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1. Adding a second surprise question triggers general practitioners to increase the thoroughness of palliative care planning: results of a pilot RCT with cage vignettes. (PubMed)

Adding a second surprise question triggers general practitioners to increase the thoroughness of palliative care planning: results of a pilot RCT with cage vignettes. In our aging society, palliative care should be a standard component of health care. However, currently it is only provided to a small proportion of patients, mostly to those with cancer, and restricted to the terminal phase. Many general practitioners (GPs) say that one of their most significant challenges is to assess the right (...) moment to start anticipatory palliative care. The "Surprise Question" (SQ1: "Would I be surprised if this patient were to die in the next 12 months"?), if answered with "no", is an easy tool to apply in identifying patients in need of palliative care. However, this tool has a low specificity. Therefore, the aim of our pilot study was to determine if adding a second, more specific "Surprise Question" (SQ2: "Would I be surprised if this patient is still alive after 12 months"?) in case SQ1 is answered

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2018 BMC Palliative Care Controlled trial quality: uncertain

2. CAGE Questions

CAGE Questions CAGE Questions Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 CAGE Questions CAGE Questions Aka: CAGE Questions (...) , Conjoint Screening Test II. Indications Screening for III. Criteria: CAGE Questions Cut Ever felt you ought to cut down on your drinking? Annoyed Have people annoyed you by criticizing your drinking? Guilt Ever felt bad or guilty about your drinking? Eye Opener Ever had an eye-opener to steady nerves in the AM? IV. Interpretation: CAGE Questions Answering Yes to 2 questions Strong Indication for Answering Yes to 3 questions Confirms V. Technique: Abbreviated CAGE Questions: Conjoint Screening Test

2018 FP Notebook

3. Is an Acetabular Cage and Cement Fixation Sufficiently Durable for the Treatment of Destructive Acetabular Metastases? (PubMed)

Is an Acetabular Cage and Cement Fixation Sufficiently Durable for the Treatment of Destructive Acetabular Metastases? Destructive bony acetabular metastases cause pain, pathological fractures, and loss of mobility. Although multiple fixation options are available, we have favored a rigid stainless steel partial pelvic cage for acetabular fixation in these patients; however, little is known about the durability of this approach. QUESTION/PURPOSES: (1) How common was loss of fixation in a small (...) series of metastatic acetabular defects treated with an acetabular cage and cemented total hip replacement? (2) What is the implant survival free from reoperation or revision at 2 and 4 years using a competing-risks survivorship estimator in patients thus treated? (3) What complications were associated with the treatment? (4) What level of postoperative mobility was achieved?Between 2006 and 2017, we treated all acetabular metastases that needed surgical intervention, not amenable to conventional

2019 Clinical Orthopaedics and Related Research

4. Single Center Post Approval Proximal Humerus Fixation With the Conventus Cage PHâ„¢ Device

Single Center Post Approval Proximal Humerus Fixation With the Conventus Cage PHâ„¢ Device Single Center Post Approval Proximal Humerus Fixation With the Conventus Cage PH™ Device - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Single Center Post Approval Proximal Humerus Fixation With the Conventus Cage PH™ Device The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03711591 Recruitment Status : Recruiting First Posted

2018 Clinical Trials

5. Test characteristics of a drug CAGE questionnaire for the detection of non-alcohol substance use disorders in trauma inpatients. (PubMed)

, 1996. All participants underwent both a 4-item drug CAGE questionnaire and the substance use disorder section of a structured psychiatric diagnostic clinical interview (SCID) (DSM-IIIR criteria), administered by staff unaware of their clinical status. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV), positive (LR+) and negative likelihood ratios (LR-), and the area under the receiver operating curve (AUC) were calculated for each individual question and the overall (...) status, mechanism of injury, and current/past DUD status (AUCs 0.75-1.00). Answering any one question in the affirmative had a sensitivity = 83.4% (95% CI: 79.1-87.1), specificity = 92.3% (95% CI: 90.2-94.1), PPV = 83.1%, LR+ = 10.8.The 4-item drug CAGE and its individual questions had good-to-excellent ability to detect DUDs in this adult trauma inpatient population, suggesting its usefulness as a screening tool.Copyright © 2018 Elsevier Ltd. All rights reserved.

2018 Injury

6. Long-Term Visual Training Increases Visual Acuity and Long-Term Monocular Deprivation Promotes Ocular Dominance Plasticity in Adult Standard Cage-Raised Mice (PubMed)

Long-Term Visual Training Increases Visual Acuity and Long-Term Monocular Deprivation Promotes Ocular Dominance Plasticity in Adult Standard Cage-Raised Mice For routine behavioral tasks, mice predominantly rely on olfactory cues and tactile information. In contrast, their visual capabilities appear rather restricted, raising the question whether they can improve if vision gets more behaviorally relevant. We therefore performed long-term training using the visual water task (VWT): adult (...) standard cage (SC)-raised mice were trained to swim toward a rewarded grating stimulus so that using visual information avoided excessive swimming toward nonrewarded stimuli. Indeed, and in contrast to old mice raised in a generally enriched environment (Greifzu et al., 2016), long-term VWT training increased visual acuity (VA) on average by more than 30% to 0.82 cycles per degree (cyc/deg). In an individual animal, VA even increased to 1.49 cyc/deg, i.e., beyond the rat range of VAs. Since visual

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2018 eNeuro

7. Optimization of mosquito egg production under mass rearing setting: effects of cage volume, blood meal source and adult population density for the malaria vector, Anopheles arabiensis. (PubMed)

developed by the Insect Pest Control Subprogramme of the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture. To improve mass-rearing outcomes for An. arabiensis, the question of whether the egg production by females would be affected by the size of the adult holding cages, the source of the blood meal and the total number of pupae that could be loaded into the cages was addressed and finally the impact of adding additional pupae to the cage daily to maintain adult numbers on egg (...) Optimization of mosquito egg production under mass rearing setting: effects of cage volume, blood meal source and adult population density for the malaria vector, Anopheles arabiensis. Anopheles arabiensis is one of the major malaria vectors that put millions of people in endemic countries at risk. Mass-rearing of this mosquito is crucial for strategies that use sterile insect technique to suppress vector populations. The sterile insect technique (SIT) package for this mosquito species is being

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2017 Malaria journal

8. CAGE Questions

CAGE Questions CAGE Questions Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 CAGE Questions CAGE Questions Aka: CAGE Questions (...) , Conjoint Screening Test II. Indications Screening for III. Criteria: CAGE Questions Cut Ever felt you ought to cut down on your drinking? Annoyed Have people annoyed you by criticizing your drinking? Guilt Ever felt bad or guilty about your drinking? Eye Opener Ever had an eye-opener to steady nerves in the AM? IV. Interpretation: CAGE Questions Answering Yes to 2 questions Strong Indication for Answering Yes to 3 questions Confirms V. Technique: Abbreviated CAGE Questions: Conjoint Screening Test

2015 FP Notebook

9. Single-stage debridement and spinal fusion using PEEK cages through a posterior approach for eradication of lumbar pyogenic spondylodiscitis: a safe treatment strategy for a detrimental condition (PubMed)

-ether-ketone (PEEK) have proven to be advantageous in diverse degenerative conditions, their saftey and practicability in lumbar spine infection remains questionable. Moreover, the efficacy of a single-step radical debridement of the infected disc space with subsequent fusion from a strictly posterior approach continues to be an issue of debate. We therefore sought to evaluate the feasibility, clinical and radiological outcome of a single-step TLIF procedure using oblique PEEK cages in the surgical (...) Single-stage debridement and spinal fusion using PEEK cages through a posterior approach for eradication of lumbar pyogenic spondylodiscitis: a safe treatment strategy for a detrimental condition Pyogenic infections of the lumbar spine are a rare but critical pathology, yet with considerably high mortality rates. In cases indicating surgical therapy, the implantation of titanium cages or autologous bone grafts represent today's gold standard. Although non-metallic implants such as poly-ether

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2015 Patient safety in surgery

10. Biomechanical Evaluation of a Novel Autogenous Bone Interbody Fusion Cage for Posterior Lumbar Interbody Fusion in a Cadaveric Model. (PubMed)

or corticocancellous iliac crest bone graft (ICBG) in combination with posterior instrumentation. However, questions remain concerning the use of synthetic intervertebral implants as well as the morbidity ICBG harvesting. Therefore, ABIF cage has been developed to obviate some of the challenges in conventional posterior lumbar interbody fusion instrumentation and to facilitate the fusion process.Eighteen adult cadaveric lumbosacral (L3-S1) specimens were tested. Test conditions included single lumbosacral segments (...) Biomechanical Evaluation of a Novel Autogenous Bone Interbody Fusion Cage for Posterior Lumbar Interbody Fusion in a Cadaveric Model. A human cadaveric biomechanical study of a novel, prefabricated autogenous bone interbody fusion (ABIF) cage.To evaluate the biomechanical properties of the ABIF cage in a single-level construct with and without transpedicular screw and rod fixation.In current practice, posterior lumbar interbody fusion is generally carried out using synthetic interbody spacers

2014 Spine

11. A re-evaluation of the question - is the pubertal resurgence in pulsatile GnRH release in the male rhesus monkey (Macaca mulatta) associated with a gonad-independent augmentation of GH secretion? (PubMed)

A re-evaluation of the question - is the pubertal resurgence in pulsatile GnRH release in the male rhesus monkey (Macaca mulatta) associated with a gonad-independent augmentation of GH secretion? A somatic signal has been posited to trigger the pubertal resurgence in pulsatile GnRH secretion that initiates puberty in highly evolved primates. That GH might provide such a signal emerged in 2000 as a result of a study reporting that circulating nocturnal GH concentrations in castrated juvenile (...) male monkeys increased in a 3-week period immediately preceding the pubertal resurgence of LH secretion. The present study was conducted to reexamine this intriguing relationship, again in an agonadal model. Four castrated juvenile male monkeys were implanted with indwelling jugular catheters, housed in remote sampling cages, and subjected to 24 hours of sequential blood sampling (every 30 min) every 2 weeks from 19.5 to 22 months of age. Twenty-four-hour profiles of circulating GH concentrations

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2015 Endocrinology

12. Accuracy of one or two simple questions to identify alcohol-use disorder in primary care: a meta-analysis. (PubMed)

to be two questions followed by the CAGE questionnaire, which achieved an overall accuracy of 90.9% and required only 3.3 questions per attendee.Two brief questions can be used as an initial screen for alcohol problems but only when combined with a second-step screen. A brief alcohol intervention should be considered in those individuals who answer positively on both steps.© British Journal of General Practice 2014. (...) Accuracy of one or two simple questions to identify alcohol-use disorder in primary care: a meta-analysis. There is much interest in ultra-short alcohol screening in primary care that may support brief alcohol interventions. Brief screening consisting of one or two questions might be used alone or in combination with longer tests as recommended by the Primary Care Service Framework.To investigate whether a simple one and two question screening might prove an accurate and acceptable screening

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2014 British Journal of General Practice

13. Questioning the role of targeted respiratory physiotherapy over and above a standard clinical pathway in the postoperative management of patients following open thoracotomy. (PubMed)

Questioning the role of targeted respiratory physiotherapy over and above a standard clinical pathway in the postoperative management of patients following open thoracotomy. Summary of: Reeve JC et al (2010) Does physiotherapy reduce the incidence of postoperative pulmonary complications following pulmonary resection via open thoracotomy? A preliminary randomised single-blind clinical trial. Eur J Cardiothorac Surg 37: 1158-1166. [Prepared by Kylie Hill, CAP Editor.]Does routine prophylactic (...) clinical pathway, which included early and frequent position changes, sitting out of bed on the first postoperative day, early ambulation and frequent pain assessment. In addition, the intervention group received daily targeted respiratory physiotherapy, which comprised deep breathing and coughing exercises, assistance with ambulation, and progressive shoulder and thoracic cage exercises.The primary outcome was incidence of postoperative pulmonary complications, defined using a standardised diagnostic

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2011 Journal of physiotherapy

14. Integrating chemistry and immunology in allergic contact dermatitis: more questions than answers? (PubMed)

Integrating chemistry and immunology in allergic contact dermatitis: more questions than answers? In this issue, Simonsson and colleagues shed light on the chemical mechanisms determining hapten formation in the skin, which precede the elicitation of an antigen-specific immune response in allergic contact dermatitis. Combining fluorescence microscopy, proteomics, and mass spectrometry, the investigators identified keratins K5 and K14, particularly cysteine 54 of K5, in the human basal epidermal (...) layer as the major molecular targets of caged thiol-reactive fluorescent haptens (i.e., bromobimanes). Anti-keratin antibody responses in mice exposed to bromobimanes suggest the generation of immunogenic epitopes by cysteine-reactive haptens. Although many issues await further investigation, Simonsson and co-workers' observations advance our understanding of the molecular basis of hapten-protein complex formation in skin.

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2011 Journal of Investigative Dermatology

15. Does a Cemented Cage Improve Revision THA for Severe Acetabular Defects? (PubMed)

Does a Cemented Cage Improve Revision THA for Severe Acetabular Defects? Evidence suggests a growing incidence of revision total hip arthroplasty (THA) including a subset with large acetabular defects. Revision THA for severe acetabular bone loss is associated with a relatively high rate of mechanical failure.We questioned whether cementing a cage to the reconstructed acetabular defect and pelvis would improve the rate of mechanical failure for patients with Type 3 defects (Paprosky et al (...) .) with and without pelvic discontinuity in comparison to historical controls.We retrospectively collected data on 33 patients who underwent 35 revision THAs using an acetabular reconstruction cage cemented to morselized allograft and either structural allograft or trabecular metal augmentation for Type 3 defects in the presence (n = 13) and absence (n = 22) of pelvic discontinuity at a mean followup of 59 months (range, 24-92 months). The primary outcome was mechanical failure, defined as revision

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2010 Clinical Orthopaedics and Related Research

16. Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders

of Research and Development to inform future research priorities. The scope was further developed with input from the topic nominators (ie, Operational Partners), the ESP Coordinating Center, the review team, and the technical expert panel (TEP). In designing the study questions and methodology at the outset of this report, the ESP consulted several technical and content experts. Broad expertise and perspectives were sought. Divergent and conflicting opinions are common and perceived as healthy scientific (...) discourse that results in a thoughtful, relevant systematic review. Therefore, in the end, study questions, design, methodologic approaches, and/or conclusions do not necessarily represent the views of individual technical and content experts. The authors gratefully acknowledge the following individuals for their contributions to this project: Operational Partners Operational partners are system-level stakeholders who have requested the report to inform decision- making. They recommend Technical Expert

2019 Veterans Affairs Evidence-based Synthesis Program Reports

17. What helps to support people affected by Adverse Childhood Experiences? A Review of Evidence

for their own non- commercial use, providing that the materials are not modified, copyright and other proprietary notices contained in the materials are retained, and the source of the material is cited clearly following the citation details provided. Otherwise users are not permitted to duplicate, reproduce, re-publish, distribute, or store material from this website without express written permission. Contents Executive Summary 1 Background 1 Overall aims 1 Review questions 2 Methods… ...2 Findings (...) ………………………………………………………………………………………………………………………..2 What helps to support young people affected by ACEs? 2 Views synthesis findings 3 Overview of interventions findings 4 Stakeholder consultation 4 Discussion 4 1 Background 6 1.1 Adverse Childhood Experiences 6 1.2 The impact of ACEs 6 1.3 The extent of ACEs in the UK 6 1.4 Definitions of ACEs 7 1.5 Policy in the UK 8 1.6 Debates around the ACE framework 8 2 Brief methods 10 2.1 Policy stakeholder engagement 10 2.2 Concepts and definitions used in this review 10 2.3 Review questions 10 2.4

2019 EPPI Centre

18. Canadian Urological Association guideline: Perioperative thromboprophylaxis and management of anticoagulation

. To address this issue, three questions were posed: 1) Are perioperative VTEs a clinically relevant problem and is there uncertainty about the best pro- phylactic management 2) Is there variation in practice within the subject area and 3) Is currently available guidance suf- ficiently inadequate to require creation of a new guideline? Applying these three questions, the panel concluded that adapting or endorsing an existing guideline would be most appropriate. In brief, the panel believes (...) , antiphospholipid antibody, or other as iden- tified by appropriate specialist); - Cage-ball mechanical heart valves. Recommendation 16: In patients receiving an antiplatelet agent who do not have a very high risk of thrombosis (see definition) the panel recommends stopping antiplatelet agents seven days prior to surgery without bridging (strong recommendation, high-quality evidence) and restarting anti- platelet therapy four days post-surgery as compared to a longer period off therapy (strong recommendation

2019 Canadian Urological Association

19. Organisation of mental health care for adults in Belgium

Agence pour une Vie de Qualité (Wallonia) BMF – BFM Budget des Moyens Financiers – Budget Financiële Middelen CA Conjoint analysis CAD Centra voor Alcohol en andere Drugproblemen (Flemish Region) CAGE Cut Down, Annoyed, Guilty, and Eye-opener CAR-CRA Centra voor Ambulante Revalidatie - Centres de Rééducation Ambulatoire CAW Centrum voor Algemeen Welzijnswerk (Flemish Region) CGG – SSM Centrum voor Geestelijke Gezondheidszorg – Service de Santé Mentale CI Confidence interval CIDI Composite

2019 Belgian Health Care Knowledge Centre

20. AIM Clinical Appropriateness Guidelines for Spine Surgery

of interbody biomechanical device(s) (eg, synthetic cage, mesh) with integral anterior instrumentation for device anchoring (eg, screws, flanges), when performed, to intervertebral disc space in conjunction with interbody arthrodesis, each interspace (List separately in addition to code for primary procedure) 22854 Insertion of intervertebral biomechanical device(s) (eg, synthetic cage, mesh) with integral anterior instrumentation for device anchoring (eg, screws, flanges), when performed, to vertebral (...) corpectomy(ies) Copyright © 2019. AIM Specialty Health. All Rights Reserved. Spine Surgery 11 (vertebral body resection, partial or complete) defect, in conjunction with interbody arthrodesis, each contiguous defect (List separately in addition to code for primary procedure) 22859 Insertion of intervertebral biomechanical device(s) (eg, synthetic cage, mesh, methylmethacrylate) to intervertebral disc space or vertebral body defect without interbody arthrodesis, each contiguous defect (List separately

2019 AIM Specialty Health

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