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Bone Age Film

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41. In a patient aged over 80 should bisphosphonates be prescribed for kyphosis that is suspected but not confirmed as arising from osteoporosis?

adults, aged 50-96 years, from the middle-class community of Rancho Bernardo, California, USA, attended a 1992-96 research clinic visit. Bone mineral density (BMD) was measured at the hip and spine, and lateral thoracolumbar spine radiographs were obtained. The degree of kyphosis was determined using the modified Cobb method. RESULTS: A total of 114 of 553 men (20.6%) and 188 of 854 women (22.0%) had one or more thoracic vertebral fractures. Degenerative disc disease was observed in 45.4% of men (...) that thoracic kyphosis is associated with substantial pain, disability, and height loss, we measured thoracic curvature, using an architect's flexicurve, of 610 women aged 65-91 years who were recruited from population-based listings. We assessed study subjects for back pain, back-related disability, height loss since age 25 years, perceived state of health, and bone mineral density (BMD) at the spine, calcaneus, proximal radius, and distal radius. Compared with the rest of the cohort, the 10% of women

2012 TRIP Answers

42. Open Label Phase Two Trial of Radium Ra 223 Dichloride With Concurrent Administration of Abiraterone Acetate Plus Prednisone in Symptomatic Castration-Resistant (Hormone-Refractory) Prostate Cancer Subjects With Bone Metastasis

Fluoride PET/CT Scan *If a bone scan is used, solitary lesions which could be contributed to causes other than prostate cancer must be confirmed with a second modality (i.e.: plain films, CT Scan or MRI. Subject has Castrate Resistant Prostate Cancer, defined as rising PSA with a testosterone level Bone Metastasis Open Label Phase Two Trial of Radium Ra 223 Dichloride With Concurrent Administration of Abiraterone Acetate Plus Prednisone in Symptomatic Castration-Resistant (Hormone-Refractory) Prostate Cancer Subjects With Bone Metastasis - Full Text View - ClinicalTrials.gov Hide

2014 Clinical Trials

43. Study to Evaluate Bone Marrow Cells in the Treatment of Chronic Wounds

(NIH) National Institute on Aging (NIA) Information provided by (Responsible Party): Dr. E.Badiavas, University of Miami Study Details Study Description Go to Brief Summary: Management of chronic wounds with: Bone Marrow Aspirate Plus Cultured Cells Group Cultured Cells Alone Group Bone Marrow Aspirate Alone Group Control Group Condition or disease Intervention/treatment Phase Ulcer Biological: Bone Marrow Aspirate Biological: Cultured Bone Marrow Cells Procedure: Control Phase 1 Study Design Go (...) and dressing changes. Wound dressings allowed will include gauze, foam dressings, occlusive films, and non-stick pads. More advanced dressing materials such as Hydrocolloids, alginates, silver containing dressings, and biomaterials can also be used. Compression will be utilized for lower extremity wounds. Other Name: Standard of Care Experimental: Cultured Bone Marrow Cells In this group, the bone marrow aspirate will be sent to the laboratory to be grown in tissue culture. Once the cell cultures have

2014 Clinical Trials

44. Real Time 3D Imaging and Surrogate Bone Model

and receive the preoperative CT scan. Subjects will be randomized into either the experimental or control group at the time of consent by the study coordinator. Subjects in the experimental group will have their pre-operative planning done using the 3D surgical simulator and surrogate bone model will be available for the surgeon during surgery. Subjects in the control group will have their pre-operative planning done using plain film x-ray and two-dimensional (2D) templates. Eligible subjects (...) Real Time 3D Imaging and Surrogate Bone Model Real Time 3D Imaging and Surrogate Bone Model - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Real Time 3D Imaging and Surrogate Bone Model The safety

2014 Clinical Trials

45. Bone Marrow Failure (Treatment)

disease. Bone marrow transplantation (BMT) candidates are patients who are younger than age 55 years who have severe disease and a matched, related donor. [ ] With current BMT regimens, most patients with severe aplastic anemia have a 60-70% long-term survival rate. Survival rates of higher than 80% are reported for patients in more favorable subgroups. Using matched, unrelated donors still is less favorable (11-20% survival rates). Patients with inherited bone marrow failure and a matched sibling (...) using preimplantation genetic diagnosis. Blood . 2004 Feb 1. 103(3):1147-51. . Molldrem JJ, Leifer E, Bahceci E, Saunthararajah Y, Rivera M, Dunbar C, et al. Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes. Ann Intern Med . 2002 Aug 6. 137(3):156-63. . Parikh S, Bessler M. Recent insights into inherited bone marrow failure syndromes. Curr Opin Pediatr . 2012 Feb. 24(1):23-32. . Media Gallery This bone marrow film at 400X magnification

2014 eMedicine.com

46. Temporal Bone, Acquired Cholesteatoma

computed tomography (CT) scan findings in middle-ear cholesteatoma in 32 pediatric patients (age range, 3-14 y), 30 of whom presented with acquired cholesteatoma (AC) and 2 with congenital cholesteatoma. CT was performed using 1-mm or 2-mm axial and coronal sections of both temporal bones. In 19 of the patients with AC (63.3%), CT showed a diffuse soft-tissue density isodense with muscle, and in 6 other patients, the mass mimicked inflammation. In the remaining 5 patients with AC, CT revealed (...) bone. Schuller view The Schuller view is a lateral view of the mastoid, obtained with the sagittal plane of the skull parallel to the film and with 30º-cephalocaudal angulation on the radiographic beam. This view shows the degree and extent of mastoid pneumatization, the status of the trabecular pattern, and the position of the lateral sinus. Stenvers view The Stenvers view is obtained with the patient facing the film and the head slightly flexed and rotated 45º toward the side opposite

2014 eMedicine Radiology

47. Bone Infarct

associated with the disease. See the images below. Lateral view of the knee in a deep-sea diver shows dysbaric osteonecrosis in the diaphysis of the femur and tibia. Note the irregular calcific deposits with a shell-like pattern, which is typical of a bone infarct. Plain radiograph in a middle-aged man with shoulder discomfort demonstrates an irregularly calcified bone infarct in the diametaphysis of the right humerus. Coronal T1-weighted MRI in a 12-year-old boy with early Legg-Calvé-Perthes disease (...) bones, patchy lucencies and sclerosis are often associated with bone collapse or fractures (see the images below). Plain radiograph in a middle-aged man with shoulder discomfort demonstrates an irregularly calcified bone infarct in the diametaphysis of the right humerus. Plain radiograph in a 68-year-old man with hip pain demonstrates patchy sclerosis of both femoral heads that is consistent with avascular necrosis. Plain radiograph of the pelvis in a man demonstrates collapse of the left femoral

2014 eMedicine Radiology

48. Bone Marrow Failure (Follow-up)

disease. Bone marrow transplantation (BMT) candidates are patients who are younger than age 55 years who have severe disease and a matched, related donor. [ ] With current BMT regimens, most patients with severe aplastic anemia have a 60-70% long-term survival rate. Survival rates of higher than 80% are reported for patients in more favorable subgroups. Using matched, unrelated donors still is less favorable (11-20% survival rates). Patients with inherited bone marrow failure and a matched sibling (...) using preimplantation genetic diagnosis. Blood . 2004 Feb 1. 103(3):1147-51. . Molldrem JJ, Leifer E, Bahceci E, Saunthararajah Y, Rivera M, Dunbar C, et al. Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes. Ann Intern Med . 2002 Aug 6. 137(3):156-63. . Parikh S, Bessler M. Recent insights into inherited bone marrow failure syndromes. Curr Opin Pediatr . 2012 Feb. 24(1):23-32. . Media Gallery This bone marrow film at 400X magnification

2014 eMedicine.com

49. Bone Marrow Transplantation, Long-Term Effects (Treatment)

expand (eg, umbilical-cord blood, haploidentical donors), ex vivo expansion of hematopoietic stem cells becomes feasible, [ ] and as supportive care improves. In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to and autoimmunity. This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. Most of the identifiable cells are lymphocytes or plasma (...) Bone Marrow Transplantation, Long-Term Effects (Treatment) Long-Term Effects of Bone Marrow Transplantation: Overview, Immunosuppression and Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation, Secondary Malignancies After Hematopoietic Stem Cell Transplantation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com

2014 eMedicine Pediatrics

50. Bone Marrow Transplantation, Long-Term Effects (Overview)

expand (eg, umbilical-cord blood, haploidentical donors), ex vivo expansion of hematopoietic stem cells becomes feasible, [ ] and as supportive care improves. In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to and autoimmunity. This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. Most of the identifiable cells are lymphocytes or plasma (...) Bone Marrow Transplantation, Long-Term Effects (Overview) Long-Term Effects of Bone Marrow Transplantation: Overview, Immunosuppression and Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation, Secondary Malignancies After Hematopoietic Stem Cell Transplantation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com

2014 eMedicine Pediatrics

51. Bone Marrow Transplantation, Long-Term Effects (Follow-up)

expand (eg, umbilical-cord blood, haploidentical donors), ex vivo expansion of hematopoietic stem cells becomes feasible, [ ] and as supportive care improves. In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to and autoimmunity. This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. Most of the identifiable cells are lymphocytes or plasma (...) Bone Marrow Transplantation, Long-Term Effects (Follow-up) Long-Term Effects of Bone Marrow Transplantation: Overview, Immunosuppression and Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation, Secondary Malignancies After Hematopoietic Stem Cell Transplantation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com

2014 eMedicine Pediatrics

52. Bone Marrow Transplantation, Long-Term Effects (Diagnosis)

expand (eg, umbilical-cord blood, haploidentical donors), ex vivo expansion of hematopoietic stem cells becomes feasible, [ ] and as supportive care improves. In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to and autoimmunity. This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. Most of the identifiable cells are lymphocytes or plasma (...) Bone Marrow Transplantation, Long-Term Effects (Diagnosis) Long-Term Effects of Bone Marrow Transplantation: Overview, Immunosuppression and Graft Versus Host Disease After Hematopoietic Stem Cell Transplantation, Secondary Malignancies After Hematopoietic Stem Cell Transplantation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com

2014 eMedicine Pediatrics

53. Is a Two-Film Skull X-ray Series as Sensitive as a Four-Film Series in the Diagnosis of Skull Fractures in Paediatric Patients

Is a Two-Film Skull X-ray Series as Sensitive as a Four-Film Series in the Diagnosis of Skull Fractures in Paediatric Patients Is a Two-Film Skull X-ray Series as Sensitive as a Four-Film Series in the Diagnosis of Skull Fractures in Paediatric Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Is a Two-Film Skull X-ray Series as Sensitive as a Four-Film Series in the Diagnosis of Skull Fractures in Paediatric Patients (4vs2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01448473 Recruitment Status

2011 Clinical Trials

54. A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors

A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01920568 Recruitment Status : Completed First Posted : August 12, 2013 Results First Posted : August 25

2013 Clinical Trials

55. Postmenopausal women with osteoporosis and osteoarthritis show different microstructural characteristics of trabecular bone in proximal tibia using high-resolution magnetic resonance imaging at 3 tesla. Full Text available with Trip Pro

Postmenopausal women with osteoporosis and osteoarthritis show different microstructural characteristics of trabecular bone in proximal tibia using high-resolution magnetic resonance imaging at 3 tesla. Osteoporosis (OP) and osteoarthritis (OA) are two common musculoskeletal disorders that affect the quality of life in aged people. An inverse relationship between OP and OA was proposed four decades ago. However, the difference in microstructure of the trabecular bone of these two disorders (...) in this study. Primary OA of hip, knee, as well as spinal arthrosis were diagnosed according to plain X-ray film findings. Osteoporosis was defined based on the latest criteria of World Health Organization (WHO). Structural and textural parameters derived from HR-MRI images of proximal tibia were calculated and compared with special software.There were significant differences in apparent bone volume fraction, trabecular thickness, mean roundness, Euler number, entropy and inverse different moment between OP

2013 BMC Musculoskeletal Disorders

56. Guidelines for Bone Scintigraphy in Children

Town and Red Cross War Memorial Children’s Hospital, Rondebosch, Cape Town, South Africa M. Mann : D. De Palma(*) Circolo Hospital and Macchi Foundation, Varese, Italy e-mail: didepal@tin.it Eur J Nucl Med Mol Imaging DOI 10.1007/s00259-010-1492-3High-quality images are crucial and require correct positioning and often immobilization of the child as well as optimal equipment.Due to the age-dependent differences in bone metabolism in the developing skeleton, the interpretation of bone scanning (...) osteoma G. Bone dysplasia and other metabolic diseases [11, 32] – Camurati-Engelmann disease – evaluating skeletal involvement (brown tumours) in children with hyperparathyroidism [33] H. Other clinical situations in paediatrics [8, 11, 34–36] – pain possibly due to bone pathology – limp or backache – fever of unknown origin – evaluating apophyseal activity in the mandibular condyles in children with mandibular asymmetry Contraindications Although uncommon in the paediatric age group, the possibility

2010 European Association of Nuclear Medicine

57. The Validity of Bone Age Assessment by an Ultrasound Apparatus (SonicBone)

The Validity of Bone Age Assessment by an Ultrasound Apparatus (SonicBone) The Validity of Bone Age Assessment by an Ultrasound Apparatus (SonicBone) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . The Validity of Bone Age Assessment by an Ultrasound Apparatus (SonicBone) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01346618 Recruitment Status : Unknown Verified November 2011 by Assaf Harofeh MC, Assaf-Harofeh Medical Center. Recruitment status was: Recruiting First Posted : May 3, 2011 Last Update

2011 Clinical Trials

58. Oral Nutrition Impact on Tear Film

: ZeaVision, Inc. Information provided by (Responsible Party): Eye and Vision Technologies and Research Institute Study Details Study Description Go to Brief Summary: Dry eye disease (DED) is a common but often inadequately treated disease of the tears and surface of the eye. It can cause poor vision and chronic pain and is more frequent with increasing age. The 1995 Report of the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eye defined dry eye as "a disorder of the tear film due (...) Oral Nutrition Impact on Tear Film Oral Nutrition Impact on Tear Film - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Oral Nutrition Impact on Tear Film (ONIT) The safety and scientific validity

2011 Clinical Trials

59. Benign Bone Tumors

similar to that of an . Some experts simply consider them large osteoid osteomas (> 2 cm). Osteoblastoma is much more common among males and appears typically between ages 10 and 35. The tumor develops in the bone of the spine, legs, hands, and feet. It is a slow-growing tumor that destroys normal bone. This tumor is painful. Imaging is with plain films, CT, and MRI. A biopsy is warranted to make an accurate diagnosis of osteoblastoma. Treatment of osteoblastoma requires surgery, often curettage (...) ligand (RANKL) inhibitor, can be used in the treatment of benign giant cell tumor of bone for large, potentially nonoperable tumors (see image Giant Cell Tumor [CT Scan]). Chondroblastoma Chondroblastoma is rare and occurs most commonly among people aged 10 to 20. Arising in the epiphysis, this tumor may continue to grow and destroy bone and the joint. It appears on imaging studies as a sclerotic marginated cyst containing spots of punctate calcification. MRI can help diagnostically by showing

2013 Merck Manual (19th Edition)

60. Idelalisib for treating refractory follicular lymphoma

with progression and death. These include, but are not Idelalisib for treating refractory follicular lymphoma (TA604) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 15 of 30limited to, the components of FLIPI I and FLIPI II, notably: age, serum beta 2 microglobulin levels, bone marrow involvement, size of the largest involved lymph node, haemoglobin levels and the presence of bulky disease. Other factors include time (...) daily. Treatment is continued until disease progression or unacceptable toxicity. Price Price The list price for idelalisib is £3,114.75 per pack of 60 x 150 mg film-coated tablets (excluding VAT, company submission). The company has a commercial arrangement for idelalisib, which would apply if the technology had been recommended. Idelalisib for treating refractory follicular lymphoma (TA604) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions

2019 National Institute for Health and Clinical Excellence - Technology Appraisals

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