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1. Adding a second surprise question triggers general practitioners to increase the thoroughness of palliative care planning: results of a pilot RCT with cage vignettes. Full Text available with Trip Pro

Adding a second surprise question triggers general practitioners to increase the thoroughness of palliative care planning: results of a pilot RCT with cage vignettes. In our aging society, palliative care should be a standard component of health care. However, currently it is only provided to a small proportion of patients, mostly to those with cancer, and restricted to the terminal phase. Many general practitioners (GPs) say that one of their most significant challenges is to assess the right (...) moment to start anticipatory palliative care. The "Surprise Question" (SQ1: "Would I be surprised if this patient were to die in the next 12 months"?), if answered with "no", is an easy tool to apply in identifying patients in need of palliative care. However, this tool has a low specificity. Therefore, the aim of our pilot study was to determine if adding a second, more specific "Surprise Question" (SQ2: "Would I be surprised if this patient is still alive after 12 months"?) in case SQ1 is answered

2018 BMC Palliative Care Controlled trial quality: uncertain

2. CAGE Questions

CAGE Questions CAGE Questions Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 CAGE Questions CAGE Questions Aka: CAGE Questions (...) , Conjoint Screening Test II. Indications Screening for III. Criteria: CAGE Questions Cut Ever felt you ought to cut down on your drinking? Annoyed Have people annoyed you by criticizing your drinking? Guilt Ever felt bad or guilty about your drinking? Eye Opener Ever had an eye-opener to steady nerves in the AM? IV. Interpretation: CAGE Questions Answering Yes to 2 questions Strong Indication for Answering Yes to 3 questions Confirms V. Technique: Abbreviated CAGE Questions: Conjoint Screening Test

2018 FP Notebook

3. Is an Acetabular Cage and Cement Fixation Sufficiently Durable for the Treatment of Destructive Acetabular Metastases? (Abstract)

Is an Acetabular Cage and Cement Fixation Sufficiently Durable for the Treatment of Destructive Acetabular Metastases? Destructive bony acetabular metastases cause pain, pathological fractures, and loss of mobility. Although multiple fixation options are available, we have favored a rigid stainless steel partial pelvic cage for acetabular fixation in these patients; however, little is known about the durability of this approach. QUESTION/PURPOSES: (1) How common was loss of fixation in a small (...) series of metastatic acetabular defects treated with an acetabular cage and cemented total hip replacement? (2) What is the implant survival free from reoperation or revision at 2 and 4 years using a competing-risks survivorship estimator in patients thus treated? (3) What complications were associated with the treatment? (4) What level of postoperative mobility was achieved?Between 2006 and 2017, we treated all acetabular metastases that needed surgical intervention, not amenable to conventional

2019 Clinical Orthopaedics and Related Research

4. Single Center Post Approval Proximal Humerus Fixation With the Conventus Cage PHâ„¢ Device

Single Center Post Approval Proximal Humerus Fixation With the Conventus Cage PHâ„¢ Device Single Center Post Approval Proximal Humerus Fixation With the Conventus Cage PH™ Device - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Single Center Post Approval Proximal Humerus Fixation With the Conventus Cage PH™ Device The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03711591 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

5. Long-Term Visual Training Increases Visual Acuity and Long-Term Monocular Deprivation Promotes Ocular Dominance Plasticity in Adult Standard Cage-Raised Mice Full Text available with Trip Pro

Long-Term Visual Training Increases Visual Acuity and Long-Term Monocular Deprivation Promotes Ocular Dominance Plasticity in Adult Standard Cage-Raised Mice For routine behavioral tasks, mice predominantly rely on olfactory cues and tactile information. In contrast, their visual capabilities appear rather restricted, raising the question whether they can improve if vision gets more behaviorally relevant. We therefore performed long-term training using the visual water task (VWT): adult (...) standard cage (SC)-raised mice were trained to swim toward a rewarded grating stimulus so that using visual information avoided excessive swimming toward nonrewarded stimuli. Indeed, and in contrast to old mice raised in a generally enriched environment (Greifzu et al., 2016), long-term VWT training increased visual acuity (VA) on average by more than 30% to 0.82 cycles per degree (cyc/deg). In an individual animal, VA even increased to 1.49 cyc/deg, i.e., beyond the rat range of VAs. Since visual

2018 eNeuro

6. Test characteristics of a drug CAGE questionnaire for the detection of non-alcohol substance use disorders in trauma inpatients. (Abstract)

, 1996. All participants underwent both a 4-item drug CAGE questionnaire and the substance use disorder section of a structured psychiatric diagnostic clinical interview (SCID) (DSM-IIIR criteria), administered by staff unaware of their clinical status. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV), positive (LR+) and negative likelihood ratios (LR-), and the area under the receiver operating curve (AUC) were calculated for each individual question and the overall (...) status, mechanism of injury, and current/past DUD status (AUCs 0.75-1.00). Answering any one question in the affirmative had a sensitivity = 83.4% (95% CI: 79.1-87.1), specificity = 92.3% (95% CI: 90.2-94.1), PPV = 83.1%, LR+ = 10.8.The 4-item drug CAGE and its individual questions had good-to-excellent ability to detect DUDs in this adult trauma inpatient population, suggesting its usefulness as a screening tool.Copyright © 2018 Elsevier Ltd. All rights reserved.

2018 Injury

7. Optimization of mosquito egg production under mass rearing setting: effects of cage volume, blood meal source and adult population density for the malaria vector, Anopheles arabiensis. Full Text available with Trip Pro

developed by the Insect Pest Control Subprogramme of the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture. To improve mass-rearing outcomes for An. arabiensis, the question of whether the egg production by females would be affected by the size of the adult holding cages, the source of the blood meal and the total number of pupae that could be loaded into the cages was addressed and finally the impact of adding additional pupae to the cage daily to maintain adult numbers on egg (...) Optimization of mosquito egg production under mass rearing setting: effects of cage volume, blood meal source and adult population density for the malaria vector, Anopheles arabiensis. Anopheles arabiensis is one of the major malaria vectors that put millions of people in endemic countries at risk. Mass-rearing of this mosquito is crucial for strategies that use sterile insect technique to suppress vector populations. The sterile insect technique (SIT) package for this mosquito species is being

2017 Malaria journal

8. CAGE Questions

CAGE Questions CAGE Questions Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 CAGE Questions CAGE Questions Aka: CAGE Questions (...) , Conjoint Screening Test II. Indications Screening for III. Criteria: CAGE Questions Cut Ever felt you ought to cut down on your drinking? Annoyed Have people annoyed you by criticizing your drinking? Guilt Ever felt bad or guilty about your drinking? Eye Opener Ever had an eye-opener to steady nerves in the AM? IV. Interpretation: CAGE Questions Answering Yes to 2 questions Strong Indication for Answering Yes to 3 questions Confirms V. Technique: Abbreviated CAGE Questions: Conjoint Screening Test

2015 FP Notebook

9. Single-stage debridement and spinal fusion using PEEK cages through a posterior approach for eradication of lumbar pyogenic spondylodiscitis: a safe treatment strategy for a detrimental condition Full Text available with Trip Pro

-ether-ketone (PEEK) have proven to be advantageous in diverse degenerative conditions, their saftey and practicability in lumbar spine infection remains questionable. Moreover, the efficacy of a single-step radical debridement of the infected disc space with subsequent fusion from a strictly posterior approach continues to be an issue of debate. We therefore sought to evaluate the feasibility, clinical and radiological outcome of a single-step TLIF procedure using oblique PEEK cages in the surgical (...) Single-stage debridement and spinal fusion using PEEK cages through a posterior approach for eradication of lumbar pyogenic spondylodiscitis: a safe treatment strategy for a detrimental condition Pyogenic infections of the lumbar spine are a rare but critical pathology, yet with considerably high mortality rates. In cases indicating surgical therapy, the implantation of titanium cages or autologous bone grafts represent today's gold standard. Although non-metallic implants such as poly-ether

2015 Patient safety in surgery

10. A re-evaluation of the question - is the pubertal resurgence in pulsatile GnRH release in the male rhesus monkey (Macaca mulatta) associated with a gonad-independent augmentation of GH secretion? Full Text available with Trip Pro

A re-evaluation of the question - is the pubertal resurgence in pulsatile GnRH release in the male rhesus monkey (Macaca mulatta) associated with a gonad-independent augmentation of GH secretion? A somatic signal has been posited to trigger the pubertal resurgence in pulsatile GnRH secretion that initiates puberty in highly evolved primates. That GH might provide such a signal emerged in 2000 as a result of a study reporting that circulating nocturnal GH concentrations in castrated juvenile (...) male monkeys increased in a 3-week period immediately preceding the pubertal resurgence of LH secretion. The present study was conducted to reexamine this intriguing relationship, again in an agonadal model. Four castrated juvenile male monkeys were implanted with indwelling jugular catheters, housed in remote sampling cages, and subjected to 24 hours of sequential blood sampling (every 30 min) every 2 weeks from 19.5 to 22 months of age. Twenty-four-hour profiles of circulating GH concentrations

2015 Endocrinology

11. Biomechanical Evaluation of a Novel Autogenous Bone Interbody Fusion Cage for Posterior Lumbar Interbody Fusion in a Cadaveric Model. (Abstract)

or corticocancellous iliac crest bone graft (ICBG) in combination with posterior instrumentation. However, questions remain concerning the use of synthetic intervertebral implants as well as the morbidity ICBG harvesting. Therefore, ABIF cage has been developed to obviate some of the challenges in conventional posterior lumbar interbody fusion instrumentation and to facilitate the fusion process.Eighteen adult cadaveric lumbosacral (L3-S1) specimens were tested. Test conditions included single lumbosacral segments (...) Biomechanical Evaluation of a Novel Autogenous Bone Interbody Fusion Cage for Posterior Lumbar Interbody Fusion in a Cadaveric Model. A human cadaveric biomechanical study of a novel, prefabricated autogenous bone interbody fusion (ABIF) cage.To evaluate the biomechanical properties of the ABIF cage in a single-level construct with and without transpedicular screw and rod fixation.In current practice, posterior lumbar interbody fusion is generally carried out using synthetic interbody spacers

2014 Spine

12. Questioning the role of targeted respiratory physiotherapy over and above a standard clinical pathway in the postoperative management of patients following open thoracotomy. Full Text available with Trip Pro

Questioning the role of targeted respiratory physiotherapy over and above a standard clinical pathway in the postoperative management of patients following open thoracotomy. Summary of: Reeve JC et al (2010) Does physiotherapy reduce the incidence of postoperative pulmonary complications following pulmonary resection via open thoracotomy? A preliminary randomised single-blind clinical trial. Eur J Cardiothorac Surg 37: 1158-1166. [Prepared by Kylie Hill, CAP Editor.]Does routine prophylactic (...) clinical pathway, which included early and frequent position changes, sitting out of bed on the first postoperative day, early ambulation and frequent pain assessment. In addition, the intervention group received daily targeted respiratory physiotherapy, which comprised deep breathing and coughing exercises, assistance with ambulation, and progressive shoulder and thoracic cage exercises.The primary outcome was incidence of postoperative pulmonary complications, defined using a standardised diagnostic

2011 Journal of physiotherapy Controlled trial quality: predicted high

13. Integrating chemistry and immunology in allergic contact dermatitis: more questions than answers? Full Text available with Trip Pro

Integrating chemistry and immunology in allergic contact dermatitis: more questions than answers? In this issue, Simonsson and colleagues shed light on the chemical mechanisms determining hapten formation in the skin, which precede the elicitation of an antigen-specific immune response in allergic contact dermatitis. Combining fluorescence microscopy, proteomics, and mass spectrometry, the investigators identified keratins K5 and K14, particularly cysteine 54 of K5, in the human basal epidermal (...) layer as the major molecular targets of caged thiol-reactive fluorescent haptens (i.e., bromobimanes). Anti-keratin antibody responses in mice exposed to bromobimanes suggest the generation of immunogenic epitopes by cysteine-reactive haptens. Although many issues await further investigation, Simonsson and co-workers' observations advance our understanding of the molecular basis of hapten-protein complex formation in skin.

2011 Journal of Investigative Dermatology

14. Canadian guidelines on opioid use disorder among older adults

for adults. (76) Listed below are questions (C-E) along with recommendations (10–12) for screening and assessment of OUD specific to older adults: Question C: In older adults, when and how should one screen for an OUD? Recommendation 10 Older adults should be screened for an OUD using validated tools, if appropriate (e.g., CAGE-AID, ASSIST , PDUQp, ORT , POMI, COMM). Medication reviews and urine drug screens should be utilized if the patient is taking opioids for CNCP or an OUD. (30,41,77-80) GRADE (...) collaboration process (25) in order to customize the selected guidelines for older adults and the Canadian context. We formulated questions in the PICOT format (Population, Intervention, Comparator, Outcome and Time) as a working group, and populated the questions with answers obtained from the previously chosen key guidelines, then supplemented this information with evidence from current literature. Working group members drafted recommendations and provided the evidence for each of the recommendations

2020 CPG Infobase

15. Designing mental health facilities that prevent the use of seclusion and restraint

questions from the commissioning agency. It is not necessarily a comprehensive review of all literature relating to the topic area. It was current at the time of production (but not necessarily at the time of publication). It is reproduced for general information and third parties rely upon it at their own risk. Designing mental health facilities that prevent the use of seclusion and restraint An Evidence Check rapid review brokered by the Sax Institute for the NSW Ministry of Health. February 2020 (...) . This report was prepared by Lisa Brophy, Sanne Oostermeijer, Catherine Minshall, Carol Harvey, Bridget Hamilton, Cath Roper, Andrew Martel, Justine Fletcher. 4 DESIGNING MENTAL HEALTH FACILITIES THAT PREVENT THE USE OF SECLUSION AND RESTRAINT | SAX INSTITUTE Contents Executive summary 5 Background 5 The role of consumers in this Evidence Check 5 Evidence Check questions 5 Summary of methods 5 Evidence of critical assessment 6 Key findings 6 Gaps in the evidence 6 Discussion of key findings 7 Conclusion 7

2020 Sax Institute Evidence Check

16. Canadian guidelines on opioid use disorder among older adults

of opioid overdose and information on supervised consumption sites, if available in the community. [GRADE Quality: Moderate; Strength: Strong] QUESTION C: In older adults, when and how should one screen for an OUD? RECOMMENDATION #10: Older adults should be screened for an OUD using validated tools, if appropriate (e.g., CAGE- AID, ASSIST, PDUQp, ORT, POMI, COMM). Medication reviews and urine drug screens should be utilized if the patient is taking opioids for CNCP or an OUD. [GRADE Quality: Low (...) , or that the cost or burden of the proposed intervention may not be justified . (Adapted from Guyatt et al, 2008)6 Canadian Guidelines on Opioid Use Disorder Among Older Adults QUESTION A: In older adults, what measures can reduce the risk of developing an OUD? RECOMMENDATION #1: In order to avoid the risk of developing an OUD, older adults with acute pain in whom opioids are being considered should receive the lowest effective dose of the least potent immediate release opioid for a duration of = 3 days

2019 CPG Infobase

17. Diagnosis and Treatment of Low Back Pain

results. The ultimate judgment regarding any specific procedure or treatment is to be made by the physician and patient in light of all circumstances presented by the patient and the needs and resources particular to the locality or institution. Objective The objective of the North American Spine Society (NASS) Clinical Guideline for the Diagnosis and Treat- ment of Low Back Pain is to provide evidence-based recommendations to address key clinical questions surrounding the diagnosis and treatment (...) in the making. There were 82 clinical questions and the literature search resulted in more than 45,000 articles. Due to the high volume of literature and the labor- intensive nature of the review, literature search dates are spread out in some instances (although most were within the same month). In addition, consideration should be given to the fact that newer research has been published since the literature searches have taken place. ? This document is based on the evidence known at the time

2020 North American Spine Society

18. Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders

of Research and Development to inform future research priorities. The scope was further developed with input from the topic nominators (ie, Operational Partners), the ESP Coordinating Center, the review team, and the technical expert panel (TEP). In designing the study questions and methodology at the outset of this report, the ESP consulted several technical and content experts. Broad expertise and perspectives were sought. Divergent and conflicting opinions are common and perceived as healthy scientific (...) discourse that results in a thoughtful, relevant systematic review. Therefore, in the end, study questions, design, methodologic approaches, and/or conclusions do not necessarily represent the views of individual technical and content experts. The authors gratefully acknowledge the following individuals for their contributions to this project: Operational Partners Operational partners are system-level stakeholders who have requested the report to inform decision- making. They recommend Technical Expert

2019 Veterans Affairs Evidence-based Synthesis Program Reports

19. Alcohol-related trauma reinjury prevention with hospital-based screening in adult populations Full Text available with Trip Pro

or others from hazardous alcohol use behaviors. [6–8] The SBIRT begins with screening patients to identify whether a patient's use of alcohol places them and others at risk and therefore warrants a brief intervention. A number of different screening tools are available including Alcohol Use Disorders Identification Test (AUDIT), Michigan Alcoholism Screening Test, and the CAGE questionnaire which is named as an acronym for its four questions about alcohol-related behaviors and feelings (Cut down (...) evaluating the impact of these interventions are lacking. METHODS An evidence-based systematic review was performed to answer the following population, intervention, comparator, outcomes question: Among adult patients presenting for acute injury, should emergency department, trauma center, or hospital-based alcohol screening with brief intervention and/or referral to treatment be instituted compared with usual care to prevent or decrease reinjury, hospital readmission, alcohol-related offenses

2020 Eastern Association for the Surgery of Trauma

20. Clinical practice guideline for evaluation of psychosocial factors influencing recovery from adult orthopaedic trauma

RECOMMENDATIONS 17 Factors Associated with Patient Outcomes 17 Rationale 17 Benefits/Harms of Implementation 21 Future Research 21 5 View background material via the PRF CPG eAppendix APPENDICES 23 Appendix I: References for Included Literature 23 Appendix II - Guideline Development Group Disclosures 29 Non-Voting Oversight Chairs’ and Voting Members’ Disclosures 29 Appendix III: PICO Questions Used to Define Literature Search 32 Appendix IV: Literature Search Strategy 33 Appendix VI – Inclusion Criteria 36 (...) (methodologists). To develop this clinical practice guideline, the clinical practice guideline development group held an introductory meeting on October 3, 2018 to establish the scope of the clinical practice guideline. As the physician experts, the clinical practice guideline development group defined the scope of the clinical practice guideline by creating PICO Questions (i.e. population, intervention, comparison, and outcome) that directed the literature search. The AAOS Medical Librarian created

2020 American Academy of Orthopaedic Surgeons

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