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Blood Lactic Acid

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181. [Rational control on postoperative blood glucose levels in infants with congenital heart disease]. (PubMed)

injection would be intravenously administrated when blood glucose levels up to 8.3, 15.0, and 18.0 mmol/L in group A, B, and C, respectively. Blood white blood count (WBC), C-reactive protein (CRP), lactic acid, alanine aminotransferase (ALT), creatinine (Cr), incidence of pulmonary infection, the length of intensive care unit (ICU) stay, incidence of hypoglycemia and mortality were compared at 72 hours after operation among three groups.WBC [×10(9)/L], CRP (mg/L) and incidence of pulmonary infection (...) A and group C. Incidence of hypoglycemia in group A was significantly higher than that in group B and group C (20.0% vs. 2.6%, 3.4%, both P < 0.05), but there was no statistical difference between group B and group C. There were no statistical differences in lactic acid (mmol/L), Cr (μmol/L) and the length of ICU stay (days) among group A, B, and C (lactic acid: 2.1 ± 0.8, 2.3 ± 0.5, 2.2 ± 0.7; Cr: 55.1 ± 13.4, 49.4 ± 15.7, 57.3 ± 11.6; the length of ICU stay: 3.5 ± 1.8, 3.2 ± 1.1, 3.6 ± 1.6, all P>0.05

2013 Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue

182. Effect of Total Mixed Ration with Fermented Feed on Ruminal In vitro Fermentation, Growth Performance and Blood Characteristics of Hanwoo Steers (Full text)

the T3 (p<0.05) from 3 h to 12 h, but insignificant (p>0.05) at 24 and 48 h. None of the specific VFAs were affected except for acetic and non volatile lactic acids, which were produced more in T2 than in T1 and T3 at 24 h and 48 h of incubation. A/P was lower in T1 and T2 than inT3 at 24 h (p<0.05) and 48 h (p>0.05) of incubation. These results confirmed that TMRF-related treatment shows a superior performance to that of TMR during the ruminal fermentation period. In experiment 2, the three diets (...) Effect of Total Mixed Ration with Fermented Feed on Ruminal In vitro Fermentation, Growth Performance and Blood Characteristics of Hanwoo Steers In this study, two experiments were conducted to evaluate the total mixed ration with fermented feed (TMRF) and total mixed ration (TMR) by rumen in vitro fermentation and their effects on the growth performance and blood characteristics of Hanwoo steers. In experiment 1, three Hanwoo steers (600±47 kg), each permanently fitted with a ruminal cannula

2012 Asian-Australasian journal of animal sciences PubMed

183. [Rational control on postoperative blood glucose levels in infants with congenital heart disease].

injection would be intravenously administrated when blood glucose levels up to 8.3, 15.0, and 18.0 mmol/L in group A, B, and C, respectively. Blood white blood count (WBC), C-reactive protein (CRP), lactic acid, alanine aminotransferase (ALT), creatinine (Cr), incidence of pulmonary infection, the length of intensive care unit (ICU) stay, incidence of hypoglycemia and mortality were compared at 72 hours after operation among three groups.WBC [×10(9)/L], CRP (mg/L) and incidence of pulmonary infection (...) A and group C. Incidence of hypoglycemia in group A was significantly higher than that in group B and group C (20.0% vs. 2.6%, 3.4%, both P < 0.05), but there was no statistical difference between group B and group C. There were no statistical differences in lactic acid (mmol/L), Cr (μmol/L) and the length of ICU stay (days) among group A, B, and C (lactic acid: 2.1 ± 0.8, 2.3 ± 0.5, 2.2 ± 0.7; Cr: 55.1 ± 13.4, 49.4 ± 15.7, 57.3 ± 11.6; the length of ICU stay: 3.5 ± 1.8, 3.2 ± 1.1, 3.6 ± 1.6, all P>0.05

2012 Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue

184. Cerebrovascular protection of β-asarone in Alzheimer's disease rats: A behavioral, cerebral blood flow, biochemical and genic study. (PubMed)

. At the end of this period all rats were sacrificed, lactic acid, pyruvic acid content, Na+K+ATPase activity were determined in brain tissue homogenate to estimate the brain biochemical changes and mRNA expression of ET-1, eNOS and APP was measured with real-time RT-PCR method.The spatial navigation task latencies, the times through platform zone and the time for the first through platform zone in the target quadrant in probe task, rCBF of right parietal lobe, the contents of lactic acid, pyruvic acid (...) Cerebrovascular protection of β-asarone in Alzheimer's disease rats: A behavioral, cerebral blood flow, biochemical and genic study. Recent studies have suggested that β-asarone have neuroprotective and cardiovascular protective effects in animal model. However, the influence of β-asarone on cerebrovascular system has not been explored so far. Therefore, present study was designed to determine whether repeated exposures to β-asarone resulted in positive effects on cerebrovascular function in AD

2012 Journal of Ethnopharmacology

185. Mild hypothermia therapy reduces blood glucose and lactate and improves neurologic outcomes in patients with severe traumatic brain injury. (PubMed)

of hypothermia group was maintained at 32.7°C for 72 hours. Arterial blood glucose and lactic acid were determined before and after hypothermia therapy. Glasgow Outcome Scale (GOS) score was assessed 3 months after the treatment.The mean glucose (7.04 ± 0.51 vs 9.71 ± 1.63 mmol/L, P < .05) in the hypothermia group was lower than in the normothermia group after hypothermia therapy. There were more patients with good neurologic function (GOS 4-5) in the hypothermia group than in the normothermia group (75.0 (...) Mild hypothermia therapy reduces blood glucose and lactate and improves neurologic outcomes in patients with severe traumatic brain injury. The study aimed to investigate the association between blood glucose or lactate and the outcomes of severe traumatic brain injury (TBI), and to evaluate the effect of mild hypothermia therapy on glucose and lactate levels.Eighty-one patients with TBI were randomly divided into normothermia (n = 41) and mild hypothermia (n = 40) group. Body temperature

2011 Journal of critical care

186. Acute physiological effects of packed red blood cell transfusion in preterm infants with different degrees of anaemia. (Full text)

with birth weights 500-1300 g, who were enrolled in a clinical trial comparing high ('liberal') and low ('restrictive') haematocrit thresholds for transfusion. Measurements were performed before and after a packed RBC transfusion of 15 ml/kg, which was administered because the infant's haematocrit had fallen below the threshold defined by study protocol. Haemoglobin, haematocrit, RBC count, reticulocyte count, lactic acid and erythropoietin were measured before and after transfusion using standard (...) methods. Cardiac output was measured by echocardiography. Oxygen consumption was determined using indirect calorimetry. Systemic oxygen transport and fractional oxygen extraction were calculated.Systemic oxygen transport rose in both groups following transfusion. Lactic acid was lower after transfusion in both groups. Oxygen consumption did not change significantly in either group. Cardiac output and fractional oxygen extraction fell after transfusion in the low haematocrit group only.These study's

2011 Archives of disease in childhood. Fetal and neonatal edition PubMed

187. Pediatric Sports-Related Concussion Produces Cerebral Blood Flow Alterations. (Full text)

and control groups, resolving by 14 days for total symptom score and 30 days for reaction time. No evidence of structural injury was found on qualitative review of MRI. No decreases in neuronal metabolite N-acetyl aspartate or elevation of lactic acid were detected by proton magnetic resonance spectroscopy. Statistically significant alterations in CBF were documented in the SRC group, with reduction in CBF predominating (38 vs 48 mL/100 g per minute; P = .027). Improvement toward control values occurred (...) Pediatric Sports-Related Concussion Produces Cerebral Blood Flow Alterations. The pathophysiology of sports-related concussion (SRC) is incompletely understood. Human adult and experimental animal investigations have revealed structural axonal injuries, decreases in the neuronal metabolite N-acetyl aspartate, and reduced cerebral blood flow (CBF) after SRC and minor traumatic brain injury. The authors of this investigation explore these possibilities after pediatric SRC.Twelve children, ages 11

2011 Pediatrics PubMed

188. The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier. (Full text)

The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier. Danshensu (3-(3, 4-dihydroxyphenyl) lactic acid), a water-soluble active component isolated from the root of Salvia miltiorrhiza Bunge, is widely used for the treatment of cerebrovascular diseases. The present study aims to investigate the role of P-glycoprotein in transport of Danshensu across the blood-brain barrier. Sprague-Dawley rats were pretreated with verapamil at a dose of 20 mg kg(-1) (verapamil group (...) ) or the same volume of normal saline (control group). Ninety minutes later, the animals were administrated with Danshensu (15 mg kg(-1)) by intravenous injection. At 15 min, 30 min, and 60 min after Danshensu administration, the levels of Danshensu in the blood and brain were detected by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The results showed that Danshensu concentrations in the brain of the rats pretreated with verapamil were significantly

2011 Evidence-based Complementary and Alternative Medicine (eCAM) PubMed

189. Validation of short-term handling and storage conditions for marrow and peripheral blood stem cell products. (PubMed)

-two-hour storage of BM, PBSC, and PBMNC products at refrigerated temperature maintains optimal cell viability and recovery. Anticoagulation with ACD-A is preferred over heparin to reduce lactic acid accumulation in the product media.© 2010 American Association of Blood Banks. (...) have not been well described.Five bone marrow (BM), four filgrastim-mobilized peripheral blood stem cell (PBSC), and four nonmobilized peripheral blood mononuclear cell (PBMNC) products were collected from healthy volunteer donors and stored at 4 or 20°C for up to 72 hours in 10% PlasmaLyte A plus anticoagulants such as 10% acid citrate dextran-A (ACD-A) and/or 10 IU/mL heparin. Products were evaluated at 0, 24, 48, and 72 hours for cellular content, viability, and metabolic activities.BM products

2011 Transfusion

190. Serum Electrolyte, Acid-Base Balance, and Enzyme Changes in Acute Halogeton Glomeratus Poisoning in Sheep (Full text)

was not observed. Blood pH, pCO(2) and pO(2) measurements demonstrated that alkalosis did not develop. Serum glutamic pyruvic transaminase, serum glutamic oxalacetic transaminase, and lactic dehydrogenase all increased. Succinic dehydrogenase was inhibited in the rumen wall but not in other tissues according to the methods used. This finding, as well as other work cited, indicates a possible interference with carbohydrate metabolism. (...) Serum Electrolyte, Acid-Base Balance, and Enzyme Changes in Acute Halogeton Glomeratus Poisoning in Sheep Fourteen sheep were used on an acute halogeton toxicity feeding experiment. Seven sheep were fed a lethal dose of Halogeton glomeratus, an oxalate-producing plant, 7 served as controls. Various serum and tissue electrolytes and enzymes were measured. Sesum calcium decreased while magnesium and phosphorus increased. Although a severe hypocalcemia resulted from the feeding of halogeton tetany

1968 Canadian Journal of Comparative Medicine PubMed

191. Acid-base Balance in Acute Gastrointestinal Bleeding (Full text)

shocked. These effects of blood transfusion are probably due to the fact that red blood cells in stored bank blood, with added acid-citrate-dextrose solution, metabolize the dextrose anaerobically to lactic acid. Monitoring of acid-base balance is recommended in patients with acute gastrointestinal bleeding who are clinically shocked. A metabolic acidosis can then be corrected with intravenous sodium bicarbonate. (...) Acid-base Balance in Acute Gastrointestinal Bleeding Acid-base balance has been studied in 21 patients with acute upper gastrointestinal bleeding. A low plasma bicarbonate concentration was found in nine patients, accompanied in each case by a base deficit of more than 3 mEq/litre, indicating a metabolic acidosis. Three patients had a low blood pH. Hyperlactataemia appeared to be a major cause of the acidosis. This was not accompanied by a raised blood pyruvate concentration

1971 British medical journal PubMed

192. Aromatic acids derived from phenylalanine in the tissues of rats with experimentally induced phenylketonuria-like characteristics (Full text)

) in 23-day-old rats, the phenyl-lactate concentration was 2.2mug/g in the liver and 0.43mug/g in the brain, and the concentration of o-hydroxyphenylacetate was 0.26mug/g in the liver. 3. Phenylacetate concentrations in brain and liver were 0.26 and 0.14mug/g respectively. 4. Suckling rats produced phenyl-lactate less rapidly than weanling rats, but accumulated higher concentrations in longer-term experiments. 5. Intraperitoneal injections of phenyl-lactic acid showed that this compound could directly (...) penetrate the blood-brain barrier, and could produce similar brain/liver ratios of phenyllactate to those found after phenylalanine injection. 6. Qualitative and quantitative similarities in urinary excretion of aromatic acids between the rats used in this study and human patients with uncontrolled phenylketonuria indicate that a patient with a circulating phenylalanine concentration of the order of those achieved in the experimental animal may have aromatic acid concentrations in brain and liver

1972 Biochemical Journal PubMed

193. Acid-base and metabolic disturbances in fulminant hepatic failure. (Full text)

Acid-base and metabolic disturbances in fulminant hepatic failure. In 28 patients with fulminant hepatic failure alkalaemia was present in 49 of a total of 65 observations. Alkalaemia was due primarlily to a low Pa, C02 in 30 instances and to raised plasma bicarbonate in 16 instances. Blood lactate, pyruvate, and acetoacetate were significantly raised, and in individual cases, blood citrate, succinate, and fumarate were elevated. Blood citrate rose progressively as the clinical condition (...) worsened. Metabolic acidosis was only present in four patients. In three of these patients, all of whom had taken an overdose of paracetamol, the acidosis was severe, present before the onset of clinical heparic failure, and associated with hypoglycaemiaand mild hypotension. In two of these patients the acidosis was shown to be due to accumulation of lactic acid. Plasma free fatty acid concentrations were elevated out of proportion to the degree of ketosis.

1975 Gut PubMed

194. Growth hormone secretion in acid-base alterations at rest and during exercise. (PubMed)

Growth hormone secretion in acid-base alterations at rest and during exercise. 1. Seven healthy males were studied during cycle ergometer exercise at 33%, 66% and 90% of VO2 max. on three occasions when NH4C1, NaHCO3 or CaCO3 (as a control substance) were administered in gelatin capsules double blind and in randomized order. Plasma growth hormone (HGH), lactic acid and hydrogen ion concentration ([H+]) were measured at frequent intervals. 2. Ammonium chloride produced highest blood [H (...) +] and NaHCO3 the lowest. These differences were maintained during exercise and in recovery. Plasma lactic acid concentrations were similar at rest. At 66%, 90% VO2 max. and recovery lactic acid was highest with NaHCO3 and lowest with NH4C1. 3. Exercise stimulated HGH secretion in all studies and the elevation was proportional to the intensity of the exercise. NH4C1 caused a variable elevation of HGH at rest and 33% VO2 max. At 66% VO2 max., plasma HGH was significantly elevated to similar concentrations

1976 Clinical science and molecular medicine

195. THE ISOLATION AND SELECTED PROPERTIES OF BLOOD MONOCYTES (Full text)

granules of the centrosphere. The phase-dense granules are osmiophilic and acid phosphatase positive. Quantitative biochemical analysis during cultivation have revealed increased levels of cytochrome oxidase, acid phosphatase, arylsulfatase, and BPN hydrolase. In addition, glucose utilization and lactic acid production are stimulated under the same conditions. The uptake of both bacteria and colloidal gold is stimulated during in vitro cultivation. The phagocytic activity of cultured monocytes may (...) THE ISOLATION AND SELECTED PROPERTIES OF BLOOD MONOCYTES A technique is described for the quantitative recovery of monocytes from horse blood by means of flotation on dense albumin solutions. Monocytes are concentrated in a surface pellicle along with a few lymphocytes which are then removed when the monocytes adhere to a glass surface. The in vitro cultivation of homogeneous populations of monocytes results in an increase in (a) cell size, (b) number of mitochondria, and (c) phase-dense

1966 The Journal of experimental medicine PubMed

196. Daily changes in the blood composition of conscious pigs with catheters in foetal and uterine vessels during late gestation (Full text)

Daily changes in the blood composition of conscious pigs with catheters in foetal and uterine vessels during late gestation 1. Catheters were inserted into the foetal carotid artery and maternal middle uterine artery and vein in twenty foetuses from fifteen sows, 91-105 days pregnant. Blood samples were collected from foetal and maternal circulations for periods of 7-21 days after surgery.2. Blood gas tensions, pH, packed cell volume (PCV) and the levels of glucose, fructose and lactic acid (...) in conscious pigs were followed in foetal and maternal bloods during late pregnancy.3. Foetal blood gas tensions, pH, PCV, lactic acid and glucose levels did not change markedly during the last 20-25 days of gestation. Blood fructose concentration fell during this period with the greatest change occurring after 100 days gestation. Foetal and maternal blood pH values were higher than those reported in the sheep, cow, mare and rhesus monkey.4. Small changes in P(CO2) and pH in foetal carotid blood were

1977 The Journal of physiology PubMed

197. Cytochemical studies of cell population in peripheral blood smears of two West African teleosts. (Full text)

Cytochemical studies of cell population in peripheral blood smears of two West African teleosts. The peripheral blood cells of two West African teleosts were examined for lipids, glycogen, desoxyribonucleic acid, succinic, lactic and glucose-6-phosphate dehydrogenases as well as DPNH- and TPNH-diaphorases, using cytochemical staining techniques. Our results suggest that both erythrocytes and thrombocytes as well as leucocytes are highly active metabolically, as indicated by strong reactions (...) for LDH, glucose-6-phosphate dehydrogenase, DPNH- and TPNH-diaphorases. There is no evidence for the Krebs' cycle in any of the blood cells, The nuclei of erythrocytes and thrombocytes appear to be sites of activity of 'mitochondrial' type.

1979 Journal of anatomy PubMed

198. BLOOD LACTATE RESPONSE DURING MODERATE EXERCISE IN NEUROCIRCULATORY ASTHENIA, ANXIETY NEUROSIS, OR EFFORT SYNDROME (Full text)

Journal Article United States J Clin Invest 7802877 0021-9738 33X04XA5AT Lactic Acid OM Anxiety Blood Lactic Acid Neurocirculatory Asthenia 4713:918l BLOOD/lactic acid NEUROCIRCULATORY ASTHENIA 1947 3 1 0 0 1947 3 1 0 1 1947 3 1 0 0 ppublish 16695423 10.1172/JCI101814 PMC435675 (...) BLOOD LACTATE RESPONSE DURING MODERATE EXERCISE IN NEUROCIRCULATORY ASTHENIA, ANXIETY NEUROSIS, OR EFFORT SYNDROME 16695423 2006 05 31 2018 12 01 0021-9738 26 2 1947 Mar The Journal of clinical investigation J. Clin. Invest. BLOOD LACTATE RESPONSE DURING MODERATE EXERCISE IN NEUROCIRCULATORY ASTHENIA, ANXIETY NEUROSIS, OR EFFORT SYNDROME. 339-42 Cohen M E ME Medical and Psychiatric Clinics and Cardiac Research Laboratory of the Massachusetts General Hospital. Consolazio F F Johnson R E RE eng

1947 Journal of Clinical Investigation PubMed

199. A STUDY IN MAN OF CEREBRAL BLOOD FLOW AND CEREBRAL GLUCOSE, LACTATE AND PYRUVATE METABOLISM BEFORE AND AFTER EATING (Full text)

0 Pyruvates 33X04XA5AT Lactic Acid 8558G7RUTR Pyruvic Acid IY9XDZ35W2 Glucose OM Brain blood supply Cerebrovascular Circulation Glucose metabolism Humans Hunger physiology Lactates metabolism Lactic Acid Male Pyruvates metabolism Pyruvic Acid BRAIN/blood supply GLUCOSE/metabolism HUNGER/physiology LACTATES/metabolism PYRUVATES/metabolism 1959 12 1 1959 12 1 0 1 1959 12 1 0 0 ppublish 14439685 10.1172/JCI103994 PMC293306 J Clin Invest. 1956 Sep;35(9):954-63 13367191 Biochem J. 1956 Sep;64(1):145 (...) A STUDY IN MAN OF CEREBRAL BLOOD FLOW AND CEREBRAL GLUCOSE, LACTATE AND PYRUVATE METABOLISM BEFORE AND AFTER EATING 14439685 1998 11 01 2018 12 01 0021-9738 38 1959 Dec The Journal of clinical investigation J. Clin. Invest. A study in man of cerebral blood flow and cerebral glucose, lactate and pyruvate metabolism before and after eating. 2154-8 ROWE G G GG MAXWELL G M GM CASTILLO C A CA FREEMAN D J DJ CRUMPTON C W CW eng Journal Article United States J Clin Invest 7802877 0021-9738 0 Lactates

1959 Journal of Clinical Investigation PubMed

200. Changes in Glucose and Lactate Content of Ascites Fluid and Blood Plasma During Growth and Decay of the ELD Ascites Tumour (Full text)

Changes in Glucose and Lactate Content of Ascites Fluid and Blood Plasma During Growth and Decay of the ELD Ascites Tumour 13874818 1998 11 01 2018 12 01 0007-0920 16 1962 Jun British journal of cancer Br. J. Cancer Changes in glucose and lactate content of ascites fluid and blood plasma during growth and decay of the ELD ascites tumour. 298-305 BURGESS E A EA SYLVEN B B eng Journal Article England Br J Cancer 0370635 0007-0920 0 Lactates 33X04XA5AT Lactic Acid IY9XDZ35W2 Glucose OM Ascites (...) Ascitic Fluid Glucose chemistry Humans Lactates chemistry Lactic Acid Neoplasms chemistry Plasma GLUCOSE/chemistry LACTATES/chemistry NEOPLASMS/chemistry 1962 6 1 1962 6 1 0 1 1962 6 1 0 0 ppublish 13874818 PMC2070941 J Natl Cancer Inst. 1954 Oct;15(2):253-73 13233882 Nature. 1957 Jul 20;180(4577):131-2 13451663 Cancer Res. 1960 Jul;20:831-6 13836188 J Histochem Cytochem. 1954 Jul;2(4):282-90 13174791 Cancer Res. 1953 Jul;13(7:1):537-41 13067073 Proc Soc Exp Biol Med. 1953 Jul;83(3):520-4 13088894 J

1962 British journal of cancer PubMed

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