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Body Mass Index

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93301. Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C. Full Text available with Trip Pro

with chronic hepatitis C.From November 2000 to July 2001, untreated consecutive adults with chronic hepatitis C admitted for liver biopsy were included in this study. On the day of liver biopsy, a questionnaire for risk factors was completed prospectively, and a blood sample was obtained for laboratory analysis.Our study included 290 patients (143 men, 147 women). Mean body mass index (BMI) was 24 (3.8) kg/m(2). Proportions of patients with genotypes 1 and 3 were, respectively, 48% and 18%. A total of 135

2003 Gut

93302. Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies. Full Text available with Trip Pro

patients were selected according to the following criteria: absence of treatment; absence of cirrhosis at initial biopsy; and serum hepatitis B surface antigen and human immunodeficiency virus antibody negativity. Degrees of necroinflammatory activity, fibrosis, and steatosis grades were assessed in the two biopsies. In addition to histological lesions, parameters studied included the source of infection, duration of infection, body mass index, alcohol intake, alanine aminotransferase levels, hepatitis

2003 Gut

93303. Relations between amount and type of alcohol and colon and rectal cancer in a Danish population based cohort study. Full Text available with Trip Pro

of beer, wine, and spirits, smoking habits, body mass index, educational level, and leisure time physical activity in Copenhagen, Denmark. The study included a random sample of 15 491 men and 13 641 women, aged 23-95 years. Incident cases of colorectal cancer were identified in the nationwide Danish Cancer Register.During a mean follow up of 14.7 years, we observed 411 colon cancers and 202 rectal cancers. We observed a dose-response relationship between alcohol and rectal cancer. Drinkers of more

2003 Gut

93304. Factors associated with falls in older patients with diffuse polyneuropathy. (Abstract)

balance testing. Falls were defined by retrospective self-report over a 2-year period.Forty (48.8%), 28 (34.1%), and 18 (22.0%) subjects reported a history of at least one fall, multiple falls, and injurious falls, respectively. Factors associated with single and multiple falls were similar, so only results for multiple and injurious falls are reported. Bivariate analysis showed that an increased body mass index (BMI) and more severe PN (as determined by the Michigan Diabetes Neuropathy Score) were

2002 Journal of the American Geriatrics Society

93305. The relationship between weight loss and all-cause mortality in older men and women with and without diabetes mellitus: the Rancho Bernardo study. (Abstract)

in southern California.One thousand eight hundred one older men and women with and without diabetes mellitus.Weight, body mass index (BMI), blood pressure, and fasting plasma glucose were measured in 1972-74 (Visit 1) when participants were aged 40 to 79 and again in 1984-87 (Visit 2). Lifetime weight history and dieting for weight control were ascertained in 1985 using a mailed questionnaire. Vital status was determined for the next 12 years, from Visit 2 (1984-87) through 1996. The Cox proportional

2002 Journal of the American Geriatrics Society

93306. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. (Abstract)

serum level was available.Self-report of functional status, objective measures of walking performance, and knee extensor strength were assessed at baseline and over six semiannual follow-up visits. Potential confounders were baseline age, race, body mass index, smoking, depression, and medical conditions.At baseline, women with high IL-6 were more often disabled and had lower walking speed. After adjusting for confounders, women in the highest IL-6 tertile (IL-6>3.10 pg/mL) were at higher risk

2002 Journal of the American Geriatrics Society

93307. Nutritional status using mini nutritional assessment and subjective global assessment predict mortality in geriatric patients. (Abstract)

at risk for PEM, or (3) being well nourished according to Subjective Global Assessment (SGA) and Mini Nutritional Assessment (MNA). Body mass index ((BMI) kg/m2), arm anthropometry, and handgrip strength were determined. In a subgroup of patients (n = 39), body composition was analyzed using dual energy x-ray absorption and bioelectrical impedance. Three-year mortality data were obtained from the Swedish population records.Twenty percent and 26% of the patients were classified as having PEM based (...) ) in patients classified as being well nourished.Fewer than one-third of newly admitted geriatric patients had a normal nutritional status according to SGA and MNA. BMI, arm anthropometry, body fat mass, and handgrip strength were reduced, and 1-, 2-, and 3-year mortality was higher in patients classified as malnourished. The present data justify the use of SGA and MNA for the assessment of nutritional status in geriatric patients.

2002 Journal of the American Geriatrics Society

93308. Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fractures. (Abstract)

occurred in 12% of the women with the least bone loss (by quartile), 14% in the second, 16% in the third, and 20% in those with the greatest bone loss. After adjustment for age, education, stroke, functional status, estrogen use, body mass index, and smoking, the results were similar. Those who lost the most BMD were almost 40% more likely than women in the lowest quartile to develop cognitive decline in the multivariate model (odds ratio (OR) = 1.4, 95% confidence interval (CI) = 1.1-1.8). A similar (...) Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fractures. To determine whether the rate of bone loss predicts subsequent cognitive decline independently of baseline bone mass and whether apolipoprotein E (ApoE) genotype explains the association.A prospective cohort study.Clinical centers in Baltimore, Maryland; Minneapolis, Minnesota; Pittsburgh, Pennsylvania; and Portland, Oregon.Four thousand four hundred sixty-two women aged 70 and older (mean

2003 Journal of the American Geriatrics Society

93309. Lower skeletal muscle nutritive blood flow in older women is related to eNOS protein content. (Abstract)

. Muscle eNOS protein content correlated with muscle nutritive blood flow (r =.66, p <.05) and body mass index (r =.74, p <.05), but it did not correlate with VO(2)peak. Muscle eNOS content was 35% lower in young than in older women (266 +/- 36 vs 407 +/- 53 pg/mg total protein; p <.05). The mean ethanol outflow-to-inflow ratio was higher (indicating lower nutritive flow) in older and young women (.666 +/-.042 and.546 +/-.043, respectively: p <.05). Resting skeletal nutritive blood flow and muscle eNOS (...) Lower skeletal muscle nutritive blood flow in older women is related to eNOS protein content. The relationship between muscle endothelial nitric oxide synthase (eNOS) content and nutritive flow was investigated in nonobese sedentary young (27.7 +/- 2.6 years) and older (56.6 +/- 2.1 years) women matched for body composition and (2)peak. A muscle biopsy was taken and nutritive blood flow was determined under resting conditions in the vastus lateralis of the quadriceps femoris muscle group

2003 Biological Sciences and Medical Sciences

93310. The influence of protein-calorie malnutrition on quality of life in nursing homes. (Abstract)

Term Care Model, which posits a pathway whereby organizational issues influence nutritional status, consisting of body mass index (BMI), serum albumin levels, and prealbumin levels, and subsequent quality of life, morbidity, and health care utilization. A cross-sectional design was used to analyze Minimum Data Set assessment data already collected from a previous study. The sample for this analysis was 311 nursing home residents, aged 65 years or older, who lived in three nursing homes in eastern

2003 Biological Sciences and Medical Sciences

93311. Lifestyle intervention of hypocaloric dieting and walking reduces abdominal obesity and improves coronary heart disease risk factors in obese, postmenopausal, African-American and Caucasian women. (Abstract)

determined the efficacy of a lifestyle weight loss intervention in reducing total and abdominal obesity and improving CHD risk factors in obese Caucasian and African-American postmenopausal women.Body composition (dual-energy x-ray absorptiometry), abdominal fat areas (computed tomography scan), lipoprotein lipids, insulin, glucose tolerance, and blood pressure were measured before and after 6 months of hypocaloric diet and low-intensity walking in 76 overweight or obese (body mass index > 25 kg/m(2 (...) )), Caucasian (72%) or African-American (28%), postmenopausal (age = 60 +/- 5 years) women who completed the study.Absolute amount of body weight lost was similar in Caucasians (-5.4 +/- 3.6 kg) and African Americans (-3.9 +/- 3.6 kg), but Caucasian women lost relatively more fat mass (p <.05). Both groups decreased their subcutaneous abdominal fat, and Caucasian women decreased their visceral fat area, but there were no racial differences in the magnitude of abdominal fat lost. The intervention decreased

2003 Biological Sciences and Medical Sciences

93312. More favorable midlife cardiovascular risk factor levels in male twins and mortality after 25 years of follow-up is related to longevity of their parents. (Abstract)

study.Cholesterol levels, body mass index, blood pressures, and pulmonary function measured over the first three examinations (average subject age 48, 58, and 63 years, respectively) were compared with the twins' paternal, maternal, and parental mean longevity divided into upper versus lower quintiles. The presence of an apolipoprotein E epsilon 4 allele typed from DNA collected at Exam 3 and mortality in the twin cohort through 1997 were also examined in relation to parental longevity quintiles.Twins

2003 Biological Sciences and Medical Sciences

93313. Diabetes mellitus as a risk factor for hip fracture in mexican american older adults. (Abstract)

were identified with diabetes. One hundred and thirty-four subjects experienced a first-time hip fracture during follow-up. Cox proportional hazard regression revealed an increased hazard ratio for hip fracture in subjects with diabetes compared to those without diabetes (hazard ratio = 1.57, 95% confidence interval [CI(95)] = 1.03, 2.39, p <.04) when adjusted for age, body mass index, smoking, and previous stroke. The hazard ratio for Mexican Americans taking insulin was 2.84 (CI(95) = 1.49, 5.43

2002 Biological Sciences and Medical Sciences

93314. Past and present habitual physical activity and its relationship with bone mineral density in men aged 50 years and older in Brazil. (Abstract)

spine (L2-L4) with a dual-energy x-ray absorptiometer. The HPA data were collected with questionnaires inquiring about physical exercise and occupational physical activity in the past and during the past 12 months and leisure and locomotor physical activity in the preceding 12 months. The relationship between BMD and HPA was analyzed using multiple linear regression models adjusted for age and body mass index (BMI).Practice of physical exercise in the past 10-20 years and leisure and locomotor (...) Past and present habitual physical activity and its relationship with bone mineral density in men aged 50 years and older in Brazil. The aim of this study was to determine the relationship between habitual physical activity (HPA) during life and bone mineral density (BMD) in men aged 50 years and older.A total of 326 men aged 50 years and older, volunteers living in São Paulo city, Brazil, were studied. BMD was measured in the whole body, femoral neck, Ward's triangle, trochanter, and lumbar

2002 Biological Sciences and Medical Sciences

93315. Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group. (Abstract)

Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group. Serum uric acid (SUA) is related not only to an increased risk of gout, but also to an increased risk of cardiovascular diseases. However, real age-related changes in SUA remain unknown.Longitudinal population-based study of epidemiological follow-up data of SUA, body mass index (BMI), and alcohol intake was conducted at a health examination center between 1989 and 1998. The subjects were

2002 Biological Sciences and Medical Sciences

93316. Sleep complaints and visual impairment among older Americans: a community-based study. (Abstract)

Sleep complaints and visual impairment among older Americans: a community-based study. This report describes the associations between sleep complaints and reported visual impairment in an urban community-residing older adult sample.A total of 1118 volunteers from a biracial cohort participated in the study (mean age = 74 +/- 6; mean body mass index = 28 +/- 10). Volunteers were recruited using a stratified, cluster sampling technique. In a standard order, several questionnaires were (...) falling asleep, 52% indicated experiencing difficulty maintaining sleep, 28% reported waking up early in the morning, and 12% reported daytime sleep longer than 2 hours. Chi-square results showed greater sleep complaints for volunteers with visual impairment. Consistent with these results, analysis of variance revealed that visually impaired volunteers had a higher index rate of sleep disturbance (F((1, 1110)) = 35.32, p <.0001).These data provide evidence that older adults reporting visual impairment

2002 Biological Sciences and Medical Sciences

93317. Undernutrition and risk of mortality in elderly patients within 1 year of hospital discharge. (Abstract)

between patient characteristics at hospital discharge and mortality were identified utilizing Cox Proportional Hazards Regression analysis.In the year following hospital discharge, 85 subjects (13%) died. After adjusting for illness severity (Acute Physiology and Chronic Health Evaluation II score) and functional status (Katz Index of Activities of Daily Living score), a body mass index (BMI) body mass depletion are at significantly increased risk of mortality within the year following hospital discharge.

2002 Biological Sciences and Medical Sciences

93318. Does inflammation or undernutrition explain the low cholesterol-mortality association in high-functioning older persons? MacArthur studies of successful aging. (Abstract)

levels of cholesterol, C-reactive protein, interleukin-6, and albumin; body mass index; prevalent medical conditions; health behaviors; and medications. Crude and multivariate logistic regression analyses were used to examine the association between serum total cholesterol levels and 7-year all-cause mortality, while adjusting for potential confounders.In univariate analysis, the risk ratio of low serum total cholesterol level (<169 mg/dL) for 7-year total mortality was 1.90 (95% confidence interval

2003 Journal of the American Geriatrics Society

93319. Association between dementia and midlife risk factors: the Radiation Effects Research Foundation Adult Health Study. (Abstract)

(SBP), body mass index, and history of diabetes mellitus) that had been evaluated in 1965-1970.VaD prevalence increased significantly with age, higher SBP, and lower milk intake. The odds ratios of VaD for age (in 5-year increments), SBP (10 mmHg increments), and milk intake (almost daily/less than four times a week) were 1.29, 1.33, and 0.35, respectively. The risk factors for VaD were compatible with the risk factors for stroke in this study population. AD prevalence increased significantly

2003 Journal of the American Geriatrics Society

93320. Sarcopenia: alternative definitions and associations with lower extremity function. (Abstract)

).Participants were assessed using dual energy x-ray absorptiometry and were classified as sarcopenic using two different approaches to adjust lean mass for body size: appendicular lean mass divided by height-squared (aLM/ht2) and appendicular lean mass adjusted for height and body fat mass (residuals).These methods differed substantially in the classification of individuals as being sarcopenic, especially those who were more obese. The former method was highly correlated with body mass index and identified (...) Sarcopenia: alternative definitions and associations with lower extremity function. To compare two sarcopenia definitions and examine the relationship between them and lower extremity function and other health related factors using data from the baseline examination of the Health Aging and Body Composition (Health ABC) Study.Observational cohort study.Two U.S. communities in Memphis, Tennessee, and Pittsburgh, Pennsylvania.Participants were aged 70 to 79 (N=2984, 52% women, 41% black

2003 Journal of the American Geriatrics Society

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