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Body Mass Index

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81. Cardiorespiratory Fitness, Body Mass Index, and Markers of Insulin Resistance in Apparently Healthy Women and Men. (Abstract)

Cardiorespiratory Fitness, Body Mass Index, and Markers of Insulin Resistance in Apparently Healthy Women and Men. Insulin resistance may be present in healthy adults and is associated with poor health outcomes. Obesity is a risk factor for insulin resistance, but most obese adults do not have insulin resistance. Fitness may be protective, but the association between fitness, weight, and insulin resistance has not been studied in a large population of healthy adults.A cross-sectional analysis (...) of cardiorespiratory fitness, body mass index, and markers of insulin resistance was performed. Study participants were enrolled at the Cooper Clinic in Dallas, Texas. The analysis included 19,263 women and 48,433 men with no history of diabetes or cardiovascular disease. Cardiorespiratory fitness was measured using exercise treadmill testing. Impaired fasting glucose (100-125 mg/dL) and elevated fasting triglycerides (≥150 mg/dL) were used as a markers of insulin resistance.Among individuals with normal weight

2020 American Journal of Medicine

82. Clinical outcomes with canagliflozin according to baseline body mass index: results from post hoc analyses of the CANVAS Program. Full Text available with Trip Pro

Clinical outcomes with canagliflozin according to baseline body mass index: results from post hoc analyses of the CANVAS Program. Sodium glucose co-transporter 2 (SGLT2) inhibitors reduce several cardiovascular risk factors, including plasma glucose, blood pressure, albuminuria and body weight. Long-term treatment lowers risks of cardiovascular and renal events. The objective of this post hoc analysis was to determine the effects of canagliflozin treatment versus placebo on clinical outcomes (...) in relation to body mass index (BMI).The CANVAS Program randomized 10 142 participants with type 2 diabetes to canagliflozin or placebo. These analyses tested the consistency of canagliflozin treatment effects across BMI levels for cardiovascular, renal, safety and body weight outcomes in three groups defined by baseline BMI: <25, 25-<30 and ≥30 kg/m2 .In total, 10 128 participants with baseline BMI measurements were included. There were 966 participants with BMI <25 kg/m2 , 3153 with BMI 25-<30 kg/m2

2020 obesity & metabolism

83. Body mass index, diabetes, and the risk of Parkinson's disease. (Abstract)

Body mass index, diabetes, and the risk of Parkinson's disease. There are conflicting findings in the literature regarding the association of body mass index and incidence of PD.This study aimed to investigate the association of body mass index with the risk of PD incidence while considering diabetes mellitus as a major confounding factor.We examined 6,800,601 individuals (aged ≥40 years) who were free of PD using the database of the Korean National Health Insurance Service. Cox proportional (...) : 0.88; 95% confidence interval: 0.88-0.93) in the obese group and (adjusted hazard ratio: 0.77; 95% confidence interval: 0.72-0.82) in the severely obese group. This association consistently persisted after stratification by diabetes mellitus status, with the steepest downward slope for PD risk present with increasing body mass index in patients with severe diabetes mellitus (i.e., long duration or complication).Being underweight and diabetes mellitus were associated with an increased risk of PD

2020 Movement Disorders

84. Relationship between body mass index and outcomes of coronary artery disease in Asian population: Insight from the FOCUS registry. (Abstract)

Relationship between body mass index and outcomes of coronary artery disease in Asian population: Insight from the FOCUS registry. Obesity is often considered as a risk factor of cardiovascular events, but recent researches showed conflicting results regarding to the effect of body weight on prognosis of coronary artery disease (CAD). This study aimed to evaluate the relationship between body mass index (BMI) and clinical outcomes of CAD in Asian population.A total of 4315 patients from

2020 International journal of cardiology

85. Association of body mass index with colorectal cancer risk by genome-wide variants. (Abstract)

Association of body mass index with colorectal cancer risk by genome-wide variants. Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk.We tested multiplicative statistical interactions between BMI (per 5 kg·m2) and approximately 2.7 million single nucleotide polymorphisms (SNPs) with colorectal cancer risk among 14,059 colorectal cancer case (53.2% women) and 14,416 control (53.8% women) participants. All analyses were

2020 Journal of the National Cancer Institute

86. Finding the Body Mass Index Cutoff for Hospital Readmission After Ambulatory Hernia Surgery. (Abstract)

Finding the Body Mass Index Cutoff for Hospital Readmission After Ambulatory Hernia Surgery. The suitability of ambulatory surgery in obese patients remains controversial. This study aimed to investigate the "cutoff" value of body mass index (BMI) associated with increased likelihood of hospital readmissions within the first 24 hours of surgery in patients undergoing ambulatory hernia repair.The study used data from the 2012-2016 American College of Surgeons National Surgical Quality

2020 Acta Anaesthesiologica Scandinavica

87. Body mass index and peripheral artery disease. (Abstract)

Body mass index and peripheral artery disease. An independent association of body mass index (BMI) with atherosclerotic cardiovascular disease is somewhat controversial and may differ by vascular bed. Sex-specific risk factors for atherosclerosis may further modify these associations. Obesity and peripheral artery disease (PAD) are both more prevalent in women. We sought to determine the association between PAD and BMI using a very large population-based study.Self-referred individuals

2020 Atherosclerosis

88. Association of Childhood Body Mass Index and Change in Body Mass Index With First Adult Ischemic Stroke. Full Text available with Trip Pro

Association of Childhood Body Mass Index and Change in Body Mass Index With First Adult Ischemic Stroke. The incidence of ischemic stroke among young adults is rising and is potentially due to an increase in stroke risk factors occurring at younger ages, such as obesity.To investigate whether childhood body mass index (BMI) and change in BMI are associated with adult ischemic stroke and to assess whether the associations are age dependent or influenced by birth weight.This investigation

2017 JAMA neurology

89. Effect of Gestational Weight Gain and Prepregnancy Body Mass Index in Adolescent Mothers on Weight and Body Mass Index of Adolescent Offspring. Full Text available with Trip Pro

Effect of Gestational Weight Gain and Prepregnancy Body Mass Index in Adolescent Mothers on Weight and Body Mass Index of Adolescent Offspring. The purpose of the study was to examine the association of the gestational weight gain and prepregnancy body mass index (BMI) of low-income adolescent mothers with the risk of their children being overweight and/or obese in late adolescence.Study subjects were low-income, primiparous adolescents (n = 360) who self-identified as black and participated

2017 The Journal of Adolescent Health

90. Tri-Ponderal Mass Index vs Body Mass Index in Estimating Body Fat During Adolescence. Full Text available with Trip Pro

Tri-Ponderal Mass Index vs Body Mass Index in Estimating Body Fat During Adolescence. Body mass index (BMI) is used to diagnose obesity in adolescents worldwide, despite evidence that weight does not scale with height squared in adolescents. To account for this, health care providers diagnose obesity using BMI percentiles for each age (BMI z scores), but this does not ensure that BMI is accurate in adolescents.To compare the accuracy of BMI vs other body fat indices of the form body mass (...) divided by heightn in estimating body fat levels in adolescents.Cross-sectional data from the 1999 to 2006 US National Health and Nutrition Examination Survey were analyzed between September 2015 and December 2016.Dual-energy x-ray absorptiometry and anthropometric data were used to determine changes in body fat levels, body proportions, and the scaling relationships among body mass, height, and percent body fat. To assess the merits of each adiposity index, 3 criteria were used: stability with age

2017 JAMA pediatrics

91. Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study. Full Text available with Trip Pro

Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study. The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the Mendelian randomization design to investigate the associations of body mass index (BMI) with 13 CVDs and arterial hypertension. We also assessed the roles of fat mass and fat-free mass on the same outcomes.Single-nucleotide polymorphisms associated (...) , atrial fibrillation, and pulmonary embolism. The odds ratio (OR) per 1 kg/m2 increase in BMI ranged from 1.06 [95% confidence interval (CI) 1.02-1.11; P = 2.6 × 10-3] for pulmonary embolism to 1.13 (95% CI 1.05-1.21; P = 1.2 × 10-3) for aortic valve stenosis. There was suggestive evidence of positive associations of genetically predicted fat mass index with nine outcomes (P < 0.05). The strongest magnitude of association was with aortic valve stenosis (OR per 1 kg/m2 increase in fat mass index 1.46

2019 European Heart Journal

92. Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index. Full Text available with Trip Pro

Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index. Central adiposity is associated with increased cardiovascular disease (CVD) risk, even among people with normal body mass index (BMI). We tested the hypothesis that regional body fat deposits (trunk or leg fat) are associated with altered risk of CVD among postmenopausal women with normal BMI.We included 2683 postmenopausal women with normal BMI (18.5 to <25 kg/m2) who (...) participated in the Women's Health Initiative and had no known CVD at baseline. Body composition was determined by dual energy X-ray absorptiometry. Incident CVD events including coronary heart disease and stroke were ascertained through February 2017. During a median 17.9 years of follow-up, 291 incident CVD cases occurred. After adjustment for demographic, lifestyle, and clinical risk factors, neither whole-body fat mass nor fat percentage was associated with CVD risk. Higher percent trunk fat

2019 European Heart Journal

93. Associations between body mass index, body composition and bone density in young adults: findings from a southern Brazilian cohort. Full Text available with Trip Pro

Associations between body mass index, body composition and bone density in young adults: findings from a southern Brazilian cohort. This study aimed to evaluate the association of body composition components and obesity with bone density.Prospective study with data on 2968 members of the 1993 Pelotas Birth Cohort from follow-ups at 18 and 22 years of age. Areal bone mineral density (aBMD, g/cm2) was evaluated for whole body, lumbar spine, and femoral neck at 22 years using dual-energy X-ray (...) absorptiometry. Simple and multiple linear regression, stratified by sex, were used to assess the effect of BMI, fat mass (FMI) and lean mass index (LMI), evaluated at 18 and 22 years, and obesity trajectories classified by FMI and categorized as "never", "only at 18 years", "only at 22 years" or "always" on aBMD.Among men, the largest coefficients were observed for BMI, followed by lean mass and fat mass. Compared to fat mass, lean mass presented the largest coefficients for all sites, with the strongest

2019 BMC Musculoskeletal Disorders

94. What change in body mass index is associated with improvement in percentage body fat in childhood obesity? A meta-regression. Full Text available with Trip Pro

What change in body mass index is associated with improvement in percentage body fat in childhood obesity? A meta-regression. Using meta-regression this paper sets out the minimum change in body mass index-SD score (BMI-SDS) required to improve adiposity as percentage body fat for children and adolescents with obesity.Meta-regression.Studies were identified as part of a large-scale systematic review of the following electronic databases: AMED, Embase, MEDLINE via OVID, Web of Science (...) in percentage body fat. Thirty-nine studies reporting change in mean percentage body fat were analysed. Meta-regression demonstrated that reduction of at least 0.6 in mean BMI-SDS ensured a mean reduction of percentage body fat mass, in the sense that the associated 95% prediction interval for change in mean percentage body fat was wholly negative.Interventions demonstrating reductions of 0.6 BMI-SDS might be termed successful in reducing adiposity, a key purpose of weight management

2019 BMJ open

95. Correction: <i>Informational value of percent body fat with body mass index for the risk of abnormal blood glucose: a nationally representative cross-sectional study</i>. Full Text available with Trip Pro

Correction: Informational value of percent body fat with body mass index for the risk of abnormal blood glucose: a nationally representative cross-sectional study. [This corrects the article DOI: 10.1136/bmjopen-2017-019200.].

2019 BMJ open

96. Association between cardiometabolic risk factors and body mass index, waist circumferences and body fat in a Zanzibari cross-sectional study. Full Text available with Trip Pro

Association between cardiometabolic risk factors and body mass index, waist circumferences and body fat in a Zanzibari cross-sectional study. To determine the prevalence of obesity indices (body mass index (BMI), waist circumference (WC), body fat per cent (BF%)) and cardiometabolic risk factors. To investigate the association between obesity indices and cardiometabolic risk factors in a Zanzibari population.Cross-sectional study.Participants randomly selected from 80 Shehias (wards) in Unguja

2019 BMJ open

97. Body mass index trajectories in early childhood in relation to cardiometabolic risk profile and body composition at 5 years of age. Full Text available with Trip Pro

Body mass index trajectories in early childhood in relation to cardiometabolic risk profile and body composition at 5 years of age. Both impaired and accelerated postnatal growth have been associated with adult risks of obesity and cardiometabolic diseases, like type 2 diabetes and cardiovascular disease. However, the timing of the onset of cardiometabolic changes and the specific growth trajectories linking early growth with later disease risks are not well understood.The aim of this study (...) was to identify distinct trajectories of BMI growth from 0 to 5 y and examine their associations with body composition and markers of cardiometabolic risk at age 5 y.In a prospective birth cohort study of 453 healthy and term Ethiopian children with BMIs assessed a median of 9 times during follow-up, we identified subgroups of distinct BMI trajectories in early childhood using latent class trajectory modeling. Associations of the identified growth trajectories with cardiometabolic markers and body composition

2019 American Journal of Clinical Nutrition

98. Operating on the Edge? Body Contouring Procedures in Patients with Body Mass Index Greater 35. (Abstract)

Operating on the Edge? Body Contouring Procedures in Patients with Body Mass Index Greater 35. Body contouring surgery after massive weight loss was shown to ameliorate the patient's quality of life and to enhance physical and psychological well-being. However, numerous patients are still obese when presenting for body contouring surgery, not able to lose additional weight for various reasons. Data regarding general feasibility, outcome, and postoperative complications in obese patients is rare (...) . The aim of this study was to investigate the outcome in body contouring procedures in obese patients.A retrospective chart review of 65 cases in 42 patients was performed. Patients with a body mass index (BMI) > 35 kg/m2 at the time of operation were enrolled and all different types of body contouring surgery were included. Complications were classified as major (need for surgical intervention) and minor complications.The median BMI of all patients was 38 kg/m2 (range 35.1-65.1 kg/m2). The majority

2019 Obesity Surgery

99. Body fat indicators perform better than body mass index in identifying abnormal lipid profiles in boys but not in girls. (Abstract)

Body fat indicators perform better than body mass index in identifying abnormal lipid profiles in boys but not in girls. BMI as a body weight indicator, may inadequately represent the biological effect of body fat on lipid profiles. This study aims to assess whether body fat indicators were superior to BMI for recognizing children with dyslipidemia.A nationwide cross-sectional study involving 8944 pediatric participants aged 6-18 years. Measures of fat mass index (FMI), fat mass percentage (FMP (...) % higher than those of BMI-based overweight, respectively, all P < 0.01. Among girls, the associations of BMI with lipid profiles were substantially similar to FMI. All these results were almost identical when FMP was used instead of FMI.DXA measured body fat performs better than BMI in identifying abnormal lipid profiles in boys but not in girls.

2019 Pediatric Research

100. Effect of Body Mass Index Category on Body Surface Area Calculation in Children Undergoing Cardiac Procedures. (Abstract)

Effect of Body Mass Index Category on Body Surface Area Calculation in Children Undergoing Cardiac Procedures. Many of the common equations used for body surface area determination were either introduced before the widespread prevalence of childhood obesity, contained very few children in their sample, or have not been assessed in overweight/obese children. Therefore, we compared 6 body surface area formulae to determine their performance across body mass index categories using cross-sectional (...) correlation coefficient (measure of precision), the Lin concordance correlation coefficient (measure of bias and precision), and the Bland-Altman limit-of-agreement. All comparisons were made across age, sex, and body mass index categories.Among the 1000 (mostly Caucasian: 76.1%) subjects, 16.7% were overweight, while 14.1% were obese and 51.2% were girls. All calculated body surface area data showed a strong positive correlation with each other and the derived reference body surface area values (0.99

2019 Anesthesia and Analgesia

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