How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,035 results for

Blood Lactic Acid

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

101. THE ROLE OF LACTIC ACID IN THE REDUCED EXCRETION OF URIC ACID IN TOXEMIA OF PREGNANCY Full Text available with Trip Pro

THE ROLE OF LACTIC ACID IN THE REDUCED EXCRETION OF URIC ACID IN TOXEMIA OF PREGNANCY 13711188 1998 11 01 2018 11 30 0021-9738 39 1960 Oct The Journal of clinical investigation J. Clin. Invest. The role of lactic acid in the reduced excretion of uric acid in toxemia of pregnancy. 1526-32 HANDLER J S JS eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Lactates 268B43MJ25 Uric Acid 33X04XA5AT Lactic Acid OM Body Fluids Female Humans Lactates pharmacology Lactic Acid Pre (...) -Eclampsia urine Pregnancy Uric Acid blood LACTATES/pharmacology PREGNANCY TOXEMIAS/urine URIC ACID/blood 1960 10 1 1960 10 1 0 1 1960 10 1 0 0 ppublish 13711188 10.1172/JCI104172 PMC441887 Proc Soc Exp Biol Med. 1957 Dec;96(3):809-13 13505867 J Clin Invest. 1940 May;19(3):525-35 16694770 J Obstet Gynaecol Br Emp. 1953 Jun;60(3):335-44 13061996 Lancet. 1955 Feb 12;268(6859):323-5 13234369 Bull N Y Acad Med. 1958 May;34(5):287-96 13523299 Am J Obstet Gynecol. 1957 Mar;73(3):492-506 13402821 J Clin Invest

1960 Journal of Clinical Investigation

102. Maternal normal range for lactic acid: a systematic review and meta-analysis

Maternal normal range for lactic acid: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web address: Timing and effect (...) of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data

2016 PROSPERO

103. Infusion of 2.5 meq/min of lactic acid minimally increases CO2 production compared to an isocaloric glucose infusion in healthy anesthetized, mechanically ventilated pigs Full Text available with Trip Pro

Infusion of 2.5 meq/min of lactic acid minimally increases CO2 production compared to an isocaloric glucose infusion in healthy anesthetized, mechanically ventilated pigs Blood acidification by lactic acid infusion converts bicarbonate to CO2. This effect can be exploited to increase the transmembrane PCO2 gradient of an extracorporeal membrane lung, resulting in a significant increase of extracorporeal CO2 removal. Lactic acid, however, is an energetic substrate and its metabolism might (...) were administered as lactic acid and approximately 48.5 kcal/h as 50% glucose solution. This sequence was repeated three times with two-hour intervals. Every hour VCO2, arterial blood gases and lactate were measured. Blood glucose level was kept constant by titrating an insulin infusion, ventilation was adjusted to maintain arterial PCO2 at 50 mmHg, a normal value for our animal model.During Lactic Acid steps VCO2 increased less than 5% compared to the Glucose steps (282 vs. 269 ml/min, P < 0.05

2013 Critical Care

104. The effect of convalescent meridian acupressure after exercise on stress hormones and lactic acid concentration changes. Full Text available with Trip Pro

The effect of convalescent meridian acupressure after exercise on stress hormones and lactic acid concentration changes. Meridian acupressure has been used as the one way recovering body conditions. The purpose of this study was to investigate whether meridian acupressure is effective on removing cortisol, norepinephrine, epinephrine, and lactic acid in blood following exercise. The subjects were 12 healthy male college students and data were processed using SPSS 12.0 statistical program (...) , it showed in order of acupressure= exercise> rest recovery. Fourth, three groups showed a significant difference in convalescent lactic acid concentration changes after exercise (P = 0.001). And it showed in order of acupressure= exercise> rest recovery after recovery treatment in the groups (P= 0.001).

2013 Journal of exercise rehabilitation Controlled trial quality: uncertain

105. Capillary lactic acid validation in an ED. (Abstract)

Capillary lactic acid validation in an ED. One of the most used methods to evaluate patients with a high risk not responding to clinical treatment is the measurement of blood levels of lactic acid (LA). The objective of this study was to compare the sensitivity and specificity of an LA test for capillary and venous blood with LA test for arterial blood in a population of patients with tissue hypoperfusion and to evaluate the time needed for each test.The following factors were evaluated

2013 American Journal of Emergency Medicine

106. Enhancement of the Immune Response Against Salmonella Infection of Mice by Heat Killed Multispecies Combination of Lactic Acid Bacteria. Full Text available with Trip Pro

Enhancement of the Immune Response Against Salmonella Infection of Mice by Heat Killed Multispecies Combination of Lactic Acid Bacteria. Heat-killed lactic acid bacteria (LAB) has advantages over live LAB in that it has a long shelf-life and is therefore easy to store and transport. From four LAB strains selected by immunomodulatory activity and adherent properties, we prepared the heat-killed multispecies combination of LAB (MLAB) and the cell walls from MLAB under two conditions (100 °C (...) could inhibit the Salmonella invasion of mice significantly. For these mice, the expression level of pro-inflammatory cytokines, such as TNF-α and IL-6, in mouse serum was reduced while that of the anti-inflammatory cytokine, i.e. IL-10, was enhanced. The HMLABs developed in this study showed higher protective effect against Salmonella invasion either of Caco-2 cells or of mice, relative to the heat-killed lactobacilli, which consisted of Lactobacillus acidophilus strains selected at random

2013 Journal of Medical Microbiology

107. [Treatment of lactic acidosis with early continuous blood purification]. (Abstract)

[Treatment of lactic acidosis with early continuous blood purification]. To observe the therapeutic effect of early continuous blood purification (CBP) on lactic acidosis patients.Using prospective randomized study method, 41 patients with lactic acidosis in intensive care unit (ICU) from January 2010 to April 2012 were randomly divided into CBP group (n=21) and control group (n=20). Among them, blood gas analysis, lactic acid, blood biochemistry were prospectively monitored at the time before (...) treatment, 12, 24 and 72 hours after treatment. They were also evaluated with acute physiology and chronic health evaluation II (APACHEII) score, and length of stay in ICU and mortality in 28 days were recorded.Lactic acid level and APACHEII score were gradually decreased after treatment in both groups. Compared with control group, lactic acid at 12, 24 and 72 hours in CBP group was obviously lowered (12 hours: 8.23±3.94 mmol/L vs. 12.47±4.62 mmol/L, 24 hours: 4.46±1.57 mmol/L vs. 10.54±3.48 mmol/L, 72

2013 Zhonghua wei zhong bing ji jiu yi xue Controlled trial quality: uncertain

108. Systematic review of the effects of Bifidobacterium lactis CNCM I-2494 in fermented dairy product by lactic acid bacteria on gastrointestinal discomfort in the general population

Systematic review of the effects of Bifidobacterium lactis CNCM I-2494 in fermented dairy product by lactic acid bacteria on gastrointestinal discomfort in the general population Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email (...) ). ">Data to be extracted: animal model Example: Dose, timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted

2015 PROSPERO

109. Systematic review and meta-analysis of the effects of a fermented milk product that includes Bifidobacteria animalis ssp lactis CNCM I-2494/DN-173010 and lactic acid bacteria on gastrointestinal discomfort in the general population

Systematic review and meta-analysis of the effects of a fermented milk product that includes Bifidobacteria animalis ssp lactis CNCM I-2494/DN-173010 and lactic acid bacteria on gastrointestinal discomfort in the general population Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record (...) , duration of ischemia and duration of reperfusion (if applicable). ">Data to be extracted: animal model Example: Dose, timing of administration, frequency of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed

2015 PROSPERO

110. Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases Full Text available with Trip Pro

Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases 5217755 1966 05 27 2018 11 13 0007-1447 1 5487 1966 Mar 05 British medical journal Br Med J Serum lactic dehydrogenase activity and folate deficiency in myelosclerosis and other haematological diseases. 577-81 Hoffbrand A V AV Kremenchuzky S S Butterworth P J PJ Mollin D L DL eng Journal Article England Br Med J 0372673 0007-1447 EC 1.1.1.27 L-Lactate Dehydrogenase AIM IM Anemia (...) metabolism Anemia, Hemolytic metabolism Anemia, Sideroblastic metabolism Clinical Enzyme Tests Folic Acid Deficiency metabolism Humans L-Lactate Dehydrogenase metabolism Leukemia metabolism Leukemia, Erythroblastic, Acute metabolism Malabsorption Syndromes complications Polycythemia Vera metabolism Primary Myelofibrosis diagnosis metabolism Thrombocytopenia metabolism Vitamin B 12 Deficiency metabolism 1966 3 5 1966 3 5 0 1 1966 3 5 0 0 ppublish 5217755 PMC1843851 Br J Radiol. 1960 Apr;33:238-42 13817522

1966 British medical journal

111. Safety Evaluation of 32P–Chromic Phosphate–Poly L Lactic Acid Particles Interstitially Implanted into Livers of Beagle Dogs Full Text available with Trip Pro

Safety Evaluation of 32P–Chromic Phosphate–Poly L Lactic Acid Particles Interstitially Implanted into Livers of Beagle Dogs The aim of this study was to investigate the safety and toxicity of biodegradable (32)P-chromic phosphate-poly L lactic acid ((32)P-CP-PLLA) particles interstitially implanted into Beagle dog livers.Eighteen healthy Beagle dogs were randomly divided into 6 groups (n=3), and were treated with drugs of different formulations or doses, as well as controls. At different (...) time points after surgery, the experimental dogs were weighed. Detection of indicators of blood chemistry and liver fibrosis, SPECT bremsstrahlung imaging, computed tomography, histological examination, continuous blood measurement, and counting of urine and fecal radioactivity were performed for these dogs.SPECT imaging showed that after implantation of radioactive particles into livers, radioactivity continuously accumulated in the implanted sites, while no radioactivity imaging was found

2012 Cancer biotherapy & radiopharmaceuticals

112. Fecal lactic acid bacteria increased in adolescents randomized to whole-grain but not refined-grain foods, whereas inflammatory cytokine production decreased equally with both interventions. Full Text available with Trip Pro

and immune health in adolescents (aged 12.7 ± 0.1 y). A variety of grain-based foods were delivered weekly to participants and their families. Participants were encouraged to eat 3 different kinds of study foods (e.g., bread, cereals, snacks)/d with goals of 0 g/d (RG) and 80 g/d (WG). Stool samples were obtained during the prebaseline and final weeks to measure bifidobacteria and lactic acid bacteria (LAB) using qPCR. Stool frequency was recorded daily. Blood was drawn at baseline and at final visits (...) Fecal lactic acid bacteria increased in adolescents randomized to whole-grain but not refined-grain foods, whereas inflammatory cytokine production decreased equally with both interventions. The intake of whole-grain (WG) foods by adolescents is reported to be approximately one-third the recommended intake of 48 g/d. This 6-wk randomized interventional study determined the effect of replacing grains within the diet with refined-grain (RG; n = 42) or WG (n = 41) foods/d on gastrointestinal

2012 The Journal of nutrition Controlled trial quality: uncertain

113. Barley grain-based diet treated with lactic acid and heat modulated plasma metabolites and acute phase response in dairy cows. Full Text available with Trip Pro

Barley grain-based diet treated with lactic acid and heat modulated plasma metabolites and acute phase response in dairy cows. This study investigated the effects of feeding barley grain treated with lactic acid (LA) and heat on the profile of plasma metabolites related to carbohydrate and lipid metabolism and variables related to rumen health and acute phase response. Eight primiparous rumen-fistulated lactating Holstein cows were randomly assigned, in a crossover design, to 1 of the 2 dietary (...) treatments consisting of 32% (DM basis) rolled barley grain steeped in an equal quantity of either tap water alone (CTR) or a 1.0% LA solution and heated at 55°C for 48 h (LAH). Each experimental period was 21 d, with the last 10 d used for measurements. Blood samples were collected on d 1, 3, 5, 7, 9, and 11 before the morning feeding and on the last day of each period at 0, 2, 4, 6, 8, 10, and 12 h postfeeding to measure glucose, lactate, cholesterol, beta-hydroxybutyrate (BHBA), NEFA, haptoglobin (Hp

2012 Journal of animal science Controlled trial quality: uncertain

114. Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital

, Teaching Assistant, Makerere University ClinicalTrials.gov Identifier: Other Study ID Numbers: AD-001 First Posted: April 18, 2012 Last Update Posted: April 18, 2012 Last Verified: April 2012 Keywords provided by Faculty of Medicine, Makerere University: Blood Storage Age Transfusion Lactic acidosis Additional relevant MeSH terms: Layout table for MeSH terms Acidosis Acidosis, Lactic Acid-Base Imbalance Metabolic Diseases (...) Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2012 Clinical Trials

115. Effect of a 21-day balneotherapy program on blood cell counts, ponogen levels, and blood biochemical indexes in servicemen in sub-health condition Full Text available with Trip Pro

). Subjects in the balneotherapy group received whole-body immersion bath therapy in thermomineral water (30 min daily) for 21 days. Their blood samples were examined 1 day before and after balneotherapy. The parameters studied included mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell (WBC), lactic acid (LAC), alanine aminotransferase (ALT), glucose (GLU), and triglycerides (TG) levels. [Results] After 21 days of balneotherapy, MCH levels and MCHC (...) Effect of a 21-day balneotherapy program on blood cell counts, ponogen levels, and blood biochemical indexes in servicemen in sub-health condition [Purpose] The aim of our study was to explore the changes in the blood of servicemen in sub-health conditions during a 21-day balneotherapy program. [Subjects and Methods] For this study, 129 servicemen in sub-health condition were recruited. The subjects were randomly divided into either the balneotherapy group (70) or the control group (59

2017 Journal of physical therapy science Controlled trial quality: uncertain

116. Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis: A Case Report and Review of the Literature. Full Text available with Trip Pro

Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis: A Case Report and Review of the Literature. Propylene glycol (PG) is used as a solvent in numerous medications, including trimethoprim/sulfamethoxazole (TMP/SMX) and lorazepam, and is metabolized in the liver to lactic acid. Cases of lactic acidosis related to PG toxicity have been described and always involved large doses of benzodiazepines and PG. We present the first case of severe lactic acidosis after a 3-day course of TMP/SMX (...) alone, involving allegedly safe amounts of PG.A 31-year-old female with neurofibromatosis and pilocytic astrocytoma, receiving temozolomide and steroids, was admitted to the intensive care unit for pneumonia and acute respiratory failure requiring intubation. Her initial hemodynamic and acid-base statuses were normal. She was treated with intravenous TMP/SMX for possible Pneumocystis jirovecii pneumonia and was successfully extubated on day 2. On day 3, she developed tachypnea and arterial blood gas

2016 Medicine

117. Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation

: saline saline Experimental: GIK group glucose-Insulin-Potassium(GIK) infusion Other: Insulin Other Name: glucose-Insulin-Potassium(GIK) infusion Outcome Measures Go to Primary Outcome Measures : degree of lactic acidosis [ Time Frame: up to 1 weeks ] Blood samples for arterial blood pH, PCO2 , PO2 , base excess, hematocrit, and plasma concentrations of lactic acid and Na were analyzed Other Outcome Measures: tracheal extubation [ Time Frame: up to 3 days ] The time of tracheal extubation (...) perioperative outcome in patients undergoing OLT. Condition or disease Intervention/treatment Phase Liver Transplantation Other: saline Other: Insulin Not Applicable Detailed Description: Intraoperative metabolic acidosis begins soon after graft reperfusion and persists for several days. The current standard treatment for severe acidosis during OLT is NaHCO3, although it may compromise myocardial performance, exacerbate lactic acid accumulation and cause central nervous system demyelination. Surgical

2016 Clinical Trials

118. Transient dilutional acidosis but no lactic acidosis upon cardiopulmonary bypass in patients undergoing coronary artery bypass grafting Full Text available with Trip Pro

Transient dilutional acidosis but no lactic acidosis upon cardiopulmonary bypass in patients undergoing coronary artery bypass grafting Dilutional acidosis may result from the introduction of a large fluid volume into the patients' systemic circulation, resulting in a considerable dilution of endogenous bicarbonate in the presence of a constant carbon dioxide partial pressure. Its significance or even existence, however, has been strongly questioned. Blood gas samples of patients operated (...) on with standard cardiopulmonary bypass (CPB) were analyzed in order to provide further evidence for the existence of dilutional acidosis.Between 07/2014 and 10/2014, a total of 25 consecutive patients scheduled for elective isolated coronary artery bypass grafting with CPB were enrolled in this prospective observational study. Blood gas samples taken regularly after CPB initiation were analyzed for dilutional effects and acid-base changes.After CPB initiation, hemoglobin concentration dropped from an average

2016 Archives of medical science : AMS

119. ECHS1 Deficiency as a Cause of Severe Neonatal Lactic Acidosis Full Text available with Trip Pro

ECHS1 Deficiency as a Cause of Severe Neonatal Lactic Acidosis Mitochondrial short-chain enoyl-CoA hydratase deficiency (ECHS1D) is caused by mutations in ECHS1 (OMIM 602292) and is a recently identified inborn error of valine and fatty acid metabolism. This defect leads to secondary mitochondrial dysfunction. The majority of previously reported patients had the Leigh syndrome, with a median life expectancy of approximately 2 years. We report two siblings born 3 years apart with prenatal (...) findings including facial dysmorphia, oligohydramnios, intrauterine growth restriction, and premature delivery. They had severe lactic acidosis with onset within the first hours of life, had congenital dilated cardiomyopathy, and died at 16 h of life and 2 days of life, respectively.Biochemical evaluation of these patients showed elevated butyryl-carnitine in the blood and elevated methylmalonyl/succinyl-CoA and decreased hydroxybutyryl-CoA in frozen liver of patient 2, confirming abnormal short-chain

2016 JIMD reports

120. Lactic Acidosis: Current Treatments and Future Directions. Full Text available with Trip Pro

Lactic Acidosis: Current Treatments and Future Directions. Mortality rates associated with severe lactic acidosis (blood pH<7.2) due to sepsis or low-flow states are high. Eliminating the triggering conditions remains the most effective therapy. Although recommended by some, administration of sodium bicarbonate does not improve cardiovascular function or reduce mortality. This failure has been attributed to both reduction in serum calcium concentration and generation of excess carbon dioxide (...) of NHE1, a cell-membrane Na(+)/H(+) exchanger. In animal studies, selective NHE1 inhibitors improve cardiovascular function, ameliorate lactic acidosis, and reduce mortality, supporting future research into their possible use in humans. Two main mechanisms contribute to lactic acid accumulation in sepsis and low-flow states: tissue hypoxia and epinephrine-induced stimulation of aerobic glycolysis. Targeting these mechanisms could allow for more specific therapy. This Acid-Base and Electrolyte Teaching

2016 American Journal of Kidney Diseases

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>