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Bone Age Film

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1881. In children less than 8 years of age who are acutely limping with no history of trauma, what is the incidence of diagnoses which can be diagnosed by x-ray?

films should be examined for bone fragmentation (Perthes'), joint space widening (sepsis, Perthes') and structural abnormalities (hip dysplasia). Especially in hip films, anteroposterior and frog-lateral views are necessary because the pathology is frequently best seen on lateral views (Figure 9). In the nonverbal patient, a screening anteroposterior film from hips to feet identifies a fracture in one fifth of patients presenting with a limp. It is useful to remember that the growth plate is weaker (...) of bone o Re-ossification of new bone o Healed stage.” [4] References 1. Fordham L, Gunderman R, Blatt ER, Bulas D, Coley BD, Podberesky DJ, Prince JS, Tosi L, Expert Panel on Pediatric Imaging. Limping child--ages 0-5 years. [online publication]. Reston (VA): American College of Radiology (ACR); 2007. ( ) 2. Beach C. Limping child. E-Medicine. March 2007. ( ) 3. Leet A and Skaggs D. Evaluation of the acutely limping child. American Family Physician;2000: 61(4). ( ) 4. Nochimson G. Legg-Calve-Perthes

2008 TRIP Answers

1882. Bone Scintigraphy

University UZ Gasthuisberg, Louvain, Belgium 10 University of Ulm, Germany Published online: 1 November 2003 © EANM 2003for bone imaging because of their good localisation in the skeleton and rapid clearance from soft tissues. Bone scintigraphy images the distribution of a radioac- tive tracer in the skeletal system. It can be performed as: a) Limited bone scintigraphy or spot views (planar im- ages of a selected portion of the skeleton) b) Whole-body bone scintigraphy (planar images of the entire (...) Bone Scintigraphy Keywords: Bone scintigraphy – Tumour imaging – Pro- cedure guidelines – Indications Eur J Nucl Med Mol Imaging (2003) 30:BP99–BP106 DOI 10.1007/s00259-003-1347-2 Aim The purpose of this document is to provide general infor- mation about bone scintigraphy in oncology. These guidelines describe procedures currently in routine clini- cal use but should not be interpreted as excluding alterna- tive procedures also employed to obtain equivalent data. It must be remembered

2003 European Association of Nuclear Medicine

1883. Fracture of Distal Radius and Ulna Healed With Shortening of One Bone. Clinical Significance at Skeletal Maturity

not find in the literature study that investigates this problem. We postulate that obvious shortening of one bone may cause an inequality of DRUJ and can be clinically significant. Condition or disease Forearm Injuries Detailed Description: We will evaluate the x-ray films of children that at the time of the injury were between the ages 1 day and 12 years. The selection of the x-ray films will be done based on the specific codes of the wrist x-rays (Ulna or Radius). The evaluation will be merely (...) to children that were treated in our hospital from 1996 to 2000.We are aiming to find cases when the fractures were healed with 1cm or more of shortening of one of the forearm's bones (Radius or Ulna). We are going to compare these cases with another 20 patients with the same characteristics as the latter groups on the exception that their fractures were healed without shortening. The two groups will be matched by age, gender and the same diagnosis. These patients will be summoned to the clinic when

2007 Clinical Trials

1884. Zoledronate in Preventing Osteoporosis and Bone Fractures in Patients With Locally Advanced Nonmetastatic Prostate Cancer Undergoing Radiation Therapy and Hormone Therapy

months prior to registration. If pelvic radiation therapy (RT) has started, it must have begun ≤ 8 weeks prior to registration; Appropriate stage for protocol entry, including no distant metastases, based upon the following minimum diagnostic workup to be done within 16 weeks prior to registration: History/physical examination; Dental evaluation, including history of dental surgery (e.g., extraction or implant); Bone scan; T and L spine films; DXA scan: To be eligible the patient must have a scan (...) Zoledronate in Preventing Osteoporosis and Bone Fractures in Patients With Locally Advanced Nonmetastatic Prostate Cancer Undergoing Radiation Therapy and Hormone Therapy Zoledronate in Preventing Osteoporosis and Bone Fractures in Patients With Locally Advanced Nonmetastatic Prostate Cancer Undergoing Radiation Therapy and Hormone Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search

2006 Clinical Trials

1885. An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation

Eligible for Study: 18 Years to 70 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age between 18 and 65 Radiographically determined discogenic origin to include at least one of the following characteristics: degenerated/dark disc on MRI, decreased disc height compared to adjacent levels on radiographic film, CT, or MRI and disc herniation on CT or MRI Radicular symptoms by history and physical exam to include at least the following (...) An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation An Assessment of P-15 Bone Putty in Anterior Cervical Fusion With Instrumentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2006 Clinical Trials

1886. Safety/Efficacy of Intravenous Zoledronic Acid When Added to Standard Therapies in Patients With Breast Cancer and Metastatic Bone Lesions

table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion criteria Confirmed diagnosis of Breast Cancer with at least one breast cancer-related bone lesion No treatment with bisphosphonates within 6 months prior to inclusion into the study Good health status (ECOG Performance status 0-2) Exclusion criteria Patients who do not have at least one breast cancer-related bone lesion (...) that is detectable on conventional radiographs of bone (plain film) at screening Abnormal renal function History of diseases with influence on bone metabolism such as Paget's disease and primary hyperparathyroidism Pregnancy and lactation Current active dental problems including infection of the teeth or jawbone (maxilla or mandibular); dental or fixture trauma, or a current or prior diagnosis of osteonecrosis of the jaw (ONJ), of exposed bone in the mouth, or of slow healing after dental procedures, recent

2006 Clinical Trials

1887. Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders

this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Clinical diagnosis of a metabolic bone disorder Exclusion Criteria: Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you (...) Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2006 Clinical Trials

1888. Regenafil Versus Demineralized Freeze Dried Bone Allograft (DFDBA) for Periodontal Defects

Regenafil Versus Demineralized Freeze Dried Bone Allograft (DFDBA) for Periodontal Defects Regenafil Versus Demineralized Freeze Dried Bone Allograft (DFDBA) for Periodontal Defects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more (...) studies before adding more. Regenafil Versus Demineralized Freeze Dried Bone Allograft (DFDBA) for Periodontal Defects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00255970 Recruitment Status : Completed First Posted : November 21, 2005 Results First Posted : August 5, 2011 Last Update Posted

2005 Clinical Trials

1889. Open-label Study, to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Bone Lesions Secondary to Multiple Myeloma.

Ages Eligible for Study: 18 Years to 80 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 2. Confirmed Diagnosis of Durie-Salmon Stage III Multiple Myeloma, with the following clinical characteristics: A. At least 1 osteolytic bone lesion demonstrable in a conventional X-ray film. B. The patient will have to be receiving treatment for primary neoplasia, at the time (...) of the start of this trial. - Ambulatory patients aged ≥ 18 years. Exclusion Criteria: Treatment with bisphosphonates in any moment during the last 12 months before visit 1. except for those patients that received only one dosis of bisphosphonates for any indication and when the administration has been 14 days before or older. Patients with an absence of a bone lesion clearly related to the primary cancer, and that is detectable in a conventional bone X-ray (simple film). Patients with a Serum Calcium

2005 Clinical Trials

1890. Identification of Peptides with Targeted Adhesion to Bone-Like Mineral via Phage Display and Computational Modeling Full Text available with Trip Pro

adhesion via cell recognition sequences, may increase cell adhesion, leading to increased osteogenesis. The aim of this study is to identify peptide sequences with preferential adsorption towards apatite-based materials. Bone-like mineral films and hydroxyapatite disks were panned with a phage library to elucidate peptide sequences with favorable adsorption. Peptide sequences were analyzed using the web-based biotechnology tool RELIC and validated with a modified ELISA, in addition to being (...) Identification of Peptides with Targeted Adhesion to Bone-Like Mineral via Phage Display and Computational Modeling The challenges in engineering bone scaffolds reflect the complexity of bone as an organ. The organic-inorganic hybrid system design aims to provide signals within a conductive apatite layer to promote cell adhesion, proliferation and ultimately differentiation into bone tissue. Dual functioning peptides designed to specifically adhere to the apatite layer, while promoting cell

2008 Cells, tissues, organs

1891. Evaluating the value of repeat bone mineral density measurement and prediction of fractures in older women: the study of osteoporotic fractures. Full Text available with Trip Pro

Evaluating the value of repeat bone mineral density measurement and prediction of fractures in older women: the study of osteoporotic fractures. Whether repeat bone mineral density (BMD) measurement adds benefit beyond the initial BMD measurement in predicting fractures in older women is unknown.We prospectively measured total hip BMD in 4124 older women (mean +/- SD age, 72 +/- 4 years) from 1989 to 1990 and again 8 years later. Incident nontraumatic hip and nonspine fractures were validated (...) by radiology reports (>95% follow-up). In addition, spine fractures were defined morphometrically in 2129 of these women by lateral spine x-ray films from 1991 to 1992 and then again 11.4 years later. Prediction of fracture risk was assessed with proportional hazards models and receiver operating characteristic curves for BMD measures.Over a mean of 5 years after the repeat BMD measure, 877 women experienced an incident nontraumatic nonspine fracture (275 hip fractures). In addition, 340 women developed

2007 Archives of Internal Medicine

1892. Effects of bisphosphonates on fracture incidence and bone metabolism in rheumatoid arthritis patients in general practice taking long-term corticosteroid therapy: a retrospective study. (Abstract)

at the start of bisphosphonate therapy were excluded from the study. Vertebral fractures were detected by obtaining plain x-ray films of the thoracic and lumbar spines at the start of bisphosphonate therapy and on completion of follow-up. We measured the incidence of new fractures, the speed of sound (SOS) at the calcaneus as measured by quantitative ultrasound, and levels of crosslinked N-telopeptide of type I collagen (NTX), a marker of bone resorption. The percentage change at each measuring point (...) Effects of bisphosphonates on fracture incidence and bone metabolism in rheumatoid arthritis patients in general practice taking long-term corticosteroid therapy: a retrospective study. There is a risk that disturbances of activities of daily living (ADL) due to rheumatoid arthritis (RA) are increased by the occurrence of fractures, including vertebral compression fractures and femoral neck fractures, in RA patients receiving oral corticosteroid therapy. Bisphosphonates are most commonly used

2008 Clinical drug investigation Controlled trial quality: uncertain

1893. Bone morphogenetic protein-2 (BMP-2) in the treatment of pyogenic vertebral osteomyelitis. (Abstract)

Bone morphogenetic protein-2 (BMP-2) in the treatment of pyogenic vertebral osteomyelitis. Retrospective case series.To present results of recombinant human bone morphogenetic protein-2 (rhBMP-2) use in medically nonresponsive pyogenic vertebral osteomyelitis (PVO), treated by anterior/posterior debridement and instrumented fusion in the cervical, thoracic, and lumbosacral spine.Surgical options for PVO vary, as do their outcomes, and can be complicated by recurrence, pseudarthrosis, and death (...) . Although rhBMP-2 use in spinal fusion is increasing, its utility in PVO is unknown. Additionally, use in areas of infection is listed as a contraindication, although this is not supported by laboratory (animal) studies or clinical studies in long bones.Between 2003 and 2005, 14 patients who underwent circumferential fusion for PVO were included in this study. Average patient age was 54 years (range, 27-77 years). Eight (57%) patients had 3 or more vertebral bodies involved. Diagnostic studies included

2007 Spine

1894. Vascular calcification: a stiff challenge for the nephrologist: does preventing bone disease cause arterial disease? Full Text available with Trip Pro

Vascular calcification: a stiff challenge for the nephrologist: does preventing bone disease cause arterial disease? There has been an explosion of interest in vascular calcification in the last 5 years. Four key "germinal" findings have fallen onto very fertile soil. First, on the background of an increasing cardiovascular disease burden it has been found that at least cross-sectionally, and in a limited fashion prospectively, achieved dialysis plasma phosphate levels are linked to all-cause (...) and cardiovascular mortality. Second, there are increasing reports of calcific uremic arteriolopathy in Australia and the United States. Third, we know know that the mechanical properties of the carotid artery, and the aorta, have a profound influence on survival for dialysis patients. Vascular calcification itself (as assessed by x-ray films and ultrasound) has been linked to aortic stiffness. Fourth, increasing numbers of studies are showing extremely extensive coronary artery calcification (CAC) in dialysis

2004 Kidney International

1895. Can nonstandardized bitewing radiographs be used to assess the presence of alveolar bone loss in epidemiologic studies? (Abstract)

Can nonstandardized bitewing radiographs be used to assess the presence of alveolar bone loss in epidemiologic studies? To compare periodontitis-associated alveolar bone loss assessment by standardized and nonstandardized radiographs in clinical and epidemiologic studies.Participants included 37 patients aged 21-66 years with prior nonstandardized bitewing radiographs scheduled to receive bitewing radiographs as part of their next routine dental care visit. Standardized bitewing radiographs (...) were taken with a Rinn film holder to position the film in the mouth and align the X-rays so that they were at 90 degrees to the film. Before taking the radiograph the bite was registered in centric relation using a polyether impression material. One registered dental hygienist took and processed all the standardized radiographs. One dentist read all radiographs using a viewing box, magnifying lens, and periodontal probe with William's markings. Radiographic bone loss was measured to the closest

2004 Community Dentistry and Oral Epidemiology

1896. Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis. (Abstract)

in a natural history study of symptomatic knee osteoarthritis (OA).MRI of the knee was performed at baseline, 15 months, and 30 months in 217 patients with primary knee OA (122 men, 95 women; mean +/- SD age 66.4 +/- 9.4 years). To assess mechanical alignment, long-limb films were obtained at 15 months. Subchondral bone marrow abnormalities, graded in the medial and lateral tibiofemoral joints, were defined as poorly marginated areas of increased signal intensity in the marrow on fat-suppressed, T2 (...) Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis. Although bone marrow lesions (BMLs) are powerful predictors of joint space loss as visualized on radiographs, the natural history of these lesions, their relationship to cartilage loss, and the association between change in these lesions and cartilage loss are unknown. These questions were tested using longitudinal magnetic resonance imaging (MRI) data

2006 Arthritis and Rheumatism

1897. Bone marrow edema and its relation to progression of knee osteoarthritis. (Abstract)

and whether these lesions are associated with limb malalignment.Natural history study.A Veterans Administration hospital in Boston, Massachusetts.Persons 45 years of age and older with symptomatic knee osteoarthritis.Baseline assessments included magnetic resonance imaging of the knee and fluoroscopically positioned radiography. During follow-up at 15 and 30 months, patients underwent repeated radiography; at 15 months, long-limb films were obtained to assess mechanical alignment. Progression was defined (...) Bone marrow edema and its relation to progression of knee osteoarthritis. While factors affecting the course of knee osteoarthritis are mostly unknown, lesions on bone scan and mechanical malalignment increase risk for radiographic deterioration. Bone marrow edema lesions on magnetic resonance imaging correspond to bone scan lesions.To determine whether edema lesions in the subarticular bone in patients with knee osteoarthritis identify knees at high risk for radiographic progression

2003 Annals of Internal Medicine

1898. Juvenile osteopetrosis: effects on blood and bone of prednisone and a low calcium, high phosphate diet. Full Text available with Trip Pro

treatment until over 24 months of age have shown a good clinical and radiological response but have remained on treatment for six years. The fourth child started treatment at 6 months and showed a good clinical response, but x ray films showed no change nine months later. He was then lost to follow up, stopped treatment, and died two years later of a septicaemia. These patients provide further evidence for the efficacy of steroids in juvenile osteopetrosis, and the combination with the low calcium, high (...) Juvenile osteopetrosis: effects on blood and bone of prednisone and a low calcium, high phosphate diet. Four children with juvenile osteopetrosis are described who were treated with a combination of prednisone and a low calcium, high phosphate diet. One of the children, treated as a neonate, achieved complete clinical and radiological remission from the disease after nine months, at which point treatment was stopped. There have been no signs of recurrence for two years. Two who did not start

1986 Archives of Disease in Childhood

1899. Feasibility Study of Interleukin 1-Alpha With Ifosfamide, CBDCA, and Etoposide With Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma

with clinical evidence of pulmonary dysfunction): DLCO greater than 50 percent, compensated for Hgb, FEV 1 greater than 55 percent and PO2 greater than 60. Negative bilateral bone marrow biopsies prior to bone marrow harvest. No evidence of metastatic disease to the pelvis on plain film or bone scan. Karnofsky performance status greater than or equal to 70 and a life expectancy greater than or equal to 60 days. No evidence of pregnancy or risk of pregnancy at the time of transplantation in women. Ability (...) Feasibility Study of Interleukin 1-Alpha With Ifosfamide, CBDCA, and Etoposide With Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma Feasibility Study of Interleukin 1-Alpha With Ifosfamide, CBDCA, and Etoposide With Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail

1999 Clinical Trials

1900. Zolendronate for the Prevention of Bone Loss in Men w/ Prostate CA on Long-Term Androgen Deprivation

baseline to 13 months [ Time Frame: Bone scan taken at baseline and month 13 ] To assess bone density change as measured by dual-energy x-ray absorptiometry Secondary Outcome Measures : Percentage change in lumbar spine and hip bone density as measured by plain film x-rays of lumbar spine and pelvis from baseline to 13 months [ Time Frame: Lumbar spine and hip bone density taken at baseline and month 13. ] To assess the percentage change in lumbar spine and hip bone density as measured by plain film x (...) Zolendronate for the Prevention of Bone Loss in Men w/ Prostate CA on Long-Term Androgen Deprivation Zolendronate for the Prevention of Bone Loss in Men w/ Prostate CA on Long-Term Androgen Deprivation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2003 Clinical Trials

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