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Blood Lactic Acid

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61. Development of a Microfluidic-Based Optical Sensing Device for Label-Free Detection of Circulating Tumor Cells (CTCs) Through Their Lactic Acid Metabolism Full Text available with Trip Pro

Development of a Microfluidic-Based Optical Sensing Device for Label-Free Detection of Circulating Tumor Cells (CTCs) Through Their Lactic Acid Metabolism This study reports a microfluidic-based optical sensing device for label-free detection of circulating tumor cells (CTCs), a rare cell species in blood circulation. Based on the metabolic features of cancer cells, live CTCs can be quantified indirectly through their lactic acid production. Compared with the conventional schemes for CTC (...) detection, this label-free approach could prevent the biological bias due to the heterogeneity of the surface antigens on cancer cells. In this study, a microfluidic device was proposed to generate uniform water-in-oil cell-encapsulating micro-droplets, followed by the fluorescence-based optical detection of lactic acid produced within the micro-droplets. To test its feasibility to quantify cancer cells, experiments were carried out. Results showed that the detection signals were proportional

2015 Sensors (Basel, Switzerland)

62. Intravaginal Lactic Acid Bacteria Modulated Local and Systemic Immune Responses and Lowered the Incidence of Uterine Infections in Periparturient Dairy Cows Full Text available with Trip Pro

Intravaginal Lactic Acid Bacteria Modulated Local and Systemic Immune Responses and Lowered the Incidence of Uterine Infections in Periparturient Dairy Cows The objective of this investigation was to evaluate whether intravaginal infusion of a lactic acid bacteria (LAB) cocktail around parturition could influence the immune response, incidence rate of uterine infections, and the overall health status of periparturient dairy cows. One hundred pregnant Holstein dairy cows were assigned to 1 (...) of the 3 experimental groups as follows: 1) one dose of LAB on wk -2 and -1, and one dose of carrier (sterile skim milk) on wk +1 relative to the expected day of parturition (TRT1); 2) one dose of LAB on wk -2, -1, and +1 (TRT2), and 3) one dose of carrier on wk -2, -1, and +1 (CTR). The LAB were a lyophilized culture mixture composed of Lactobacillus sakei FUA3089, Pediococcus acidilactici FUA3138, and Pediococcus acidilactici FUA3140 with a cell count of 108-109 cfu/dose. Blood samples and vaginal

2015 PloS one

63. Pharmacological Postconditioning with Lactic Acid and Hydrogen Rich Saline Alleviates Myocardial Reperfusion Injury in Rats Full Text available with Trip Pro

Pharmacological Postconditioning with Lactic Acid and Hydrogen Rich Saline Alleviates Myocardial Reperfusion Injury in Rats This study investigated whether pharmacological postconditioning with lactic acid and hydrogen rich saline can provide benefits similar to that of mechanical postconditioning. To our knowledge, this is the first therapeutic study to investigate the co-administration of lactic acid and hydrogen. SD rats were randomly divided into 6 groups: Sham, R/I, M-Post, Lac, Hyd (...) , and Lac + Hyd. The left coronary artery was occluded for 45 min. Blood was withdrawn from the right atrium to measure pH. The rats were sacrificed at different time points to measure mitochondrial absorbance, infarct size, serum markers and apoptotic index. Rats in Lac + Hyd group had similar blood pH and ROS levels when compared to the M-Post group. Additionally, the infarct area was reduced to the same extent in Lac + Hyd and M-Post groups with a similar trends observed for serum markers

2015 Scientific reports

64. Overview of acid-base and electrolyte disorders

) or the reabsorption of filtered bicarbonate (proximal RTA) is impaired to a degree disproportionate to any existing impairment of the glomerular filtration rate. Batlle D, Moorthi KM, Schluter W, et al. Distal renal tubular acidosis and the potassium enigma. Semin Nephrol. 2006 Nov;26(6):471-8. http://www.ncbi.nlm.nih.gov/pubmed/17275585?tool=bestpractice.com The acid retention or bicarbonate loss results in the development of hyperchloraemic metabolic acidosis marked by low serum bicarbonate and arterial blood (...) Overview of acid-base and electrolyte disorders Overview of acid-base and electrolyte disorders - Summary of relevant conditions | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Overview of acid-base and electrolyte disorders Last reviewed: February 2019 Last updated: November 2018 Introduction Disorders of blood chemistry may be caused by dietary factors, underlying medical conditions, and medical treatments. Resulting imbalances include acidosis (pH

2018 BMJ Best Practice

65. Overview of acid-base and electrolyte disorders

) or the reabsorption of filtered bicarbonate (proximal RTA) is impaired to a degree disproportionate to any existing impairment of the glomerular filtration rate. Batlle D, Moorthi KM, Schluter W, et al. Distal renal tubular acidosis and the potassium enigma. Semin Nephrol. 2006 Nov;26(6):471-8. http://www.ncbi.nlm.nih.gov/pubmed/17275585?tool=bestpractice.com The acid retention or bicarbonate loss results in the development of hyperchloraemic metabolic acidosis marked by low serum bicarbonate and arterial blood (...) Overview of acid-base and electrolyte disorders Overview of acid-base and electrolyte disorders - Summary of relevant conditions | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Overview of acid-base and electrolyte disorders Last reviewed: February 2019 Last updated: November 2018 Introduction Disorders of blood chemistry may be caused by dietary factors, underlying medical conditions, and medical treatments. Resulting imbalances include acidosis (pH

2018 BMJ Best Practice

66. PHYSIOLOGICAL DISTURBANCES DURING EXPERIMENTAL DIPHTHERITIC INTOXICATION. I. BLOOD SUGAR, LACTIC ACID AND NON-PROTEIN AND AMINO-ACID NITROGEN Full Text available with Trip Pro

PHYSIOLOGICAL DISTURBANCES DURING EXPERIMENTAL DIPHTHERITIC INTOXICATION. I. BLOOD SUGAR, LACTIC ACID AND NON-PROTEIN AND AMINO-ACID NITROGEN 16694162 2006 05 31 2018 11 13 0021-9738 12 5 1933 Sep The Journal of clinical investigation J. Clin. Invest. PHYSIOLOGICAL DISTURBANCES DURING EXPERIMENTAL DIPHTHERITIC INTOXICATION. I. BLOOD SUGAR, LACTIC ACID AND NON-PROTEIN AND AMINO-ACID NITROGEN. 767-78 Yannet H H Department of Pediatrics, Yale University School of Medicine, New Haven. Darrow D C DC

1933 Journal of Clinical Investigation

67. Alterations in the lactic acid content of the blood as a result of light exercise, and associated changes in the co2-combining power of the blood and in the alveolar co2 pressure Full Text available with Trip Pro

Alterations in the lactic acid content of the blood as a result of light exercise, and associated changes in the co2-combining power of the blood and in the alveolar co2 pressure 16994099 2007 02 05 2018 11 13 0022-3751 69 2 1930 Apr 14 The Journal of physiology J. Physiol. (Lond.) Alterations in the lactic acid content of the blood as a result of light exercise, and associated changes in the co(2)-combining power of the blood and in the alveolar co(2) pressure. 214-37 Owles W H WH eng Journal

1930 The Journal of physiology

68. Ertugliflozin l-pyroglutamic acid / metformin hydrochloride (Segluromet) - Diabetes Mellitus, Type 2

Ertugliflozin l-pyroglutamic acid / metformin hydrochloride (Segluromet) - Diabetes Mellitus, Type 2 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 25 January 2018 EMA/86928/2018 Committee for Medicinal Products for Human Use (...) under the curve AUCinf area under the concentration-time curve from 0 to infinity AUClast area under the concentration –time curve from zero to time of last measurable concentration BCS biopharmaceutical classification system bid twice daily BMD bone mineral density BMI body mass index Broad pool pooled safety data from all seven ertugliflozin phase III studies BUN blood urea nitrogen CFU colony forming units CHMP Committee for Medicinal Products for Human use CI confidence interval cLDA constrained

2018 European Medicines Agency - EPARs

69. Blood Lactic Acid

Blood Lactic Acid Blood Lactic Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Blood Lactic Acid Blood Lactic Acid Aka: Blood (...) for use in sick children (esp. , ) and their disposition Increased organ dysfunction in children with elevated Lactic Acid >4 mmol/L Predicted need for critical care in children with and pre-hospital elevated Lactic Acid >4 mmol/L Predicted in-hospital mortality for critically ill children VI. References (2013) Endo and Acid Base Disorders, EM Bootcamp, Las Vegas Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Blood Lactic Acid

2015 FP Notebook

70. A TEST FOR MYOCARDIAL INFARCTION—The Present Status of the Use of Serum Lactic Acid Dehydrogenase Full Text available with Trip Pro

A TEST FOR MYOCARDIAL INFARCTION—The Present Status of the Use of Serum Lactic Acid Dehydrogenase Determination of the amount of lactic acid dehydrogenase in the blood has been demonstrated as a useful aid in the diagnosis of myocardial necrosis. The reliability of the test and the time element of the appearance and disappearance of the enzyme in the blood give it advantages over transminase determinations. In addition there appears to be a correlation of lactic acid dehydrogenase content

1958 California Medicine

71. Serum Enzymes in Patients with Carcinoma of Lung: Lactic-Acid Dehydrogenase, Phosphohexose Isomerase, Alkaline Phosphatase and Glutamic Oxaloacetic Transaminase Full Text available with Trip Pro

Serum Enzymes in Patients with Carcinoma of Lung: Lactic-Acid Dehydrogenase, Phosphohexose Isomerase, Alkaline Phosphatase and Glutamic Oxaloacetic Transaminase Serial determinations of serum lactic-acid dehydrogenase (LDH), phosphohexose isomerase (PHI), alkaline phosphatase (AP), and glutamic oxaloacetic transaminase (GOT) were carried out in 30 patients with primary and four with secondary neoplasms of the lung. Enzyme values were correlated with the stage of illness, with tumour histology

1967 Canadian Medical Association Journal

72. Serum lactic acid dehydrogenase isozyme determination in myocardial infarction. Full Text available with Trip Pro

Serum lactic acid dehydrogenase isozyme determination in myocardial infarction. 6037727 1967 10 20 2018 11 13 0032-5473 43 497 1967 Mar Postgraduate medical journal Postgrad Med J Serum lactic acid dehydrogenase isozyme determination in myocardial infarction. 141-5 Handa S P SP eng Journal Article England Postgrad Med J 0234135 0032-5473 0 Isoenzymes EC 1.1.1.27 L-Lactate Dehydrogenase IM Adult Aged Electrophoresis Female Humans Isoenzymes L-Lactate Dehydrogenase blood Male Middle Aged (...) Myocardial Infarction blood 1967 3 1 1967 3 1 0 1 1967 3 1 0 0 ppublish 6037727 PMC2466071 J Biol Chem. 1961 Feb;236:401-4 13729250 Ann N Y Acad Sci. 1961 Nov 2;94:877-89 13925614 J Lab Clin Med. 1964 Sep;64:355-74 14215454 Ann N Y Acad Sci. 1961 Nov 2;94:890-7 13906986 Med Clin North Am. 1966 Jan;50(1):193-209 5906562 Proc Soc Exp Biol Med. 1957 Jan;94(1):96-9 13400881 Proc Natl Acad Sci U S A. 1959 May;45(5):753-63 16590440 Cancer Res. 1961 Feb;21:271-4 13714258 Ann N Y Acad Sci. 1961 Nov 2;94:912-32

1967 Postgraduate medical journal

73. Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis Full Text available with Trip Pro

administration. Routine metabolic investigations revealed elevated pyruvate and lactate levels in urine, and magnetic resonance spectroscopy showed a lactic acid peak and decreased N-acetylaspartate levels. Mitochondrial disorders, e.g., pyruvate dehydrogenase (PDH) deficiency, were the major differential diagnoses. However, both hypoglycemia and the elevated lactate to pyruvate ratio in serum (=55.2) were not typical for PDH deficiency. We used "Mendeliome sequencing", a next-generation sequencing approach (...) Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis Neonatal lactic acidosis can be associated to severe inborn errors of metabolism. Rapid identification of the underlying disorder may improve the clinical management through reliable counseling of the parents and adaptation of the treatment.We present the case of a term newborn with persistent hypoglycemia on postnatal day 1, who developed severe lactic acidosis, aggravating under intravenous glucose

2016 Molecular and cellular pediatrics

74. Combined metformin-associated lactic acidosis and euglycemic ketoacidosis Full Text available with Trip Pro

/l and blood glucose 63 mg/dl) on metformin and insulin treatment. Patient 2: a 79-year-old woman on metformin treatment (pH = 6.80, lactic acid 14.7 mmol/l, serum ketoacids 6.4 mmol/l and blood glucose 76 mg/dl). Patient 3: a 71-year-old man on metformin, canagliflozin and liraglutide treatment (pH = 7.21, lactic acid 5.9 mmol/l, serum ketoacids 16 mmol/l and blood glucose 150 mg/dl). In all patients, ketoacidosis receded on glucose infusion and renal replacement therapy.This case series (...) Combined metformin-associated lactic acidosis and euglycemic ketoacidosis In renal failure metformin can lead to lactic acidosis. Additional inhibition of hepatic gluconeogenesis by accumulation of the drug may aggravate fasting-induced ketoacidosis. We report the occurrence of metformin-associated lactic acidosis (MALA) with concurrent euglycemic ketoacidosis (MALKA) in three patients with renal failure.Patient 1: a 78-year-old woman (pH = 6.89, lactic acid 22 mmol/l, serum ketoacids 7.4 mmol

2017 Wiener klinische Wochenschrift

75. THE EFFECT OF BREATHING OXYGEN-ENRICHED AIR DURING EXERCISE UPON PULMONARY VENTILATION AND UPON THE LACTIC ACID CONTENT OF BLOOD AND URINE Full Text available with Trip Pro

THE EFFECT OF BREATHING OXYGEN-ENRICHED AIR DURING EXERCISE UPON PULMONARY VENTILATION AND UPON THE LACTIC ACID CONTENT OF BLOOD AND URINE 16693717 2006 05 31 2018 11 13 0021-9738 3 2 1926 Dec The Journal of clinical investigation J. Clin. Invest. THE EFFECT OF BREATHING OXYGEN-ENRICHED AIR DURING EXERCISE UPON PULMONARY VENTILATION AND UPON THE LACTIC ACID CONTENT OF BLOOD AND URINE. 317-25 Hewlett A W AW The Department of Medicine, Stanford Medical School. Barnett G D GD Lewis J K JK eng

1926 Journal of Clinical Investigation

76. The lactic acid in the blood of a resting man Full Text available with Trip Pro

The lactic acid in the blood of a resting man 16993640 2007 02 05 2018 11 13 0022-3751 58 6 1924 May 23 The Journal of physiology J. Physiol. (Lond.) The lactic acid in the blood of a resting man. 455-60 Long C N CN eng Journal Article England J Physiol 0266262 0022-3751 1924 5 23 0 0 1924 5 23 0 1 1924 5 23 0 0 ppublish 16993640 PMC1405565 J Physiol. 1907 Mar 27;35(4):247-309 16992858 J Physiol. 1920 Aug 23;54(3):167-77 16993456 J Physiol. 1922 Jul 21;56(5):367-81 16993538 J Physiol. 1922 May

1924 The Journal of physiology

77. The concentration of lactic acid in the blood in experimental alkalæmia and acidæmia Full Text available with Trip Pro

The concentration of lactic acid in the blood in experimental alkalæmia and acidæmia 16993658 2007 02 05 2018 11 13 0022-3751 58 2-3 1923 Dec 28 The Journal of physiology J. Physiol. (Lond.) The concentration of lactic acid in the blood in experimental alkalaemia and acidaemia. 244-58 Anrep G V GV Cannan R K RK eng Journal Article England J Physiol 0266262 0022-3751 1923 12 28 0 0 1923 12 28 0 1 1923 12 28 0 0 ppublish 16993658 PMC1405497 Biochem J. 1919 Jul;13(2):135-47 16742850 Biochem J

1923 The Journal of physiology

78. Does muscular contraction affect the local blood supply in the absence of lactic acid formation? Full Text available with Trip Pro

Does muscular contraction affect the local blood supply in the absence of lactic acid formation? 16994183 2007 02 05 2018 11 13 0022-3751 71 4 1931 Apr 24 The Journal of physiology J. Physiol. (Lond.) Does muscular contraction affect the local blood supply in the absence of lactic acid formation? 356-61 Ni T G TG eng Journal Article England J Physiol 0266262 0022-3751 1931 4 24 0 0 1931 4 24 0 1 1931 4 24 0 0 ppublish 16994183 PMC1403090 J Physiol. 1901 Feb 28;26(3-4):173-209 16992575 J Physiol

1931 The Journal of physiology

79. The relationship between sugar in blood and lactic acid in brain Full Text available with Trip Pro

The relationship between sugar in blood and lactic acid in brain 16744835 2006 06 05 2018 11 13 0264-6021 26 2 1932 The Biochemical journal Biochem. J. The relationship between sugar in blood and lactic acid in brain. 381-7 Holmes E G EG The Pharmacological Laboratory, Cambridge. Sherif M A MA eng Journal Article England Biochem J 2984726R 0264-6021 1932 1 1 0 0 1932 1 1 0 1 1932 1 1 0 0 ppublish 16744835 PMC1260916 Biochem J. 1925;19(3):492-9 16743531 Biochem J. 1929;23(4):748-59 16744262

1932 Biochemical Journal

80. THE LACTIC ACID OF THE BLOOD IN HEPATIC DISEASE Full Text available with Trip Pro

THE LACTIC ACID OF THE BLOOD IN HEPATIC DISEASE 16694087 2006 05 31 2018 11 13 0021-9738 11 5 1932 Sep The Journal of clinical investigation J. Clin. Invest. THE LACTIC ACID OF THE BLOOD IN HEPATIC DISEASE. 957-71 Snell A M AM Division of Medicine, The Mayo Clinic, Rochester, Minn. Roth G M GM eng Journal Article United States J Clin Invest 7802877 0021-9738 1932 9 1 0 0 1932 9 1 0 1 1932 9 1 0 0 ppublish 16694087 10.1172/JCI100462 PMC435859 J Clin Invest. 1926 Dec;3(2):317-25 16693717 J Clin

1932 Journal of Clinical Investigation

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