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C-Reactive Protein as Cardiac Risk Factor

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2. The Collaborative Assessment, OTCA12, on “C-reactive protein point-of-care testing (CRP POCT) to guide antibiotic prescribing in primary care settings for acute respiratory tract infections (RTIs)

OF BIAS FOR ANALYTICAL PERFORMANCE 234 FIGURE A6: RISK OF BIAS OF INCLUDED STUDIES IN SYSTEMATIC REVIEW 3 (ANALYTICAL PERFORMANCE) 235 C-reactive protein point-of-care testing to guide antibiotic prescribing for acute respiratory tract infections in primary care EUnetHTA Joint Action 3 WP4 8 LIST OF ABBREVIATIONS ADR adverse drug reaction AMR antimicrobial resistance AOM acute otitis media AUC area under the curve BMI body mass index CAP community-acquired pneumonia CE Conformité Européenne CI (...) detection test C-reactive protein point-of-care testing to guide antibiotic prescribing for acute respiratory tract infections in primary care EUnetHTA Joint Action 3 WP4 9 REA relative effectiveness assessment ROC receiver operating characteristic RCT randomised controlled trial RR relative risk RTI respiratory tract infection SD standard deviation SDI social demographic index SKUP Scandinavian Evaluation of Laboratory Equipment for Point of Care Testing SR systematic review URTI upper respiratory

2019 EUnetHTA

3. HTA of C-reactive protein point-of-care testing to guide antibiotic prescribing

HTA of C-reactive protein point-of-care testing to guide antibiotic prescribing Health Technology Assessment (HTA) of CRP POCT Health Information and Quality Authority i Health Technology Assessment of C-reactive protein point-of-care testing to guide antibiotic prescribing for acute respiratory tract infections in primary care settings April 2019 Health Technology Assessment (HTA) of CRP POCT Health Information and Quality Authority ii Health Technology Assessment (HTA) of CRP POCT Health (...) and inappropriate consumption of antibiotics. Most antibiotics are prescribed in primary care settings and frequently to treat respiratory tract infections, which account for approximately one quarter of primary care attendances. The objective of C-reactive protein point-of-care testing (CRP POCT) is to assist the clinician in ruling out serious bacterial infection, thereby supporting a decision not to prescribe an antibiotic to those who are unlikely to benefit from treatment. HIQA’s health technology

2019 Health Information and Quality Authority

4. C-Reactive Protein as Cardiac Risk Factor

C-Reactive Protein as Cardiac Risk Factor C-Reactive Protein as Cardiac Risk Factor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 C (...) -Reactive Protein as Cardiac Risk Factor C-Reactive Protein as Cardiac Risk Factor Aka: C-Reactive Protein as Cardiac Risk Factor , CRP as Cardiac Risk Marker , High-Sensitivity CRP in Evaluating Cardiac Risk , hs-CRP for CAD Evaluation From Related Chapters II. Indications Not recommended for routine screening currently Not specific for Large day to day variablity in values No clear strategy for elevated values may be used in high-risk patient >3 mg/L predicts more ischemic episodes Elevated may

2018 FP Notebook

5. Preoperative C-Reactive Protein as a Risk Factor for Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery for Colon Carcinoma (PubMed)

Preoperative C-Reactive Protein as a Risk Factor for Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery for Colon Carcinoma Postoperative delirium (POD) is a very common complication in operative disciplines, especially in those elderly patients after cardiac surgery. This study aimed to investigate the relationship between C-reactive protein (CRP) and POD in elderly patients undergoing laparoscopic surgery for colon carcinoma.160 elderly patients scheduled to undergo

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2017 BioMed research international

6. [Systematic review and meta-analysis of the predictive value of C-reactive protein in postoperative infections]

, with homogeneous internal validity criteria, before recommending CRP as a risk marker for these infections. Funding None reported. Bibliographic details Nunes BK, Lacerda RA, Jardim JM. Revisión sistemática y meta-análisis sobre el valor predictivo de la proteína C-reactiva en infección postoperatorias. [Systematic review and meta-analysis of the predictive value of C-reactive protein in postoperative infections] Revista da Escola de Enfermagem da USP 2011; 45(6): 1488-1494 PubMedID Original Paper URL Indexing (...) [Systematic review and meta-analysis of the predictive value of C-reactive protein in postoperative infections] Revisión sistemática y meta-análisis sobre el valor predictivo de la proteína C-reactiva en infección postoperatorias [Systematic review and meta-analysis of the predictive value of C-reactive protein in postoperative infections] Revisión sistemática y meta-análisis sobre el valor predictivo de la proteína C-reactiva en infección postoperatorias [Systematic review and meta-analysis

2011 DARE.

7. Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events. (PubMed)

Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events. Cardiac myosin binding protein-C (cMyBP-C) is a heart muscle-specific thick filament protein. Elevated level of serum cMyBP-C is an indicator of early myocardial infarction (MI), but its value as a predictor of future cardiovascular disease is unknown. Based on the presence of significant amount of cMyBP-C in the serum of previous study subjects independent of MI, we hypothesized that circulating (...) , invasive cardiovascular procedure, or cardiovascular-related hospitalization) and 7 critical events (CE; such as death, MI, stroke, or pulmonary embolism) occurred. After adjusting for sex and cardiovascular risk factors with multivariate Cox regression, a 96% sensitive prestress cMyBP-C threshold carried a hazard ratio of 8.1 with p = 0.041 for primary events. Most subjects (6 of 7) who had CE showed normal ejection fraction on echocardiography. Prestress cMyBP-C demonstrated area under receiver

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2017 American Journal of Cardiology

8. Associations of immunometabolic risk factors with symptoms of depression and anxiety: the role of cardiac vagal activity. (PubMed)

were measured with the Center for Epidemiological Studies Depression Scale (CES-D) and the Beck Depression Inventory-II (BDI-II), and anxious symptoms with the Trait Anxiety scale of the State-Trait Anxiety Inventory (STAI-T). Immunometabolic risk factors included fasting levels of triglycerides, high-density lipoproteins, glucose, and insulin, as well as blood pressure, waist circumference, body mass index, C-reactive protein, and interleukin-6. Measures of cardiac autonomic activity were high (...) Associations of immunometabolic risk factors with symptoms of depression and anxiety: the role of cardiac vagal activity. This study examined 1) the cross-sectional relationships between symptoms of depression/anxiety and immunometabolic risk factors, and 2) whether these relationships might be explained in part by cardiac vagal activity.Data were drawn from the Adult Health and Behavior registries (n = 1785), comprised of community dwelling adults (52.8% women, aged 30-54). Depressive symptoms

2018 Brain, behavior, and immunity

9. Cardiovascular risk factors predicting cardiac events are different in patients with rheumatoid arthritis, psoriatic arthritis, and psoriasis. (PubMed)

Cardiovascular risk factors predicting cardiac events are different in patients with rheumatoid arthritis, psoriatic arthritis, and psoriasis. Increased cardiovascular risk in rheumatoid arthritis (RA) is well established. Examining traditional cardiovascular risk factors alone underestimates cardiovascular risk in RA. Systematic inflammation, measured by erythrocyte sedimentation rate or C-reactive protein is also a major risk factor. However, the contribution of traditional cardiovascular (...) risk factors (such as obesity and hyperlipidaemia) compared to inflammation is uncertain in psoriatic arthritis (PsA) and RA. We examine the incidence of major adverse cardiac events (MACE) among patients with RA, PsA psoriasis, and controls adjusting for risk factors, inflammation and disease modifying anti-rheumatic drug treatment, to better define cardiovascular risk.Using the Secure Anonymised Information Linkage databank, comprising routinely collected Welsh health data from 1999 to 2013

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2018 Seminars in arthritis and rheumatism

10. Cardiac valve calcification and use of anticoagulants: Preliminary observation of a potentially modifiable risk factor. (PubMed)

Cardiac valve calcification and use of anticoagulants: Preliminary observation of a potentially modifiable risk factor. Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP (...) reduction in C reactive protein (CRP) (p < 0.001) during follow-up.This study generates the hypothesis that the use of Rivaroxaban associates with a reduction of cardiac valve calcification deposition and progression as compared to Warfarin, in a cohort of CKD stage 3b-4 patients. Future endeavors are needed to confirm and to establish the mechanisms responsible for these findings.Copyright © 2018 Elsevier B.V. All rights reserved.

2018 International journal of cardiology

11. Cardiac function in adolescents with obesity: cardiometabolic risk factors and impact on physical fitness. (PubMed)

parameters or CPET parameters in the entire group.In obese adolescents, left ventricular septum thickness, left atrial diameter, mitral A-wave velocity, E/e' ratio were significantly elevated (p < 0.05), as opposed to lean controls, while mitral e'-wave velocity was significantly lowered (p < 0.01). Elevated homeostatic model assessment of insulin resistance and blood insulin, c-reactive protein, and uric acid concentrations (all significantly elevated in obese adolescents) were independent risk factors (...) Cardiac function in adolescents with obesity: cardiometabolic risk factors and impact on physical fitness. To gain greater insights in the etiology and clinical consequences of altered cardiac function in obese adolescents. Therefore, we aimed to examine cardiac structure and function in obese adolescents, and to examine associations between altered cardiac function/structure and cardiometabolic disease risk factors or cardiopulmonary exercise capacity.In 29 obese (BMI 31.6 ± 4.2 kg/m², age

2018 International Journal of Obesity

12. Independent Prognostic Value of High-sensitivity C-reactive Protein in Patients with Coronary Artery Ectasia (PubMed)

Independent Prognostic Value of High-sensitivity C-reactive Protein in Patients with Coronary Artery Ectasia Despite its severity, coronary artery ectasia (CAE) is still poorly understood. High-sensitivity C-reactive protein (hs-CRP) has been recognized as a prognostic factor in some cardiovascular diseases but not assessed in CAE. The aim of this observational study was to investigate the prognostic value of hs-CRP in CAE.Our analysis evaluated the effect of the baseline hs-CRP (...) comprising the classical risk factors (P value for IDI = 0.0330).A higher level of hs-CRP was independently associated with cardiac death and nonfatal myocardial infarction in CAE patients. The hs-CRP level may therefore provide prognostic information for the risk stratification of CAE patients.

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2016 Chinese medical journal

13. C-Reactive Protein as Cardiac Risk Factor

C-Reactive Protein as Cardiac Risk Factor C-Reactive Protein as Cardiac Risk Factor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 C (...) -Reactive Protein as Cardiac Risk Factor C-Reactive Protein as Cardiac Risk Factor Aka: C-Reactive Protein as Cardiac Risk Factor , CRP as Cardiac Risk Marker , High-Sensitivity CRP in Evaluating Cardiac Risk , hs-CRP for CAD Evaluation From Related Chapters II. Indications Not recommended for routine screening currently Not specific for Large day to day variablity in values No clear strategy for elevated values may be used in high-risk patient >3 mg/L predicts more ischemic episodes Elevated may

2015 FP Notebook

14. Risk factors for breast cancer: A review of the evidence 2018

178 Summary 180 5 Appendix A Acknowledgements 192 Breast cancer risk factors: A review of the evidence v Appendix B IARC and WCRF/AICR classifications 194 Appendix C IARC and WCRF/AICR categories of evidence and criteria for grading carcinogenicity 196 Appendix D Data tables 200 Glossaries 512 Abbreviations 519 References 529 Breast cancer risk factors: A review of the evidence vi Figures Figure 4.1 Age–specific incidence of breast cancer in Australia, by age group, 2017 16 Figure 4.2 Age (...) Table 5.1 Evidence classifications 180 Table 5.2 Summary of risk estimates for factors where the body of evidence has been classified as either ‘Convincing’ or ‘Probable’ 183 Table C.1 International Agency for Research on Cancer (2015): Categories of evidence of carcinogenicity 196 Table C.2 World Cancer Research Fund/American Institute for Cancer Research (2018): Criteria for grading evidence for cancer prevention 198 Table D.1 Birthweight and risk of breast cancer 200 Table D.2 Height and risk

2018 Cancer Australia

15. The effect of short-term cardiac rehabilitation after acute myocardial infarction on high-sensitivity C-reactive protein. (PubMed)

The effect of short-term cardiac rehabilitation after acute myocardial infarction on high-sensitivity C-reactive protein. High-sensitivity C-reactive protein (hsCRP) is an important biomarker of risk for coronary heart disease morbidity and mortality. We investigated the influence of short-term cardiac rehabilitation (CR) after acute myocardial infarction (AMI) on values of hsCRP and classical risk factors, including metabolic syndrome.hsCRP and classical risk factors were measured before (...) and after completed 2-week CR program in 30 men after AMI. The comparison group comprised 30 age-balanced healthy men, with no risk factors for coronary heart disease.As expected, in comparison to healthy individuals, patients had higher values of hsCRP; furthermore, smokers had significantly higher hsCRP values than nonsmokers. Patients had more expressed markers of metabolic syndrome and due to pharmacological therapy lower blood pressure, total cholesterol and low-density lipoprotein cholesterol (LDL

2014 Metabolic syndrome and related disorders

16. Clinical significance and risk factors for new onset and recurring atrial fibrillation following cardiac surgery - a retrospective data analysis. (PubMed)

increase, p < 0.0001), a combination of CABG and valve surgery (OR = 1.711, p = 0.047), higher C-reactive protein (OR = 1.06 per unit increase, p < 0.0001) and creatinine plasma concentration (OR = 1.287 per unit increase, p = 0.032) significantly predicted new onset AF. Higher Horowitz index values were associated with a reduced risk (OR = 0.996 per unit increase, p = 0.012). In a separate model, higher plasma creatinine concentration (OR = 2.125 per unit increase, p = 0.022) was a significant risk (...) Clinical significance and risk factors for new onset and recurring atrial fibrillation following cardiac surgery - a retrospective data analysis. Although mortality after cardiac surgery has significantly decreased in the last decade, patients still experience clinically relevant postoperative complications. Among others, atrial fibrillation (AF) is a common consequence of cardiac surgery, which is associated with prolonged hospitalization and increased mortality.We retrospectively analyzed

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2017 BMC Anesthesiology

17. The Relationship Between Cardiac Conduction Times, Cardiovascular Risk Factors, and Inflammation in Patients with Early Arthritis. (PubMed)

The Relationship Between Cardiac Conduction Times, Cardiovascular Risk Factors, and Inflammation in Patients with Early Arthritis. To investigate the prevalence of conduction disorders in patients with early arthritis and the relationship with inflammation and traditional cardiovascular (CV) risk factors.Patients with rheumatoid arthritis (RA) have a 2-fold higher risk of sudden cardiac death, possibly owing to conduction disorders. This increased risk might already be present at the clinical (...) onset of arthritis. Therefore, we assessed electrocardiography, blood pressure, 28-joint Disease Activity Score (DAS28), lipid profile, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) level in 480 patients with early arthritis at baseline and after 1 year.The prevalence of conduction disorders was 12.5%. Conduction times at baseline were not associated with DAS28, ESR, or CRP levels and did not change during antirheumatic treatment. Baseline and the improvement in DAS28 (European

2017 Journal of Rheumatology

18. Is High Serum LDL/HDL Cholesterol Ratio an Emerging Risk Factor for Sudden Cardiac Death? Findings from the KIHD Study (PubMed)

Is High Serum LDL/HDL Cholesterol Ratio an Emerging Risk Factor for Sudden Cardiac Death? Findings from the KIHD Study Low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c), which are components of total cholesterol, have each been suggested to be linked to the risk of sudden cardiac death (SCD). However, the relationship between LDL-c/HDL-c ratio and the risk of SCD has not been previously investigated. We aimed to assess the associations of LDL-c, HDL-c (...) index, systolic blood pressure, smoking, alcohol consumption, physical activity, years of education, diabetes, previous myocardial infarction, family history of coronary heart disease, and serum high sensitivity C-reactive protein, there was approximately a two-fold increase in the risk of SCD (HR 1.94, 95% CI 1.21-3.11; p=0.006), comparing the top (>4.22) versus bottom (≤2.30) quintile of serum LDL-c/HDL-c ratio.In this middle-aged male population, LDL-c or HDL-c was not associated with the risk

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2017 Journal of atherosclerosis and thrombosis

19. Interleukin-6 and C-reactive protein and risk for death and cardiovascular events in patients with atrial fibrillation. (PubMed)

Interleukin-6 and C-reactive protein and risk for death and cardiovascular events in patients with atrial fibrillation. Inflammation has been associated with cardiovascular disease and the burden of atrial fibrillation (AF). In this study we evaluate inflammatory biomarkers and future cardiovascular events in AF patients in the RE-LY study.Interleukin-6 (IL-6), C-reactive protein (CRP) (n = 6,187), and fibrinogen (n = 4,893) were analyzed at randomization; outcomes were evaluated by Cox models (...) adjusted for cardiac (troponin and N-terminal fragment B-type natriuretic peptide [NT-proBNP]) and renal (cystatin-C) biomarkers on top of clinical risk factors IL-6 remained significantly related to vascular death (P < .0001), major bleeding (P < .0170) and the composite thromboembolic outcome (P < .0001), and CRP to myocardial infarction (.0104). Fibrinogen was not associated with any outcome. C-index for stroke or systemic embolism increased from 0.615 to 0.642 (P = .0017) when adding IL-6

2015 American Heart Journal

20. Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments: A Scientific Statement From the American Heart Association

). Inflammation and Thrombosis The risk of ASCVD in South Asians may be increased by a prothrombotic milieu made up of higher levels of homocysteine, plasminogen activator inhibitor-1, and Lp(a), , along with a proinflammatory state, characterized by higher levels of inflammatory markers such as CRP (C-reactive protein), leptin, interleukin-6, and tumor necrosis factor-α. The role of inflammation in the initiation, progression, and clinical sequelae of atherosclerosis is a subject of intense investigation (...) are generally younger at the time of their first MI. , Dyslipidemia Dyslipidemia is likely an important factor contributing to the increased CVD risk observed in South Asian populations. The typical lipoprotein pattern seen in individuals of South Asian descent who are living in Western societies is characterized by hypertriglyceridemia and low levels of HDL cholesterol (HDL-C). Although levels of low-density lipoprotein (LDL) cholesterol (LDL-C) may not appear elevated, this population has a high incidence

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2018 American Heart Association

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