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Blood Lactic Acid

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121. The oxygen uptake, glucose utilization and lactic acid production of guinea-pig skin in relation to oxygen tension Full Text available with Trip Pro

Metabolism Glucose metabolism Humans Lactic Acid metabolism Oxygen blood Skin metabolism 5630:1293 GLUCOSE/metabolism LACTIC ACID/metabolism OXYGEN/in blood SKIN/metabolism 1956 1 1 1956 1 1 0 1 1956 1 1 0 0 ppublish 13293152 PMC1274511 Biochem J. 1946;40(4):516-24 16748047 Exp Cell Res. 1954 Nov;7(2):374-80 13220584 Proc R Soc Lond B Biol Sci. 1951 Oct 30;138(893):562-75 14911810 Biochem J. 1946;40(4):513-6 16748046 Biochem J. 1946;40(4):525-9 16748048 J Invest Dermatol. 1954 Apr;22(4):299-315 13152401 (...) The oxygen uptake, glucose utilization and lactic acid production of guinea-pig skin in relation to oxygen tension 13293152 2003 05 01 2018 12 01 0264-6021 62 1 1956 Jan The Biochemical journal Biochem. J. The oxygen uptake, glucose utilization and lactic acid production of guinea-pig skin in relation to oxygen tension. 57-61 CRUICKSHANK C N CN TROTTER M D MD eng Journal Article England Biochem J 2984726R 0264-6021 33X04XA5AT Lactic Acid IY9XDZ35W2 Glucose S88TT14065 Oxygen OM Carbohydrate

1956 Biochemical Journal

122. THE FATE OF CIRCULATING LACTIC ACID IN THE HUMAN LUNG Full Text available with Trip Pro

THE FATE OF CIRCULATING LACTIC ACID IN THE HUMAN LUNG 14354018 2003 05 01 2018 12 01 0021-9738 34 3 1955 Mar The Journal of clinical investigation J. Clin. Invest. The fate of circulating lactic acid in the human lung. 471-6 MITCHELL A M AM COURNAND A A eng Journal Article United States J Clin Invest 7802877 0021-9738 33X04XA5AT Lactic Acid OM Blood Lactic Acid blood Lung blood supply 5528:4685:85:318:336 BLOOD LACTIC ACID/in blood LUNGS/blood supply 1955 3 1 1955 3 1 0 1 1955 3 1 0 0 ppublish

1955 Journal of Clinical Investigation

123. Lactic Acid Response to Epinephrine Full Text available with Trip Pro

Lactic Acid Response to Epinephrine 13381146 2002 05 01 2018 12 01 0044-0086 29 2 1956 Nov The Yale journal of biology and medicine Yale J Biol Med Lactic acid response to epinephrine in experimental liver disease: a review. 96-104 NALEBUFF D J DJ WINTERNITZ W W WW eng Journal Article United States Yale J Biol Med 0417414 0044-0086 33X04XA5AT Lactic Acid YKH834O4BH Epinephrine OM Epinephrine pharmacology Humans Lactic Acid blood Liver Diseases 5731:27582 EPINEPHRINE/effects LACTIC ACID/in blood

1956 The Yale journal of biology and medicine

124. Proceedings: Adrenergic blockade and the pulmonary pressor response to lactic acid. Full Text available with Trip Pro

Proceedings: Adrenergic blockade and the pulmonary pressor response to lactic acid. 238708 1975 10 30 2018 11 13 0007-1188 54 2 1975 Jun British journal of pharmacology Br. J. Pharmacol. Proceedings: Adrenergic blockade and the pulmonary pressor response to lactic acid. 262P James W R WR Thomas A J AJ eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Adrenergic alpha-Antagonists 0 Adrenergic beta-Antagonists 0 Lactates IM Adrenergic alpha-Antagonists pharmacology Adrenergic beta (...) -Antagonists pharmacology Animals Blood Pressure drug effects Drug Interactions Lactates antagonists & inhibitors pharmacology Pulmonary Circulation drug effects Sheep 1975 6 1 1975 6 1 0 1 1975 6 1 0 0 ppublish 238708 PMC1666597 Q J Exp Physiol Cogn Med Sci. 1969 Apr;54(2):156-72 5193730 J Clin Invest. 1971 May;50(5):1028-43 5552405

1975 British journal of pharmacology

125. Serial lactic acid measurements in respiratory distress syndrome. Full Text available with Trip Pro

Serial lactic acid measurements in respiratory distress syndrome. 5018647 1972 06 22 2016 11 22 1468-2044 47 251 1972 Feb Archives of disease in childhood Arch. Dis. Child. Serial lactic acid measurements in respiratory distress syndrome. 152 Beca J P JP eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Lactates S88TT14065 Oxygen IM Humans Hypoxia metabolism Infant, Newborn Lactates blood Oxygen blood Oxygen Consumption Prognosis Respiratory Distress Syndrome, Newborn blood 1972 2

1972 Archives of Disease in Childhood

126. Effect of toxaphene on pyruvic and lactic acid levels in the rat. Full Text available with Trip Pro

Effect of toxaphene on pyruvic and lactic acid levels in the rat. Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again no alterations of pyruvic or lactic acid levels were found. It is concluded that observed alterations of the activity of lactic acid

1979 Environmental health perspectives

127. A Clinical Study to Investigate the Dermal and Ocular Tolerance of a Developmental Cosmetic Facial Serum Formulation in Healthy Females With Sensitive Skin

or disease Intervention/treatment Phase Skin Care Other: Developmental Serum Other: Physiogel Calming Relief Anti-Redness Serum Not Applicable Detailed Description: This is a single-center, non-comparative clinical 'in-use' study to determine the local cutaneous and ocular tolerance of a developmental cosmetic facial serum formulation in healthy female subjects aged 18 to 65 years (inclusive) with clinically evaluated sensitive skin, as determined by a positive response to a Lactic Acid Sting Test (LAST (...) procedures and requirements. A subject with sensitive facial skin, defined as a positive response to a lactic acid sting test in the nasolabial area. A subject with a dermatologist signs and symptoms of cutaneous irritation score of greater than or equal to 0.5 (very slight) for erythema. A subject with a dermatologist signs and symptoms of cutaneous irritation score of greater than or equal to 0.5 (very slight) for dryness. A subject with a dermatologist signs and symptoms of cutaneous irritation score

2018 Clinical Trials

128. Prognostic value of serum lipase levels in patients with small bowel obstruction Full Text available with Trip Pro

and mortality, were evaluated. Of 344 patients, 38 (11%) had elevated serum lipase levels. Patients with radiographic diagnosis of pancreatitis were excluded. Patients with elevated lipase had significantly higher levels of creatinine and lactic acid levels, length of stay, need for intensive care monitoring, and death than patients with normal lipase levels. The need for surgical intervention was not significantly different between the two groups. Logistic regression analysis showed elevated serum lipase (...) Prognostic value of serum lipase levels in patients with small bowel obstruction Elevated serum pancreatic enzymes have been described among patients with small bowel obstruction (SBO) initially misdiagnosed as having pancreatitis. We studied whether serum lipase elevation carries prognostic value in patients with SBO. Patients with SBO and at least one serum lipase level measured were included. Demographic, laboratory, and imaging information, as well as need for surgery or intensive care unit

2018 Proceedings (Baylor University. Medical Center)

129. Effects of the Brown Seaweed Laminaria japonica Supplementation on Serum Concentrations of IgG, Triglycerides, and Cholesterol, and Intestinal Microbiota Composition in Rats Full Text available with Trip Pro

-associated genera (Alistipes, Bacteroides, and Prevotella), and lactic acid bacterial genera (Subdoligranulum, Streptococcus, Lactobacillus, Enterococcus, and Bifidobacterium) increased in all treatment groups. On the contrary, butyric acid producing genera including Subdoligranulum, Roseburia, Eubacterium, Butyrivibrio, and Anaerotruncus increased significantly only in FHLJ group. The overall results support multiple prebiotic effects of seaweed L. japonica on rats as determined by body weight reduction (...) Effects of the Brown Seaweed Laminaria japonica Supplementation on Serum Concentrations of IgG, Triglycerides, and Cholesterol, and Intestinal Microbiota Composition in Rats The intestinal microbial communities play critical roles in various aspects of body function of the host. Prebiotics, such as dietary fiber, can affect health of the host by altering the composition of intestinal microbiota. Although brown seaweed Laminaria japonica is rich in dietary fiber, studies on its prebiotic

2018 Frontiers in nutrition

130. Serum Lactate and Mortality in Emergency Department Patients with Cancer Full Text available with Trip Pro

Serum Lactate and Mortality in Emergency Department Patients with Cancer Patients with malignancy represent a particular challenge for the emergency department (ED) given their higher acuity, longer ED length of stay, and higher admission rate. It is unknown if patients with malignancies and hyperlactatemia are at increased risk of mortality. If serum lactic acid could improve detection of at-risk patients with cancer, it would be useful in risk stratification. There is also little evidence (...) that "alarm" values of serum lactate (such as >/=4 mmol/L) are appropriate for the population of patients with cancer.This was a continuous retrospective cohort study of approximately two years (2012-2014) at a single, tertiary hospital ED; 5,440 patients had serum lactic acid measurements performed in the ED. Of the 5,440 patients in whom lactate was drawn, 1,837 were cancer patients, and 3,603 were non-cancer patients. Cumulative unadjusted mortality (determined by hospital records and an external death

2018 Western Journal of Emergency Medicine

131. Milk Fermented by Specific Lactobacillus Strains Regulates the Serum Levels of IL-6, TNF-α and IL-10 Cytokines in a LPS-Stimulated Murine Model Full Text available with Trip Pro

Milk Fermented by Specific Lactobacillus Strains Regulates the Serum Levels of IL-6, TNF-α and IL-10 Cytokines in a LPS-Stimulated Murine Model Studies report that metabolites, such as peptides, present in fermented milk with specific lactic acid bacteria, may regulate cytokine production and exert an anti-inflammatory effect. Hence, the cytokine regulatory effect of fermented milk by specific Lactobacillus strains was evaluated in a lipopolysaccharide (LPS)-stimulated murine model. From

2018 Nutrients

132. Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men. Full Text available with Trip Pro

glycocholic acid, P = 0.04), and modulation of 4 indole derivative compounds (including indole lactic acid, P = 0.01). Fasting serum samples after 2 wk of daily intake of milk or yogurt could also be differentiated based on their metabolic profiles (OPLS-DA Q2 = 0.56) and were discussed in light of the postprandial results.Metabolic pathways related to amino acids, indole derivatives, and bile acids were modulated in healthy men by the intake of yogurt. Further investigation to explore novel health (...) ). Serum samples were taken from fasting participants at the end of each test phase. The serum metabolome was assessed through the use of LC-MS-based untargeted metabolomics.Postprandial serum metabolomes after milk or yogurt intake could be differentiated [orthogonal projections to latent structures discriminant analysis (OPLS-DA) Q2 = 0.74]. Yogurt intake was characterized by higher concentrations of 7 free amino acids (including proline, P = 0.03), reduced concentrations of 5 bile acids (including

2018 Journal of Nutrition Controlled trial quality: uncertain

133. Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites. Full Text available with Trip Pro

glucose, and fasting status. In a fully adjusted logistic regression model dichotomized for the absence or presence of quantifiable metabolite amounts, VAT, BMI and WC were inversely related to urinary choline (ß = -0.18, p = 2.73*10-3), glycolic acid (ß = -0.20, 0.02), and guanidinoacetic acid (ß = -0.12, p = 0.04), and positively related to ethanolamine (ß = 0.18, p = 0.02) and dimethylamine (ß = 0.32, p = 0.02). BMI and WC were additionally inversely related to urinary glutamine and lactic acid (...) . Moreover, WC was inversely associated with the detection of serine. VAT, but none of the other anthropometric parameters, was related to serum essential amino acids, such as valine, isoleucine, and phenylalanine among men. Compared to other adiposity measures, VAT demonstrated the strongest and most significant relations to urinary and serum metabolites. The distinct relations of VAT, SAT, VSR, BMI, and WC to metabolites emphasize the importance of accurately differentiating between body fat

2017 PLoS ONE

134. D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome Full Text available with Trip Pro

D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome D-lactic acidosis or D-lactate encephalopathy is a rare condition that occurs primarily in individuals who have a history of short bowel syndrome. The unabsorbed carbohydrates act as a substrate for colonic bacteria to form D-lactic acid among other organic acids. The acidic pH generated as a result of D-lactate production further propagates production of D-lactic acid, hence giving rise to a vicious cycle. D-lactic acid (...) accumulation in the blood can cause neurologic symptoms such as delirium, ataxia, and slurred speech. Diagnosis is made by a combination of clinical and laboratory data including special assays for D-lactate. Treatment includes correcting the acidosis and decreasing substrate for D-lactate such as carbohydrates in meals. In addition, antibiotics can be used to clear colonic flora. Although newer techniques for diagnosis and treatment are being developed, clinical diagnosis still holds paramount importance

2015 Gastroenterology research and practice

135. Effect of lactate versus acetate-based intravenous fluids on acid-base balance in patients undergoing free flap reconstructive surgeries. (Abstract)

Effect of lactate versus acetate-based intravenous fluids on acid-base balance in patients undergoing free flap reconstructive surgeries. Use of lactated intravenous fluids during long surgeries could cause lactate accumulation and lactic acidosis. Acetate-based solutions could be advantageous as they are devoid of lactate. The primary aim of the study was to assess the effect of use of an acetated solution or Ringer's lactate (RL) as intraoperative fluid on lactate levels in patients without (...) of 10 ml/kg/h to maintain systolic blood pressure above 90 mmHg. Blood loss >20% was replaced with packed cells. Arterial blood gas analysis was done 2nd hourly till 8 h. Chi-square test was used to compare categorical variables. Independent sample t-test was used to compare means.Intraoperative lactate levels were significantly high in RL group at 2, 4, 6, and 8 h. The pH was comparable between groups except at 8 h where RL group had a significantly lower pH than SF group (7.42 ± 0.1 vs. 7.4 ± 0.1

2019 Journal of anaesthesiology, clinical pharmacology Controlled trial quality: uncertain

136. Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion. (Abstract)

evaluated. Throughout perfusion, kidneys from both groups exhibited comparable behavior regarding vascular flow (P = .66), oxygen consumption (P = .88), and reconstitution of tissue adenosine triphosphate (P = .057). Lactic acid levels were significantly higher in kidneys perfused with PRBC (P = .007). Histological findings were comparable between groups, and there was no evidence of histological damage caused by the HBOC. This feasibility experiment demonstrates that a HBOC solution can offer (...) Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion. Normothermic machine perfusion presents a novel platform for pretransplant assessment and reconditioning of kidney grafts. Maintaining the metabolic activity of a preserved graft at physiologic levels requires an adequate oxygen supply, typically delivered by crystalloid solutions supplemented with red blood cells. In this study, we explored the feasibility

2019 American Journal of Transplantation

137. PLGA Spherical Nucleic Acids Full Text available with Trip Pro

PLGA Spherical Nucleic Acids A new class of polymer spherical nucleic acid (SNA) conjugates comprised of poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) cores is reported. The nucleic acid shell that defines the PLGA-SNA exhibits a half-life of more than 2 h in fetal bovine serum. Importantly, the PLGA-SNAs can be utilized to encapsulate a hydrophobic model drug, coumarin 6, which can then be released in a polymer composition-dependent tunable manner, while the dissociation rate (...) of the nucleic acid shell remains relatively constant, regardless of core composition. Like prototypical gold NP conjugate SNAs, PLGA-SNAs freely enter Raw-Blue cells and can be used to activate toll-like receptor 9 in a sequence- and dose-dependent manner. Taken together, the data show that this novel nanoconstruct provides a means for controlling the release kinetics of encapsulated cargos in the context of the SNA platform, which may be useful for developing combination therapeutics.© 2018 WILEY-VCH

2018 Advanced materials (Deerfield Beach, Fla.)

138. Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials Full Text available with Trip Pro

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials New multifunctional materials containing additives derived from natural resources as powdered rosemary ethanolic extract were obtained by melt mixing and processed in good conditions without degradation and loss of additives. Incorporation of powdered rosemary ethanolic extract (R) into poly(lactic acid) (PLA) improved elongation at break, rheological properties, antibacterial and antioxidant (...) biocompatibility based on the determination of surface properties demonstrated a good hydrophilicity, better spreading and division of fibroblasts, and increased platelet cohesion. The implantation of PLA/R pellets, was proven to possess a good in vivo biocompatibility, and resulted in similar changes in blood parameters and biochemical responses with the control group, suggesting that these PLA-based materials demonstrate very desirable properties as potential biomaterials, useful in human medicine for tissue

2018 Materials

139. Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.

: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: i. Diagnosis of sepsis or septic shock within 12 hours of admission to the ICU ii. Informed consent as dictated by IRB and local practice. iii. Compliance with the 3 hour sepsis bundle 30ml/kg of intravenous crystalloid fluid (e.g.: sodium chloride 0.9%) for lactic acid >4 and/or systolic blood pressure <90mmHg / mean arterial pressure <65mmHg Lactic acid level drawn (...) -2016. de Grooth HJ, Choo WP, Spoelstra-de Man AM et al. Pharmacokinetics of four high- dose regimens of intravenous Vitamin C in critically ill patients [Abstract]. Intensive Care Med 2016. Ascorbic Acid Injection. http://www.drugs.com/pro/ascorbic-acid-injection.html . 2015. The Torrance Company. 6-12-2016. Nooraei N, Fathi M, Edalat L et al. Effect of Vitamin C on serum cortisol after etomidate induction of anesthesia. J Cell Mol Anesth 2016; 1:28-33. Marik PE. The physiology of volume

2018 Clinical Trials

140. A Metabolomic and Lipidomic Serum Signature from Nonhuman Primates Administered with a Promising Radiation Countermeasure, Gamma-Tocotrienol Full Text available with Trip Pro

and lipidomic changes using ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry (QTOF-MS) in serum samples of NHPs administered GT3. Our study, using 12 NHPs, demonstrates that alterations in metabolites manifest only 24 h after GT3 administration. Furthermore, metabolic changes are associated with transient increase in the bioavailability of antioxidants, including lactic acid and cholic acid and anti-inflammatory metabolites 3 deoxyvitamin D3, and docosahexaenoic (...) A Metabolomic and Lipidomic Serum Signature from Nonhuman Primates Administered with a Promising Radiation Countermeasure, Gamma-Tocotrienol The development of radiation countermeasures for acute radiation syndrome (ARS) has been underway for the past six decades, leading to the identification of multiple classes of radiation countermeasures. However, to date, only two growth factors (Neupogen and Neulasta) have been approved by the United States Food and Drug Administration (US FDA

2017 International journal of molecular sciences

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