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Blood Lactic Acid

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161. Lactic Acidosis (Treatment)

is a new buffering agent with potential use in metabolic acidosis. It is an equimolecular mixture of sodium bicarbonate and sodium carbonate. Like THAM, Carbicarb has a buffering capacity similar to sodium bicarbonate but does not generate carbon dioxide. In animal models of hypoxic lactic acidosis, Carbicarb reduced circulating lactate and improved tissue and blood acid-base status compared with sodium bicarbonate. Carbicarb is currently not available for use. Previous Next: Hemodialysis Dialysis may (...) for the aerobic oxidation of glucose, pyruvate, and lactate. Dichloroacetate may inhibit glycolysis and, thereby, lactate production. The data from animal studies and one placebo-controlled, double-blind clinical trial showed dichloroacetate to be superior to placebo in improving the acid-base status of the patients; however, it did not alter hemodynamics or survival. Theoretical reasons and some clinical evidence exist for thiamine treatment to improve lactic acidosis associated with thiamine deficiency

2014 eMedicine.com

162. Lactic Acidosis (Follow-up)

is a new buffering agent with potential use in metabolic acidosis. It is an equimolecular mixture of sodium bicarbonate and sodium carbonate. Like THAM, Carbicarb has a buffering capacity similar to sodium bicarbonate but does not generate carbon dioxide. In animal models of hypoxic lactic acidosis, Carbicarb reduced circulating lactate and improved tissue and blood acid-base status compared with sodium bicarbonate. Carbicarb is currently not available for use. Previous Next: Hemodialysis Dialysis may (...) for the aerobic oxidation of glucose, pyruvate, and lactate. Dichloroacetate may inhibit glycolysis and, thereby, lactate production. The data from animal studies and one placebo-controlled, double-blind clinical trial showed dichloroacetate to be superior to placebo in improving the acid-base status of the patients; however, it did not alter hemodynamics or survival. Theoretical reasons and some clinical evidence exist for thiamine treatment to improve lactic acidosis associated with thiamine deficiency

2014 eMedicine.com

163. Lactic Acidosis (Treatment)

organ failure. [ , , ] The duration and degree of increased serum lactic acid appear to predict morbidity and mortality. Abramson et al identified 100% survival with normalization of serum lactate concentration (< 2 mmol/L) within the first 24 hours following multiple trauma, 78% survival if normalization occurred in 24-48 hours, and only 14% survival if after 48 hours. [ ] With the onset of bedside serum lactate analyzers, measurements can be obtained in minutes with excellent correlation (...) . Chronically, renal compensation occurs by means of reabsorption of HCO 3 . [ , ] Acidosis arises from an increased production of acids, a loss of alkali, or a decreased renal excretion of acids. The underlying etiology of metabolic acidosis is classically categorized into those that cause an elevated anion gap (AG) (see the calculator) and those that do not. Lactic acidosis, identified by a state of acidosis and an elevated plasma lactate concentration is one type of anion gap metabolic acidosis and may

2014 eMedicine Emergency Medicine

164. Lactic Acidosis (Follow-up)

organ failure. [ , , ] The duration and degree of increased serum lactic acid appear to predict morbidity and mortality. Abramson et al identified 100% survival with normalization of serum lactate concentration (< 2 mmol/L) within the first 24 hours following multiple trauma, 78% survival if normalization occurred in 24-48 hours, and only 14% survival if after 48 hours. [ ] With the onset of bedside serum lactate analyzers, measurements can be obtained in minutes with excellent correlation (...) . Chronically, renal compensation occurs by means of reabsorption of HCO 3 . [ , ] Acidosis arises from an increased production of acids, a loss of alkali, or a decreased renal excretion of acids. The underlying etiology of metabolic acidosis is classically categorized into those that cause an elevated anion gap (AG) (see the calculator) and those that do not. Lactic acidosis, identified by a state of acidosis and an elevated plasma lactate concentration is one type of anion gap metabolic acidosis and may

2014 eMedicine Emergency Medicine

165. Lactic Acidosis (Diagnosis)

organ failure. [ , , ] The duration and degree of increased serum lactic acid appear to predict morbidity and mortality. Abramson et al identified 100% survival with normalization of serum lactate concentration (< 2 mmol/L) within the first 24 hours following multiple trauma, 78% survival if normalization occurred in 24-48 hours, and only 14% survival if after 48 hours. [ ] With the onset of bedside serum lactate analyzers, measurements can be obtained in minutes with excellent correlation (...) . Chronically, renal compensation occurs by means of reabsorption of HCO 3 . [ , ] Acidosis arises from an increased production of acids, a loss of alkali, or a decreased renal excretion of acids. The underlying etiology of metabolic acidosis is classically categorized into those that cause an elevated anion gap (AG) (see the calculator) and those that do not. Lactic acidosis, identified by a state of acidosis and an elevated plasma lactate concentration is one type of anion gap metabolic acidosis and may

2014 eMedicine Emergency Medicine

166. Lactic Acidosis (Overview)

organ failure. [ , , ] The duration and degree of increased serum lactic acid appear to predict morbidity and mortality. Abramson et al identified 100% survival with normalization of serum lactate concentration (< 2 mmol/L) within the first 24 hours following multiple trauma, 78% survival if normalization occurred in 24-48 hours, and only 14% survival if after 48 hours. [ ] With the onset of bedside serum lactate analyzers, measurements can be obtained in minutes with excellent correlation (...) . Chronically, renal compensation occurs by means of reabsorption of HCO 3 . [ , ] Acidosis arises from an increased production of acids, a loss of alkali, or a decreased renal excretion of acids. The underlying etiology of metabolic acidosis is classically categorized into those that cause an elevated anion gap (AG) (see the calculator) and those that do not. Lactic acidosis, identified by a state of acidosis and an elevated plasma lactate concentration is one type of anion gap metabolic acidosis and may

2014 eMedicine Emergency Medicine

167. Serum Electrolyte, Acid-Base Balance, and Enzyme Changes in Acute Halogeton Glomeratus Poisoning in Sheep Full Text available with Trip Pro

was not observed. Blood pH, pCO(2) and pO(2) measurements demonstrated that alkalosis did not develop. Serum glutamic pyruvic transaminase, serum glutamic oxalacetic transaminase, and lactic dehydrogenase all increased. Succinic dehydrogenase was inhibited in the rumen wall but not in other tissues according to the methods used. This finding, as well as other work cited, indicates a possible interference with carbohydrate metabolism. (...) Serum Electrolyte, Acid-Base Balance, and Enzyme Changes in Acute Halogeton Glomeratus Poisoning in Sheep Fourteen sheep were used on an acute halogeton toxicity feeding experiment. Seven sheep were fed a lethal dose of Halogeton glomeratus, an oxalate-producing plant, 7 served as controls. Various serum and tissue electrolytes and enzymes were measured. Sesum calcium decreased while magnesium and phosphorus increased. Although a severe hypocalcemia resulted from the feeding of halogeton tetany

1968 Canadian Journal of Comparative Medicine

168. Lactic Acidosis During and After Seizures

of lactate levels. Baseline lactate serum level is expected to be less than 2.2 mM/L. Capillary Lactic Acid Levels With Seizures [ Time Frame: Within 10 minutes of end of the seizure ] The investigators will assess the capillary lactic acid within 10 minutes after end of a seizure. Values will consist of lactic acid measurements in blood, within 10 minutes after the end of a seizure. Units of measurement will be mM/L. Baseline lactate serum level is expected to be less than 2.2 mM/L. Intravenous Lactic (...) Description Go to Brief Summary: This project looks at the time course of lactic acid rise (if any) after seizures. Salivary and capillary lactic acid are tested. This type of measurement may be useful in signalling the occurrence or recent history of a seizure. Condition or disease Epilepsy Detailed Description: Lactic acid is released from cells during seizures and elevates lactic acid levels in blood and saliva. The time course of this rise is unknown. If lactic acid rises within a few minutes

2013 Clinical Trials

169. [The use of sodium bicarbonate in stages in treating hypoperfusion induced lactic acidemia in septic shock]. (Abstract)

, in "stage" group, lactic acid (Lac) was significantly lowered (1.50±1.08 mmol/L vs. 2.93±1.09 mmol/L), and pH, mixed venous oxygen saturation (SvO2), oxygen extraction ratio (O2ER), cardiac index (CI), oxygen delivery (DO2) were significantly increased (pH:7.29±0.05 vs. 7.20±0.05, SvO2: 0.75±0.18 vs. 0.66±0.17, O2ER: 0.32±0.06 vs. 0.25±0.06, CI: 113.36±13.34 ml×s(-1)×m(-2) vs. 83.35±13.34 ml×s(-1)×m(-2), DO2: 840±170 ml×min(-1)×m(-2) vs. 630±171 ml×min(-1)×m(-2), all P<0.01).The use of sodium (...) [The use of sodium bicarbonate in stages in treating hypoperfusion induced lactic acidemia in septic shock]. To explore the use of sodium bicarbonate in stages in treating hypoperfusion induced lactic acidemia due to septic shock.In this prospective randomized, double-blind, controlled clinical trial, a total of 65 patients of hypoperfusion induced lactic acidemia due to septic shock admitted between April 2006 and April 2010 were assigned to two groups. Thirty-five patients of "stage" group

2013 Zhonghua wei zhong bing ji jiu yi xue Controlled trial quality: predicted high

170. Effects of auricular acupuncture on heart rate, oxygen consumption and blood lactic acid for elite basketball athletes. Full Text available with Trip Pro

Effects of auricular acupuncture on heart rate, oxygen consumption and blood lactic acid for elite basketball athletes. This study investigated the effects of auricular acupuncture on athletes' recovery abilities after exercise. Subjects were selected from twenty-four male elite university basketball players, randomly divided into two groups: auricular acupuncture group (AAG), and normal control group (NCG), each group containing twelve subjects. Auricular acupuncture was experimented to each (...) AAG athlete while no auricular acupuncture was conducted to each NCG athlete. Each subject in both groups performed a ride on the stationary bike until exhausted. The data of heart rate (HR(max)), oxygen consumption (VO(2 max)), and blood lactic acid were measured at four points of time: during the rest period after warm-ups and at the 5th, 30th and 60th minutes post-exercise, respectively. One-way ANOVA and repeated Scheffé methods were used to test the differences of the data between these two

2011 The American journal of Chinese medicine Controlled trial quality: uncertain

171. A comparison of intra-operative blood loss and acid-base balance between vasopressor and inotrope strategy during living donor liver transplantation: a randomised, controlled study. (Abstract)

A comparison of intra-operative blood loss and acid-base balance between vasopressor and inotrope strategy during living donor liver transplantation: a randomised, controlled study. Administration of vasopressors or inotropes during liver transplant surgery is almost universal, as this procedure is often accompanied by massive haemorrhage, acid-base imbalance, and cardiovascular instability. However, the actual agents that should be used and the choice between a vasopressor and an inotrope (...) strategy are not clear from existing published evidence. In this prospective, randomised, controlled and single-blinded study, we compared the effects of a vasopressor strategy on intra-operative blood loss and acid-base status with those of an inotrope strategy during living donor liver transplantation. Seventy-six adult liver recipients with decompensated cirrhosis were randomly assigned to receive a continuous infusion of either phenylephrine at a dose of 0.3-0.4 μg.kg(-1).min(-1) or dopamine

2012 Anaesthesia Controlled trial quality: uncertain

172. Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs Full Text available with Trip Pro

mitochondrial function in liver and other tissues.Twenty healthy pigs were sedated and mechanically ventilated. Ten were infused with a large dose of metformin (4 to 8 g) and five were not (sham controls). Five others were infused with lactic acid to clarify whether lactic acidosis per se diminishes global oxygen use. Arterial pH, lactatemia, global oxygen consumption (VO2) (metabolic module) and delivery (DO2) (cardiac output by thermodilution) were monitored for nine hours. Oxygen extraction was computed (...) as VO2/DO2. Activities of the main components of the mitochondrial respiratory chain (complex I, II and III, and IV) were measured with spectrophotometry (and expressed relative to citrate synthase activity) in heart, kidney, liver, skeletal muscle and platelets taken at the end of the study.Pigs infused with metformin (6 ± 2 g; final serum drug level 77 ± 45 mg/L) progressively developed lactic acidosis (final arterial pH 6.93 ± 0.24 and lactate 18 ± 7 mmol/L, P < 0.001 for both). Their VO2 declined

2012 Critical Care

173. Lactic Acidosis in Diabetes Full Text available with Trip Pro

Lactic Acidosis in Diabetes Lactic acidosis is occasionally responsible for metabolic acidosis in diabetics. It may occur in the presence of normal blood levels of the ketone bodies, and such cases are often described as having "non-ketotic diabetic acidosis." Lactic acid may contribute to the metabolic acidosis in patients with true diabetic ketoacidosis, but the blood lactate concentrations in these patients are not usually very high. In some patients the ketoacidosis is replaced by a lactic (...) acidosis during treatment. This usually occurs in association with a serious underlying disorder and is associated with a poor prognosis. A transient increase in blood lactate concentration was in fact observed in most patients after the beginning of treatment, but the significance of this finding is uncertain.

1969 British medical journal

174. Lactic acidosis. Full Text available with Trip Pro

Lactic acidosis. 4997498 1971 09 07 2018 11 13 0065-7778 82 1971 Transactions of the American Clinical and Climatological Association Trans. Am. Clin. Climatol. Assoc. Lactic acidosis. 70-6 Relman A S AS eng Journal Article Review United States Trans Am Clin Climatol Assoc 7507559 0065-7778 0 Bicarbonates 0 Lactates 142M471B3J Carbon Dioxide IM Acid-Base Equilibrium Acidosis blood etiology Bicarbonates blood Carbon Dioxide blood Diabetic Ketoacidosis blood Humans Hydrogen-Ion Concentration (...) Hyperventilation complications Lactates blood 4 1970 10 26 1970 10 26 0 1 1970 10 26 0 0 ppublish 4997498 PMC2441055 J Biol Chem. 1969 Jan 25;244(2):384-90 4237582 Am J Med. 1961 Jun;30:840-8 13716482 J Clin Invest. 1965 Jan;44:21-30 14254253

1971 Transactions Of The American Clinical And Climatological Association

175. Lactic acidosis and ketoacidosis: biochemical and clinical implications. Full Text available with Trip Pro

. Before treatment can be planned the biochemical basis of lactic acidosis and ketoacidosis must be understood -- especially the fact that lactic acidosis is not a single disease entity but has many possible causes. Among important considerations is the relation between the blood concentrations of bicarbonate and organic acid anions. After recovery from metabolic acidosis of the unmeasured anion gap type, metabolic alkalosis is common. Decreased bicarbonate excretion plays an important role (...) Lactic acidosis and ketoacidosis: biochemical and clinical implications. A case of lactic acidosis presented the opportunity for review of the association between lactic acidosis and ketoacidosis. The diagnosis of lactic acidosis or the combination of lactic acidosis and ketoacidosis is established clinically by the detection of a metabolic acidosis of the "unmeasured anion gap" type in the absence of significant renal failure, poison intake or a strongly positive clinical test for ketones

1977 Canadian Medical Association Journal

176. Lactic Acidosis as a Result of Iron Deficiency Full Text available with Trip Pro

Lactic Acidosis as a Result of Iron Deficiency Iron-deficient rats have an impaired work performance, even when their anemia is corrected by exchange transfusion. Muscle activity is associated with a higher blood lactate concentration than is observed in iron-replete animals. The accumulation of lactate is a result of excessive production as lactate clearance from the blood was shown to be unaffected. By adjusting the work load to a lower level, it was possible to divide iron-deficient animals (...) of a normal pH in iron-deficient and iron-replete animals did not prevent the impairment in work associated with high blood lactate concentrations. Additional evidence was obtained that energy substrate (blood glucose and free fatty acids, muscle glycogen) was adequate in irondeficient animals. Oxygen tension in their vena caval blood was higher than in controls. Furthermore, the in situ behavior of electrically stimulated gastroenemius and soleus muscles appeared similar to that of control animals

1979 Journal of Clinical Investigation

177. Reversible lactic acidosis associated with repeated intravenous infusions of sorbitol and ethanol. Full Text available with Trip Pro

Reversible lactic acidosis associated with repeated intravenous infusions of sorbitol and ethanol. Infusions of fructose or sorbitol are used commonly in parenteral nutrition and may cause lactic acidosis. A case is reported in whom blood lactate concentration was monitored frequently over a 5-day period during intravenous feeding with a sorbitol-ethanol-amino acid mixture. During the first five infusions blood lactate rose only moderately, but with the final infusion lactate rose to 11-1 mmol (...) /l and the patient had a severe metabolic acidosis. In retrospect the patient had shown deterioration in renal and hepatic function tests during the preceding 24 hr. On terminating the infusions the blood lactate concentration fell rapidly. It is suggested that great care should be exercised when using such infusions in ill patients and acid base status and renal and hepatic function should be monitored frequently.

1977 Postgraduate medical journal

178. Exploration of Candidate Biomarkers for Human Psoriasis Based on GC-MS Serum Metabolomics. (Abstract)

with psoriasis and healthy individuals. Compared with healthy individuals, patients with psoriasis had higher levels of amino acids including asparagine, aspartic acid, isoleucine, phenylalanine, ornithine and proline; higher levels of lactic acid and urea; and lower levels of crotonic acid, azelaic acid, ethanolamine and cholesterol.It appears that the glycolysis pathway and amino acid metabolic activity are increased in patients with psoriasis. These metabolic perturbations may stem from increased demand (...) Exploration of Candidate Biomarkers for Human Psoriasis Based on GC-MS Serum Metabolomics. Recent studies have shown that dysregulated metabolic pathways are linked to psoriasis pathogenesis. However, an extensive, unbiased metabolic analysis in patients with psoriasis has not been completely explored. The metabolome represents the end products of proteomics or cellular processes that may be closely associated with the pathogenesis of psoriasis.To determine the differences in serum metabolomic

2016 British Journal of Dermatology

179. Admission serum lactate predicts mortality in aneurysmal subarachnoid hemorrhage. (Abstract)

(group B; P <. 0001). The range was 0.01 to 14.7. Multivariable analysis controlling for Hunt and Hess grades showed lactic acid levels to be an independent predictor of mortality with a P value of .0018.In aneurysmal SAH, elevated serum lactate levels on admission may have a predictive role for mortality and represent a marker of disease severity. Currently, lactic acid levels are not ordered on all patients with SAH but perhaps should be part of the routine initial blood work and may serve (...) Admission serum lactate predicts mortality in aneurysmal subarachnoid hemorrhage. Aneurysmal subarachnoid hemorrhage (SAH) is the most devastating form of hemorrhagic stroke. Primary predictors of mortality are based on initial clinical presentation. Initial serum lactic acid levels have been shown to predict mortality and disease severity. Initial serum lactate may be an objective predictor or mortality.Retrospective review of aneurysmal SAH in a large academic center over a 42-month period

2015 American Journal of Emergency Medicine

180. Maternal early pregnancy serum metabolites and risk of gestational diabetes mellitus. Full Text available with Trip Pro

metabolites (linoleic acid, oleic acid, myristic acid, d-galactose, d-sorbitol, o-phosphocolamine, l-alanine, l-valine, 5-hydroxy-l-tryptophan, l-serine, sarcosine, l-pyroglutamic acid, l-mimosine, l-lactic acid, glycolic acid, fumaric acid, and urea) differentiated GDM cases from controls. Fold changes of relative abundance of these metabolites among GDM cases compared with controls ranged from 1.47 (linoleic acid) to 0.78 (5-hydroxy-l-tryptophan). Addition of these selected metabolites to a set of well (...) Maternal early pregnancy serum metabolites and risk of gestational diabetes mellitus. Significant gaps remain in the understanding of genetic and environmental risk factors, as well as related mechanisms that contribute to gestational diabetes mellitus (GDM).This study aimed to investigate early pregnancy maternal serum metabolites and subsequent risk of GDM.Information on participant characteristics and GDM diagnosis was collected using in-person interviews and medical record abstraction

2015 Journal of Clinical Endocrinology and Metabolism

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