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41. THE DIAGNOSTIC VALUE OF THE PLACENTAL BLOOD FILM IN ÆSTIVO-AUTUMNAL MALARIA (PubMed)

, bone marrow, and placenta, yet our anatomical records will not support that theory. A sluggish blood sinus with a large endothelial surface, a higher internal body temperature, and red blood cells burdened with parasites of a certain age beyond the ring form seem to be important factors in the localization and development of the aestivo-autumnal parasite. 9. The racial disparity of malarial infections shown in this series is believed to be due to local conditions and a wrong impression is apt (...) THE DIAGNOSTIC VALUE OF THE PLACENTAL BLOOD FILM IN ÆSTIVO-AUTUMNAL MALARIA 1. The placental blood film examination is worthy of routine application wherever aestivo-autumnal malaria is endemic. This type of malaria when associated with labor and the early days of the puerperium can be more easily and certainly diagnosed by the use of this film and a polychrome stain than by employing the usual films made from the mother's peripheral blood at the time of labor. The placental film

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1915 The Journal of experimental medicine

42. Open Label Phase Two Trial of Radium Ra 223 Dichloride With Concurrent Administration of Abiraterone Acetate Plus Prednisone in Symptomatic Castration-Resistant (Hormone-Refractory) Prostate Cancer Subjects With Bone Metastasis

Fluoride PET/CT Scan *If a bone scan is used, solitary lesions which could be contributed to causes other than prostate cancer must be confirmed with a second modality (i.e.: plain films, CT Scan or MRI. Subject has Castrate Resistant Prostate Cancer, defined as rising PSA with a testosterone level Bone Metastasis Open Label Phase Two Trial of Radium Ra 223 Dichloride With Concurrent Administration of Abiraterone Acetate Plus Prednisone in Symptomatic Castration-Resistant (Hormone-Refractory) Prostate Cancer Subjects With Bone Metastasis - Full Text View - ClinicalTrials.gov Hide

2014 Clinical Trials

43. Real Time 3D Imaging and Surrogate Bone Model

and receive the preoperative CT scan. Subjects will be randomized into either the experimental or control group at the time of consent by the study coordinator. Subjects in the experimental group will have their pre-operative planning done using the 3D surgical simulator and surrogate bone model will be available for the surgeon during surgery. Subjects in the control group will have their pre-operative planning done using plain film x-ray and two-dimensional (2D) templates. Eligible subjects (...) Real Time 3D Imaging and Surrogate Bone Model Real Time 3D Imaging and Surrogate Bone Model - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Real Time 3D Imaging and Surrogate Bone Model The safety

2014 Clinical Trials

44. Study to Evaluate Bone Marrow Cells in the Treatment of Chronic Wounds

(NIH) National Institute on Aging (NIA) Information provided by (Responsible Party): Dr. E.Badiavas, University of Miami Study Details Study Description Go to Brief Summary: Management of chronic wounds with: Bone Marrow Aspirate Plus Cultured Cells Group Cultured Cells Alone Group Bone Marrow Aspirate Alone Group Control Group Condition or disease Intervention/treatment Phase Ulcer Biological: Bone Marrow Aspirate Biological: Cultured Bone Marrow Cells Procedure: Control Phase 1 Study Design Go (...) and dressing changes. Wound dressings allowed will include gauze, foam dressings, occlusive films, and non-stick pads. More advanced dressing materials such as Hydrocolloids, alginates, silver containing dressings, and biomaterials can also be used. Compression will be utilized for lower extremity wounds. Other Name: Standard of Care Experimental: Cultured Bone Marrow Cells In this group, the bone marrow aspirate will be sent to the laboratory to be grown in tissue culture. Once the cell cultures have

2014 Clinical Trials

45. A Study of AGS-16C3F vs. Axitinib in Metastatic Renal Cell Carcinoma

: Consistent and correct usage of established oral contraception. Established intrauterine device (IUD) or intrauterine system (IUS). Barrier methods of contraception: condom or occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository Exclusion Criteria: Has previously been treated with axitinib, AGS-16C3F, or AGS-16M8F Has untreated brain metastasis. In the case of a solitary brain metastasis which has been resected, there must be evidence of a disease-free (...) A Study of AGS-16C3F vs. Axitinib in Metastatic Renal Cell Carcinoma A Study of AGS-16C3F vs. Axitinib in Metastatic Renal Cell Carcinoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of AGS-16C3F

2015 Clinical Trials

46. Bone Marrow Failure (Follow-up)

disease. Bone marrow transplantation (BMT) candidates are patients who are younger than age 55 years who have severe disease and a matched, related donor. [ ] With current BMT regimens, most patients with severe aplastic anemia have a 60-70% long-term survival rate. Survival rates of higher than 80% are reported for patients in more favorable subgroups. Using matched, unrelated donors still is less favorable (11-20% survival rates). Patients with inherited bone marrow failure and a matched sibling (...) using preimplantation genetic diagnosis. Blood . 2004 Feb 1. 103(3):1147-51. . Molldrem JJ, Leifer E, Bahceci E, Saunthararajah Y, Rivera M, Dunbar C, et al. Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes. Ann Intern Med . 2002 Aug 6. 137(3):156-63. . Parikh S, Bessler M. Recent insights into inherited bone marrow failure syndromes. Curr Opin Pediatr . 2012 Feb. 24(1):23-32. . Media Gallery This bone marrow film at 400X magnification

2014 eMedicine.com

47. Bone Marrow Failure (Treatment)

disease. Bone marrow transplantation (BMT) candidates are patients who are younger than age 55 years who have severe disease and a matched, related donor. [ ] With current BMT regimens, most patients with severe aplastic anemia have a 60-70% long-term survival rate. Survival rates of higher than 80% are reported for patients in more favorable subgroups. Using matched, unrelated donors still is less favorable (11-20% survival rates). Patients with inherited bone marrow failure and a matched sibling (...) using preimplantation genetic diagnosis. Blood . 2004 Feb 1. 103(3):1147-51. . Molldrem JJ, Leifer E, Bahceci E, Saunthararajah Y, Rivera M, Dunbar C, et al. Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes. Ann Intern Med . 2002 Aug 6. 137(3):156-63. . Parikh S, Bessler M. Recent insights into inherited bone marrow failure syndromes. Curr Opin Pediatr . 2012 Feb. 24(1):23-32. . Media Gallery This bone marrow film at 400X magnification

2014 eMedicine.com

48. Bone Marrow Transplantation, Long-Term Effects (Overview)

expand (eg, umbilical-cord blood, haploidentical donors), ex vivo expansion of hematopoietic stem cells becomes feasible, [ ] and as supportive care improves. In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to and autoimmunity. This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. Most of the identifiable cells are lymphocytes or plasma (...) Bone Marrow Transplantation, Long-Term Effects (Overview) Long-Term Effects of Bone Marrow Transplantation: Overview, Immunosuppression and Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation, Secondary Malignancies After Hematopoietic Stem Cell Transplantation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com

2014 eMedicine Pediatrics

49. Bone Infarct

associated with the disease. See the images below. Lateral view of the knee in a deep-sea diver shows dysbaric osteonecrosis in the diaphysis of the femur and tibia. Note the irregular calcific deposits with a shell-like pattern, which is typical of a bone infarct. Plain radiograph in a middle-aged man with shoulder discomfort demonstrates an irregularly calcified bone infarct in the diametaphysis of the right humerus. Coronal T1-weighted MRI in a 12-year-old boy with early Legg-Calvé-Perthes disease (...) bones, patchy lucencies and sclerosis are often associated with bone collapse or fractures (see the images below). Plain radiograph in a middle-aged man with shoulder discomfort demonstrates an irregularly calcified bone infarct in the diametaphysis of the right humerus. Plain radiograph in a 68-year-old man with hip pain demonstrates patchy sclerosis of both femoral heads that is consistent with avascular necrosis. Plain radiograph of the pelvis in a man demonstrates collapse of the left femoral

2014 eMedicine Radiology

50. Temporal Bone, Acquired Cholesteatoma

computed tomography (CT) scan findings in middle-ear cholesteatoma in 32 pediatric patients (age range, 3-14 y), 30 of whom presented with acquired cholesteatoma (AC) and 2 with congenital cholesteatoma. CT was performed using 1-mm or 2-mm axial and coronal sections of both temporal bones. In 19 of the patients with AC (63.3%), CT showed a diffuse soft-tissue density isodense with muscle, and in 6 other patients, the mass mimicked inflammation. In the remaining 5 patients with AC, CT revealed (...) bone. Schuller view The Schuller view is a lateral view of the mastoid, obtained with the sagittal plane of the skull parallel to the film and with 30º-cephalocaudal angulation on the radiographic beam. This view shows the degree and extent of mastoid pneumatization, the status of the trabecular pattern, and the position of the lateral sinus. Stenvers view The Stenvers view is obtained with the patient facing the film and the head slightly flexed and rotated 45º toward the side opposite

2014 eMedicine Radiology

51. Bone Marrow Transplantation, Long-Term Effects (Diagnosis)

expand (eg, umbilical-cord blood, haploidentical donors), ex vivo expansion of hematopoietic stem cells becomes feasible, [ ] and as supportive care improves. In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to and autoimmunity. This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. Most of the identifiable cells are lymphocytes or plasma (...) Bone Marrow Transplantation, Long-Term Effects (Diagnosis) Long-Term Effects of Bone Marrow Transplantation: Overview, Immunosuppression and Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation, Secondary Malignancies After Hematopoietic Stem Cell Transplantation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com

2014 eMedicine Pediatrics

52. Bone Marrow Transplantation, Long-Term Effects (Follow-up)

expand (eg, umbilical-cord blood, haploidentical donors), ex vivo expansion of hematopoietic stem cells becomes feasible, [ ] and as supportive care improves. In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to and autoimmunity. This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. Most of the identifiable cells are lymphocytes or plasma (...) Bone Marrow Transplantation, Long-Term Effects (Follow-up) Long-Term Effects of Bone Marrow Transplantation: Overview, Immunosuppression and Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation, Secondary Malignancies After Hematopoietic Stem Cell Transplantation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com

2014 eMedicine Pediatrics

53. Bone Marrow Transplantation, Long-Term Effects (Treatment)

expand (eg, umbilical-cord blood, haploidentical donors), ex vivo expansion of hematopoietic stem cells becomes feasible, [ ] and as supportive care improves. In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to and autoimmunity. This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. Most of the identifiable cells are lymphocytes or plasma (...) Bone Marrow Transplantation, Long-Term Effects (Treatment) Long-Term Effects of Bone Marrow Transplantation: Overview, Immunosuppression and Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation, Secondary Malignancies After Hematopoietic Stem Cell Transplantation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com

2014 eMedicine Pediatrics

54. In a patient aged over 80 should bisphosphonates be prescribed for kyphosis that is suspected but not confirmed as arising from osteoporosis?

adults, aged 50-96 years, from the middle-class community of Rancho Bernardo, California, USA, attended a 1992-96 research clinic visit. Bone mineral density (BMD) was measured at the hip and spine, and lateral thoracolumbar spine radiographs were obtained. The degree of kyphosis was determined using the modified Cobb method. RESULTS: A total of 114 of 553 men (20.6%) and 188 of 854 women (22.0%) had one or more thoracic vertebral fractures. Degenerative disc disease was observed in 45.4% of men (...) that thoracic kyphosis is associated with substantial pain, disability, and height loss, we measured thoracic curvature, using an architect's flexicurve, of 610 women aged 65-91 years who were recruited from population-based listings. We assessed study subjects for back pain, back-related disability, height loss since age 25 years, perceived state of health, and bone mineral density (BMD) at the spine, calcaneus, proximal radius, and distal radius. Compared with the rest of the cohort, the 10% of women

2012 TRIP Answers

55. Guidelines for Bone Scintigraphy in Children

Town and Red Cross War Memorial Children’s Hospital, Rondebosch, Cape Town, South Africa M. Mann : D. De Palma(*) Circolo Hospital and Macchi Foundation, Varese, Italy e-mail: didepal@tin.it Eur J Nucl Med Mol Imaging DOI 10.1007/s00259-010-1492-3High-quality images are crucial and require correct positioning and often immobilization of the child as well as optimal equipment.Due to the age-dependent differences in bone metabolism in the developing skeleton, the interpretation of bone scanning (...) osteoma G. Bone dysplasia and other metabolic diseases [11, 32] – Camurati-Engelmann disease – evaluating skeletal involvement (brown tumours) in children with hyperparathyroidism [33] H. Other clinical situations in paediatrics [8, 11, 34–36] – pain possibly due to bone pathology – limp or backache – fever of unknown origin – evaluating apophyseal activity in the mandibular condyles in children with mandibular asymmetry Contraindications Although uncommon in the paediatric age group, the possibility

2010 European Association of Nuclear Medicine

56. Postmenopausal women with osteoporosis and osteoarthritis show different microstructural characteristics of trabecular bone in proximal tibia using high-resolution magnetic resonance imaging at 3 tesla. (PubMed)

Postmenopausal women with osteoporosis and osteoarthritis show different microstructural characteristics of trabecular bone in proximal tibia using high-resolution magnetic resonance imaging at 3 tesla. Osteoporosis (OP) and osteoarthritis (OA) are two common musculoskeletal disorders that affect the quality of life in aged people. An inverse relationship between OP and OA was proposed four decades ago. However, the difference in microstructure of the trabecular bone of these two disorders (...) in this study. Primary OA of hip, knee, as well as spinal arthrosis were diagnosed according to plain X-ray film findings. Osteoporosis was defined based on the latest criteria of World Health Organization (WHO). Structural and textural parameters derived from HR-MRI images of proximal tibia were calculated and compared with special software.There were significant differences in apparent bone volume fraction, trabecular thickness, mean roundness, Euler number, entropy and inverse different moment between OP

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2013 BMC Musculoskeletal Disorders

57. A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors

A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01920568 Recruitment Status : Completed First Posted : August 12, 2013 Results First Posted : August 25

2013 Clinical Trials

58. Conductor-Assisted Nasal Sonography: An Innovative Technique for Rapid and Accurate Detection of Nasal Bone Fracture. (PubMed)

), and negative predictive value (NPV) of nasal bone fracture identified by CANS and other plain films versus nasal bone fracture evidenced by CT scan, taken as the gold standard, were measured.Of these patients (52 males and 19 females; mean age, 40 years ± 19.8 years), 52 of 71 were diagnosed with nasal fractures by facial CT scans. No demographic difference was found in fracture and nonfracture groups. In addition to nasal sonography and facial CT scan, 23 patients also received nasal X-ray examination, 17 (...) Conductor-Assisted Nasal Sonography: An Innovative Technique for Rapid and Accurate Detection of Nasal Bone Fracture. Nasal bone is frequently involved in craniofacial trauma. We sought to investigate the role of conductor-assisted nasal sonography (CANS) in patients with nasal trauma.In all, 71 patients sustaining midfacial trauma who underwent CANS examination with simultaneous facial computed tomography (CT) scans were reviewed. Sensitivity, specificity, positive predictive value (PPV

2011 Journal of Trauma

59. Measurement of Patient Skin Dose in Vertebroplasty Using Radiochromic Dosimetry Film. (PubMed)

Measurement of Patient Skin Dose in Vertebroplasty Using Radiochromic Dosimetry Film. We studied the radiation doses to which patients were exposed during 17 vertebroplasty operations.The radiation doses during vertebroplasty were measured to determine maximum skin dose (MSD), a measure of the likelihood of radiation-induced skin effects.Vertebroplasty is performed with use of fluoroscopic guidance for needle placement and to monitor bone cement injection. This procedure requires relatively (...) long duration of fluoroscopic guidance, and so, it demands dose measurements for patients.From May 2006 to April 2008, 16 patients (7 men and 9 women; mean age 70.19 years, range 30-87 years) underwent a total of 17 vertebroplasty procedures. Total dose-area product (DAP), duration of fluoroscopy, and the parameters for anteroposterior (AP) and lateral (LAT) fluoroscopic and fluorography projections were recorded for each procedure. Gafchromic films were placed on the patients' skin to measure

2010 Spine

60. Benign Bone Tumors

similar to that of an . Some experts simply consider them large osteoid osteomas (> 2 cm). Osteoblastoma is much more common among males and appears typically between ages 10 and 35. The tumor develops in the bone of the spine, legs, hands, and feet. It is a slow-growing tumor that destroys normal bone. This tumor is painful. Imaging is with plain films, CT, and MRI. A biopsy is warranted to make an accurate diagnosis of osteoblastoma. Treatment of osteoblastoma requires surgery, often curettage (...) ligand (RANKL) inhibitor, can be used in the treatment of benign giant cell tumor of bone for large, potentially nonoperable tumors (see image Giant Cell Tumor [CT Scan]). Chondroblastoma Chondroblastoma is rare and occurs most commonly among people aged 10 to 20. Arising in the epiphysis, this tumor may continue to grow and destroy bone and the joint. It appears on imaging studies as a sclerotic marginated cyst containing spots of punctate calcification. MRI can help diagnostically by showing

2013 Merck Manual (19th Edition)

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