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Blood Lactic Acid

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161. Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer

Information provided by (Responsible Party): Katherine D. Crew, Columbia University Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether it is feasible to give a combination of Metformin and omega-3 fatty acids for one year to women with a history of early stage breast cancer. We will also evaluate whether the metformin and omega-3 fatty acids combination causes changes in breast tissue, blood, and mammograms. Condition or disease Intervention/treatment (...) with increased risk of metformin-associated lactic acidosis (e.g., congestive heart failure defined as New York Heart Association [NYHA] Class III or IV functional status, history of acidosis of any type, intake of 3 or more alcoholic beverages per day on average over the past 6 months) Currently taking metformin, sulfonylureas, thiazolidinediones, or insulin for any reason History of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin or omega-3 fatty acids

2014 Clinical Trials

162. Regional Blood Acidification Enhances Extracorporeal Carbon Dioxide Removal: A 48-hour Animal Study. (PubMed)

pigs were connected to a low-flow veno-venous extracorporeal circuit (blood flow rate, 0.25 l/min) including a membrane lung. Blood acidification was achieved in eight pigs by continuous infusion of 2.5 mEq/min of lactic acid at the membrane lung inlet. The acid infusion was interrupted for 1 h at the 24 and 48 h. Two control pigs did not receive acidification. At baseline and every 8 h thereafter, the authors measured blood lactate, gases, chemistry, and the amount of carbon dioxide removed (...) mEq/l. No sign of organ and erythrocyte damage was recorded.Infusion of lactic acid at the membrane lung inlet consistently increased VCO2ML providing a safe removal of carbon dioxide from only 250 ml/min extracorporeal blood flow in amounts equivalent to 50% production of an adult man.

2014 Anesthesiology

163. Multimodal Ultrasound-Photoacoustic Imaging of Tissue Engineering Scaffolds and Blood Oxygen Saturation In and Around the Scaffolds (PubMed)

challenges and/or provide complementary information. US-PA imaging was employed to characterize poly(lactic-co-glycolic acid) (PLGA) polymer scaffolds or single-walled carbon nanotube (SWCNT)-incorporated PLGA (SWCNT-PLGA) polymer scaffolds as well as blood oxygen saturation within and around the scaffolds. Ex vivo, PLGA and SWCNT-PLGA scaffolds were placed at 0.5, 2, and 6 mm depths in chicken breast tissues. PLGA scaffolds could be localized with US imaging, but generate no PA signal (excitation (...) Multimodal Ultrasound-Photoacoustic Imaging of Tissue Engineering Scaffolds and Blood Oxygen Saturation In and Around the Scaffolds Preclinical, noninvasive imaging of tissue engineering polymeric scaffold structure and/or the physiological processes such as blood oxygenation remains a challenge. In vitro or ex vivo, the widely used scaffold characterization modalities such as porosimetry, electron or optical microscopy, and X-ray microcomputed tomography have limitations or disadvantages-some

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2014 Tissue engineering. Part C, Methods

164. Protective effects of traditional Chinese medicine formula NaoShuanTong capsule on haemorheology and cerebral energy metabolism disorders in rats with blood stasis (PubMed)

corpuscle electrophoresis index significantly decreased in all the three dose NSTC groups. Moreover, treatment with high-dose NSTC could significantly improve Na+-K+ adenosine triphosphatase (ATPase) and Ca2+ ATPase activity, as well as lower lactic acid level in brain tissues. These results demonstrated the protective effects of NSTC on haemorheology and cerebral energy metabolism disorders, which may provide scientific information for the further understanding of mechanism(s) of NSTC as a clinical (...) Protective effects of traditional Chinese medicine formula NaoShuanTong capsule on haemorheology and cerebral energy metabolism disorders in rats with blood stasis NaoShuanTong capsule (NSTC), an oral traditional Chinese medicine formula, is composed of Pollen Typhae, Radix Paeoniae Rubra, Rhizoma Gastrodiae, Radix Rhapontici and Radix Curcumae. It has been widely used to treat ischemic stroke in clinic for many years in China. In addition to neuronal apoptosis, haemorheology and cerebral

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2014 Biotechnology, biotechnological equipment

165. Uric Acid Nephropathy (Diagnosis)

is important in urate secretion. In disorders such as sickle cell disease, hypertension, and eclampsia, hyperuricemia out of proportion with decreases in glomerular filtration result from decreased renal blood flow. Organic acids, such as lactic acid and ketoacids, also can impair the proximal secretion of uric acid. Acute uric acid nephropathy Overproduction of uric acid occurs primarily when tissue breakdown is accelerated. Acute uric acid nephropathy is the term applied to the development of acute (...) and secretion. Extracellular volume expansion or contraction, respectively, enhances or reduces uric acid excretion through the paired movement of sodium. Consequently, in cases of extracellular compartment depletion, urate excretion is diminished. Physiologically, the major factors that affect urate excretion are the tubular fluid pH, the tubular fluid flow rate, and renal blood flow. The first 2 factors primarily diminish uric acid and urate precipitation in the collecting ducts, while the third

2014 eMedicine.com

166. Folic Acid Deficiency (Diagnosis)

in food is bioavailable, whereas nearly 100% of folic acid supplements are absorbed when consumed fasting, and approximately 85% of folic acid supplementation is absorbed when consumed with food. [ ] Previous Next: Epidemiology Frequency United States The current standard of practice is that serum folate levels less than 3 ng/mL and a red blood cell (RBC) folate level less than 140 ng/mL puts an individual at high risk of folate deficiency. The RBC folate level generally indicates folate stored (...) folic acid supplementation prior to conception and for the first 3 months of pregnancy. [ ] Flour fortification with folic acid has been shown to result in significant improvements in folate status among women of reproductive age, in areas where folate deficiency is high. [ ] Casey et al examined the effects over 1 year of a free weekly iron-folic acid supplementation and deworming program in 52,000 Vietnamese women of childbearing age. [ ] The investigators collected demographic data and blood

2014 eMedicine.com

167. Folic Acid Deficiency (Overview)

in food is bioavailable, whereas nearly 100% of folic acid supplements are absorbed when consumed fasting, and approximately 85% of folic acid supplementation is absorbed when consumed with food. [ ] Previous Next: Epidemiology Frequency United States The current standard of practice is that serum folate levels less than 3 ng/mL and a red blood cell (RBC) folate level less than 140 ng/mL puts an individual at high risk of folate deficiency. The RBC folate level generally indicates folate stored (...) folic acid supplementation prior to conception and for the first 3 months of pregnancy. [ ] Flour fortification with folic acid has been shown to result in significant improvements in folate status among women of reproductive age, in areas where folate deficiency is high. [ ] Casey et al examined the effects over 1 year of a free weekly iron-folic acid supplementation and deworming program in 52,000 Vietnamese women of childbearing age. [ ] The investigators collected demographic data and blood

2014 eMedicine.com

168. Uric Acid Nephropathy (Overview)

is important in urate secretion. In disorders such as sickle cell disease, hypertension, and eclampsia, hyperuricemia out of proportion with decreases in glomerular filtration result from decreased renal blood flow. Organic acids, such as lactic acid and ketoacids, also can impair the proximal secretion of uric acid. Acute uric acid nephropathy Overproduction of uric acid occurs primarily when tissue breakdown is accelerated. Acute uric acid nephropathy is the term applied to the development of acute (...) and secretion. Extracellular volume expansion or contraction, respectively, enhances or reduces uric acid excretion through the paired movement of sodium. Consequently, in cases of extracellular compartment depletion, urate excretion is diminished. Physiologically, the major factors that affect urate excretion are the tubular fluid pH, the tubular fluid flow rate, and renal blood flow. The first 2 factors primarily diminish uric acid and urate precipitation in the collecting ducts, while the third

2014 eMedicine.com

169. Dietary amylose and amylopectin ratio and resistant starch content affects plasma glucose, lactic acid, hormone levels and protein synthesis in splanchnic tissues. (PubMed)

Dietary amylose and amylopectin ratio and resistant starch content affects plasma glucose, lactic acid, hormone levels and protein synthesis in splanchnic tissues. Experiments were conducted to determine the effects of feeding different starch sources on piglets. Four diets were formulated with maize, brown rice, sticky rice and Hi-Maize 1043 as starch sources, with resistant starch (RS) contents of 2.3%, 0.9%, 0.0%, 20.6%, and amylose and amylopectin ratio of 0.23%, 0.21%, 0.18%, 0.06 (...) ) plasma contents of glucose, insulin, lactic acid and T(3), while sticky rice increased plasma contents of glucose and insulin. The insulin contents in piglets fed the sticky rice diet was 69.2 microIU/ml at 1 h post-feeding which was highest among the starch diets. The FSR in the pancreas, spleen, duodenum, jejunum, ileum and colon in the corn group were much higher (p < 0.05) than that in the sticky rice group. These results suggest that RS is potentially beneficial for improving insulin sensitivity

2010 Journal of animal physiology and animal nutrition

170. Feeding rolled barley grain steeped in lactic acid modulated energy status and innate immunity in dairy cows. (PubMed)

Feeding rolled barley grain steeped in lactic acid modulated energy status and innate immunity in dairy cows. Feeding dairy cows large proportions of cereal grain is commonly associated with rumen acidosis, activation of innate immunity, and perturbation of intermediary metabolism. We previously showed that steeping barley grain in 0.5% lactic acid (LA) decreased the rate of starch degradation, lowered the risk of subacute rumen acidosis, modulated rumen fermentation profile, and increased milk (...) experimental period lasted 21 d, with the first 11 d for diet adaptation. Blood and rumen samples were collected on d 12, 15, 17, and 21 of the experimental period before the morning feeding to evaluate the effects of dietary treatment on preprandial day-to-day variation of plasma and rumen variables. To establish the effect of treatment on diurnal variation of plasma variables, blood samples were collected on the last day of each period at 0, 2, 4, 6, 8, 10, and 12h after the morning feeding (i.e., 0800 h

2010 Journal of dairy science

171. Immune-stimulating effects of lactic acid bacteria in vivo and in vitro. (PubMed)

Immune-stimulating effects of lactic acid bacteria in vivo and in vitro. The health-promoting effects of lactic acid bacteria (LAB) are well recognised, making them a popular functional food ingredient. Commercially available probiotic products are often promoted as capable of improving immune defences also in healthy subjects. However, while strain-specific differences exist in the effects of LAB, conventional yoghurt bacteria have proved beneficial as well. For comparing the immunological (...) induced cytokine secretion in peripheral blood mononuclear cells in a similar manner and this effect was reduced in a Caco-2 cell model, suggesting a modulating influence of gut epithelial cells. While both conventional and probiotic strains modulate the immune response, specific properties may offer therapeutic options in the treatment of certain diseases.

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2010 The Proceedings of the Nutrition Society

172. Blood Substitutes (Follow-up)

, the complement pathway, and platelets. At present, the only institutions working actively on this product are in Japan. The ultimate RBC substitute would contain not only hemoglobin but also other contents of the red blood cell also encapsulated in an artificial membrane. However, production of such a product would be extremely challenging. Efforts have been made to use polyactide, a biodegradable polymer that is converted to lactic acid in the body, to create artificial red blood cells. These cells contain (...) , Winslow RM. MP4, a new nonvasoactive PEG-Hb conjugate. Transfusion . 2003 Apr. 43(4):509-16. . Young MA, Riddez L, Kjellström BT, Bursell J, Winslow F, Lohman J. MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Crit Care Med . 2005 Aug. 33(8):1794-804. . Chang TM. Blood substitutes based on nanobiotechnology. Trends Biotechnol . 2006 Aug. 24(8):372-7. . Buehler PW, Zhou Y, Cabrales P, et al. Synthesis, biophysical

2014 eMedicine.com

173. Blood Substitutes (Diagnosis)

, the complement pathway, and platelets. At present, the only institutions working actively on this product are in Japan. The ultimate RBC substitute would contain not only hemoglobin but also other contents of the red blood cell also encapsulated in an artificial membrane. However, production of such a product would be extremely challenging. Efforts have been made to use polyactide, a biodegradable polymer that is converted to lactic acid in the body, to create artificial red blood cells. These cells contain (...) , Winslow RM. MP4, a new nonvasoactive PEG-Hb conjugate. Transfusion . 2003 Apr. 43(4):509-16. . Young MA, Riddez L, Kjellström BT, Bursell J, Winslow F, Lohman J. MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Crit Care Med . 2005 Aug. 33(8):1794-804. . Chang TM. Blood substitutes based on nanobiotechnology. Trends Biotechnol . 2006 Aug. 24(8):372-7. . Buehler PW, Zhou Y, Cabrales P, et al. Synthesis, biophysical

2014 eMedicine.com

174. Blood Substitutes (Treatment)

, the complement pathway, and platelets. At present, the only institutions working actively on this product are in Japan. The ultimate RBC substitute would contain not only hemoglobin but also other contents of the red blood cell also encapsulated in an artificial membrane. However, production of such a product would be extremely challenging. Efforts have been made to use polyactide, a biodegradable polymer that is converted to lactic acid in the body, to create artificial red blood cells. These cells contain (...) , Winslow RM. MP4, a new nonvasoactive PEG-Hb conjugate. Transfusion . 2003 Apr. 43(4):509-16. . Young MA, Riddez L, Kjellström BT, Bursell J, Winslow F, Lohman J. MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Crit Care Med . 2005 Aug. 33(8):1794-804. . Chang TM. Blood substitutes based on nanobiotechnology. Trends Biotechnol . 2006 Aug. 24(8):372-7. . Buehler PW, Zhou Y, Cabrales P, et al. Synthesis, biophysical

2014 eMedicine.com

175. Blood Substitutes (Overview)

, the complement pathway, and platelets. At present, the only institutions working actively on this product are in Japan. The ultimate RBC substitute would contain not only hemoglobin but also other contents of the red blood cell also encapsulated in an artificial membrane. However, production of such a product would be extremely challenging. Efforts have been made to use polyactide, a biodegradable polymer that is converted to lactic acid in the body, to create artificial red blood cells. These cells contain (...) , Winslow RM. MP4, a new nonvasoactive PEG-Hb conjugate. Transfusion . 2003 Apr. 43(4):509-16. . Young MA, Riddez L, Kjellström BT, Bursell J, Winslow F, Lohman J. MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine. Crit Care Med . 2005 Aug. 33(8):1794-804. . Chang TM. Blood substitutes based on nanobiotechnology. Trends Biotechnol . 2006 Aug. 24(8):372-7. . Buehler PW, Zhou Y, Cabrales P, et al. Synthesis, biophysical

2014 eMedicine.com

176. The action of adrenaline on muscle blood flow and blood lactate in man (PubMed)

The action of adrenaline on muscle blood flow and blood lactate in man 13320403 2003 05 01 2018 12 01 0022-3751 132 2 1956 May 28 The Journal of physiology J. Physiol. (Lond.) The action of adrenaline on muscle blood flow and blood lactate in man. 372-8 BARCROFT H H COBBOLD A F AF eng Journal Article England J Physiol 0266262 0022-3751 0 Lactates 33X04XA5AT Lactic Acid YKH834O4BH Epinephrine OM Blood Cardiovascular System Epinephrine pharmacology Hemodynamics Humans Lactates blood Lactic Acid (...) Male Muscles blood supply 5630:28740 BLOOD EPINEPHRINE/effects LACTATES/in blood MUSCLES/blood supply 1956 5 28 1956 5 28 0 1 1956 5 28 0 0 ppublish 13320403 PMC1363501 J Appl Physiol. 1952 Nov;5(5):228-32 12999658 J Physiol. 1952 Dec;118(4):575-87 13023655 J Physiol. 1953 Apr 28;120(1-2):146-54 13062228 Biochem J. 1953 Sep;55(2):289-91 13093678 J Physiol. 1955 May 27;128(2):268-76 14392607 Physiol Rev. 1951 Apr;31(2):151-87 14833926 J Physiol. 1949 Aug;109(1-2):232-9 15394321 J Physiol. 1946 Apr

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1956 The Journal of physiology

177. STUDIES ON THE BLOOD VESSELS IN THE MEMBRANES OF CHICK EMBRYOS : PART IV. MODIFICATION OF IRRITABILITY OF THE BLOOD VESSELS (PubMed)

of lactic acid was without result. We also employed solutions buffered with potassium and sodium phosphate. When the irrigation was undertaken with these solutions having a pH range varying from 7.7 to 5.9 we observed neither a direct action nor one which modified the preparation in such a way as to change its susceptibility to faradic stimulation. Important investigations have been published recently by Atzler and Lehmann (2) on the direct influence of the hydrogen ion concentration on the behavior (...) of blood vessels. Hammett and Zoll believed that, as the result of their experiments in which they attempted to bring about stimulation with solutions of concentrated carbon dioxide, they were able to exclude the possibility of action due to acid alone and therefore ascribed to carbon dioxide a specific effect. In our own experiments the method of irrigation does not permit an inference whether, or how far, an acid effect plays a rôle in the carbon dioxide experiments. For beside the question

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1930 The Journal of experimental medicine

178. Combined walking exercise and alkali therapy in patients with CKD4-5 regulates intramuscular free amino acid pools and ubiquitin E3 ligase expression. (PubMed)

Combined walking exercise and alkali therapy in patients with CKD4-5 regulates intramuscular free amino acid pools and ubiquitin E3 ligase expression. Muscle-wasting in chronic kidney disease (CKD) arises from several factors including sedentary behaviour and metabolic acidosis. Exercise is potentially beneficial but might worsen acidosis through exercise-induced lactic acidosis. We studied the chronic effects of exercise in CKD stage 4-5 patients (brisk walking, 30 min, 5 times/week), and non (...) -exercising controls; each group receiving standard oral bicarbonate (STD), or additional bicarbonate (XS) (Total n = 26; Exercising + STD n = 9; Exercising +XS n = 6; Control + STD n = 8; Control + XS n = 3). Blood and vastus lateralis biopsies were drawn at baseline and 6 months. The rise in blood lactate in submaximal treadmill tests was suppressed in the Exercising + XS group. After 6 months, intramuscular free amino acids (including the branched chain amino acids) in the Exercising + STD group showed

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2013 European journal of applied physiology

179. Acid-Base Patterns in Acute Severe Asthma. (PubMed)

-base patterns in ASA (314 patients), taking into account both natural history of disease and treatment, in patients free of other diseases altering acid-base status. Data were collected from patients admitted for ASA without prior history of chronic bronchitis, emphysema, kidney or liver disease, heart failure, uncontrolled diabetes mellitus or gastrointestinal illness. Informed consent was obtained for all patients, after study protocol approval by the Institutional Review Board.Arterial blood (...) ) and PaCO(2) levels.Predominant acid-base patterns observed in ASA in this patient population included primary hypocapnia, or less frequently, primary hypercapnia. Lactic acidosis occurred in 11% of patients and presented consistently as a mixed acid-base disorder. These findings suggest lactic acidosis results from the combined effects of both ASA and medication-related sympathetic effects.

2013 Journal of Asthma

180. Effects of glycine-arginine-α-ketoisocaproic acid supplementation in college-age trained females during multi-bouts of resistance exercise. (PubMed)

) and metabolic parameters during repeated bouts of submaximal leg extensions in college-age females. Nine resistance-trained females participated in a randomized, counterbalanced, double blind study. Subjects were randomly assigned to placebo or GAKIC (10.2 g) and performed six sets of 50% of one repetition maximum leg extensions (two legs simultaneously) to failure. One week later, subjects ingested the other supplement and performed the same exercise protocol. Furthermore, blood lactic acid, blood glucose (...) , and heart rate were also measured preexercise and 5 s after the completion of the exercise protocol (postexercise). GAKIC supplementation significantly increased leg extension total load volume (GAKIC = 1721.7 ± 479.9 kg; placebo = 1479.1 ± 396.8 kg, p < .01). Heart rate and blood lactic acid were significantly increased (p < .01 for both measures) postexercise compared to preexercise, but were not significantly different between GAKIC and placebo (p = .40 for heart rate; p = .88 for lactic acid). Blood

2013 Journal of dietary supplements

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