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Blood Lactic Acid

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141. The effects of a post-exercise carbohydrate and protein supplement on repeat performance, serum chemistry, insulin and glucagon in competitive weight-pulling dogs Full Text available with Trip Pro

The effects of a post-exercise carbohydrate and protein supplement on repeat performance, serum chemistry, insulin and glucagon in competitive weight-pulling dogs The physiological demands of weight-pulling dogs have yet to be investigated. Two groups of competitive weight-pulling dogs both underwent two identical pull series 3 h apart. The control group (n 8) was compared with a group fed a rapidly digestible carbohydrate and protein supplement after the first pull series (n 9). Blood (...) was drawn before and after each pull series as well as at 15 and 30 min after the first pull series finished. Biochemistry values remained unremarkable throughout the study in both groups regardless of supplementation or exercise over time. Lactic acid showed mild significant increases post-exercise (2·1 (sd 1·2) mmol/l) compared with baseline (1·4 (sd 0·3) mmol/l; P = 0·03) after the initial pull series. When examining the effects of time there was a significant increase in insulin from baseline

2017 Journal of nutritional science

142. Sustained Low Serum Substance P Levels in Non-Surviving Septic Patients Full Text available with Trip Pro

for SOFA score, diabetes mellitus, age, and lactic acid levels. The most interesting findings of our study were that there is an association between serum SP levels during the first week and sepsis mortality, and that serum SP levels during the first week could be used as a biomarker of sepsis mortality. (...) Sustained Low Serum Substance P Levels in Non-Surviving Septic Patients Previously, researchers found higher serum substance P (SP) concentrations in survivors of severe sepsis than in non-survivors at the time of severe sepsis diagnosis. The objectives of our current study were to determine whether there is an association between serum SP levels during the first week and sepsis mortality, sepsis severity, serum levels of tumor necrosis factor (TNF)-α and interleukin (IL)-10, and whether serum

2017 International journal of molecular sciences

143. [Effects of perioperative thermoregulation on patients' body temperature, peripheral circulation and blood coagulation time in patients undergoing elective vertical hemi laryngectomy]. (Abstract)

groups: preoperative inflatable heating blanket group (A group, n=20), warmed irrigation group (B group, n=20), and control group (C group, n=20). The core temperature were recorded after entering the operating room, before induction, 20th minute during operation, entering PACU and 2nd hour after operation respectively. Blood samples were got at the end of operation to test pH, lactic acid, PT and APTT. After waking patients' SpO₂ and thermal comfort were recorded.Result:The core temperatures at time (...) points of 20th minute during operation and entering PACU were significantly different between C group and A group, C group and B group. There were significant difference in lactic acid, PT, APTT and SpO₂ between C group and A group, C group and B group. Patients' thermal comfort in all three groups were different.Conclusion:Inflatable heating blanket during operation combined with using it before operation or fluid warmers during operation for perioperative body temperature protection duringelective

2018 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery Controlled trial quality: uncertain

144. [Clinical application of electrical velocimetry in monitoring pediatric blood volume after cardiopulmonary bypass]. (Abstract)

medicine was adjusted according to the monitoring stroke volume variation (SVV) hemodynamic parameters. Whereas for CVP group empirical volume of fluid infusion was managed by the monitoring traditional hemodynamic parameters such as CVP, blood pressure, heart rate, urine volume and blood gas analysis.Heart rate (HR), mean artery pressure (MAP), blood lactic acid (LA), oxygenation index (PaO(2)/FiO(2)) at 2, 4 and 6 h after operation were observed and compared between two groups. Mechanical ventilation (...) )/FiO(2) ratio was higher in EV group than that of CVP group[ (362±23) vs. (310±43), (380±33) vs. (330±38), (386±57) vs. (350±63.1) respectively, t=5.818 8, 5.419 2, 2.317 2; P=0.002, 0.001, 0.024]. However HR and blood lactic acid level was lower in EV group than the CVP group [(166±10) vs. (179±14)/min, (156±11) vs. (168±16)/min, (138±10) vs. (149±13)/min respectively; t=3.930 7, 3.511 1, 3.671 5; P=0.002, 0.009, 0.005]; [7% vs. 33%, 3% vs. 20%, 0 vs. 13%, χ(2)=5.104 2、4.043 1、4.285 7, P=0.045 3

2018 Zhonghua er ke za zhi = Chinese journal of pediatrics Controlled trial quality: uncertain

145. Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise Full Text available with Trip Pro

of serum lactic acid (increased from 1.3 ± 0.4 to 6.9 ± 1.7 mM), creatinine (from 77.5 ± 6.3 U/L to 102.2 ± 7.0 μM), and lactate dehydrogenase (from 318.5 ± 26.2 to 380.5 ± 33.2 U/L) confirmed the effect of exercise. WBC count also significantly increased (from 6.6 ± 1.0 to 8.4 ± 1.4 G/L). The level of O-GlcNAc modified proteins in WBCs showed significant elevation after exercise (85 ± 51%, p < 0.05). Flow cytometry revealed that most of this change could be attributed to lymphocytes and monocytes.Our (...) Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise Protein O-linked N-acetylglucosamine (O-GlcNAc) is a dynamic posttranslational modification influencing the function of many intracellular proteins. Recently it was revealed that O-GlcNAc regulation is modified under various stress states, including ischemia and oxidative stress. Aside from a few contradictory studies based on animal models, the effect of exercise on O-GlcNAc is unexplored.To

2018 Frontiers in immunology

146. Immune responses, intestinal microbiota, performance and blood characteristics of Japanese quail fed on diets containing camphor. (Abstract)

; whereas, diet supplementation with camphor had no significant effect on lymphoid organ weights and heterophil-to-lymphocyte ratio. The greatest AIV antibody titers were seen in groups, which received 1000 and 5000 ppm of camphor (P<0.05) and the values of NDV antibody titers increased with an increase in the camphor consumption. Furthermore, dietary inclusion of 500 ppm of camphor positively decreased coliform populations in the gastrointestinal tract (GIT). In addition, an increase in lactic acid (...) Immune responses, intestinal microbiota, performance and blood characteristics of Japanese quail fed on diets containing camphor. This study aimed to investigate the effect of supplemental camphor on the performance and immune functions of Japanese quail by feeding graded levels (0 (control), 250, 500, 750, 1000, 5000 or 10 000 ppm) of camphor during a 42-day feeding trial. In all, 280 1-day-old quail chicks were randomly assigned into 28 cages of 10 chicks each with separate feeders

2018 Animal : an international journal of animal bioscience Controlled trial quality: uncertain

147. The Serum Anion Gap in the Evaluation of Acid-Base Disorders: What Are Its Limitations and Can Its Effectiveness Be Improved? Full Text available with Trip Pro

The Serum Anion Gap in the Evaluation of Acid-Base Disorders: What Are Its Limitations and Can Its Effectiveness Be Improved? The serum anion gap has been utilized to identify errors in the measurement of electrolytes, to detect paraproteins, and, most relevant to the nephrologist, to evaluate patients with suspected acid-base disorders. In regard to the latter purpose, traditionally an increased anion gap is identified when it exceeds the upper limit of normal for a particular clinical (...) laboratory measurement. However, because there is a wide range of normal values (often 8-10 mEq/L), an increase in anion concentration can be present in the absence of an increased anion gap. In addition, the type of retained anion can affect the magnitude of the increase in anion gap relative to change in serum [HCO3(-)] being greater with lactic acidosis compared with ketoacidosis. This review examines the methods of calculation of the serum anion gap in textbooks and published literature, the effect

2013 Clinical Journal of the American Society of Nephrology

148. Effect of acid-base balance on postoperative course in children with hypoplastic left heart syndrome after the modified Norwood procedure. Full Text available with Trip Pro

. It is believed that the most important cause of hemodynamic instability is the fluctuations in redistribution between pulmonary and systemic blood flow.The paper analyzes the postoperative course in 40 neonates with HLHS following the modified Norwood procedure performed under deep hypothermic cardiopulmonary bypass hospitalized in Cardiac Surgical Intensive Care Unit (CSICU) in the years 2014-2015. For all hospitalized children, the arterial blood acid-base balance (ABB) parameters (pH, pO2, pCO2, HCO3 (...) , base excess (BE), and lactic acid) were measured 2 times a day during the first 5 postoperative days. The main goal of the studies is to analysis of ABB parameters and their influence on the clinical state of newborns with HLHS. Several descriptors were concerned to describe the neonates clinical state: the date of the surgery (the day of life when the child was operated on), the duration (number of days) of mechanical ventilation employment, the time of hospitalization in intensive care unit

2017 Medicine

149. Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment Full Text available with Trip Pro

the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility. Here, we combined poly(lactic-co-glycolic acid) (PLGA) with red blood-cell membrane (RBCm), and evaluated whether GA-loaded RBCm nanoparticles can retain and improve the antitumor efficacy of GA with relatively lower toxicity in colorectal cancer treatment compared with free GA. We also confirmed (...) Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inhe rent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites

2017 International journal of nanomedicine

150. CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina Full Text available with Trip Pro

) caused by coronary microvascular dysfunction.We examined CYP2C19 genotypes in patients with MVA (n = 81). MVA was defined as absence of coronary artery stenosis and epicardial spasms, and the presence of inversion of lactic acid levels between intracoronary and coronary sinuses in acetylcholine-provocation test or the adenosine-triphosphate-induced coronary flow reserve ratio was below 2.5. CYP2C19 PM have two loss-of-functon alleles (*2, *3). We measured serum dihydroxyeicosatrienoic acid (DHET (...) CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the impact of CYP2C19 polymorphisms and EETs on the patients with microvascular angina (MVA

2017 International journal of cardiology. Heart & vasculature

151. Clinical Trial for Vespa Amino Acid Mixture (VAAM®)

into different meter race including 1500-, 800- and 400-meter races. Outcome Measures Go to Primary Outcome Measures : change of running time scores at 10 weeks [ Time Frame: 10 weeks ] change of the plasma lactic acid clearance rate after running at 10 weeks [ Time Frame: 10 weeks ] change of red blood cells after running at 10 weeks [ Time Frame: 10 weeks ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk (...) and Technology Co., Ltd. Study Details Study Description Go to Brief Summary: ATP is generated mainly through anaerobic metabolism during strenuous exercise, which is then followed by the generation of lactic acid. However, this process can only be maintained for a short time, approximately one minute, because the accumulation of lactic acid in the muscles may affect muscle performance. The efficiency of lactic acid metabolism is one of the most important reasons for endurance improvement. The purpose

2017 Clinical Trials

152. The Effects of an Olive Fruit Polyphenol-Enriched Yogurt on Body Composition, Blood Redox Status, Physiological and Metabolic Parameters and Yogurt Microflora. Full Text available with Trip Pro

regardless of condition. A tendency towards significance for decreased levels of low density lipoprotein (LDL) cholesterol (p = 0.06) and thiobarbituric acid reactive substances (p < 0.05) following two weeks of polyphenol-enriched yogurt consumption was observed. The population of lactic acid bacteria (LAB) and production of lactate in yogurt were significantly enhanced after addition of olive polyphenols, contrary to the population of yeasts and molds. The results indicate that consumption (...) The Effects of an Olive Fruit Polyphenol-Enriched Yogurt on Body Composition, Blood Redox Status, Physiological and Metabolic Parameters and Yogurt Microflora. In the present study we investigated the effects of an olive polyphenol-enriched yogurt on yogurt microflora, as well as hematological, physiological and metabolic parameters, blood redox status and body composition. In a randomized double-blind, crossover design, 16 (6 men, 10 women) nonsmoking volunteers with non-declared pathology

2017 Nutrients Controlled trial quality: uncertain

153. Colla Corii Asini Treating Anemia in Pregnant Women With Thalassemia(Presenting the Syndrome of Blood Deficiency)

Colla Corii Asini Treating Anemia in Pregnant Women With Thalassemia(Presenting the Syndrome of Blood Deficiency) Colla Corii Asini Treating Anemia in Pregnant Women With Thalassemia(Presenting the Syndrome of Blood Deficiency) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Colla Corii Asini Treating Anemia in Pregnant Women With Thalassemia(Presenting the Syndrome of Blood Deficiency) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2017 Clinical Trials

154. IgA and IgM protein primarily drive plasma corona‐induced adhesion reduction of PLGA nanoparticles in human blood flow Full Text available with Trip Pro

IgA and IgM protein primarily drive plasma corona‐induced adhesion reduction of PLGA nanoparticles in human blood flow The high abundance of immunoglobulins (Igs) in the plasma protein corona on poly(lactic-co-glycolic) acid (PLGA)-based vascular-targeted carriers (VTCs) has previously been shown to reduce their adhesion to activated endothelial cells (aECs) in human blood flow. However, the relative role of individual Ig classes (e.g., IgG, IgA, and IgM) in causing adhesion reduction remains (...) largely unknown. Here, we characterized the influence of specific Ig classes in prescribing the binding efficiency of PLGA nano-sized VTCs in blood flow. Specifically, we evaluated the flow adhesion to aECs of PLGA VTCs with systematic depletion of various Igs in their corona. Adhesion reduction was largely eliminated for PLGA VTCs when all Igs were removed from the corona. Furthermore, re-addition of IgA or IgM to the Igs-depleted corona reinstated the low adhesion of PLGA VTCs, as evidenced by ∼40

2017 Bioengineering & Translational Medicine

155. Biomaterial microlasers implantable in the cornea, skin, and blood Full Text available with Trip Pro

Biomaterial microlasers implantable in the cornea, skin, and blood Stand-alone laser particles that are implantable into biological tissues have potential to enable novel optical imaging, diagnosis and therapy. Here we demonstrate several types of biocompatible microlasers and their lasing action within biological systems. Dye-doped polystyrene beads were embedded in the cornea and optically pumped to generate narrowband emission. We fabricated microbeads with poly(lactic-co-glycolic acid (...) ) and poly(lactic acid)-substances approved for medical use-and demonstrate lasing from within tissues and whole blood. Furthermore, we demonstrate biocompatible cholesterol-derivative microdroplet lasers via self-assembly to an onion-like radially-resonant photonic crystal structure.

2017 Optica

156. Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3,3’-diindolylmethane nanoparticles through blood brain barrier prevents glioma progression Full Text available with Trip Pro

Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3,3’-diindolylmethane nanoparticles through blood brain barrier prevents glioma progression Current therapy for Glioblastoma is insufficient because of the presence of blood brain barrier. It limits the transport of essential drugs to the tumor sites. To overcome this limitation we strategized the delivery of an anticancer compound 3,3'-diindolylmethane by encapsulation in poly (lactic-co-glycolic acid) nanoparticles (...) . These nanoparticles were tagged with a novel peptide against somatostatin receptor 2 (SSTR2), a potential target in glioma. The nanoformulation (27-87nm) had loading and encapsulation efficiency of 7.2% and 70% respectively. It was successfully internalized inside the glioma cells resulting in apoptosis. Furthermore, an in vivo bio-distribution study revealed the selective accumulation of the nanoformulation into rat brain tumor sites by crossing the blood brain barrier. This resulted in abrogation of epidermal

2017 Oncotarget

157. Lactic Acidosis (Diagnosis)

. Therefore, regional hypoperfusion of tissues may be present despite normal blood lactate concentrations. Lactic acid levels can also lag several hours after the oxygen delivery critical threshold (DO2 crit) has been crossed. Indeed, patients may be accruing a significant amount of oxygen debt before lactate levels start to increase. It has been demonstrated that mixed venous saturation can fall below 50% before serum hyperlactatemia is evident. [ ] Lactic acidosis in disease Lactic acidosis occurring (...) represents increased anaerobic metabolism due to tissue hypoperfusion. (See .) D-lactate is a byproduct of bacterial metabolism and may accumulate in patients with short-gut syndrome or in those with a history of gastric bypass or small-bowel resection. [ ] By the turn of the 20th century, many physicians recognized that patients who are critically ill could exhibit unaccompanied by elevation of ketones or other measurable anions. In 1925, Clausen identified the accumulation of lactic acid in blood

2014 eMedicine.com

158. Lactic Acidosis (Overview)

. Therefore, regional hypoperfusion of tissues may be present despite normal blood lactate concentrations. Lactic acid levels can also lag several hours after the oxygen delivery critical threshold (DO2 crit) has been crossed. Indeed, patients may be accruing a significant amount of oxygen debt before lactate levels start to increase. It has been demonstrated that mixed venous saturation can fall below 50% before serum hyperlactatemia is evident. [ ] Lactic acidosis in disease Lactic acidosis occurring (...) represents increased anaerobic metabolism due to tissue hypoperfusion. (See .) D-lactate is a byproduct of bacterial metabolism and may accumulate in patients with short-gut syndrome or in those with a history of gastric bypass or small-bowel resection. [ ] By the turn of the 20th century, many physicians recognized that patients who are critically ill could exhibit unaccompanied by elevation of ketones or other measurable anions. In 1925, Clausen identified the accumulation of lactic acid in blood

2014 eMedicine.com

159. Lactic Acidosis (Treatment)

is a new buffering agent with potential use in metabolic acidosis. It is an equimolecular mixture of sodium bicarbonate and sodium carbonate. Like THAM, Carbicarb has a buffering capacity similar to sodium bicarbonate but does not generate carbon dioxide. In animal models of hypoxic lactic acidosis, Carbicarb reduced circulating lactate and improved tissue and blood acid-base status compared with sodium bicarbonate. Carbicarb is currently not available for use. Previous Next: Hemodialysis Dialysis may (...) for the aerobic oxidation of glucose, pyruvate, and lactate. Dichloroacetate may inhibit glycolysis and, thereby, lactate production. The data from animal studies and one placebo-controlled, double-blind clinical trial showed dichloroacetate to be superior to placebo in improving the acid-base status of the patients; however, it did not alter hemodynamics or survival. Theoretical reasons and some clinical evidence exist for thiamine treatment to improve lactic acidosis associated with thiamine deficiency

2014 eMedicine.com

160. Lactic Acidosis (Follow-up)

is a new buffering agent with potential use in metabolic acidosis. It is an equimolecular mixture of sodium bicarbonate and sodium carbonate. Like THAM, Carbicarb has a buffering capacity similar to sodium bicarbonate but does not generate carbon dioxide. In animal models of hypoxic lactic acidosis, Carbicarb reduced circulating lactate and improved tissue and blood acid-base status compared with sodium bicarbonate. Carbicarb is currently not available for use. Previous Next: Hemodialysis Dialysis may (...) for the aerobic oxidation of glucose, pyruvate, and lactate. Dichloroacetate may inhibit glycolysis and, thereby, lactate production. The data from animal studies and one placebo-controlled, double-blind clinical trial showed dichloroacetate to be superior to placebo in improving the acid-base status of the patients; however, it did not alter hemodynamics or survival. Theoretical reasons and some clinical evidence exist for thiamine treatment to improve lactic acidosis associated with thiamine deficiency

2014 eMedicine.com

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