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Blood Lactic Acid

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1681. Effects of digoxin on muscle reflexes in normal humans. (Abstract)

potassium and lactic acid during dynamic handgrip exercises, and local circulatory arrest in 11 healthy subjects. Digoxin enhanced MBP during exercise but not during the post-handgrip ischemia and had no effect on HR, V(E), SpO(2), and MSNA. Venous plasma potassium and lactic acid were also not affected by digoxin-induced skeletal muscle Na(+)-K(+)-ATPase blockade. We conclude that digoxin increased MBP during dynamic exercise in healthy humans, independently of changes in potassium and lactic acid (...) Effects of digoxin on muscle reflexes in normal humans. Blockade of the skeletal muscle Na(+)-K(+)-ATPase pump by digoxin could result in a more marked hyperkaliema during a forearm exercise, which in turn could stimulate the mechano- and metaboreceptors. In a randomized, double-blinded, placebo-controlled, and cross-over-design study, we measured mean blood pressure (MBP), heart rate (HR), ventilation (V(E)), oxygen saturation (SpO(2)), muscle sympathetic nerve activity (MSNA), venous plasma

2009 European journal of applied physiology Controlled trial quality: uncertain

1682. Physiopathologic factors resulting in poor outcome in childhood severe malaria in Cameroon. (Abstract)

Physiopathologic factors resulting in poor outcome in childhood severe malaria in Cameroon. We evaluated plasma creatinine, urea, bilirubin, lactic acid, and nitric oxide values in children with malaria to identify indices of disease severity and predictors of fatal outcomes.Children 0 to 15 years old were recruited, clinical data recorded, and blood samples collected. Plasma creatinine, urea, bilirubin, lactic acid, and nitric oxide (NO) values were determined by spectrophotometry.Values

2009 Pediatric Infectious Dsease Journal

1683. Lactic acid bacteria differ in their ability to induce functional regulatory T cells in humans. (Abstract)

Lactic acid bacteria differ in their ability to induce functional regulatory T cells in humans. Trials with probiotic lactic acid bacteria have yielded different results, which may be due to the strains used. Lactobacilli and bifidobacteria are known to be potent modulators of the immune system. The capacity of these bacteria used as probiotics to influence both T helper type 1 (Th1)- and Th2-mediated diseases has been shown before. However, the ability of strains to induce forkhead box P3 (...) were assessed. Results Probiotic strains differ in their capacity to induce regulatory T cells. FOXP3(+) cells were induced from CD25(-) cells and were able to suppress effector T cells. Naturally occurring regulatory T cells were not affected by co-culture with lactobacilli. IL-10 concentrations found in the supernatant showed a trend towards the same differences between strains. Blockade of IL-10 did not influence the up-regulation of FOXP3. No differences between lactic acid bacteria were found

2009 Clinical and Experimental Allergy

1684. Blood acidification enhances carbon dioxide removal of membrane lung: an experimental study. (Abstract)

% of the total CO2 content) is easily removed by the ML, we tested whether acidifying the blood entering the ML to convert bicarbonate ions towards dissolved CO2 could enhance the CO2 transfer though the ML.Six pigs were connected to an extracorporeal circuit comprising a ML. The extracorporeal blood flow was 500 ml/min, while the gas flow was 10 l/min. A 15-min continuous infusion of 0.5 N lactic acid was added to the extracorporeal blood flow before the ML at a rate of 1, 2 and 5 mEq/min. Between steps we (...) waited for a reequilibration time of at least 30 min.Acid infusion at 0, 1, 2 and 5 mEq/min increased pCO2 (56.19 +/- 7.92, 68.24 +/- 11.73, 84.28 +/- 11.17 and 136.66 +/- 18.46 mmHg, respectively) and decreased pH (7.39 +/- 0.05, 7.30 +/- 0.05, 7.20 +/- 0.05 and 6.91 +/- 0.05, respectively). ML CO2 removal increased 11, 23 and 70% during acid infusion at 1, 2 and 5 mEq/min, respectively.Blood acidification at the inlet of a ML with infusion of 1, 2 and 5 mEq/min of lactic acid can increase the CO2

2009 Intensive Care Medicine

1685. Liver transplantation for glycogen storage disease type Ia. (Abstract)

. Hemoglobin levels and serum triglyceride, total cholesterol, blood glucose, and lactic acid concentrations improved in all patients after LT. Corn starch feeding was not required in any patient after LT. Renal function worsened in three patients despite modifications to primary immunosuppressive medications. All patients are alive at last follow-up (range 25-48 months) and all post-transplant complications have resolved.By removing all possible adenomatous tissue and reversing the underlying hepatic

2009 Journal of Hepatology

1686. Seasonal changes in suppressive capacity of CD4 CD25 T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25 population. (Abstract)

-associated transcription factor Foxp3 were examined. Lactic acid stripping of IgE was used to determine IgE dependence of T cell responses.The seasonal reduction in suppression by CD4(+) CD25(+) T cells was confirmed and was shown to be allergen specific because suppression of HDM-stimulated cultures was not affected significantly. The CD4(+) CD25(+) population contained IL-5 and IL-10 producing cells but increases in their frequencies with seasonal pollen exposure were not significant. Both activation (...) Seasonal changes in suppressive capacity of CD4 CD25 T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25 population. Suppression of allergen-stimulated peripheral blood CD4(+) CD25(-) effector T cells by CD4(+) CD25(+) regulatory T cells obtained from subjects with allergic rhinoconjunctivitis is reduced during the pollen season when compared with out of season.We examined possible explanations for this effect

2009 Clinical and Experimental Allergy

1687. Allergy Therapy by Intranasal Administration with Recombinant Lactococcus lactis Producing Bovine beta-Lactoglobulin. (Abstract)

Allergy Therapy by Intranasal Administration with Recombinant Lactococcus lactis Producing Bovine beta-Lactoglobulin. In the last years, the use of probiotics such as lactic acid bacteria (LAB) has been proposed as an attractive alternative for the management of allergic diseases. A partial prevention from sensitization to bovine beta-lactoglobulin (BLG), one of the major cows' milk allergens, could be achieved in mice after intranasal administration with a recombinant LAB strain, Lactococcus (...) lactis, producing BLG (LL-BLG). This study aimed to evaluate the effects of the LL-BLG strain in a therapeutic protocol.Three groups of mice were first orally sensitized to cows' milk and then intranasally administered with either the LL-BLG strain, BLG protein alone or saline solution. Serum samples were collected to analyze BLG-specific IgE, IgG1 and IgG2a, and mice were further intranasally challenged with BLG to elicit a specific allergic reaction.Treatment with LL-BLG, but not with BLG alone

2009 International Archives of Allergy and Immunology

1688. Clinical efficacy of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi for perennial allergic rhinitis. Full Text available with Trip Pro

Clinical efficacy of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi for perennial allergic rhinitis. Recently, some common foods in daily life, especially lactic acid bacteria, have been found to have anti-allergic effects. We previously isolated a halophilic lactic acid bacterium, Tetragenococcus halophilus Th221, from soy sauce moromi, a mixture of koji and salt solution, and showed that it possesses an immunomodulatory activity that promotes T helper (...) periods in the high-dose group. The change in serum total immunoglobulin E improved significantly at the end of the trial compared with the beginning in this group (p < 0.05). The safety of Th221 treatment was confirmed by laboratory tests and inspection of the general condition of each subject.Th221 can be expected to safely improve the symptoms of PAR.

2009 Allergology international : official journal of the Japanese Society of Allergology Controlled trial quality: uncertain

1689. Effect of fermented milk prepared with two probiotic strains on Japanese cedar pollinosis in a double-blind placebo-controlled clinical study. (Abstract)

pollen. Fermented milk prepared with the tested bacteria or placebo yoghurt was administered to 40 subjects with a clinical history of JCP for 10 weeks. Subjective symptoms, self-care measures and blood samples were compared between the two groups. Peripheral blood mononuclear cells (PBMCs) were collected from seven patients with JCP and in vitro cytokine production by the isolated PBMCs was analysed in the presence of heat-killed lactic acid bacteria. Consumption of the fermented milk significantly (...) decreased the mean symptom score for nasal blockage after 9 weeks (P<0.05) and mean symptom-medication scores after 9 and 10 weeks when compared with the placebo group (P<0.01 and P<0.05 respectively). The tested strains of lactic acid bacteria affected cytokine production by isolated PBMCs in vitro in a strain-dependent manner. LGG significantly inhibited IL-4 and IL-5 production by PBMCs stimulated by both Cry j 1 and PHA. TMC0356 only suppressed IL-5 production stimulated by PHA. The fermented milk

2009 International journal of food microbiology Controlled trial quality: uncertain

1690. Diazoxide protects myocardial mitochondria, metabolism, and function during cardiac surgery: a double-blind randomized feasibility study of diazoxide-supplemented cardioplegia. Full Text available with Trip Pro

) or placebo (n = 20 in each group). Mitochondria were assessed before and after ischemia and reperfusion in myocardial biopsy specimens. Myocardial oxygen and glucose and lactic acid extraction ratios were measured before ischemia and in the first 20 minutes of reperfusion. Hemodynamic data were collected, and troponin I, creatine kinase-MB, and N-terminal prohormone brain natriuretic peptide levels were measured. All outcomes were analyzed by using mixed-effects modeling for repeated measures.No deaths (...) , strokes, or infarcts were observed. Patients received, on average, 36.2 +/- 1.2 mg of diazoxide and 37.3 +/- 1.9 mg of placebo (P = .6). Diazoxide added to cardioplegia prevented mitochondrial swelling (8899 +/- 474 vs 9273 +/- 688 pixels before and after the procedure, respectively; P = .6) compared with that seen in the placebo group (8474 +/- 163 vs 11,357 +/- 759 pixels, P = .004). No oxygen debt was observed in the diazoxide group. Glucose consumption and lactic acid production returned

2009 The Journal of thoracic and cardiovascular surgery Controlled trial quality: predicted high

1691. Effects of acupuncture stimulation on recovery ability of male elite basketball athletes. (Abstract)

separate runs on the treadmill. The data of heart rate (HR(max)), oxygen consumption (VO(2max)), and blood lactic acid were measured during the rest period and at 3 recovery points of time (5th, 30th and 60th min) post-exercise. The results showed that the acupuncture group (PC6 and ST36) has significantly lower HR(max), VO(2max) and blood lactic acid than both the sham and normal groups at the 30th min post-exercise. Blood lactic acid of the acupuncture group was also significantly lower than

2009 The American journal of Chinese medicine Controlled trial quality: uncertain

1692. [Study the effects of high-volume hemofiltration and fluid resuscitation on removing blood lactic acid and pro-inflammatory cytokines in patients with refractory septic shock]. (Abstract)

[Study the effects of high-volume hemofiltration and fluid resuscitation on removing blood lactic acid and pro-inflammatory cytokines in patients with refractory septic shock]. To evaluate the effects of high-volume hemofiltration (HVHF) and fluid resuscitation on the levels of arterial lactate and inflammatory cytokines, the acute physiology and chronic health evaluation II (APACHE II) score, and sepsis-related organ failure assessment (SOFA) score in patients with refractory septic shock (...) treatment in both groups. After treatment, the serum concentration of IL-6, PCT and hs-CRP levels in group B were reduced significantly more than that in group A at 1 day and 3 days (P < 0.05 or P < 0.01). (3) The APACHE II and SOFA scores in both groups were reduced gradually on 3 days and 7 days after treatment, but the APACHE II and SOFA scores on 7 days in group B were lower compared with group A (P < 0.05 and P < 0.01).HVHF and fluid resuscitation could reduce arterial lactate and cytokines

2009 Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Controlled trial quality: uncertain

1693. Acid-base status and hemodynamic stability during propofol and sevoflurane-based anesthesia in patients undergoing uncomplicated intracranial surgery. (Abstract)

=31). The anesthesia protocol including rocuronium and remifentanil infusion was otherwise similar in both groups. Arterial blood samples were drawn every 2 hours during the procedure and upon arrival in the intensive care unit to assess acid-base status. The number of hypotensive and hypertensive events served to assess hemodynamic stability. Metabolic acidosis was more frequent during propofol than sevoflurane anesthesia (7 out of 29 and 1 out of 31, P=0.02). Its severity was linearly correlated (...) Acid-base status and hemodynamic stability during propofol and sevoflurane-based anesthesia in patients undergoing uncomplicated intracranial surgery. Propofol anesthesia may induce metabolic disturbances and sevoflurane anesthesia arterial hypotension. This study compares both techniques regarding acid-base and hemodynamic status during intracranial surgery. Sixty-one patients were randomized into 2 groups according to anesthesia maintenance, a propofol group (n=30), and a sevoflurane group (n

2009 Journal of neurosurgical anesthesiology Controlled trial quality: uncertain

1694. [Effect of blood glucose control on level of lactic acid in patients with cardic-valve replacement]. (Abstract)

[Effect of blood glucose control on level of lactic acid in patients with cardic-valve replacement]. To evaluate the effect of different control levels of glucose on the serum lactic acid during operation, and to investigate the relation between glucose and lactic acid to find a new way of myocardial protection.Volunteers were divided into an experiment group(n=38) and a control group(n=33) by random sampling and double blind method. The experiment group received intensive insulin therapy (...) and the control group received traditional therapy. The arterial blood gas samples of all the patients at different time points after the operation were harvested in the intensive care unit for blood gas analysis. The related data were collected and analyzed.The serum glucose level in the 2 groups decreased firstly, then increased, and recovered finally. The serum lactic acid level in the 2 groups increased firstly, decreased later, then reincreased, and recovered finally. The highest level of the serum

2009 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Controlled trial quality: uncertain

1695. [The influence of intensive insulin therapy on hemodynamics in patients with septic shock]. (Abstract)

% and 11.7%, respectively (all P<0.05). On the other hands, there was no significant difference between target and routine group in mean artery pressure, acute physiology and chronic health evaluation II (APACHEII) score, blood lactic acid (all P>0.05), although the incidence of severe hypoglycemia was higher in target group than the routine group (38.5% vs. 28.6%, P>0.05).Intensive insulin therapy and blood glucose control may improve hemodynamic status and enhance cardiac function in patients (...) [The influence of intensive insulin therapy on hemodynamics in patients with septic shock]. To elucidate effects of intensive insulin therapy and target glucose control on hemodynamics and cardiac function in patients with septic shock.Twenty-seven patients of septic shock with myocardial depression were divided into routine group (14 cases, level of blood glucose was 4.1 to 6.1 mmol/L) and target group (13 cases, level of blood glucose was 6.2 to 8.3 mmol/L). Hemodynamics and cardiac function

2009 Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Controlled trial quality: uncertain

1696. Amphotericin B in poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) nanoparticles against paracoccidioidomycosis. Full Text available with Trip Pro

Amphotericin B in poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) nanoparticles against paracoccidioidomycosis. The present study reports on the preparation and testing of a desoxycholate amphotericin B (D-AMB) sustained delivery system based on poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) polymeric blends (Nano-D-AMB) aimed at reducing the number of AMB administrations required to treat mycosis.BALB/c mice were infected with the yeast (...) were non-infected and the infected mice mock treated with PBS.Nano-D-AMB presented results comparable to free D-AMB, with a marked antifungal efficacy. The Nano-D-AMB-treated group presented lower loss of body weight and absence of stress sign (piloerection and hypotrichosis) observed after D-AMB treatment. No renal [blood urea nitrogen (BUN), creatinine] or hepatic (pyruvic and oxalacetic glutamic transaminases) biochemical abnormalities were found. The micronucleus assay showed no significant

2009 Journal of Antimicrobial Chemotherapy

1697. Calendula

(radiation dermatitis) . Early research suggests that applying calendula ointment on the skin might reduce radiation dermatitis in people receiving radiation therapy for breast cancer. However, other early research shows that using a calendula cream is no different than petroleum jelly for reducing radiation dermatitis. Thinning of the wall of the vagina (vaginal atrophy) . Early research suggests that applying a gel containing calendula, Lactobacillus sporogenes, isoflavones, and lactic acid (...) to the vagina for 4 weeks reduces symptoms of vaginal atrophy such as vaginal itching, burning, dryness, and pain during intercourse. Vaginal yeast infection . Early research shows that applying calendula cream inside the vagina for 7 days does not treat yeast infections as effectively as using clotrimazole cream. Leg ulcers . Early research shows that applying a calendula ointment to the skin speeds up the healing of leg ulcers caused by poor blood circulation. Wound healing . Early research shows

2009 National Centre for Complementary and Alternative Medicine

1698. Niacin and Niacinamide (Vitamin B3)

, itching and tingling), a side effect of niacin treatment. Possibly effective for... Hardening of the arteries (atherosclerosis) . Taking niacin by mouth along with medicines called bile acid sequestrants seems to reduce hardening of the arteries in men with this condition. It seems to work best in people with high levels of blood fats called triglycerides prior to treatment. Taking niacin with cholesterol-lowering medications also seems to reduce the risk of adverse heart-related adverse events (...) blood fat levels due to antiretroviral treatment. Metabolic syndrome . Taking niacin seems to increase levels of high-density lipoprotein (HDL or "good") cholesterol and reduce levels of blood fats called triglycerides in people with metabolic syndrome. Taking the niacin along with a prescription omega-3 fatty acid seems to work even better. Insufficient evidence to rate effectiveness for... Alzheimer's disease . People who consume higher amounts of niacin from food and multivitamins seem to have

2009 National Centre for Complementary and Alternative Medicine

1699. Biotin

effective is it? Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate. The effectiveness ratings for BIOTIN are as follows: Likely effective for... Biotin deficiency . Taking biotin can help treat low blood levels of biotin. It can also prevent blood levels of biotin from becoming too low. Low (...) blood levels of biotin can cause thinning of the hair and rash around the eyes, nose, and mouth. Other symptoms include depression, lack of interest, hallucinations, and tingling in the arms and legs. Low biotin levels can occur in people who are pregnant, who have had long-term tube feeding, who are malnourished, who have undergone rapid weight loss, or who have a specific inherited condition. Cigarette smoking might also cause low blood levels of biotin. Possibly ineffective for... Skin rash

2009 National Centre for Complementary and Alternative Medicine

1700. Riboflavin (Vitamin B2)

(pre-eclampsia) . In women that are 4 months pregnant, starting to take riboflavin by mouth does reduce the risk of pre-eclampsia during pregnancy. Insufficient evidence to rate effectiveness for... Lactic acidosis (a serious blood-acid imbalance) in people with acquired immunodeficiency syndrome (AIDS) . Early research shows that taking riboflavin by mouth might by helpful for treating lactic acidosis caused by drugs called nucleoside analog reverse transcriptase inhibitors (NRTIs) in patients (...) of their diet seem to have a lower risk of developing cataracts. Also, taking supplements containing riboflavin plus niacin seems to help prevent cataracts. High amounts of homocysteine in the blood (hyperhomocysteinemia) . Taking riboflavin by mouth for 12 weeks decreases levels of homocysteine by up to 40% in some people. Also, taking riboflavin along with folic acid and pyridoxine seems to lower homocysteine levels by 26% in people with high homocysteine levels caused by drugs that are used to prevent

2009 National Centre for Complementary and Alternative Medicine

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