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Blood Lactic Acid

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41. Overview of acid-base and electrolyte disorders

Overview of acid-base and electrolyte disorders Overview of acid-base and electrolyte disorders - Summary of relevant conditions | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Overview of acid-base and electrolyte disorders Last reviewed: February 2019 Last updated: November 2018 Introduction Disorders of blood chemistry may be caused by dietary factors, underlying medical conditions, and medical treatments. Resulting imbalances include acidosis (pH (...) ://www.ncbi.nlm.nih.gov/pubmed/3344005?tool=bestpractice.com This is also referred to as hyperchloraemic or non-anion gap metabolic acidosis. Where SAG is increased, causes include diabetic ketoacidosis, alcoholic ketoacidosis, lactic acidosis, kidney disease, or ingestion of methanol, ethanol, ethylene glycol, propylene glycol, 5-oxoproline (e.g., in patients with chronic ingestion of paracetamol), or salicylic acid. With simple metabolic acidosis, the normal adaptive respiratory response will decrease the arterial

2018 BMJ Best Practice

42. Prognostic value of national early warning score (news 2) and the lactic acid in the prehospital scope

Prognostic value of national early warning score (news 2) and the lactic acid in the prehospital scope Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence: Organisation web (...) of administration, route of administration, vehicle. ">Data to be extracted: intervention of interest Example: Serum creatinine; continuous; umol/L (may be recalculated from mg/dL). ">Data to be extracted: primary outcome(s) Example: Blood urea nitrogen; continuous; mmol/L (may be recalculated from mg/dL); Renal histological damage as assessed by Jablonski scale; continuous; Jablonski score. ">Data to be extracted: secondary outcome(s) Example: 1st author, year of publication, language, journal. ">Data

2018 PROSPERO

43. Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus. (PubMed)

Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus. Lactococcus lactis ssp. lactis JCM5805 has been shown to be a rare lactic acid bacterium that can activate plasmacytoid dendritic cells in both murine and human species. In this study, we carried out a randomised placebo-controlled double-blind experiment to evaluate its effect on the pathogenesis of influenza (...) -like illness during the winter season. A total of 213 volunteers were divided into two groups, which received either yogurt made with L. lactis JCM5805 or a placebo beverage daily for 10 weeks. In the JCM5805 group, the cumulative incidence days of 'cough' and 'feverishness', which are defined as major symptoms of an influenza-like illness, were significantly decreased compared with the placebo group. In addition, peripheral blood mononuclear cells prepared from volunteers were cultured

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2015 The British journal of nutrition

44. Development of Alendronate-conjugated Poly (lactic-co-glycolic acid)-Dextran Nanoparticles for Active Targeting of Cisplatin in Osteosarcoma (PubMed)

Development of Alendronate-conjugated Poly (lactic-co-glycolic acid)-Dextran Nanoparticles for Active Targeting of Cisplatin in Osteosarcoma In this study, we developed a novel poly (lactic-co-glycolic acid)-dextran (PLD)-based nanodelivery system to enhance the anticancer potential of cisplatin (CDDP) in osteosarcoma cells. A nanosized CDDP-loaded PLGA-DX nanoparticle (PLD/CDDP) controlled the release rate of CDDP up to 48 h. In vitro cytotoxicity assay showed a superior anticancer effect (...) compared to free CDDP with a nearly 2-fold higher arrest in case of PLD/CDDP treated group (~60%). Importantly, PLD/CDDP exhibited a most significant anti-tumor activity with maximum tumor growth inhibition. The superior inhibitory effect was further confirmed by a marked reduction in the number of CD31 stained tumor blood vessels and decrease in the Ki67 staining intensity for PLD/CDDP treated animal group. Overall, CDDP formulations could provide a promising and most effective platform

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2015 Scientific reports

45. Intravaginal Lactic Acid Bacteria Modulated Local and Systemic Immune Responses and Lowered the Incidence of Uterine Infections in Periparturient Dairy Cows (PubMed)

Intravaginal Lactic Acid Bacteria Modulated Local and Systemic Immune Responses and Lowered the Incidence of Uterine Infections in Periparturient Dairy Cows The objective of this investigation was to evaluate whether intravaginal infusion of a lactic acid bacteria (LAB) cocktail around parturition could influence the immune response, incidence rate of uterine infections, and the overall health status of periparturient dairy cows. One hundred pregnant Holstein dairy cows were assigned to 1 (...) of the 3 experimental groups as follows: 1) one dose of LAB on wk -2 and -1, and one dose of carrier (sterile skim milk) on wk +1 relative to the expected day of parturition (TRT1); 2) one dose of LAB on wk -2, -1, and +1 (TRT2), and 3) one dose of carrier on wk -2, -1, and +1 (CTR). The LAB were a lyophilized culture mixture composed of Lactobacillus sakei FUA3089, Pediococcus acidilactici FUA3138, and Pediococcus acidilactici FUA3140 with a cell count of 108-109 cfu/dose. Blood samples and vaginal

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2015 PloS one

46. Pharmacological Postconditioning with Lactic Acid and Hydrogen Rich Saline Alleviates Myocardial Reperfusion Injury in Rats (PubMed)

Pharmacological Postconditioning with Lactic Acid and Hydrogen Rich Saline Alleviates Myocardial Reperfusion Injury in Rats This study investigated whether pharmacological postconditioning with lactic acid and hydrogen rich saline can provide benefits similar to that of mechanical postconditioning. To our knowledge, this is the first therapeutic study to investigate the co-administration of lactic acid and hydrogen. SD rats were randomly divided into 6 groups: Sham, R/I, M-Post, Lac, Hyd (...) of myocardial injury and apoptotic index. Although the level of P-ERK in Lac + Hyd group was lower, P-p38/JNK, TNFα, Caspase-8, mitochondrial absorbance and Cyt-c were all similar in Lac + Hyd and M-Post groups. The Lac and Hyd groups were able to partially mimic this protective role. These data suggested that pharmacological postconditioning with lactic acid and hydrogen rich saline nearly replicates the benefits of mechanical postconditioning.

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2015 Scientific reports

47. Development of a Microfluidic-Based Optical Sensing Device for Label-Free Detection of Circulating Tumor Cells (CTCs) Through Their Lactic Acid Metabolism (PubMed)

Development of a Microfluidic-Based Optical Sensing Device for Label-Free Detection of Circulating Tumor Cells (CTCs) Through Their Lactic Acid Metabolism This study reports a microfluidic-based optical sensing device for label-free detection of circulating tumor cells (CTCs), a rare cell species in blood circulation. Based on the metabolic features of cancer cells, live CTCs can be quantified indirectly through their lactic acid production. Compared with the conventional schemes for CTC (...) detection, this label-free approach could prevent the biological bias due to the heterogeneity of the surface antigens on cancer cells. In this study, a microfluidic device was proposed to generate uniform water-in-oil cell-encapsulating micro-droplets, followed by the fluorescence-based optical detection of lactic acid produced within the micro-droplets. To test its feasibility to quantify cancer cells, experiments were carried out. Results showed that the detection signals were proportional

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2015 Sensors (Basel, Switzerland)

48. Ertugliflozin l-pyroglutamic acid / metformin hydrochloride (Segluromet) - Diabetes Mellitus, Type 2

Ertugliflozin l-pyroglutamic acid / metformin hydrochloride (Segluromet) - Diabetes Mellitus, Type 2 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 25 January 2018 EMA/86928/2018 Committee for Medicinal Products for Human Use (...) under the curve AUCinf area under the concentration-time curve from 0 to infinity AUClast area under the concentration –time curve from zero to time of last measurable concentration BCS biopharmaceutical classification system bid twice daily BMD bone mineral density BMI body mass index Broad pool pooled safety data from all seven ertugliflozin phase III studies BUN blood urea nitrogen CFU colony forming units CHMP Committee for Medicinal Products for Human use CI confidence interval cLDA constrained

2018 European Medicines Agency - EPARs

49. Blood Lactic Acid

Blood Lactic Acid Blood Lactic Acid Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Blood Lactic Acid Blood Lactic Acid Aka: Blood (...) for use in sick children (esp. , ) and their disposition Increased organ dysfunction in children with elevated Lactic Acid >4 mmol/L Predicted need for critical care in children with and pre-hospital elevated Lactic Acid >4 mmol/L Predicted in-hospital mortality for critically ill children VI. References (2013) Endo and Acid Base Disorders, EM Bootcamp, Las Vegas Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Blood Lactic Acid

2015 FP Notebook

50. A Randomized Double Blind Controlled Safety Trial Evaluating d-Lactic Acid Production in Healthy Infants Fed a Lactobacillus reuteri-containing Formula. (PubMed)

was collected before study formula intake and at all visits up to 112 days and blood at 14 days.d-Lactic acid concentration in the probiotic group was below the non-inferiority margin at 28 days: treatment effect -0.03 (95% confidence interval [CI]: [-0.48 to 0.41]) mmol/mol creatinine but was above the non-inferiority margin at 7 and 14 days-treatment effect 0.50 (95% CI: [0.05-0.96]) mmol/mol creatinine and 0.45 (95% CI: [0.00-0.90]) mmol/mol creatinine, respectively. Blood acid excess and pH (...) A Randomized Double Blind Controlled Safety Trial Evaluating d-Lactic Acid Production in Healthy Infants Fed a Lactobacillus reuteri-containing Formula. d-Lactic acidosis in infants fed lactic acid bacteria-containing products is a concern.The primary objective of this non-inferiority trial was to compare urinary d-lactic acid concentrations during the first 28 days of life in infants fed formula containing Lactobacillus reuteri (1.2 × 10(6) colony forming units (CFU)/ml) with those fed

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2014 Nutrition and metabolic insights

51. [The significance of lactic acid in early diagnosis and goal-directed therapy of septic shock patients]. (PubMed)

group was defined using blood lactic acid concentration < 2 mmol/L as treatment guide target. Control group was defined according to the traditional diagnostic criteria of shock which systolic blood pressure was less than 90 mmHg (1 mmHg= 0.133 kPa) or systolic blood pressure value fell > 40 mmHg baseline or oliguria ( < 0.5 ml. kg-1.h-1) et al traditional septic shock diagnosis criteria and bundle treatment was performed. Organ dysfunction index, the sequential organ failure score (SOFA), acute (...) that of control group [15.38% (4/26) vs. 16.13% ( 5/31), Χ2=0.000, P=1.000]. The 28-day mortality of lactic group was lower than that of control group [26.92 % (7/26) vs. 54.84% (17/31). Χ2=4.520, P=0.033].By blood lactic acid monitoring, inadequacy of organization perfusion i.e. septic shock can be found in the early stage, thus early intervention can be performed and improve resuscitation result and reduce the mortality of septic shock patients. Blood lactic acid ≥ 4 mmol/L can be used as one

2014 Zhonghua wei zhong bing ji jiu yi xue

52. PHYSIOLOGICAL DISTURBANCES DURING EXPERIMENTAL DIPHTHERITIC INTOXICATION. I. BLOOD SUGAR, LACTIC ACID AND NON-PROTEIN AND AMINO-ACID NITROGEN (PubMed)

PHYSIOLOGICAL DISTURBANCES DURING EXPERIMENTAL DIPHTHERITIC INTOXICATION. I. BLOOD SUGAR, LACTIC ACID AND NON-PROTEIN AND AMINO-ACID NITROGEN 16694162 2006 05 31 2018 11 13 0021-9738 12 5 1933 Sep The Journal of clinical investigation J. Clin. Invest. PHYSIOLOGICAL DISTURBANCES DURING EXPERIMENTAL DIPHTHERITIC INTOXICATION. I. BLOOD SUGAR, LACTIC ACID AND NON-PROTEIN AND AMINO-ACID NITROGEN. 767-78 Yannet H H Department of Pediatrics, Yale University School of Medicine, New Haven. Darrow D C DC

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1933 Journal of Clinical Investigation

53. Alterations in the lactic acid content of the blood as a result of light exercise, and associated changes in the co2-combining power of the blood and in the alveolar co2 pressure (PubMed)

Alterations in the lactic acid content of the blood as a result of light exercise, and associated changes in the co2-combining power of the blood and in the alveolar co2 pressure 16994099 2007 02 05 2018 11 13 0022-3751 69 2 1930 Apr 14 The Journal of physiology J. Physiol. (Lond.) Alterations in the lactic acid content of the blood as a result of light exercise, and associated changes in the co(2)-combining power of the blood and in the alveolar co(2) pressure. 214-37 Owles W H WH eng Journal

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1930 The Journal of physiology

54. Effects of auricular acupuncture on heart rate, oxygen consumption and blood lactic acid for elite basketball athletes. (PubMed)

Effects of auricular acupuncture on heart rate, oxygen consumption and blood lactic acid for elite basketball athletes. This study investigated the effects of auricular acupuncture on athletes' recovery abilities after exercise. Subjects were selected from twenty-four male elite university basketball players, randomly divided into two groups: auricular acupuncture group (AAG), and normal control group (NCG), each group containing twelve subjects. Auricular acupuncture was experimented to each (...) AAG athlete while no auricular acupuncture was conducted to each NCG athlete. Each subject in both groups performed a ride on the stationary bike until exhausted. The data of heart rate (HR(max)), oxygen consumption (VO(2 max)), and blood lactic acid were measured at four points of time: during the rest period after warm-ups and at the 5th, 30th and 60th minutes post-exercise, respectively. One-way ANOVA and repeated Scheffé methods were used to test the differences of the data between these two

2011 The American journal of Chinese medicine

55. Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis: A Case Report and Review of the Literature. (PubMed)

Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis: A Case Report and Review of the Literature. Propylene glycol (PG) is used as a solvent in numerous medications, including trimethoprim/sulfamethoxazole (TMP/SMX) and lorazepam, and is metabolized in the liver to lactic acid. Cases of lactic acidosis related to PG toxicity have been described and always involved large doses of benzodiazepines and PG. We present the first case of severe lactic acidosis after a 3-day course of TMP/SMX (...) alone, involving allegedly safe amounts of PG.A 31-year-old female with neurofibromatosis and pilocytic astrocytoma, receiving temozolomide and steroids, was admitted to the intensive care unit for pneumonia and acute respiratory failure requiring intubation. Her initial hemodynamic and acid-base statuses were normal. She was treated with intravenous TMP/SMX for possible Pneumocystis jirovecii pneumonia and was successfully extubated on day 2. On day 3, she developed tachypnea and arterial blood gas

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2016 Medicine

56. Lactic Acidosis: Current Treatments and Future Directions. (PubMed)

Lactic Acidosis: Current Treatments and Future Directions. Mortality rates associated with severe lactic acidosis (blood pH<7.2) due to sepsis or low-flow states are high. Eliminating the triggering conditions remains the most effective therapy. Although recommended by some, administration of sodium bicarbonate does not improve cardiovascular function or reduce mortality. This failure has been attributed to both reduction in serum calcium concentration and generation of excess carbon dioxide (...) of NHE1, a cell-membrane Na(+)/H(+) exchanger. In animal studies, selective NHE1 inhibitors improve cardiovascular function, ameliorate lactic acidosis, and reduce mortality, supporting future research into their possible use in humans. Two main mechanisms contribute to lactic acid accumulation in sepsis and low-flow states: tissue hypoxia and epinephrine-induced stimulation of aerobic glycolysis. Targeting these mechanisms could allow for more specific therapy. This Acid-Base and Electrolyte Teaching

2016 American Journal of Kidney Diseases

57. Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation

: saline saline Experimental: GIK group glucose-Insulin-Potassium(GIK) infusion Other: Insulin Other Name: glucose-Insulin-Potassium(GIK) infusion Outcome Measures Go to Primary Outcome Measures : degree of lactic acidosis [ Time Frame: up to 1 weeks ] Blood samples for arterial blood pH, PCO2 , PO2 , base excess, hematocrit, and plasma concentrations of lactic acid and Na were analyzed Other Outcome Measures: tracheal extubation [ Time Frame: up to 3 days ] The time of tracheal extubation (...) perioperative outcome in patients undergoing OLT. Condition or disease Intervention/treatment Phase Liver Transplantation Other: saline Other: Insulin Not Applicable Detailed Description: Intraoperative metabolic acidosis begins soon after graft reperfusion and persists for several days. The current standard treatment for severe acidosis during OLT is NaHCO3, although it may compromise myocardial performance, exacerbate lactic acid accumulation and cause central nervous system demyelination. Surgical

2016 Clinical Trials

58. ECHS1 Deficiency as a Cause of Severe Neonatal Lactic Acidosis (PubMed)

ECHS1 Deficiency as a Cause of Severe Neonatal Lactic Acidosis Mitochondrial short-chain enoyl-CoA hydratase deficiency (ECHS1D) is caused by mutations in ECHS1 (OMIM 602292) and is a recently identified inborn error of valine and fatty acid metabolism. This defect leads to secondary mitochondrial dysfunction. The majority of previously reported patients had the Leigh syndrome, with a median life expectancy of approximately 2 years. We report two siblings born 3 years apart with prenatal (...) findings including facial dysmorphia, oligohydramnios, intrauterine growth restriction, and premature delivery. They had severe lactic acidosis with onset within the first hours of life, had congenital dilated cardiomyopathy, and died at 16 h of life and 2 days of life, respectively.Biochemical evaluation of these patients showed elevated butyryl-carnitine in the blood and elevated methylmalonyl/succinyl-CoA and decreased hydroxybutyryl-CoA in frozen liver of patient 2, confirming abnormal short-chain

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2016 JIMD reports

59. Transient dilutional acidosis but no lactic acidosis upon cardiopulmonary bypass in patients undergoing coronary artery bypass grafting (PubMed)

Transient dilutional acidosis but no lactic acidosis upon cardiopulmonary bypass in patients undergoing coronary artery bypass grafting Dilutional acidosis may result from the introduction of a large fluid volume into the patients' systemic circulation, resulting in a considerable dilution of endogenous bicarbonate in the presence of a constant carbon dioxide partial pressure. Its significance or even existence, however, has been strongly questioned. Blood gas samples of patients operated (...) on with standard cardiopulmonary bypass (CPB) were analyzed in order to provide further evidence for the existence of dilutional acidosis.Between 07/2014 and 10/2014, a total of 25 consecutive patients scheduled for elective isolated coronary artery bypass grafting with CPB were enrolled in this prospective observational study. Blood gas samples taken regularly after CPB initiation were analyzed for dilutional effects and acid-base changes.After CPB initiation, hemoglobin concentration dropped from an average

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2016 Archives of medical science : AMS

60. ON THE BLOOD LACTIC ACID RESPONSE TO MEASURED EXERCISE IN HYPOXIC HUMAN SUBJECTS (PubMed)

ON THE BLOOD LACTIC ACID RESPONSE TO MEASURED EXERCISE IN HYPOXIC HUMAN SUBJECTS 16695540 2006 05 31 2008 11 20 0021-9738 27 2 1948 Mar The Journal of clinical investigation J. Clin. Invest. ON THE BLOOD LACTIC ACID RESPONSE TO MEASURED EXERCISE IN HYPOXIC HUMAN SUBJECTS. 176-86 Tepperman J J Yale Aeromedical Unit, Department of Physiology, Yale University School of Medicine, New Haven. Tepperman H M HM Patton B W BW eng Journal Article United States J Clin Invest 7802877 0021-9738 1948 3 1 0 0

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1948 Journal of Clinical Investigation

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