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CNS Infection

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41. A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5 Full Text available with Trip Pro

A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5 As one of the key members of the coxsackievirus B group, coxsackievirus B5 (CV-B5) can cause many central nervous system diseases, such as viral encephalitis, aseptic meningitis, and acute flaccid paralysis. Notably, epidemiological data indicate that outbreaks of CV-B5-associated central nervous system (CNS) diseases have been reported worldwide throughout history. In this study, which was conducted (...) and can sustain CNS infections in a manner similar to that observed in humans. This model will be a useful tool for studies on pathogenesis, vaccines, and anti-viral drug evaluations.

2018 Emerging Microbes & Infections

42. Central Nervous System Infections in Denmark

of Infections of the Brain Information provided by (Responsible Party): Jacob Bodilsen, Aalborg Universitetshospital Study Details Study Description Go to Brief Summary: The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by a prospective registration of clinical characteristics and outcome of all adult (>17 years of age) patients (...) with community-acquired CNS infections diagnosed and/or treated at departments of infectious diseases in Denmark since 1st of January 2015. Condition or disease Intervention/treatment Central Nervous System Infections Bacterial Meningitis Viral Meningitis Aseptic Meningitis Encephalitis Brain Abscess Neuroborreliosis Neurosyphilis Lyme Disease Tertiary Syphilis Cerebral Abscess Meningitis Other: Community-acquired CNS infections Detailed Description: The investigators include data on diagnosis at admission

2018 Clinical Trials

43. Longitudinal Association Between Human Parechovirus Central Nervous System Infection And Gross-motor Neurodevelopment in Young Children. (Abstract)

Longitudinal Association Between Human Parechovirus Central Nervous System Infection And Gross-motor Neurodevelopment in Young Children. A paucity of studies investigated the association between human parechovirus (HPeV) central nervous system (CNS) infection and motor and neurocognitive development of children. This study describes the gross-motor function (GMF) in young children during 24 months after HPeV-CNS infection compared with children in whom no pathogen was detected.GMF of children (...) was assessed with Alberta Infant Motor Scale, Bayley Scales of Infant and Toddler Development or Movement Assessment Battery for Children. We conducted multivariate analyses and adjusted for age at onset, maternal education and time from infection.Of 91 included children, at onset <24 months of age, 11 had HPeV-CNS infection and in 47 no pathogen was detected. Nineteen children were excluded because of the presence of other infection, preterm birth or genetic disorder, and in 14 children, parents refused

2018 Pediatric Infectious Dsease Journal

44. BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system Full Text available with Trip Pro

66985, we demonstrated that the virus is capable of invading and damaging the host's central nervous system (CNS). Brain and cerebellum of infected animals revealed histological alterations such as the presence of inflammatory infiltrates, thickening of pia matter and disorganization of white matter. Additionally, it was also seen that infection lead to altered morphology of neuroglial cells and apoptotic cell death. Such observations highlighted possible alterations that DENV may promote (...) BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system Dengue is a mild flu-like arboviral illness caused by dengue virus (DENV) that occurs in tropical and subtropical countries. An increasing number of reports have been indicating that dengue is also associated to neurological manifestations, however, little is known regarding the neuropathogenesis of the disease. Here, using BALB/c mice intravenously infected with DENV-2 strain

2018 Scientific reports

45. Diagnostic accuracy of the FilmArray Meningitis / Encephalitis (ME) panel for the diagnosis of infections of the Central Nervous System. Systematic review of the literature

Diagnostic accuracy of the FilmArray Meningitis / Encephalitis (ME) panel for the diagnosis of infections of the Central Nervous System. Systematic review of the literature Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability

2020 PROSPERO

46. Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China Full Text available with Trip Pro

Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living with HIV in China is limited.Intensive cerebrospiral fluid (CSF) testing was performed to evaluate for bacterial, viral (...) %) for CMV, 2 (3.7%) for VZV, 1 (1.9%) for EBV, 1 (1.9%) for HHV-6 and 1 (1.9%) for JCV. No patient was positive for HSV. Pathogen-based treatment and high GCS score tended to have a lower mortality rate, whereas patients with multiple pathogens infection, seizures or intracranial hypertension showed higher odds of death.CNS OIs are frequent and multiple pathogens often coexist in CSF. Cryptococcal meningitis is the most prevalent CNS disorders among AIDS. The utility of molecular diagnostics

2017 AIDS research and therapy

47. Differences between central nervous system infection and neuropsychiatric systemic lupus erythematosus in patients with systemic lupus erythematosus Full Text available with Trip Pro

Differences between central nervous system infection and neuropsychiatric systemic lupus erythematosus in patients with systemic lupus erythematosus Objective Neuropsychiatric systemic lupus erythematosus (NPSLE) is a manifestation of systemic lupus erythematosus (SLE). Central nervous system (CNS) infection is a consequence of intensive immunosuppressive therapy that patients with SLE might undergo. This study aimed to compare the differences between NPSLE and CNS infections in patients (...) with SLE. Methods Patients with SLE and NPSLE or CNS infections were retrospectively reviewed. Clinical manifestations, laboratory test results, and prognoses were recorded. The independent sample t-test or chi-square test was used to compare data. Results Patients with CNS infections (n = 20) had more serious headache, high fever (>39.0°C), and vomiting compared with patients with NPSLE (n = 48). Patients with CNS infections also had a larger prednisone dose at the time of symptom onset, larger

2017 The Journal of international medical research

48. Raised Frequency of Central Nervous System Malformations Related to Zika Virus Infection in Two Birth Defects Surveillance Systems in Bogotá and Cali, Colombia. (Abstract)

Raised Frequency of Central Nervous System Malformations Related to Zika Virus Infection in Two Birth Defects Surveillance Systems in Bogotá and Cali, Colombia.

2017 Pediatric Infectious Dsease Journal

49. E6201 for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS)

E6201 for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) E6201 for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. E6201 for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03332589 Recruitment Status : Recruiting First Posted : November 6

2017 Clinical Trials

50. Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn's Disease: Report of the TOSCA Study: MADCAM-1Antibody and CNS Immune Surveillance. Full Text available with Trip Pro

Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn's Disease: Report of the TOSCA Study: MADCAM-1Antibody and CNS Immune Surveillance. Progressive multifocal leukoencephalopathy [PML], a brain infection associated with anti-integrin drugs that inhibit lymphocyte translocation from bloodstream to tissue, can be fatal. Decreased central nervous system [CNS] immune surveillance leading to this infection has been reported in patients (...) with multiple sclerosis or Crohn's disease treated with anti-integrin antibody natalizumab. PF-00547659 is an investigational human monoclonal antibody for inflammatory bowel disease, targeted against α4β7-mucosal addressin cell-adhesion molecule-1 [the integrin ligand selectively expressed in the gut]. We hypothesised that this selective agent would not affect central nervous system immune surveillance.Cerebrospinal fluid from five healthy volunteers, and from 10 patients with Crohn's disease previously

2017 Journal of Crohn's & colitis

51. A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous

: Recruiting First Posted : August 10, 2018 Last Update Posted : March 4, 2019 See Sponsor: Hoffmann-La Roche Information provided by (Responsible Party): Hoffmann-La Roche Study Details Study Description Go to Brief Summary: This study will evaluate the efficacy and safety of cobimetinib plus atezolizumab in participants with BRAFV600 wild-type melanoma with central nervous system (CNS) metastases and of cobimetinib plus atezolizumab and vemurafenib in BRAFV600 mutation-positive melanoma patients with CNS (...) A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma

2018 Clinical Trials

52. Hyperpyrexia in life-threatening central nervous system infection – It is the timepoint of fever which matters: A plea to select the best timing and optimal methods of temperature management Full Text available with Trip Pro

Hyperpyrexia in life-threatening central nervous system infection – It is the timepoint of fever which matters: A plea to select the best timing and optimal methods of temperature management 30276323 2018 11 14 2455-4626 3 4 2017 Oct-Dec Brain circulation Brain Circ Hyperpyrexia in life-threatening central nervous system infection - It is the timepoint of fever which matters: A plea to select the best timing and optimal methods of temperature management. 183-185 10.4103/bc.bc_31_17 Erich (...) 27;310(20):2174-83 24105303 Nat Rev Immunol. 2017 Mar;17(3):208-214 28163301 Crit Care Med. 2004 Feb;32(2):559-64 14758179 Ther Hypothermia Temp Manag. 2015 Sep;5(3):126-34 25875898 Brain. 2003 May;126(Pt 5):1015-25 12690042 N Engl J Med. 2002 Nov 14;347(20):1549-56 12432041 PLoS One. 2014 Mar 25;9(3):e91976 24667767 Neurocrit Care. 2011 Sep;15(2):287-94 21755388 Stroke. 2010 Dec;41(12):2969-72 21030704 Int J Infect Dis. 2016 Oct;51:73-77 27418580 Clin Microbiol Infect. 2017 Sep;23(9):601-606

2017 Brain Circulation

53. Central Nervous System Infection Associated with <i>Orientia tsutsugamushi</i> in South Korea. Full Text available with Trip Pro

Central Nervous System Infection Associated with Orientia tsutsugamushi in South Korea. Orientia tsutsugamushi is a major cause of vector-borne infection in Asia. Prompt recognition and appropriate treatment are crucial because of its potentially fatal complications and lack of response to beta-lactam antibiotics. The present study retrospectively evaluated the clinical characteristics and laboratory findings of 16 patients with scrub typhus-related central nervous system (CNS (...) with CNS infections in scrub typhus endemic areas.

2017 American Journal of Tropical Medicine & Hygiene

54. Invasive mold infections of the central nervous system in patients with hematologic cancer or stem cell transplantation (2000-2016): uncommon, with improved survival but still deadly often. (Abstract)

Invasive mold infections of the central nervous system in patients with hematologic cancer or stem cell transplantation (2000-2016): uncommon, with improved survival but still deadly often. Historically considered to have very poor outcome, there is paucity of recent data regarding invasive mold infections (IMIs) of the central nervous system (CNS) in patients with hematologic cancer (HC) or stem cell transplantation (SCT).We reviewed the records of HC patients and/or SCT recipients who were (...) . In multivariate analysis, co-infection was associated with increased (p = 0.005), while steroid tapering was associated with decreased mortality (p = 0.01).Although less lethal, improved outcome in these uncommon infections was related only to immune response in histopathology, steroid tapering and possibly surgical drainage. In a contemporary 16-year cohort of 40 patients with hematologic cancer and mold infections of Central Nervous System, 42-day mortality was 48%. Improved survival was related to immune

2017 Journal of Infection

55. Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense infection. Full Text available with Trip Pro

Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense infection. The progression of human African trypanosomiasis from the early hemolymphatic stage to the late meningoencephalitic stage is of critical diagnostic importance as it determines the choice of potentially toxic drug regimens. Current diagnostic criteria involving analysis of cerebrospinal fluid (CSF) for parasites and/or pleocytosis are sensitive, but recent evidence suggests that specificity may (...) and reduced concentrations of mannose and urea were discriminatory for the presentation of daytime somnolence and gait ataxia.CSF metabolite concentrations provide markers for neuroinflammatory responses during central nervous system (CNS) invasion by trypanosomes and are associated with the presentation of neurological disturbances independently of disease stage determined by current criteria. This suggests that applying a dichotomous-stage diagnosis on the basis of CSF pleocytosis does not accurately

2017 Journal of Infectious Diseases

56. Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil. Full Text available with Trip Pro

Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil. Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations.We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult patients from Campinas (...) -10), and hepatocyte growth factor differentiated between patients with or without neurological complications. Interestingly, higher levels of interleukin 22, monocyte chemoattractant protein 1, TNF-α, and IP-10 were observed in ZIKV-infected pregnant women carrying fetuses with fetal growth-associated malformations. Notably, infants with congenital central nervous system deformities had significantly higher levels of interleukin 18 and IP-10 but lower levels of hepatocyte growth factor than those

2017 Journal of Infectious Diseases

57. Dynamic and direct pathogen loads surveillance to reflect disease progression and therapeutic efficacy in central nervous system infection using a novel semi-quantitive sequencing platform. (Abstract)

Dynamic and direct pathogen loads surveillance to reflect disease progression and therapeutic efficacy in central nervous system infection using a novel semi-quantitive sequencing platform. 29146298 2018 02 13 1532-2742 76 3 2018 Mar The Journal of infection J. Infect. Dynamic and direct pathogen load surveillance to monitor disease progression and therapeutic efficacy in central nervous system infection using a novel semi-quantitive sequencing platform. 307-310 S0163-4453(17)30353-5 10.1016 (...) /j.jinf.2017.11.002 Ai Jing-Wen JW Department of infectious disease, Huashan Hospital of Fudan University, Shanghai, China. Zhang Hao-Cheng HC Department of infectious disease, Huashan Hospital of Fudan University, Shanghai, China. Cui Peng P Department of infectious disease, Huashan Hospital of Fudan University, Shanghai, China. Xu Bin B Department of infectious disease, Huashan Hospital of Fudan University, Shanghai, China. Gao Yan Y Department of infectious disease, Huashan Hospital of Fudan

2017 Journal of Infection

58. The aetiologies of central nervous system infections in hospitalised Cambodian children. Full Text available with Trip Pro

The aetiologies of central nervous system infections in hospitalised Cambodian children. Central nervous system (CNS) infections are an important cause of childhood morbidity and mortality. The aetiologies of these potentially vaccine-preventable infections have not been well established in Cambodia.We did a one year prospective study of children hospitalised with suspected CNS infection at Angkor Hospital for Children, Siem Reap. Cerebrospinal fluid specimens (CSF) samples underwent culture (...) , multiplex PCR and serological analysis to identify a range of bacterial and viral pathogens. Viral metagenomics was performed on a subset of pathogen negative specimens.Between 1st October 2014 and 30th September 2015, 284 analysable patients were enrolled. The median patient age was 2.6 years; 62.0% were aged <5 years. CSF white blood cell count was ≥10 cells/μL in 116/272 (42.6%) cases. CNS infection was microbiologically confirmed in 55 children (19.3%). Enteroviruses (21/55), Japanese encephalitis

2017 BMC Infectious Diseases

59. Central Nervous System Infections Associated with Immunosuppressive Therapy for Rheumatic Disease. Full Text available with Trip Pro

Central Nervous System Infections Associated with Immunosuppressive Therapy for Rheumatic Disease. Patients on immunosuppressive therapy for rheumatic diseases are at increased risk of infection. Although infections of the central nervous system (CNS) are less common compared with other sites, patients on broadly immunosuppressive and biologic immunomodulatory agents may be susceptible to more severe, disseminated forms of infection, including of the CNS. Certain key principles regarding (...) infection risk apply across immunosuppressive therapies, including increased risk with higher doses and longer duration of therapy and with combination therapy. Providers should be aware of the CNS infection risk related to immunosuppressant use to help guide best practices for screening and prophylaxis.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 Rheumatic Diseases Clinics of North America

60. Central Nervous System Infection Diagnosis by Next-Generation Sequencing: A Glimpse Into the Future? Full Text available with Trip Pro

Central Nervous System Infection Diagnosis by Next-Generation Sequencing: A Glimpse Into the Future? Japanese encephalitis virus was detected by deep sequencing for the first time in urine of a 16-year-old boy with encephalitis. Seroconversion and polymerase chain reaction analysis confirmed the metagenomics finding. Urine is useful for diagnosis of flaviviral encephalitis, whereas deep sequencing can be a panpathogen assay for the diagnosis of life-threatening infectious diseases.

2017 Open forum infectious diseases

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