-9498-060-1 doi: 10.2900/260119 Catalogue number TQ-04-17-433-EN-N © European Centre for Disease Prevention and Control, 2017 Reproduction is authorised, provided the source is acknowledged TECHNICAL

2017 European Centre for Disease Prevention and Control - Technical Guidance

165. Sexually Transmitted Infections

Sexually Transmitted Infections about Sexual Health and STIs Sexually Transmitted Infections SUMMARY OF GUIDELINES 2017 July 2017 EditionSexually Transmitted Infections Education Foundation resources HPV Tollfree 0508 11 12 13 www.hpv.org.nz Health professionals’ resources 1. Guidelines for the Management of Genital, Anal and Throat HPV Infection in New Zealand – 9th Edition 2017 Only available online at www.hpv.org.nz 2. Sexually Transmitted Infections – Summary of Guidelines 2017 Patient (...) information pamphlets 1. Some Questions and Answers about HPV and Genital Warts 2. Cervical Smears and Human Papillomavirus Infection (HPV) 3. Preventing HPV Cancers by Vaccination: What Everyone Should Know 4. HPV and Men 5. HPV and Throat Cancer: Common Questions and Answers HERPES Tollfree 0508 11 12 13 www.herpes.org.nz Health professionals’ resources 1. Guidelines for the Management of Genital Herpes in New Zealand – 12th Edition 2017 Only available online at www.herpes.org.nz 2. Sexually Transmitted

2017 New Zealand Sexual Health Society

166. The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications

The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications 1 Mullish BH, et al. Gut 2018;0:1–22. doi:10.1136/gutjnl-2018-316818 Guidelines The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines Benjamin H Mullish, 1,2 (...) ) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ. 1. AbsTrACT Interest in the therapeutic potential of faecal microbiota transplant (FMT) has been increasing globally in recent years, particularly as a result of randomised studies in which it has been used as an intervention. The main focus of these studies has been the treatment of recurrent or refractory Clostridium difficile infection (CDI), but there is also an emerging evidence base regarding potential

2018 British Society of Gastroenterology

167. Management of Surgical Site Infections

Management of Surgical Site Infections 1 View background material via the SSI SR eAppendix 1 View data summaries via the SSI SR eAppendix 2 View the SSI Companion Consensus Statements SYSTEMATIC LITERATURE REVIEW ON THE MANAGEMENT OF SURGICAL SITE INFECTIONS Adopted by the American Academy of Orthopaedic Surgeons Board of Directors June 9, 2018 Douglas Lundy, MD; Alexander McLaren, MD; Peter F Sturm, MD; Sudheer Reddy, MD; Gregory S Stacy, MD; Gwo-Chin Lee, MD; Hrayr Basmajian, MD; Thomas (...) Infections. https://www.aaos.org/ssi. Published June 9, 2018. 2 View background material via the SSI SR eAppendix 1 View data summaries via the SSI SR eAppendix 2 View the SSI Companion Consensus Statements Disclaimer This Systematic literature review was developed by an AAOS physician volunteer Systematic literature review development group based on a systematic review of the current scientific and clinical information and accepted approaches to treatment and/or diagnosis. This Systematic literature

2018 American Academy of Orthopaedic Surgeons

168. CNS-derived CCL21 is both sufficient to drive homeostatic CD4+ T cell proliferation and necessary for efficient CD4+ T cell migration into the CNS parenchyma following Toxoplasma gondii infection. (PubMed)

CNS-derived CCL21 is both sufficient to drive homeostatic CD4+ T cell proliferation and necessary for efficient CD4+ T cell migration into the CNS parenchyma following Toxoplasma gondii infection. Injury, infection and autoimmune triggers increase CNS expression of the chemokine CCL21. Outside the CNS, CCL21 contributes to chronic inflammatory disease and autoimmunity by three mechanisms: recruitment of lymphocytes into injured or infected tissues, organization of inflammatory infiltrates (...) mice, although CCL21 levels in GFAP-CCL21 brains were higher than levels expressed in inflamed Toxoplasma-infected non-transgenic brains. Following Toxoplasma infection, T-cell extravasation into submeningeal, perivascular and ventricular sites of infected CNS was not CCL21-dependent, occurring even in CCL19/CCL21-deficient mice. However, migration of extravasated CD4+, but not CD8+ T cells from extra-parenchymal CNS sites into the CNS parenchyma was CCL21-dependent. CD4+ T cells preferentially

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2011 Brain, behavior, and immunity

169. CRACKCast E133 – Parasitic Infections

of malarial infection: uncomplicated and severe Uncomplicated Malaria: The patient will have symptoms of malaria The patient will have positive parasitological test The patient will NOT have signs of severe malaria Severe Malaria (Think Falciprum >>>> Vivax): Risk factors: Non-immune individuals Immunocompromised patients (including asplenic individuals) Children 6 to 36 months of age Pregnant women Features: CNS: Altered consciousness, (+/- meningismus) seizures, focal deficits (cerebral malaria) GI (...) Viral hemorrhagic fever Life-threatening infections: Secondary bacterial infection / sepsis Emerging viral illness – e.g. Ebola, MERS CoV, HIV Cerebral malaria [9] Other than malaria, list 3 other organisms that cause the following: CNS infection: Neurocysticercosis Echinococcus (hydatid cysts) African Trypanosomiasis (sleeping sickness) Trichinella spiralis Anemia: Helminthic infections (with concomitant eosinophilia) Babesiosis Whipworm Hookworm Tapeworms / flatworm / fluke Pulmonary Symptoms: E

2017 CandiEM

170. CRACKCast E083 – Infective Endocarditis and Valvular Disease

pathogenesis Exaggerated immuno. response to Group A beta-hemolytic strep. –> antibodies cross reacting with tissues in the heart/joints/skin/CNS ***anyone with a hx of ARF are predisposed to recurrent infections and heart damage ARF does not equal RHD! Rheumatic heart disease occurs 15-20 yrs post ARF as a type of acquired valvular disease Clinical Features post initial pharyngitis: latency period 1-5 weeks then signs of ARF appear >30% of people DON’T remember having pharyngitis Fever, Arthritis (...) CRACKCast E083 – Infective Endocarditis and Valvular Disease CRACKCast E083 - Infective Endocarditis and Valvular Disease - CanadiEM CRACKCast E083 – Infective Endocarditis and Valvular Disease In , by Chris Lipp June 5, 2017 This episode of CRACKCast covers Rosen’s chapter 83, Infective Endocarditis and Valvular Disease. In this exciting episode we dive deep into how to diagnose and manage IE, and also explores what every emergency physician needs to know about the spectrum of diseases

2017 CandiEM

171. Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals ? protocol version 5.3

Definition of active HAI 50 HAI case definition codes, overview 51 BSI origin (BSI source) code list 52 Case definitions of healthcare-associated infections 53 SSI: SURGICAL SITE INFECTION 53 PN: PNEUMONIA 54 UTI: URINARY TRACT INFECTION 55 BSI: BLOODSTREAM INFECTION 56 CRI: CATHETER-RELATED INFECTION 57 BJ: BONE AND JOINT INFECTION 58 CNS: CENTRAL NERVOUS SYSTEM INFECTION 59 CVS: CARDIOVASCULAR SYSTEM INFECTION 60 EENT: EYE, EAR, NOSE, THROAT, OR MOUTH INFECTION 62 LRI: LOWER RESPIRATORY TRACT INFECTION (...) Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals ? protocol version 5.3 www.ecdc.europa.eu Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals Protocol version 5.3 TECHNICAL DOCUMENT ECDC TECHNICAL DOCUMENT Point prevalence survey of healthcare- associated infections and antimicrobial use in European acute care hospitals Protocol version 5.3, ECDC PPS 2016–2017 ii

2016 European Centre for Disease Prevention and Control - Technical Guidance

172. Diagnosis and Management of Utinary Tract Infection in Long Term Care Facilities

Diagnosis and Management of Utinary Tract Infection in Long Term Care Facilities DIAGNOSIS AND MANAGEMENT OF URINARY TRACT INFECTION IN LONG TERM CARE FACILITIES Clinical Practice Guideline | January 2015 These recommendations are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. They should be used as an adjunct to sound clinical decision making. OBJECTIVE Alberta clinicians caring for residents (...) in long term care facilities (LTCF)* will: ? Increase the accuracy of clinical diagnosis of urinary tract infections (UTI) ? Reduce inappropriate prescribing of antibiotics for asymptomatic bacteriuria ? Optimize antibiotic therapy for treatment of UTI while minimizing short and long term risks associated with antibiotic use ? Optimize testing and use of laboratory services for UTI TARGET POPULATION Older adults living in LTCF *LTCF is any congregate living environment for older or disabled persons

2016 Toward Optimized Practice

173. Treatment of Helicobacter pylori Infection

Treatment of Helicobacter pylori Infection 212 The American Journal of GASTROENTEROLOGY VOLUME 112 | FEBRUARY 2017 www.nature.com/ajg CLINICAL GUIDELINES INTRODUCTION Helicobacter pylori infection remains one of the most common chronic bacterial infections aff ecting humans. Since publication of the last American College of Gastroenterology (ACG) Clinical Guideline in 2007, signifi cant scientifi c advances have been made regarding the management of H. pylori infection. Th e most signif- icant (...) advances have been made in the arena of medical treatment. Th us, this guideline is intended to provide clinicians working in North America with updated recommendations on the treatment of H. pylori infection. For the purposes of this document, we have defi ned North America as the United States and Canada. When- ever possible, recommendations are based upon the best available evidence from the world’s literature with special attention paid to literature from North America. When evidence from North

2017 American College of Gastroenterology

174. Prevention, Diagnosis & Management of infective endocarditis

Prevention, Diagnosis & Management of infective endocarditis CLINICAL PRACTICE GUIDELINES FOR THE PREVENTION, DIAGNOSIS & MANAGEMENT OF INFECTIVE ENDOCARDITISPUBLISHED BY: Clinical Practice Guidelines (CPG) Secretariat c/o Health Technology Assessment (HTA) Unit Medical Development Division Ministry of Health Malaysia 4 th floor, Block E1, Parcel E 62590 Putrajaya COPYRIGHT The owners of this publication are the National Heart Association of Malaysia (NHAM) and the Academy of Medicine Malaysia (...) committee, a multidisciplinary team will be formed for the specific purpose of updating this CPG.TABLE OF CONTENTS FORWARD BY THE DIRECTOR GENERAL OF HEALTH 4 INFECTIVE ENDOCARDITIS CLINICAL PRACTICE GUIDELINES EXPERT PANEL 5 EXTERNAL REVIEWERS 7 GRADES OF RECOMMENDATION AND LEVELS OF EVIDENCE 10 RATIONALE AND PROCESS OF THE INFECTIVE ENDOCARDITIS GUIDELINES DEVELOPMENT 11 SUMMARY OF THE CLINICAL PRACTICE GUIDELINES FOR THE PREVENTION, DIAGNOSIS AND MANAGEMENT OF INFECTIVE ENDOCARDITIS 15 1.0

2017 Ministry of Health, Malaysia

175. [Clinical trial of the antibacterial combination sulfamoxole/trimethoprim (CN 3123). 2. Results of a multicenter clinical trial of CN 3123 in infections of the kidneys and urinary tract]. (PubMed)

[Clinical trial of the antibacterial combination sulfamoxole/trimethoprim (CN 3123). 2. Results of a multicenter clinical trial of CN 3123 in infections of the kidneys and urinary tract]. During the clinical trial of N1-(4,5-dimethyl-2-oxazolyl)-sulfanilamide (sulfamoxole) and 2,4-diamino-5-(3,4,5-trimethoxy-benzyl)-pyrimidine (trimethoprim) (CN 3123, Nevin, Supristol) results from 925 treated cases of bacterial infections of the urinary organs were documented. The analysis revealed (...) or, in mixed infections, not all the strains of pathogen were eradicated. 2. There was a higher success rate in acute urinary tract infections which had not previously been treated than in chronic or previously treated cases. 3. The therapeutic results in the principal indications were as follows: Pyelonephritis: 73.9% good and 16.5% fair effect clinically; 63.6% good and 21.6% some effect bacteriologically. Pyelitis: 81.1% good and 18.9% fair effect clinically; 70.4% good and 25.9% some effect

1976 Arzneimittel-Forschung

176. MyD88 is crucial for the development of a protective CNS immune response to Toxoplasma gondii infection (PubMed)

MyD88 is crucial for the development of a protective CNS immune response to Toxoplasma gondii infection Toxoplasmosis is one of the most common parasitic infections in humans. It can establish chronic infection and is characterized by the formation of tissue cysts in the brain. The cysts remain largely quiescent for the life of the host, but can reactivate and cause life-threatening toxoplasmic encephalitis in immunocompromised patients, such as those with AIDS, neoplastic diseases and organ (...) transplants. Toll-like receptor (TLR) adaptor MyD88 activation is required for the innate sensing of Toxoplasma gondii. Mice deficient in MyD88 have defective IL-12 and Th1 effector responses, and are highly susceptible to the acute phase of T. gondii infection. However, the role of this signaling pathway during cerebral infection is poorly understood and requires examination.MyD88-deficient mice and control mice were orally infected with T. gondii cysts. Cellular and parasite infiltration

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2013 Journal of neuroinflammation

177. Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection (PubMed)

different antimicrobial classes. Patients were classified into MDRGNB culture-positive (MDRGNB-CP; 125 patients) and culture-negative (MDRGNB-CN; 692 patients) groups based on the presence or absence of any MDRGNB identified from either active surveillance or clinical cultures during index hospitalization. Subsequent MDRGNB infection and mortality within 12 months after index hospitalization were recorded. We determined the frequency and risk factors for subsequent MDRGNB infection and mortality (...) associated with previous MDRGNB culture status.In total, 129 patients had at least one subsequent MDRGNB infection (MDRGNB-CP, 48.0%; MDRGNB-CN, 10.0%), and 148 patients died (MDRGNB-CP, 31.2%; MDRGNB-CN, 15.9%) during the follow-up period. MDR Escherichia coli and Acinetobacter baumannii were the predominant colonization microorganisms; patients with Proteus mirabilis and Pseudomonas aeruginosa had the highest hazard risk for developing subsequent infection. After controlling for other confounders

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2018 Antimicrobial resistance and infection control

178. Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques (PubMed)

Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques Studies utilizing highly pathogenic simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) have largely focused on the immunopathology of the central nervous system (CNS) during end-stage neurological AIDS and SIV encephalitis. However, this may not model pathophysiology in earlier stages of infection. In this nonaccelerated (...) , and activated microglial cells. Rare SHIV-infected cells in the brain parenchyma and meninges were identified by RNAScope in situ hybridization. In the meninges, there was also a trend toward increased CD4+ infiltration in SHIV-infected animals but no differences in CD68/CD163+ cells between SHIV-infected and uninfected control animals. These data suggest that in a model that closely recapitulates human disease, CNS inflammation and SHIV in CSF are predominantly mediated by T cell-mediated processes during

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2018 Journal of virology

179. Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women

Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03633721 Recruitment Status

2018 Clinical Trials

180. Do Culture-Negative Periprosthetic Joint Infections Have a Worse Outcome Than Culture-Positive Periprosthetic Joint Infections? A Systematic Review and Meta-Analysis (PubMed)

Do Culture-Negative Periprosthetic Joint Infections Have a Worse Outcome Than Culture-Positive Periprosthetic Joint Infections? A Systematic Review and Meta-Analysis Culture-negative periprosthetic joint infections (CN PJI) have not been well studied, and due to the lack of consensus on PJI, especially with culture-negative infections, there are considerable uncertainties. Due to the challenging clinical issue of CN PJI the aim of this systematic review is to describe incidence, diagnosis (...) as the antibiotic treatment, alone or in combination with other antibiotics. The rate of succesfully treated infections varied from 85% to 95 % in all included studies. The two-stage exchange arthroplasty had the best outcome, based on the infection-free survival rate of 95%, five years after treatment.We conclude that CN PJI have the same or even better results than culture-positive infections. Nonetheless, a standardized diagnostic protocol and evidence-based treatment strategies for CN PJI should

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2018 BioMed research international

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