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Body Mass Index

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81. The effect of maternal body mass index on duration of induced labor. (Abstract)

The effect of maternal body mass index on duration of induced labor. Obese primiparous women with induction of labor are at high risk for a cesarean section. There are contradictory results regarding time in induced labor in relation to maternal body mass index (BMI). It is important to characterize the course of induced labor to prevent unnecessary cesarean section. We aimed to evaluate whether the duration of labor was associated with maternal BMI in primiparous women with induction

2020 Acta Obstetricia et Gynecologica Scandinavica

82. Impact of Diabetes and Low Body Mass Index on Tuberculosis Treatment Outcomes. (Abstract)

Impact of Diabetes and Low Body Mass Index on Tuberculosis Treatment Outcomes. Diabetes was identified as a tuberculosis (TB) risk factor mostly in retrospective studies with limited assessment of metabolic variables. The prospective Effects of Diabetes on Tuberculosis Severity study compared adults with pulmonary TB in Chennai, India, who were classified as having diabetes or normal glucose tolerance at enrollment.Baseline TB severity, sputum conversion, and treatment outcomes (cure, failure (...) , death, or lost) were compared between groups with respect to glycemic status and body mass index (BMI).The cohort of 389 participants included 256 with diabetes and 133 with normal glucose tolerance. Low BMI (<18.5 kg/m2) was present in 99 (74.4%) of non-diabetic participants and 85 (33.2%) of those with diabetes. Among participants with normal or high BMI, rates of cure, treatment failure, or death did not vary by glycemic status. Participants with low BMI had the highest radiographic severity

2020 Clinical Infectious Diseases

83. Neonatal outcome by planned mode of delivery in women with a body mass index of 35 or more: a retrospective cohort study. (Abstract)

Neonatal outcome by planned mode of delivery in women with a body mass index of 35 or more: a retrospective cohort study. To compare neonatal outcomes of women with a body mass index (BMI) of ≥35 kg/m2 who underwent a trial of labour with those of women who underwent a planned primary caesarean section (CS).A retrospective cohort study of births between April 2012 and March 2014.A provincial database: Better Outcomes Registry & Network (BORN) Ontario, Canada.A cohort of 8752 women with a BMI

2020 BJOG

84. Delivery outcomes in women with body mass index of 40 kg/m<sup>2</sup> or greater stratified by planned and actual mode of delivery: a systematic review and meta-analysis. (Abstract)

Delivery outcomes in women with body mass index of 40 kg/m2 or greater stratified by planned and actual mode of delivery: a systematic review and meta-analysis. Pregnant women with a body mass index (BMI) ≥40kg/m2 are at an increased risk of requiring planned- and unplanned cesarean deliveries (CD). The aim of this systematic review is to compare delivery outcomes in women with BMI ≥40kg/m2 based on planned and actual mode of delivery.Five databases were searched for English

2020 Acta Obstetricia et Gynecologica Scandinavica

85. Maternal body mass index and risk of obstetric, maternal, and neonatal outcomes: A cohort study of nulliparous women with spontaneous onset of labor. (Abstract)

Maternal body mass index and risk of obstetric, maternal, and neonatal outcomes: A cohort study of nulliparous women with spontaneous onset of labor. This study investigates associations between maternal body mass index (BMI) early in pregnancy and obstetric interventions, maternal and neonatal outcomes.This is a cohort study of nulliparous women originally included in a cluster randomized controlled trial carried out at 14 Norwegian obstetric units between 2014 and 2017. The sample included

2020 Acta Obstetricia et Gynecologica Scandinavica

86. Low body mass index is associated with ectopic pregnancy following assisted reproductive techniques: a retrospective study. (Abstract)

Low body mass index is associated with ectopic pregnancy following assisted reproductive techniques: a retrospective study. To investigate the association between body mass index (BMI) and ectopic pregnancy (EP) following embryo transfer (ET).Retrospective cohort study.University-affiliated hospital.A total of 16 378 pregnancies derived from either fresh ET or frozen-thawed ET between January 2008 and December 2017.We used the generalised estimating equation (GEE) to analyse the association

2020 BJOG

87. Changes in Body Mass Index Are Related to Faster Cognitive Decline Among African American Older Adults. (Abstract)

Changes in Body Mass Index Are Related to Faster Cognitive Decline Among African American Older Adults. The purpose of this study was to: (1) examine relationships between body mass index (BMI) stability and cognitive decline in older African Americans; and (2) investigate differences in the relationships between women and men.The present study is a secondary data analysis of the Minority Aging Research Study, which is a longitudinal, cohort study of risk factors for cognitive decline

2020 Journal of the American Geriatrics Society

88. Complex interaction of fasting glucose, body mass index, age and sex on all-cause mortality: a cohort study in 15 million Korean adults. Full Text available with Trip Pro

Complex interaction of fasting glucose, body mass index, age and sex on all-cause mortality: a cohort study in 15 million Korean adults. The aim of this work was to examine whether synergistic associations with mortality exist for BMI and fasting blood glucose (FBG) and to identify FBG-BMI combined subgroups with higher mortality according to sex and age.A total of 15,149,275 Korean adults participated in health examinations during 2003-2006 and were followed up until December 2018. Mortality

2020 Diabetologia

89. Genetic and Environmental Influences on Blood Pressure and Body Mass Index in the National Academy of Sciences-National Research Council World War II Veteran Twin Registry. Full Text available with Trip Pro

Genetic and Environmental Influences on Blood Pressure and Body Mass Index in the National Academy of Sciences-National Research Council World War II Veteran Twin Registry. Blood pressure (BP) and obesity phenotypes may covary due to shared genetic or environmental factors or both. Furthermore, it is possible that the heritability of BP differs according to obesity status-a form of G×E interaction. This hypothesis has never been tested in White twins. The present study included 15 924 White (...) male twin pairs aged between 15 and 33 years from the National Academy of Sciences-National Research Council World War II Veteran Twin Registry. Systolic and diastolic BPs, as well as height and weight, were measured at the induction physical examination. Body mass index (BMI) was used as the index of general obesity. Quantitative genetic modeling was performed using Mx software. Univariate analysis showed that narrow sense heritabilities (95% CI) for systolic BP, diastolic BP, height, and BMI were

2020 Hypertension

90. Estrogens and Glucocorticoids in Mammary Adipose Tissue: Relationships with Body Mass Index and Breast Cancer Features. Full Text available with Trip Pro

Estrogens and Glucocorticoids in Mammary Adipose Tissue: Relationships with Body Mass Index and Breast Cancer Features. Adipose tissue is an important site for extragonadal steroid hormone biosynthesis through the expression and activity of P450 aromatase, 11β-hydroxysteroid dehydrogenase (HSD) 1, and 17β-HSDs. The contribution of steroid hormones produced by adjacent adipose tissue for the progression and survival of breast tumors is unknown.To quantify estrogens (estradiol, estrone (...) steroids were reliably detected and quantified in mammary adipose tissues. Women with ER+/PR+ tumor had higher relative estradiol amount than women with ER-/PR- tumor (P < .05). The ratio of estradiol-to-estrone was higher in lean women than in women with a body mass index (BMI) ≥ 25 kg/m2 (P < .05). Mixed-model analyses showed that estradiol, cortisone, and cortisol were negatively associated with tumor size (P < .05). Relationships between glucocorticoids and tumor size remained significant after

2020 Journal of Clinical Endocrinology and Metabolism

91. Long-Term Outcomes Stratified by Body Mass Index in Patients Undergoing Transcatheter Aortic Valve Implantation. (Abstract)

Long-Term Outcomes Stratified by Body Mass Index in Patients Undergoing Transcatheter Aortic Valve Implantation. Transcatheter aortic valve implantation (TAVI) is emerging as the default strategy for older patients with severe, symptomatic, trileaflet aortic stenosis. Increased body-mass index (BMI) is associated with a protective effect in patients undergoing percutaneous coronary intervention. We assessed whether elevated BMI was associated with a similar association in TAVI. We evaluated

2020 American Journal of Cardiology

92. Relation of Body Mass Index to Outcomes in Patients With Heart Failure Implanted With Left Ventricular Assist Devices. (Abstract)

Relation of Body Mass Index to Outcomes in Patients With Heart Failure Implanted With Left Ventricular Assist Devices. We aimed at characterizing the impact of low and high body mass index (BMI) on outcomes after left-ventricular assist device (LVAD) surgery and define the predictors of mortality in patients with abnormal BMI (low/high). This study was conducted in 19 centers from 2006 to 2016. Patients were divided based on their baseline BMI into 3 groups of BMI: low (BMI ≤18.5 kg/m²); normal

2020 American Journal of Cardiology

93. Clinical implications of body mass index in metastatic breast cancer patients treated with abemaciclib and endocrine therapy. (Abstract)

Clinical implications of body mass index in metastatic breast cancer patients treated with abemaciclib and endocrine therapy. There is limited data regarding the impact of body mass index (BMI) on outcomes in advanced breast cancer (BC), especially in patients treated with endocrine therapy (ET) + CDK 4/6 inhibitors.Pooled analysis of individual patient-level data from MONARCH 2 and 3 trials. Patients were classified according to baseline BMI into underweight (<18.5 kg/m2), normal (18.5-24.9 kg (...) PFS regardless of BMI, showing that overweight/obese patients also benefit from this regimen. Our results elicit the possibility of a better effect of abemaciclib in normal/underweight patients compared to overweight/obese. More studies analyzing body composition parameters in patients under CDK 4/6 inhibitors may further clarify this hypothesis.© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

2020 Journal of the National Cancer Institute

94. Relationship of Body Mass Index and Waist Circumference With Risk of New-Onset Proteinuria in Hypertensive Patients. (Abstract)

Relationship of Body Mass Index and Waist Circumference With Risk of New-Onset Proteinuria in Hypertensive Patients. The association of the combination of body mass index (BMI) and waist circumference (WC) with the risk of proteinuria has previously not been comprehensively investigated and results have been inconclusive.To examine BMI and WC in relation to new-onset proteinuria in Chinese hypertensive patients.Post hoc analysis of the renal substudy of the China Stroke Primary Prevention Trial

2020 Journal of Clinical Endocrinology and Metabolism

95. Body Mass Index and Polycystic Ovary Syndrome: A 2-Sample Bidirectional Mendelian Randomization Study. (Abstract)

Body Mass Index and Polycystic Ovary Syndrome: A 2-Sample Bidirectional Mendelian Randomization Study. Observational studies have shown a link between elevated body mass index (BMI) and the risk of polycystic ovary syndrome (PCOS). While Mendelian randomization (MR) studies in Europeans have suggested a causal role of increased BMI in PCOS, whether the same role is suggested in Asians has yet to be investigated. We used MR studies to infer causal effects using genetic data from East Asian

2020 Journal of Clinical Endocrinology and Metabolism

96. Prognostic Impact of Underweight (Body Mass Index &lt;20 kg/m<sup>2</sup>) in Patients With Severe Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement (from the German Aortic Valve Registry [GARY]) (Abstract)

Prognostic Impact of Underweight (Body Mass Index <20 kg/m2) in Patients With Severe Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement (from the German Aortic Valve Registry [GARY]) According to the Valve Academic Resortium, underweight is one parameter in the definition of frailty, which is associated with increased mortality after transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR (...) ). Aims of our study were (1) to examine the impact of underweight on mortality after TAVI and SAVR and (2) to determine the effect of intervention mode (TAVI vs SAVR) on mortality in underweight patients from the German Aortic Valve Registry. Overall, 35,109 patients treated with TAVI or SAVR were studied. Outcomes of underweight (body mass index [BMI] <20 kg/m2) TAVI and SAVR patients were compared using propensity score weighting. Prevalence of underweight was 5.7% in patients who underwent TAVI

2020 American Journal of Cardiology

97. Body Mass Index in Young Women and Risk of Cardiomyopathy: A Long-Term Follow-Up Study in Sweden. Full Text available with Trip Pro

Body Mass Index in Young Women and Risk of Cardiomyopathy: A Long-Term Follow-Up Study in Sweden. Incidence rates of cardiomyopathies, which are a common cause of heart failure in young people, have increased during the last decades. An association between body weight in adolescence and future cardiomyopathy among men was recently identified. Whether or not this holds true also for women is unknown. The aim was therefore to determine whether for young women being overweight or obese (...) is associated with a higher risk of developing cardiomyopathy.This was a registry-based national prospective cohort study with data collected from the Swedish Medical Birth Register, 1982 to 2014, with up to 33 years of follow-up. Included women were of childbearing age (18-45 years) during the initial antenatal visit in their first or second pregnancy (n=1 393 346). We obtained baseline data on body mass index (BMI), smoking, education, and previous disorders. After exclusions, mainly because of previous

2020 Circulation

98. Age-dependent survival impact of body mass index in patients with oesophageal squamous cell carcinoma. (Abstract)

Age-dependent survival impact of body mass index in patients with oesophageal squamous cell carcinoma. Patients with oesophageal squamous cell carcinoma (ESCC) generally have distinctive body compositions; being underweight is highly prevalent and sarcopenic obesity is rare. We investigated the survival impacts of body mass index (BMI) in elderly (≥65 years) and non-elderly patients undergoing surgery for ESCC.In total, 379 ESCC patients were retrospectively reviewed. Patients were divided (...) into 3 groups according to BMI; low (<20), medium (20-25) and high (≥25). The skeletal muscle index (SMI) was calculated and its relationship with BMI was analysed. Univariate and multivariate Cox hazards models were applied to determine independent predictors of poor overall survival (OS) and cancer-specific survival (CSS).The low-, medium- and high-BMI groups included 102 (26.9%), 231 (60.9%) and 46 (12.1%) patients, respectively. High BMI with low SMI was rare (n = 6, 1.6%). Patients with low BMI

2020 European Journal of Surgical Oncology

99. The Role of Body Mass Index on Hearing Outcomes After Stapes Surgery. (Abstract)

The Role of Body Mass Index on Hearing Outcomes After Stapes Surgery. Increased body mass index (BMI) has been associated with postoperative complications in multiple surgical specialties. In otologic surgery involving the stapes, where appropriate patient positioning and surgical dexterity are necessary for proper prosthesis placement, patients with higher BMI could make surgery more challenging. The purpose of this study is to evaluate the impact of BMI on outcomes after stapes

2020 Otology and Neurotology

100. Increased Body Mass Index Is Associated With A Nondilutional Reduction in Antimüllerian Hormone. (Abstract)

Increased Body Mass Index Is Associated With A Nondilutional Reduction in Antimüllerian Hormone. Controversy exists regarding if and how body mass index (BMI) impacts antimüllerian hormone (AMH) in women with and without polycystic ovary syndrome (PCOS). Understanding the BMI-AMH relationship has critical implications for clinical interpretation of laboratory values and could illuminate underlying ovarian physiology.To test the hypotheses that (1) BMI is associated with reduced AMH in PCOS (...) in multivariate regression models. Increasing BMI was associated with reduced AFC in PCOS but not OVAs. Body surface area (BSA), which unlike BMI is strongly proportional to plasma volume, was added to investigate a potential dilutive effect of body size on AMH concentrations. After controlling for BSA, BMI retained independent associations with AMH in both cohorts; BSA no longer associated with AMH.In an adjusted analysis, BMI, but not BSA, was associated with reduced AMH; these data do not support a role

2020 Journal of Clinical Endocrinology and Metabolism

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