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Blood Lactic Acid

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141. [Clinical application of electrical velocimetry in monitoring pediatric blood volume after cardiopulmonary bypass]. (PubMed)

medicine was adjusted according to the monitoring stroke volume variation (SVV) hemodynamic parameters. Whereas for CVP group empirical volume of fluid infusion was managed by the monitoring traditional hemodynamic parameters such as CVP, blood pressure, heart rate, urine volume and blood gas analysis.Heart rate (HR), mean artery pressure (MAP), blood lactic acid (LA), oxygenation index (PaO(2)/FiO(2)) at 2, 4 and 6 h after operation were observed and compared between two groups. Mechanical ventilation (...) )/FiO(2) ratio was higher in EV group than that of CVP group[ (362±23) vs. (310±43), (380±33) vs. (330±38), (386±57) vs. (350±63.1) respectively, t=5.818 8, 5.419 2, 2.317 2; P=0.002, 0.001, 0.024]. However HR and blood lactic acid level was lower in EV group than the CVP group [(166±10) vs. (179±14)/min, (156±11) vs. (168±16)/min, (138±10) vs. (149±13)/min respectively; t=3.930 7, 3.511 1, 3.671 5; P=0.002, 0.009, 0.005]; [7% vs. 33%, 3% vs. 20%, 0 vs. 13%, χ(2)=5.104 2、4.043 1、4.285 7, P=0.045 3

2018 Zhonghua er ke za zhi = Chinese journal of pediatrics

142. Lactic Acidosis During Entecavir(ETV)Treatment

lamivudine Additional relevant MeSH terms: Layout table for MeSH terms Acidosis Acidosis, Lactic Acid-Base Imbalance Metabolic Diseases Lamivudine Entecavir Reverse Transcriptase Inhibitors Nucleic Acid Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Anti-Retroviral Agents Antiviral Agents Anti-Infective Agents Anti-HIV Agents (...) Lactic Acidosis During Entecavir(ETV)Treatment Lactic Acidosis During Entecavir(ETV)Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Lactic Acidosis During Entecavir(ETV)Treatment (ETV) The safety

2011 Clinical Trials

143. Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases (PubMed)

Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases 5217755 1966 05 27 2018 11 13 0007-1447 1 5487 1966 Mar 05 British medical journal Br Med J Serum lactic dehydrogenase activity and folate deficiency in myelosclerosis and other haematological diseases. 577-81 Hoffbrand A V AV Kremenchuzky S S Butterworth P J PJ Mollin D L DL eng Journal Article England Br Med J 0372673 0007-1447 EC 1.1.1.27 L-Lactate Dehydrogenase AIM IM Anemia (...) metabolism Anemia, Hemolytic metabolism Anemia, Sideroblastic metabolism Clinical Enzyme Tests Folic Acid Deficiency metabolism Humans L-Lactate Dehydrogenase metabolism Leukemia metabolism Leukemia, Erythroblastic, Acute metabolism Malabsorption Syndromes complications Polycythemia Vera metabolism Primary Myelofibrosis diagnosis metabolism Thrombocytopenia metabolism Vitamin B 12 Deficiency metabolism 1966 3 5 1966 3 5 0 1 1966 3 5 0 0 ppublish 5217755 PMC1843851 Br J Radiol. 1960 Apr;33:238-42 13817522

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1966 British medical journal

144. Reversible lactic acidosis associated with repeated intravenous infusions of sorbitol and ethanol. (PubMed)

Reversible lactic acidosis associated with repeated intravenous infusions of sorbitol and ethanol. Infusions of fructose or sorbitol are used commonly in parenteral nutrition and may cause lactic acidosis. A case is reported in whom blood lactate concentration was monitored frequently over a 5-day period during intravenous feeding with a sorbitol-ethanol-amino acid mixture. During the first five infusions blood lactate rose only moderately, but with the final infusion lactate rose to 11-1 mmol (...) /l and the patient had a severe metabolic acidosis. In retrospect the patient had shown deterioration in renal and hepatic function tests during the preceding 24 hr. On terminating the infusions the blood lactate concentration fell rapidly. It is suggested that great care should be exercised when using such infusions in ill patients and acid base status and renal and hepatic function should be monitored frequently.

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1977 Postgraduate medical journal

145. Lactic acidosis and ketoacidosis: biochemical and clinical implications. (PubMed)

. Before treatment can be planned the biochemical basis of lactic acidosis and ketoacidosis must be understood -- especially the fact that lactic acidosis is not a single disease entity but has many possible causes. Among important considerations is the relation between the blood concentrations of bicarbonate and organic acid anions. After recovery from metabolic acidosis of the unmeasured anion gap type, metabolic alkalosis is common. Decreased bicarbonate excretion plays an important role (...) Lactic acidosis and ketoacidosis: biochemical and clinical implications. A case of lactic acidosis presented the opportunity for review of the association between lactic acidosis and ketoacidosis. The diagnosis of lactic acidosis or the combination of lactic acidosis and ketoacidosis is established clinically by the detection of a metabolic acidosis of the "unmeasured anion gap" type in the absence of significant renal failure, poison intake or a strongly positive clinical test for ketones

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1977 Canadian Medical Association Journal

146. Lactic Acidosis as a Result of Iron Deficiency (PubMed)

Lactic Acidosis as a Result of Iron Deficiency Iron-deficient rats have an impaired work performance, even when their anemia is corrected by exchange transfusion. Muscle activity is associated with a higher blood lactate concentration than is observed in iron-replete animals. The accumulation of lactate is a result of excessive production as lactate clearance from the blood was shown to be unaffected. By adjusting the work load to a lower level, it was possible to divide iron-deficient animals (...) of a normal pH in iron-deficient and iron-replete animals did not prevent the impairment in work associated with high blood lactate concentrations. Additional evidence was obtained that energy substrate (blood glucose and free fatty acids, muscle glycogen) was adequate in irondeficient animals. Oxygen tension in their vena caval blood was higher than in controls. Furthermore, the in situ behavior of electrically stimulated gastroenemius and soleus muscles appeared similar to that of control animals

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1979 Journal of Clinical Investigation

147. Lactic Acidosis in Diabetes (PubMed)

Lactic Acidosis in Diabetes Lactic acidosis is occasionally responsible for metabolic acidosis in diabetics. It may occur in the presence of normal blood levels of the ketone bodies, and such cases are often described as having "non-ketotic diabetic acidosis." Lactic acid may contribute to the metabolic acidosis in patients with true diabetic ketoacidosis, but the blood lactate concentrations in these patients are not usually very high. In some patients the ketoacidosis is replaced by a lactic (...) acidosis during treatment. This usually occurs in association with a serious underlying disorder and is associated with a poor prognosis. A transient increase in blood lactate concentration was in fact observed in most patients after the beginning of treatment, but the significance of this finding is uncertain.

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1969 British medical journal

148. Lactic acidosis. (PubMed)

Lactic acidosis. 4997498 1971 09 07 2018 11 13 0065-7778 82 1971 Transactions of the American Clinical and Climatological Association Trans. Am. Clin. Climatol. Assoc. Lactic acidosis. 70-6 Relman A S AS eng Journal Article Review United States Trans Am Clin Climatol Assoc 7507559 0065-7778 0 Bicarbonates 0 Lactates 142M471B3J Carbon Dioxide IM Acid-Base Equilibrium Acidosis blood etiology Bicarbonates blood Carbon Dioxide blood Diabetic Ketoacidosis blood Humans Hydrogen-Ion Concentration (...) Hyperventilation complications Lactates blood 4 1970 10 26 1970 10 26 0 1 1970 10 26 0 0 ppublish 4997498 PMC2441055 J Biol Chem. 1969 Jan 25;244(2):384-90 4237582 Am J Med. 1961 Jun;30:840-8 13716482 J Clin Invest. 1965 Jan;44:21-30 14254253

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1971 Transactions Of The American Clinical And Climatological Association

149. Propofol Infusion Syndrome: An Unusual Case of Lactic Acidosis

in children, but has become increasingly recognized in adults. The mechanism of PRIS is thought to be secondary to an imbalance between energy demand and utilization which occurs by impairment of mitochondrial oxidative phosphorylation and free fatty acid utilization, ultimately leading to lactic acidosis and muscular necrosis. In animal models, propofol uncouples oxidative phosphorylation and energy production in the mitochondria [1] and inhibits electron flow through the electron transport chain (...) . In addition, cardiac contractility is also reduced as propofol antagonizes beta-adrenergic receptor and calcium channel binding [2-4] Because this syndrome can be fatal, special attention should be taken to all those exposed to propofol at a rate >5mg/kr/hr for more than 48 hours. If a patient requires sedation for longer than this period, alternative forms of sedation should be explored. In addition, any patient on high dose propofol for more than 24 hours should have close monitoring of both lactic acid

2008 Clinical Correlations

150. The complex acid-base problem – my interpretation

The complex acid-base problem – my interpretation db's Medical Rants » Blog Archive » The complex acid-base problem – my interpretation Internal medicine, American health care, and especially medical education 1 Posted by rcentor | Posted on 30-07-2015 Category : Patient had been feeling poorly for a few days with progressive dyspnea and weakness. Denied fever, chills or sweats. No past medical history – had avoided physicians for more than 40 years. 141 96 36 105 2.8 20 1.5 On 2 liters nasal (...) oxygen pH 7.45 pCO2 29 pO2 55 HCO3 20 My interpretation 1. The patient has an increased anion gap (25). Given the history of progressive illness, this generally suggests mild lactic acidosis and mild starvation ketosis. The bicarbonate seems a bit high for an anion gap this high (that should alway clue you into the next step. 2. She had a normal albumin, thus the delta gap = 25-12 or 13. We add 13 back to the observed bicarbonate and get 33. Thus, she also has a metabolic alkalosis. This makes

2015 db's Medical Rants blog

151. Systematic review and meta-analysis of the effects of a fermented milk product that includes Bifidobacteria animalis ssp lactis CNCM I-2494/DN-173010 and lactic acid bacteria on gastrointestinal discomfort in the general population

Systematic review and meta-analysis of the effects of a fermented milk product that includes Bifidobacteria animalis ssp lactis CNCM I-2494/DN-173010 and lactic acid bacteria on gastrointestinal discomfort in the general population Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record (...) , duration of ischemia and duration of reperfusion (if applicable). ">Data to be extracted: animal model Example: Dose, timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed

2015 PROSPERO

152. Systematic review of the effects of Bifidobacterium lactis CNCM I-2494 in fermented dairy product by lactic acid bacteria on gastrointestinal discomfort in the general population

Systematic review of the effects of Bifidobacterium lactis CNCM I-2494 in fermented dairy product by lactic acid bacteria on gastrointestinal discomfort in the general population Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email (...) ). ">Data to be extracted: animal model Example: Dose, timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted

2015 PROSPERO

153. Acute hypervolemic hemodilution effect on oxygen metabolism and blood pharmacokinetics in patients undergoing acute laparotomy during induction of general anesthesia. (PubMed)

mins before induction and 8 ml/kg after induction. Patients of group B received 6 ml/kg/h Plasmalyte A. Hemodynamic parameters MAP, HR and CVP were collected at 6 set points during the surgery: T1: before AHH; T2: before anesthesia induction; T3: right intubation; T4: 10 min after intubation; T5: 20 min after intubation; T6: skin incision. Arterial and venous blood samples were taken for blood gas analysis and determination of lactic acid, Hb and Hct: T1: before AHH, T2: right after AHH, T3: 0.5 h (...) Acute hypervolemic hemodilution effect on oxygen metabolism and blood pharmacokinetics in patients undergoing acute laparotomy during induction of general anesthesia. To investigate acute hypervolemic hemodilution effect on oxygen metabolism and blood pharmacokinetics in patients undergoing acute laparotomy during Induction of general anesthesia.Forty ASA I-II patients undergoing acute laparotomy were randomly divided into 2 groups (n=20 each): Patients of group A received Voluven 7 ml/kg in 20

2015 Hepato-gastroenterology

154. Effect of manual lymph drainage on removal of blood lactate after submaximal exercise. (PubMed)

on the same treadmill ergometer, at a running speed equivalent to the IAT. One group received MLD treatment, while the control subjects received no treatment. [Results] Following an increase immediately after exercise, lactic acid (LA) and lactate dehydrogenase (LDH) serum levels dropped rapidly and significantly at the end of MLD application and two hours after SE in the subjects receiving MLD. The course of creatine kinase (CK) and myoglobin levels was comparable, and with myoglobin showing (...) Effect of manual lymph drainage on removal of blood lactate after submaximal exercise. [Purpose] It has been well-established that exercise-induced muscle damage occurs following intense exercise. Massage is commonly used to manage muscle damage resulting from exercise. However the effect of massage after exercise is still not clear. The purpose of this study was to examine the effect of manual lymph drainage on muscle damage and on the removal of blood lactate following submaximal exercise (SE

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2015 Journal of physical therapy science

155. Daily Physical Activity After Meals -Long Term Effects on Blood Glucose

lasts an average of 12 weeks ] Measured at the end of 10 minutes ergometer cycle test an given intensity (low), by indirect calorimetry Change in Physical fitness measured as perceived exertion during an exercise test [ Time Frame: Measured pre and post intervention which lasts an average of 12 weeks ] Borg RPE scale measured at the end of 10 minutes ergometer cycle test an given intensity (low) Change in Physical fitness measured as lactic acid during an exercise test [ Time Frame: Measured pre (...) Daily Physical Activity After Meals -Long Term Effects on Blood Glucose Daily Physical Activity After Meals -Long Term Effects on Blood Glucose - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Daily Physical

2015 Clinical Trials

156. Using ultrasonography to monitor liver blood flow for liver transplant from donors supported on extracorporeal membrane oxygenation. (PubMed)

/minute; P = 0.09). No significant change in levels of total bilirubin, alanine transaminase, and lactic acid were reported during ECMO (P = 0.17, P = 0.08, and P = 0.09, respectively). Before the liver is procured, ultrasonographic monitoring of hepatic blood flow could be a valuable aid to improve the viability of a liver transplant by allowing for real-time calibration of ECMO perfusion in brain-dead liver donors. In our study, ultrasonographic monitoring helped prevent warm ischemic injury (...) Using ultrasonography to monitor liver blood flow for liver transplant from donors supported on extracorporeal membrane oxygenation. Extracorporeal membrane oxygenation (ECMO) has been used to support brain-dead donors for liver procurement. This study investigated the potential role of ultrasonographic monitoring of hepatic perfusion as an aid to improve the viability of liver transplants obtained from brain-dead donors who are supported on ECMO. A total of 40 brain-dead patients maintained

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2015 Liver Transplantation

157. Whole Body Periodic Acceleration on Blood Lactate and Recovery

." The frequency of the translation (up to 180 cycles/minute; cpm) as well as the distance traveled (2-24mm) by the bed can be adjusted by the patient or health care professional. The science behind the therapeutic effects of WBPA still remains largely unknown. The objective of this study is to determine if WBPA may be used as an effective way to reduce lactic acid concentrations during recovery after intense exercise more rapidly than previously established methods. Condition or disease Intervention/treatment (...) Phase Acidosis, Lactic Device: Whole Body Periodic Acceleration Not Applicable Detailed Description: Each visit Subjects will perform a graded treadmill exercise test. They will rest for 10 minutes. At the end of the rest period, resting vital signs (HR and BP) will be recorded as well as resting oxygen consumption (VO2). Resting capillary blood sample will be taken and analyzed by the Accutrend portable lactate analyzer to measure blood lactate levels. The cardiac and metabolic recordings

2015 Clinical Trials

158. Osteogenesis of peripheral blood mesenchymal stem cells in self assembling peptide nanofiber for healing critical size calvarial bony defect (PubMed)

-assembling peptide (SAP) and cultured in osteogenic medium. The results indicated SAP can serve as a promising scaffold for PBMSCs survival and osteogenic differentiation in 3D conditions. Furthermore, the SAP seeded with the induced PBMSCs was splinted by two membranes of poly(lactic)-glycolic acid (PLGA) to fabricate a composited scaffold which was then used to repair a critical-size calvarial bone defect model in rat. Twelve weeks later the defect healing and mineralization were assessed by H&E (...) Osteogenesis of peripheral blood mesenchymal stem cells in self assembling peptide nanofiber for healing critical size calvarial bony defect Peripheral blood mesenchymal stem cells (PBMSCs) may be easily harvested from patients, permitting autologous grafts for bone tissue engineering in the future. However, the PBMSC's capabilities of survival, osteogenesis and production of new bone matrix in the defect area are still unclear. Herein, PBMSCs were seeded into a nanofiber scaffold of self

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2015 Scientific reports

159. Blood Flow Within Active Myofascial Trigger Points Following Massage

: University of Colorado, Denver ClinicalTrials.gov Identifier: Other Study ID Numbers: 14-1582 First Posted: March 17, 2015 Last Update Posted: September 1, 2017 Last Verified: August 2017 Keywords provided by University of Colorado, Denver: Blood flow Glucose lactic acid Additional relevant MeSH terms: Layout table for MeSH terms Headache Tension-Type Headache Pain Neurologic Manifestations Signs and Symptoms Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases (...) Blood Flow Within Active Myofascial Trigger Points Following Massage Blood Flow Within Active Myofascial Trigger Points Following Massage - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Blood Flow Within

2015 Clinical Trials

160. Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry (PubMed)

-values <0.05). Levels of maltose, palmitic acid, glycerol, ethanolamine, glutamic acid, and lactic acid were increased in cancer samples while amino acids tryptophan, lysine and histidine decreased. Many of the metabolites were found to be significantly different in both studies, suggesting that metabolomics appears to be robust enough to find systemic changes from lung cancer, thus showing the potential of this type of analysis for lung cancer detection. (...) Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and monitoring of treatment. We report results from two separate studies using gas chromatography time-of-flight

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2015 Metabolites

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