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Blood Lactic Acid

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101. A TEST FOR MYOCARDIAL INFARCTION—The Present Status of the Use of Serum Lactic Acid Dehydrogenase (PubMed)

A TEST FOR MYOCARDIAL INFARCTION—The Present Status of the Use of Serum Lactic Acid Dehydrogenase Determination of the amount of lactic acid dehydrogenase in the blood has been demonstrated as a useful aid in the diagnosis of myocardial necrosis. The reliability of the test and the time element of the appearance and disappearance of the enzyme in the blood give it advantages over transminase determinations. In addition there appears to be a correlation of lactic acid dehydrogenase content

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1958 California Medicine

102. Serial lactic acid measurements in respiratory distress syndrome. (PubMed)

Serial lactic acid measurements in respiratory distress syndrome. 5018647 1972 06 22 2016 11 22 1468-2044 47 251 1972 Feb Archives of disease in childhood Arch. Dis. Child. Serial lactic acid measurements in respiratory distress syndrome. 152 Beca J P JP eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Lactates S88TT14065 Oxygen IM Humans Hypoxia metabolism Infant, Newborn Lactates blood Oxygen blood Oxygen Consumption Prognosis Respiratory Distress Syndrome, Newborn blood 1972 2

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1972 Archives of Disease in Childhood

103. Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials

to minimise reviewer error and bias were used for study selection and data extraction but it was unclear whether similar methods were used for quality assessment. Appropriate methods were used for pooling data and for exploring the influence of different study characteristics. Two authors from this review received fees from CALPIS, Japan, which produces lactic acid beverages and milk-based beverages. In the meta-analyses presented, the confidence intervals were wide and this indicated a high degree (...) Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta

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2013 DARE.

104. Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.

: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: i. Diagnosis of sepsis or septic shock within 12 hours of admission to the ICU ii. Informed consent as dictated by IRB and local practice. iii. Compliance with the 3 hour sepsis bundle 30ml/kg of intravenous crystalloid fluid (e.g.: sodium chloride 0.9%) for lactic acid >4 and/or systolic blood pressure <90mmHg / mean arterial pressure <65mmHg Lactic acid level drawn (...) Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis. Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2018 Clinical Trials

105. Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials (PubMed)

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials New multifunctional materials containing additives derived from natural resources as powdered rosemary ethanolic extract were obtained by melt mixing and processed in good conditions without degradation and loss of additives. Incorporation of powdered rosemary ethanolic extract (R) into poly(lactic acid) (PLA) improved elongation at break, rheological properties, antibacterial and antioxidant (...) biocompatibility based on the determination of surface properties demonstrated a good hydrophilicity, better spreading and division of fibroblasts, and increased platelet cohesion. The implantation of PLA/R pellets, was proven to possess a good in vivo biocompatibility, and resulted in similar changes in blood parameters and biochemical responses with the control group, suggesting that these PLA-based materials demonstrate very desirable properties as potential biomaterials, useful in human medicine for tissue

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2018 Materials

106. [Effects of perioperative thermoregulation on patients' body temperature, peripheral circulation and blood coagulation time in patients undergoing elective vertical hemi laryngectomy]. (PubMed)

groups: preoperative inflatable heating blanket group (A group, n=20), warmed irrigation group (B group, n=20), and control group (C group, n=20). The core temperature were recorded after entering the operating room, before induction, 20th minute during operation, entering PACU and 2nd hour after operation respectively. Blood samples were got at the end of operation to test pH, lactic acid, PT and APTT. After waking patients' SpO₂ and thermal comfort were recorded.Result:The core temperatures at time (...) points of 20th minute during operation and entering PACU were significantly different between C group and A group, C group and B group. There were significant difference in lactic acid, PT, APTT and SpO₂ between C group and A group, C group and B group. Patients' thermal comfort in all three groups were different.Conclusion:Inflatable heating blanket during operation combined with using it before operation or fluid warmers during operation for perioperative body temperature protection duringelective

2018 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

107. Immune responses, intestinal microbiota, performance and blood characteristics of Japanese quail fed on diets containing camphor. (PubMed)

; whereas, diet supplementation with camphor had no significant effect on lymphoid organ weights and heterophil-to-lymphocyte ratio. The greatest AIV antibody titers were seen in groups, which received 1000 and 5000 ppm of camphor (P<0.05) and the values of NDV antibody titers increased with an increase in the camphor consumption. Furthermore, dietary inclusion of 500 ppm of camphor positively decreased coliform populations in the gastrointestinal tract (GIT). In addition, an increase in lactic acid (...) Immune responses, intestinal microbiota, performance and blood characteristics of Japanese quail fed on diets containing camphor. This study aimed to investigate the effect of supplemental camphor on the performance and immune functions of Japanese quail by feeding graded levels (0 (control), 250, 500, 750, 1000, 5000 or 10 000 ppm) of camphor during a 42-day feeding trial. In all, 280 1-day-old quail chicks were randomly assigned into 28 cages of 10 chicks each with separate feeders

2018 Animal : an international journal of animal bioscience

108. Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise (PubMed)

of serum lactic acid (increased from 1.3 ± 0.4 to 6.9 ± 1.7 mM), creatinine (from 77.5 ± 6.3 U/L to 102.2 ± 7.0 μM), and lactate dehydrogenase (from 318.5 ± 26.2 to 380.5 ± 33.2 U/L) confirmed the effect of exercise. WBC count also significantly increased (from 6.6 ± 1.0 to 8.4 ± 1.4 G/L). The level of O-GlcNAc modified proteins in WBCs showed significant elevation after exercise (85 ± 51%, p < 0.05). Flow cytometry revealed that most of this change could be attributed to lymphocytes and monocytes.Our (...) Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise Protein O-linked N-acetylglucosamine (O-GlcNAc) is a dynamic posttranslational modification influencing the function of many intracellular proteins. Recently it was revealed that O-GlcNAc regulation is modified under various stress states, including ischemia and oxidative stress. Aside from a few contradictory studies based on animal models, the effect of exercise on O-GlcNAc is unexplored.To

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2018 Frontiers in immunology

109. Lactic Acidosis (Overview)

represents increased anaerobic metabolism due to tissue hypoperfusion. (See .) D-lactate is a byproduct of bacterial metabolism and may accumulate in patients with short-gut syndrome or in those with a history of gastric bypass or small-bowel resection. [ ] By the turn of the 20th century, many physicians recognized that patients who are critically ill could exhibit unaccompanied by elevation of ketones or other measurable anions. In 1925, Clausen identified the accumulation of lactic acid in blood (...) + . Extracellular H + combines with lactate leaving the cell, forming lactic acid, while intracellular OH- binds to H + generated during the hydrolysis of ATP to form water. Therefore, cellular transport of lactate helps to moderate increases in cytosolic H + resulting from hydrolysis of anaerobically generated ATP. Next: Etiology Declines in cellular oxygen delivery lead to more oxygen extraction from the capillary blood. This action redistributes the cardiac output to organs according to their ability

2014 eMedicine.com

110. Lactic Acidosis (Treatment)

is a new buffering agent with potential use in metabolic acidosis. It is an equimolecular mixture of sodium bicarbonate and sodium carbonate. Like THAM, Carbicarb has a buffering capacity similar to sodium bicarbonate but does not generate carbon dioxide. In animal models of hypoxic lactic acidosis, Carbicarb reduced circulating lactate and improved tissue and blood acid-base status compared with sodium bicarbonate. Carbicarb is currently not available for use. Previous Next: Hemodialysis Dialysis may (...) for the aerobic oxidation of glucose, pyruvate, and lactate. Dichloroacetate may inhibit glycolysis and, thereby, lactate production. The data from animal studies and one placebo-controlled, double-blind clinical trial showed dichloroacetate to be superior to placebo in improving the acid-base status of the patients; however, it did not alter hemodynamics or survival. Theoretical reasons and some clinical evidence exist for thiamine treatment to improve lactic acidosis associated with thiamine deficiency

2014 eMedicine.com

111. Lactic Acidosis (Follow-up)

is a new buffering agent with potential use in metabolic acidosis. It is an equimolecular mixture of sodium bicarbonate and sodium carbonate. Like THAM, Carbicarb has a buffering capacity similar to sodium bicarbonate but does not generate carbon dioxide. In animal models of hypoxic lactic acidosis, Carbicarb reduced circulating lactate and improved tissue and blood acid-base status compared with sodium bicarbonate. Carbicarb is currently not available for use. Previous Next: Hemodialysis Dialysis may (...) for the aerobic oxidation of glucose, pyruvate, and lactate. Dichloroacetate may inhibit glycolysis and, thereby, lactate production. The data from animal studies and one placebo-controlled, double-blind clinical trial showed dichloroacetate to be superior to placebo in improving the acid-base status of the patients; however, it did not alter hemodynamics or survival. Theoretical reasons and some clinical evidence exist for thiamine treatment to improve lactic acidosis associated with thiamine deficiency

2014 eMedicine.com

112. Lactic Acidosis (Treatment)

. Chronically, renal compensation occurs by means of reabsorption of HCO 3 . [ , ] Acidosis arises from an increased production of acids, a loss of alkali, or a decreased renal excretion of acids. The underlying etiology of metabolic acidosis is classically categorized into those that cause an elevated anion gap (AG) (see the calculator) and those that do not. Lactic acidosis, identified by a state of acidosis and an elevated plasma lactate concentration is one type of anion gap metabolic acidosis and may (...) result from numerous conditions. [ , , ] It remains the most common cause of metabolic acidosis in hospitalized patients. The normal blood lactate concentration in unstressed patients is 0.5-1 mmol/L. Patients with critical illness can be considered to have normal lactate concentrations of less than 2 mmol/L. Hyperlactatemia is defined as a mild to moderate persistent increase in blood lactate concentration (2-4 mmol/L) without metabolic acidosis, whereas lactic acidosis is characterized

2014 eMedicine Emergency Medicine

113. Lactic Acidosis (Overview)

. Chronically, renal compensation occurs by means of reabsorption of HCO 3 . [ , ] Acidosis arises from an increased production of acids, a loss of alkali, or a decreased renal excretion of acids. The underlying etiology of metabolic acidosis is classically categorized into those that cause an elevated anion gap (AG) (see the calculator) and those that do not. Lactic acidosis, identified by a state of acidosis and an elevated plasma lactate concentration is one type of anion gap metabolic acidosis and may (...) result from numerous conditions. [ , , ] It remains the most common cause of metabolic acidosis in hospitalized patients. The normal blood lactate concentration in unstressed patients is 0.5-1 mmol/L. Patients with critical illness can be considered to have normal lactate concentrations of less than 2 mmol/L. Hyperlactatemia is defined as a mild to moderate persistent increase in blood lactate concentration (2-4 mmol/L) without metabolic acidosis, whereas lactic acidosis is characterized

2014 eMedicine Emergency Medicine

114. Lactic Acidosis (Diagnosis)

represents increased anaerobic metabolism due to tissue hypoperfusion. (See .) D-lactate is a byproduct of bacterial metabolism and may accumulate in patients with short-gut syndrome or in those with a history of gastric bypass or small-bowel resection. [ ] By the turn of the 20th century, many physicians recognized that patients who are critically ill could exhibit unaccompanied by elevation of ketones or other measurable anions. In 1925, Clausen identified the accumulation of lactic acid in blood (...) + . Extracellular H + combines with lactate leaving the cell, forming lactic acid, while intracellular OH- binds to H + generated during the hydrolysis of ATP to form water. Therefore, cellular transport of lactate helps to moderate increases in cytosolic H + resulting from hydrolysis of anaerobically generated ATP. Next: Etiology Declines in cellular oxygen delivery lead to more oxygen extraction from the capillary blood. This action redistributes the cardiac output to organs according to their ability

2014 eMedicine.com

115. Lactic Acidosis (Diagnosis)

. Chronically, renal compensation occurs by means of reabsorption of HCO 3 . [ , ] Acidosis arises from an increased production of acids, a loss of alkali, or a decreased renal excretion of acids. The underlying etiology of metabolic acidosis is classically categorized into those that cause an elevated anion gap (AG) (see the calculator) and those that do not. Lactic acidosis, identified by a state of acidosis and an elevated plasma lactate concentration is one type of anion gap metabolic acidosis and may (...) result from numerous conditions. [ , , ] It remains the most common cause of metabolic acidosis in hospitalized patients. The normal blood lactate concentration in unstressed patients is 0.5-1 mmol/L. Patients with critical illness can be considered to have normal lactate concentrations of less than 2 mmol/L. Hyperlactatemia is defined as a mild to moderate persistent increase in blood lactate concentration (2-4 mmol/L) without metabolic acidosis, whereas lactic acidosis is characterized

2014 eMedicine Emergency Medicine

116. Lactic Acidosis (Follow-up)

. Chronically, renal compensation occurs by means of reabsorption of HCO 3 . [ , ] Acidosis arises from an increased production of acids, a loss of alkali, or a decreased renal excretion of acids. The underlying etiology of metabolic acidosis is classically categorized into those that cause an elevated anion gap (AG) (see the calculator) and those that do not. Lactic acidosis, identified by a state of acidosis and an elevated plasma lactate concentration is one type of anion gap metabolic acidosis and may (...) result from numerous conditions. [ , , ] It remains the most common cause of metabolic acidosis in hospitalized patients. The normal blood lactate concentration in unstressed patients is 0.5-1 mmol/L. Patients with critical illness can be considered to have normal lactate concentrations of less than 2 mmol/L. Hyperlactatemia is defined as a mild to moderate persistent increase in blood lactate concentration (2-4 mmol/L) without metabolic acidosis, whereas lactic acidosis is characterized

2014 eMedicine Emergency Medicine

117. Effect of acid-base balance on postoperative course in children with hypoplastic left heart syndrome after the modified Norwood procedure. (PubMed)

. It is believed that the most important cause of hemodynamic instability is the fluctuations in redistribution between pulmonary and systemic blood flow.The paper analyzes the postoperative course in 40 neonates with HLHS following the modified Norwood procedure performed under deep hypothermic cardiopulmonary bypass hospitalized in Cardiac Surgical Intensive Care Unit (CSICU) in the years 2014-2015. For all hospitalized children, the arterial blood acid-base balance (ABB) parameters (pH, pO2, pCO2, HCO3 (...) , base excess (BE), and lactic acid) were measured 2 times a day during the first 5 postoperative days. The main goal of the studies is to analysis of ABB parameters and their influence on the clinical state of newborns with HLHS. Several descriptors were concerned to describe the neonates clinical state: the date of the surgery (the day of life when the child was operated on), the duration (number of days) of mechanical ventilation employment, the time of hospitalization in intensive care unit

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2017 Medicine

118. Clinical Trial for Vespa Amino Acid Mixture (VAAM®)

into different meter race including 1500-, 800- and 400-meter races. Outcome Measures Go to Primary Outcome Measures : change of running time scores at 10 weeks [ Time Frame: 10 weeks ] change of the plasma lactic acid clearance rate after running at 10 weeks [ Time Frame: 10 weeks ] change of red blood cells after running at 10 weeks [ Time Frame: 10 weeks ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk (...) and Technology Co., Ltd. Study Details Study Description Go to Brief Summary: ATP is generated mainly through anaerobic metabolism during strenuous exercise, which is then followed by the generation of lactic acid. However, this process can only be maintained for a short time, approximately one minute, because the accumulation of lactic acid in the muscles may affect muscle performance. The efficiency of lactic acid metabolism is one of the most important reasons for endurance improvement. The purpose

2017 Clinical Trials

119. Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment (PubMed)

the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility. Here, we combined poly(lactic-co-glycolic acid) (PLGA) with red blood-cell membrane (RBCm), and evaluated whether GA-loaded RBCm nanoparticles can retain and improve the antitumor efficacy of GA with relatively lower toxicity in colorectal cancer treatment compared with free GA. We also confirmed (...) Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inhe rent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites

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2017 International journal of nanomedicine

120. The Effects of an Olive Fruit Polyphenol-Enriched Yogurt on Body Composition, Blood Redox Status, Physiological and Metabolic Parameters and Yogurt Microflora. (PubMed)

regardless of condition. A tendency towards significance for decreased levels of low density lipoprotein (LDL) cholesterol (p = 0.06) and thiobarbituric acid reactive substances (p < 0.05) following two weeks of polyphenol-enriched yogurt consumption was observed. The population of lactic acid bacteria (LAB) and production of lactate in yogurt were significantly enhanced after addition of olive polyphenols, contrary to the population of yeasts and molds. The results indicate that consumption (...) The Effects of an Olive Fruit Polyphenol-Enriched Yogurt on Body Composition, Blood Redox Status, Physiological and Metabolic Parameters and Yogurt Microflora. In the present study we investigated the effects of an olive polyphenol-enriched yogurt on yogurt microflora, as well as hematological, physiological and metabolic parameters, blood redox status and body composition. In a randomized double-blind, crossover design, 16 (6 men, 10 women) nonsmoking volunteers with non-declared pathology

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2017 Nutrients

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