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CNS Infection

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61. A Clinical Trial to Evaluate the Reversibility of Abacavir/Lamivudine/Dolutegravir CNS-Related Neurotoxicity After Switching to Tenofovir/Alafenamide/Emtricitabine/Darunavir/Cobicistat (TAF/FTC/DRV/c)

): Fundacion SEIMC-GESIDA Study Details Study Description Go to Brief Summary: A phase IV, multicentre, randomised, open-label, pilot clinical trial to evaluate the Reversibility of abacavir/lamivudine/dolutegravir ( ABC/3TC/DTG) CNS-Related Neurotoxicity After Switching to tenofovir alafenamide/emtricitabine/darunavir/cobicistat (TAF/FTC/DRV/c) Condition or disease Intervention/treatment Phase HIV Infections Drug: Symtuza® (TAF/FTC/DRV/c) Drug: ABC/3TC/DTG + Symtuza® (TAF/FTC/DRV/c) Phase 4 Detailed (...) that the patient meets this criterion. A positive screening test for sleep disorders detected using the sleep quality index (Pittsburgh ). Exclusion Criteria: Determination of at least one HIV viral load ≥ 50 copies/mL in the last 12 weeks. Allergy, intolerance or existence of resistance mutations to any of the components of TAF/FTC/DRV/c. History of active CNS infections. Active psychosis, major depression with psychotic symptoms or autolytic ideation. Dementia or mental retardation. Drug use with a diagnosis

2018 Clinical Trials

62. Nitrosporeusine analogue ameliorates Chandipura virus induced inflammatory response in CNS via NFκb inactivation in microglia (PubMed)

Nitrosporeusine analogue ameliorates Chandipura virus induced inflammatory response in CNS via NFκb inactivation in microglia Chandipura Virus (CHPV), a negative-stranded RNA virus belonging to the Rhabdoviridae family, has been previously reported to bring neuronal apoptosis by activating several factors leading to neurodegeneration. Following virus infection of the central nervous system, microglia, the ontogenetic and functional equivalents of macrophages in somatic tissues gets activated (...) and starts secreting chemokines, thereby recruiting peripheral leukocytes into the brain parenchyma. In the present study, we have systemically examined the effect of CHPV on microglia and the activation of cellular signalling pathways leading to chemokine expression upon CHPV infection. Protein and mRNA expression profiles of chemokine genes revealed that CHPV infection strongly induces the expression of CXC chemokine ligand 10 (CXCL10) and CC chemokine ligand 5 (CCL5) in microglia. CHPV infection

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2018 PLoS neglected tropical diseases

63. Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins (PubMed)

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins Deficiency in the cytosolic DNA sensor RNA Polymerase III (POL III) was recently described in children with severe varicella-zoster virus (VZV) infection in the CNS or lungs. Here, we describe a pair of monozygotic female twins, who both experienced severe recurrent CNS vasculitis caused by VZV reactivation. The clinical presentation and findings included recurrent episodes of headache, dizziness (...) impaired antiviral and inflammatory responses to the POL III agonist poly(dA:dT) and increased viral replication compared with controls.Altogether, these cases add genetic and immunologic evidence to the novel association between defects in sensing of AT-rich DNA present in the VZV genome and increased susceptibility to severe manifestations of VZV infection in the CNS in humans.

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2018 Neurology® neuroimmunology & neuroinflammation

64. Polymorphisms in Cytochrome P450 are associated with Extensive Efavirenz Pharmacokinetics and CNS Toxicities in an HIV Cohort in Botswana (PubMed)

Polymorphisms in Cytochrome P450 are associated with Extensive Efavirenz Pharmacokinetics and CNS Toxicities in an HIV Cohort in Botswana Inter-individual variability in efavirenz (EFV) pharmacokinetics and dynamics is dominantly driven by the polymorphism in cytochrome P450 (CYP) isoenzyme 2B6 516G>T. We hypothesized that additional CYP polymorphisms mediate the relationship between CYP2B6 516G>T, EFV metabolism, and clinical events. We investigated 21 SNPs in 814 HIV-infected adults (...) to intermediate metabolizers. Composite CYP2B6 metabolism was not associated with composite early treatment failure. In conclusion, our data suggest that CNS-related toxicities might not be solely the result of super-therapeutic parent EFV concentrations in HIV-infected individuals in patients of African ancestry.

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2018 The pharmacogenomics journal

65. Phase I study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreo-retinal lymphoma. (PubMed)

Phase I study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreo-retinal lymphoma. The combination of pomalidomide (POM) and dexamethasone (DEX) was evaluated for relapsed/refractory primary central nervous system lymphoma (PCNSL) and primary vitreoretinal lymphoma (PVRL) to determine the maximal tolerated dose (MTD) of POM as the primary objective, and overall response rate (ORR), progression-free survival (PFS), and safety profile as secondary objectives (...) (8%). Grade 3/4 nonhematologic toxicities included lung infection (12%), sepsis (4%), fatigue (8%), syncope (4%), dyspnea (4%), hypoxia (4%), respiratory failure (8%), and rash (4%). POM/DEX treatment is feasible with significant therapeutic activity against relapsed/refractory PCNSL and PVRL. This trial was registered at www.clinicaltrials.gov as #NCT01722305.© 2018 by The American Society of Hematology.

2018 Blood

66. Severe CNS angiostrongyliasis in a young marine: a case report and literature review. (PubMed)

Severe CNS angiostrongyliasis in a young marine: a case report and literature review. Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis worldwide. Infection typically occurs through ingestion of undercooked molluscs or vegetables contaminated by infective larvae. Endemic regions were previously limited to southeast Asia and the Pacific basin; however, this parasite is seeing an alarming increase in global distribution with reported cases in more than 30 countries (...) , including several states in the USA. Although infection typically results in meningitis, a broad spectrum of CNS involvement and severity is emerging as diagnostic methods (such as real-time PCR) continue to improve diagnosis. In this Grand Round, we report a case of a 20-year-old active duty US marine serving in Okinawa, Japan, afflicted with severe CNS angiostrongyliasis marked by radiculomyelitis with quadriparesis, hyperaesthesia, and urinary retention. We present this case to highlight

2018 Lancet infectious diseases

67. Congenital Zika Syndrome and Extra-CNS detection of Zika virus in a pre-term newborn in Mexico. (PubMed)

Congenital Zika Syndrome and Extra-CNS detection of Zika virus in a pre-term newborn in Mexico. During pregnancy, the Zika virus (ZIKV) replicates in the placenta and central nervous system (CNS) of infected fetuses; nevertheless, the ability of ZIKV to replicate in other fetal tissues has not been extensively characterized.We researched whether dissemination of congenitally-acquired ZIKV outside the CNS exists by searching for the accumulation of the viral envelope protein, ZIKV ribonucleic (...) -Barr) and the thymus, kidneys, and adrenal glands (human herpesvirus 6). The kidneys were identified as a significant niche for viral replication, given that infectious particles were successfully isolated from renal tissues.Our findings demonstrate the ability of congenitally-acquired ZIKV to produce disseminated infections and the viral tropism towards epithelial cells.© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.

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2018 Clinical Infectious Diseases

68. Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites. (PubMed)

Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites. There are limited data on the pharmacogenetics and pharmacokinetics of the CNS penetration of efavirenz.We investigated genetic polymorphisms associated with CSF concentrations of efavirenz and its metabolites and explored the relationships with neurocognitive performance.We included 47 HIV-infected South African black adults with and without HIV-associated neurocognitive disorder on efavirenz/tenofovir

2018 Journal of Antimicrobial Chemotherapy

69. The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus. (PubMed)

The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus. OBJECTIVE What determines the extent of tissue destruction during brain abscess formation is not known. Pyogenic brain infections cause destruction of brain tissue that greatly exceeds the area occupied by microbes, as seen in experimental studies, pointing to cytotoxic factors other than microbes in pus. This study examined whether brain abscess pus contains cytotoxic (...) of the identified proteins have well-known neurotoxic effects, e.g., eosinophil cationic protein and nonsecretory ribonuclease (also known as eosinophil-derived neurotoxin). The cellular response to brain infection was highly complex, as reflected by the presence of proteins that were specific for neutrophils, eosinophils, macrophages, platelets, fibroblasts, or mast cells in addition to plasma and erythrocytic proteins. Other proteins (neurofilaments, myelin basic protein, and glial fibrillary acidic protein

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2017 Journal of Neurosurgery

70. Aggressive Antipyretics for Fever Reduction in CNS Malaria

and malaria parasite behavior is complex. Additional in vitro data suggest that at febrile temperatures uninfected red blood cells (RBCs) are more likely to adhere to infected RBCs, worsening the process of sequestration, increasing the parasite burden obstructing microvascular cerebral blood flow, and perhaps contributing to ongoing immunopathogenesis in CNS malaria. In this exploratory clinical trial of aggressive antipyretic therapy, children hospitalized with CNS malaria will be randomized to usual (...) a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 2 Years to 11 Years (Child) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Evidence of P. falciparum malaria infection by peripheral blood smear or rapid diagnostic test CNS symptoms associated with malaria. CEREBRAL MALARIA: Impaired

2017 Clinical Trials

71. Endovascular treatment of HIV-associated spontaneous common carotid artery pseudoaneurysm in a case of miliary and CNS tuberculosis. (PubMed)

Endovascular treatment of HIV-associated spontaneous common carotid artery pseudoaneurysm in a case of miliary and CNS tuberculosis. HIV and tuberculosis infections are known to be associated with vasculopathy including occlusive disease and aneurysm formation. We report a case of 43-year-old male with miliary and central nervous system (CNS) tuberculosis; recently, diagnosed as HIV seropositive, on antiretroviral and antitubercular treatment presenting with painful neck swelling. He was found

2017 British Journal of Neurosurgery

72. Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudinal analysis of T cell subsets. (PubMed)

Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudinal analysis of T cell subsets. HIV-infected patients may present an unforeseen clinical worsening after initiating antiretroviral therapy known as immune reconstitution inflammatory syndrome (IRIS). This syndrome is characterized by a heightened inflammatory response toward infectious or non-infectious triggers, and it may affect different organs. Diagnosis of IRIS involving the central nervous system (CNS-IRIS (...) and dorsal spinal cord lesions, compatible with paradoxical toxoplasmosis-associated CNS-IRIS, a condition with very few reported cases. A stereotactic biopsy was planned but was postponed based on its inherent risks. Patient showed clinical improvement with no requirement of corticosteroid therapy. Routine laboratorial analysis was complemented with longitudinal evaluation of blood T cell subsets at 0, 1, 2, 3 and 6 months upon HAART initiation. A control group composed by 9 HIV-infected patients from

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2017 BMC Infectious Diseases

73. Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn's Disease: Report of the TOSCA Study: MADCAM-1Antibody and CNS Immune Surveillance. (PubMed)

Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn's Disease: Report of the TOSCA Study: MADCAM-1Antibody and CNS Immune Surveillance. Progressive multifocal leukoencephalopathy [PML], a brain infection associated with anti-integrin drugs that inhibit lymphocyte translocation from bloodstream to tissue, can be fatal. Decreased central nervous system [CNS] immune surveillance leading to this infection has been reported in patients (...) subsets, or CD4:CD8 ratio, whereas circulating β7+ memory cells increased significantly. A total of 28/35 [80%] patients had a clinical response and 27/34 [79%] had disease remission. Treatment-related adverse events, none serious, were reported in 23/49 [47%] patients.In patients with active Crohn's disease, natalizumab therapy increases the risk for PML, and the increased risk is thought to be associated with iatrogenic leukopenia within the CNS. PML under PF-00547659 may be a lesser concern

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2017 Journal of Crohn's & colitis

74. Concept Clearance » Altered Neural Pathways, Receptors and Networks in HIV-induced CNS Dysfunction

Concept Clearance » Altered Neural Pathways, Receptors and Networks in HIV-induced CNS Dysfunction NIMH » Altered Neural Pathways, Receptors and Networks in HIV-induced CNS Dysfunction Mental Health Information Outreach Research Funding News & Events About Us Transforming the understanding and treatment of mental illnesses. Search the NIMH Website: > > > Concept Clearance • February 9, 2017 Presenter: Dianne Rausch, Ph.D. Division of AIDS Research Goal: The goal of this initiative (...) is to encourage research on understanding altered neuronal networks and pathways in HIV-1 induced central nervous system (CNS) dysfunction in the context of viral suppression and antiretroviral therapy (ART), by utilizing novel research models and diagnostic tools to bridge the gap between pathogenesis research and observed clinical outcomes. Rationale: The majority of the basic NeuroAIDS research has focused on outcomes seen in the pre-antiretroviral therapy (ART) era. Such efforts focus on neuronal damage

2017 NIMH blog

75. NMES to Improve Eyelid Functions in Cranial Nerve (CN) III and VII Palsy

: Idiopathic onset of CN III and/or CN IV palsy. Traumatic injury to the eye or eyelid. Active wounds in the treatment area. Presence of swelling or infection in or surrounding the affected eye. Diminished sensation in the area to be treated. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its (...) NMES to Improve Eyelid Functions in Cranial Nerve (CN) III and VII Palsy NMES to Improve Eyelid Functions in Cranial Nerve (CN) III and VII Palsy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NMES

2017 Clinical Trials

76. Phase I Study of APX005M in Pediatric CNS Tumors

Phase I Study of APX005M in Pediatric CNS Tumors Phase I Study of APX005M in Pediatric CNS Tumors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Phase I Study of APX005M in Pediatric CNS Tumors The safety (...) system tumor that is growing, spreading, or getting worse (progressive), or newly diagnosed diffuse intrinsic pontine glioma. APX005M can trigger activation of B cells, monocytes, and dendritic cells and stimulat cytokine release from lymphocytes and monocytes. APX005M can mediate a direct cytotoxic effect on CD40+ tumor cells. Condition or disease Intervention/treatment Phase Glioblastoma Multiforme High-grade Astrocytoma NOS CNS Primary Tumor, Nos Ependymoma, NOS Diffuse Intrinsic Pontine Gliomas

2017 Clinical Trials

77. Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers

Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03173950 Recruitment Status : Recruiting First Posted : June 2, 2017 Last Update Posted : March

2017 Clinical Trials

78. E6201 for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS)

E6201 for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) E6201 for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. E6201 for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03332589 Recruitment Status : Recruiting First Posted : November 6

2017 Clinical Trials

79. Study Of Durvalumab and Lenalidomide In R/R EBV Associated DLBCL Subtypes, Primary CNS And Testicular DLBCL

Study Of Durvalumab and Lenalidomide In R/R EBV Associated DLBCL Subtypes, Primary CNS And Testicular DLBCL Study Of Durvalumab and Lenalidomide In R/R EBV Associated DLBCL Subtypes, Primary CNS And Testicular DLBCL - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Study Of Durvalumab and Lenalidomide In R/R EBV Associated DLBCL Subtypes, Primary CNS And Testicular DLBCL (DuRIANS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03212807 Recruitment Status : Withdrawn (FDA Hold for Combination Studies

2017 Clinical Trials

80. Biomarker Driven Intensified ChemoImmunotherapy With Early CNS Prophylaxis

Biomarker Driven Intensified ChemoImmunotherapy With Early CNS Prophylaxis Biomarker Driven Intensified ChemoImmunotherapy With Early CNS Prophylaxis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Biomarker Driven Intensified ChemoImmunotherapy With Early CNS Prophylaxis (Bio-CHIC) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03293173 Recruitment Status : Recruiting First Posted : September 26, 2017 Last Update

2017 Clinical Trials

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