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Brain Lesion in Children

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1. Can S100B Serum Biomarker Testing Reduce Head Computed Tomography Scanning in Children With Mild Traumatic Brain Injury? Full Text available with Trip Pro

., Phillips, N. et al. Paediatric Research in Emergency Departments International Collaborative. Accuracy of PECARN, CATCH, and CHALICE head injury decision rules in children: a prospective cohort study. Lancet . 2017 ; 389 : 2393–2402 This study addressed whether the serum biomarker S100B has prognostic value in concert with clinical risk stratification to predict traumatic intracranial lesions in children with mild traumatic brain injury. S100B is a glial-specific protein expressed primarily (...) as a screening tool for the early assessment of minor head injury. Ann Emerg Med . 2012 ; 59 : 209–218 However, the use of this test has not been well established in the pediatric population. The results of the primary meta-analysis suggest that S100B is a biomarker of exclusion and cannot confirm traumatic intracranial lesions. The high negative predictive value of 100% (95% CI 99% to 100%) implies that S100B could reduce the number of CT scans in children with mild traumatic brain injury; however, the low

2019 Annals of Emergency Medicine Systematic Review Snapshots

2. The impact of group occupational therapy using a cueing system on executive function of preschool-aged children with brain lesions Full Text available with Trip Pro

The impact of group occupational therapy using a cueing system on executive function of preschool-aged children with brain lesions [Purpose] This study investigates the effects of group occupational therapy using a cueing system on the executive function of preschool-aged children with brain lesions. [Subjects and Methods] Six preschool-aged children with brain lesions participated in this study. A 24-session occupational therapy program (1 session/week, 50 minutes/session) designed based (...) behavioral approach known as the cueing system may assist improving executive functions in preschool-aged children with brain lesions.

2018 Journal of physical therapy science

3. Early intervention at home in infants with congenital brain lesion with CareToy revised: a RCT protocol. Full Text available with Trip Pro

Early intervention at home in infants with congenital brain lesion with CareToy revised: a RCT protocol. Congenital brain lesions expose infants to be at high-risk for being affected by neurodevelopmental disorders such as cerebral palsy (CP). Early interventions programs can significantly impact and improve their neurodevelopment. Recently, in the framework of the European CareToy (CT) Project ( www.caretoy.eu ), a new medical device has been created to deliver an early, intensive, customized (...) , intervention program, carried out at home by parents but remotely managed by expert and trained clinicians. Reviewing results of previous studies on preterm infants without congenital brain lesion, the CT platform has been revised and a new system created (CT-R). This study describes the protocol of a randomised controlled trial (RCT) aimed to evaluate, in a sample of infants at high-risk for CP, the efficacy of CT-R intervention compared to the Infant Massage (IM) intervention.This RCT will be multi

2018 BMC Pediatrics

4. Radiation Necrosis and White Matter Lesions in Pediatric Patients With Brain Tumors Treated With Pencil Beam Scanning Proton Therapy. (Abstract)

Radiation Necrosis and White Matter Lesions in Pediatric Patients With Brain Tumors Treated With Pencil Beam Scanning Proton Therapy. To assess the rate of radiation necrosis (RN) and white matter lesions (WMLs) in pediatric patients with primary brain tumors treated with pencil beam scanning (PBS) proton therapy (PT) with or without concomitant chemotherapy at the PSI.Between 1999 and 2015, 171 pediatric patients (age <18 years) were treated with PT. Median age at diagnosis was 3.3 years (...) (range, 0.3-17.0 years), and the median delivered dose was 54 Gy (relative biological effectiveness) (range, 40.0-74.1 Gy). Radiation necrosis and WMLs were defined as a new area of abnormal signal intensity on T2-weighted images or increased signal intensity on T2-weighted images, and contrast enhancement on T1 occurring in the brain parenchyma included in the radiation treatment field, which did not demonstrate any abnormality before PT. Radiation necrosis and WMLs were graded according

2018 Biology and Physics

5. Brain Lesions in Children with Unilateral Spastic Cerebral Palsy Full Text available with Trip Pro

Brain Lesions in Children with Unilateral Spastic Cerebral Palsy Unilateral spastic cerebral palsy (US CP) is the second most common subtype of cerebral palsy.The aim of the study was to analyze neuroimaging findings in children with unilateral spastic cerebral palsy.The study was hospital based, which has included 106 patients with US CP (boys 72/girls 34, term 82/preterm 24). Neuroimaging findings were classified into 5 groups: Brain maldevelopment, predominant white matter injury (...) , predominant gray matter injury, non specific findings and normal neuroimaging findings.Predominant white matter lesions where the most frequent (48/106,45.28%; term 35/preterm 13), without statistically significant difference between term and preterm born children (x2=0.4357; p=0.490517). Predominant gray matter lesions had 32/106 children, 30.19%; (term 25/preterm 7, without statistically significant difference between term and preterm born children (x2=0.902; p=0.9862). Brain malformations had 10/106

2017 Medical Archives

6. Neuronal Biomarker Ubiquitin C-Terminal Hydrolase Detects Traumatic Intracranial Lesions on Computed Tomography in Children and Youth with Mild Traumatic Brain Injury Full Text available with Trip Pro

Neuronal Biomarker Ubiquitin C-Terminal Hydrolase Detects Traumatic Intracranial Lesions on Computed Tomography in Children and Youth with Mild Traumatic Brain Injury This study examined the performance of serum ubiquitin C-terminal hydrolase (UCH-L1) in detecting traumatic intracranial lesions on computed tomography (CT) scan (+CT) in children and youth with mild and moderate TBI (mmTBI) and assessed its performance in trauma control patients without head trauma. This prospective cohort study (...) with a GCS of 15, the AUC for detecting lesions was 0.83 (95% CI, 0.72-0.94). Similarly, in children under 5 years of age, the AUC was 0.79 (95% CI, 0.59-1.00). Performance for detecting intracranial lesions at a UCH-L1 cut-off level of 0.18 ng/mL yielded a sensitivity of 100%, a specificity of 47%, and a negative predictive value of 100%. UCH-L1 showed good performance in infants and toddlers younger than 5 years and performed well in children and youth with a GCS score of 15. Before clinical

2017 Journal of neurotrauma

7. Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury

Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury CLINICAL PRACTICE GUIDELINE FOR THE MANAGEMENT OF COMMUNICATION AND SWALLOWING DISORDERS FOLLOWING PAEDIATRIC TRAUMATIC BRAIN INJURY GUIDELINE© Murdoch Childrens Research Institute and the National Health and Medical Research Council Centre of Research Excellence on Psychosocial Rehabilitation in Traumatic Brain Injury 2017 Publisher: Murdoch Childrens Research (...) Institute Publication date: February 2017 ISBN Print: 978-0-9876209-0-3 ISBN Online: 978-0-9876209-1-0 Suggested citation: Morgan A, Mei C, Anderson V, Waugh M-C, Cahill L, & the TBI Guideline Expert Working Committee. Clinical Practice Guideline for the Management of Communication and Swallowing Disorders following Paediatric Traumatic Brain Injury. Melbourne: Murdoch Childrens Research Institute; 2017. Expert working committee: Jeanette Baker Katie Banerjee Mandy Beatson Candice Brady Kate Brommeyer

2017 Clinical Practice Guidelines Portal

8. Brain Lesions among Orally Fed and Gastrostomy-Fed Dysphagic Preterm Infants: Can Routine Qualitative or Volumetric Quantitative Magnetic Resonance Imaging Predict Feeding Outcomes? Full Text available with Trip Pro

used to evaluate MRI findings vs. feeding outcomes. ANCOVA was performed on the regression model to measure the association of maturity and brain volume between groups.Out of 43 infants, 44% were oral-fed and 56% were G-tube fed at hospital discharge (but not at time of the study). There was no relationship between qualitative brain lesions and feeding outcomes. Volumetric analysis revealed that cerebellum was greater (p < 0.05) in G-tube fed infants, whereas cerebrum volume was greater (p < 0.05 (...) Brain Lesions among Orally Fed and Gastrostomy-Fed Dysphagic Preterm Infants: Can Routine Qualitative or Volumetric Quantitative Magnetic Resonance Imaging Predict Feeding Outcomes? The usefulness of qualitative or quantitative volumetric magnetic resonance imaging (MRI) in early detection of brain structural changes and prediction of adverse outcomes in neonatal illnesses warrants further investigation. Our aim was to correlate certain brain injuries and the brain volume of feeding-related

2017 Frontiers in pediatrics

9. Punctate White Matter Lesions Associated With Altered Brain Development And Adverse Motor Outcome In Preterm Infants Full Text available with Trip Pro

Punctate White Matter Lesions Associated With Altered Brain Development And Adverse Motor Outcome In Preterm Infants Preterm infants who develop neurodevelopmental impairment do not always have recognized abnormalities on cerebral ultrasound, a modality routinely used to assess prognosis. In a high proportion of infants, MRI detects punctate white matter lesions that are not seen on ultrasonography. To determine the relation of punctate lesions to brain development and early neurodevelopmental (...) outcome we used multimodal brain MRI to study a large cohort of preterm infants. Punctate lesions without other focal cerebral or cerebellar lesions were detected at term equivalent age in 123 (24.3%) (59 male) of the 506 infants, predominantly in the centrum semiovale and corona radiata. Infants with lesions had higher gestational age, birth weight, and less chronic lung disease. Punctate lesions showed a dose dependent relation to abnormalities in white matter microstructure, assessed with tract

2017 Scientific reports

10. Combining Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging in Diagnosing Focal Brain Lesions in Children Full Text available with Trip Pro

Combining Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging in Diagnosing Focal Brain Lesions in Children Introduction We attempted to find the sensitivity and specificity of various pediatric brain masses in the Pakistani population while keeping histopathology or clinical diagnosis as the gold standard.   Methods This was a retrospective study that was conducted from January 2007 to January 2016. We reviewed the records of 204 patients that presented to the radiology department (...) of Aga Khan University Hospital (AKUH). Out of the 204, 135 pediatric patients in the 0-18 age group with focal brain lesions who underwent magnetic resonance spectroscopy (MRS) and a biopsy or clinical diagnosis were included. If histopathology was available, it was taken as the gold standard test; otherwise, clinical diagnosis was considered the gold standard.   Results We had a total of 135 patients, of which 71 (52.6%) were male and 64 (47.4%) were female. The mean age represented was 7.2 ± 4.5

2017 Cureus

11. Evaluation of the added value of 1H-magnetic resonance spectroscopy for the diagnosis of pediatric brain lesions in clinical practice Full Text available with Trip Pro

Evaluation of the added value of 1H-magnetic resonance spectroscopy for the diagnosis of pediatric brain lesions in clinical practice Magnetic resonance spectroscopy (MRS) aids noninvasive diagnosis of pediatric brain tumors, but use in clinical practice is not well documented. We aimed to review clinical use of MRS, establish added value in noninvasive diagnosis, and investigate potential impact on patient care.Sixty-nine children with lesions imaged using MRS and reviewed by the tumor board (...) through avoiding and guiding biopsy and aiding tumor characterization.MRS can improve accuracy and confidence in noninvasive diagnosis of pediatric brain lesions in clinical practice. There is potential to improve outcomes through avoiding biopsy of indolent lesions, aiding tumor characterization, and facilitating earlier family discussions and treatment planning.

2017 Neuro-oncology practice

12. Brain tumours (primary) and brain metastases in adults

, DWI series and T1 pre- and post-contrast volume) as the initial diagnostic test for suspected brain metastases, unless MRI is contraindicated. 1.6.2 T o help establish current disease status, offer extracranial imaging (appropriate to the primary tumour type) to people with any radiologically suspected brain metastases that may be suitable for focal treatment. 1.6.3 Perform all intracranial and extracranial diagnostic imaging and, if appropriate, biopsy of extracranial disease, before referral (...) Brain tumours (primary) and brain metastases in adults Br Brain tumours (primary) and br ain tumours (primary) and brain ain metastases in adults metastases in adults NICE guideline Published: 11 July 2018 nice.org.uk/guidance/ng99 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

13. Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report. Full Text available with Trip Pro

Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report. Tuberculous meningitis is a highly morbid, often fatal disease.We describe a case of an Italian child. DIAGNOSES:: we diagnosed early a Tuberculous meningitis complicated by the occurrence of hydrocephalus, stroke, and paradoxical reaction with brain pseudo-abscesses.The child started readily a specific therapy associated with steroids

2018 Medicine

14. Brain Lesion in Children involving the Posterior Fossa

on the term "Brain Lesion in Children involving the Posterior Fossa." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Childhood Infratentorial Neoplasm (C1332973) Concepts Neoplastic Process ( T191 ) English Childhood Infratentorial Neoplasms , Childhood Infratentorial Neoplasm , Childhood Infratentorial Tumors , Childhood Infratentorial Tumor , Pediatric Infratentorial Neoplasm , Pediatric Infratentorial Tumor Derived (...) Brain Lesion in Children involving the Posterior Fossa Brain Lesion in Children involving the Posterior Fossa Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse

2018 FP Notebook

15. Brain Lesion in Children

Lesion in Children Aka: Brain Lesion in Children , Brain Tumor in Children , Pediatric Brain Tumor From Related Chapters II. Epidemiology Peak : age 3 to 12 years old Most common childhood solid neoplasm Second only to for overall cancer III. Etiology Cranial exposure to radiation Meningiomas Astrocytomas Glioblastoma multiforme tic Factors in 19% of cases overall in 30% of Glioblastoma Multiforme Associated conditions Tuberous sclerosis Turcot Syndrome Li-Fraumeni cancer syndrome Von Hippel Lindau (...) Brain Lesion in Children Brain Lesion in Children Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Brain Lesion in Children Brain

2018 FP Notebook

16. Intracranial Lesions in Children and Adolescents with Morbid Obesity Full Text available with Trip Pro

Intracranial Lesions in Children and Adolescents with Morbid Obesity Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuro-endocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions.To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted (...) to the paediatric endocrinology department with this complaint.Cross-sectional study.A total of 120 cases admitted to the paediatric endocrinology department with the complaint of morbid obesity between 2002 and 2015 were included in this study. A detailed history was taken and a physical examination was performed; biochemical, hormonal parameters were evaluated. Contrast dynamic magnetic resonance imaging was performed in order to visualize cranial pathologies.An intracranial lesions was detected in 16.6

2017 Balkan medical journal

17. Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease Full Text available with Trip Pro

Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease Silent white matter changes (WMCs) on brain imaging are common in individuals with sickle cell disease (SCD) and are associated with cognitive deficits in children. We investigated the factors predictive of WMCs in adults with homozygous SCD and no history of neurological conditions. Patients were recruited from a cohort of adults with homozygous SCD followed up at an adult (...) sickle cell referral center for which steady-state measurements of biological parameters and magnetic resonance imaging scans of the brain were available. WMCs were rated by consensus, on a validated age-related WMC scale. The prevalence of WMCs was 49% (95% confidence interval [CI], 39%-60%) in the 83 patients without vasculopathy included. In univariable analysis, the patients who had WMCs were more likely to be older (P = .003) and to have hypertension (P = .02), a lower mean corpuscular volume (P

2017 Blood advances

18. SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2018 Clinical Trials

19. Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy Full Text available with Trip Pro

Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function.Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function (...) , communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes.Brain lesions were most frequently located in the ventral posterior lateral

2018 NeuroImage : Clinical

20. MRI brain lesions in asymptomatic boys with X-linked adrenoleukodystrophy. (Abstract)

MRI brain lesions in asymptomatic boys with X-linked adrenoleukodystrophy. To describe the brain MRI findings in asymptomatic patients with childhood cerebral adrenoleukodystrophy (CCALD).We retrospectively reviewed a series of biochemically or genetically confirmed cases of adrenoleukodystrophy followed at our institution between 2001 and 2015. We identified and analyzed 219 brain MRIs from 47 asymptomatic boys (median age 6.0 years). Patient age, MRI scan, and brain lesion characteristics (...) (e.g., contrast enhancement, volume, and Loes score) were recorded. The rate of lesion growth was estimated using a linear mixed effect model.Sixty percent of patients (28/47) showed brain lesions (median Loes score of 3.0 points; range 0.5-11). Seventy-nine percent of patients with CCALD (22/28) had contrast enhancement on first lesional or subsequent MRI. Lesion progression (Loes increase of ≥0.5 point) was seen in 50% of patients (14/28). The rate of lesion growth (mL/mo) was faster in younger

2019 Neurology

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