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Blood Collection Tube

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81. Diagnostic accuracy of ESAT-6 free IGRA compared to QuantiFERON-TB Gold In-tube. Full Text available with Trip Pro

in comparison to QuantiFERON-TB Gold In-Tube (QFT).Participants with different levels of M.tb exposure and TB disease were enrolled to determine the ESAT-6 free IGRA cut-off, to test assay performance in independent cohorts compared to standard QFT and to perform a technical qualification of antigen-coated blood collection tubes.ESAT-6 free IGRA antigen recognition was evaluated in South African adolescents with positive and negative QFT status. The ESAT-6 free IGRA cut-off was established at 0.61 IU/mL (...) , based on ROC analysis in M.tb-unexposed controls and microbiologically-confirmed pulmonary TB patients. In an independent cohort of healthy South African adolescents, levels of IFN released in QFT and ESAT-6 free IGRA were highly correlated (p<0.0001, r=0.83) and yielded comparable positivity rates: 41.5% and 43.5% respectively, with 91% concordance between the tests (kappa = 0.82, 95% CI: 0.74-0.90; McNemar's p=0.48). ESAT-6 free IGRA blood collection tubes had acceptable lot-to-lot variability

2019 Clinical Infectious Diseases

82. Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age. (Abstract)

Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age. Folic acid (400 μg/d) taken during the periconceptional period reduces neural tube defect (NTD) risk by >75%. Achieving red cell folate (RCF) or plasma folate (PF) >905 nmol/L and >35 nmol/L, respectively, has been associated with a low risk of NTDs. We determined whether daily consumption of folic acid fortified milk increases blood (...) folate concentrations to levels associated with a low risk of NTDs in Singaporean women of childbearing age.In this double-blind placebo-controlled trial, 70 non-pregnant women (21-35 y) were randomly assigned to receive fortified milk (FM) powder providing 400 μg folic acid per day or unfortified placebo milk (PM) powder for 12 weeks. Blood samples were collected at baseline and at 6 and 12 weeks.At 12 weeks, mean (95% CI) RCF and PF concentrations were 376 (240, 512) and 39 (26, 51) nmol/L higher

2016 Asia Pacific journal of clinical nutrition Controlled trial quality: predicted high

83. Red Blood Cell Folate Insufficiency among Nonpregnant Women of Childbearing Age in Guatemala 2009 to 2010: Prevalence and Predicted Neural Tube Defects Risk Full Text available with Trip Pro

Red Blood Cell Folate Insufficiency among Nonpregnant Women of Childbearing Age in Guatemala 2009 to 2010: Prevalence and Predicted Neural Tube Defects Risk The World Health Organization recently released recommendations stating that red blood cell (RBC) folate concentrations should be above 400 ng/L (906 nmol/L) for optimal prevention of folate-sensitive neural tube defects (NTDs). The objective of this study was to determine the distribution of folate insufficiency (FI) (<906 nmol/L (...) ) and potential risk of NTDs based on RBC folate concentrations among nonpregnant women of child-bearing age in Guatemala.A national and regional multistage cluster probability survey was completed during 2009 to 2010 among Guatemalan women of child-bearing age 15 to 49 years of age. Demographic and health information and blood samples for RBC folate analyses were collected from 1473 women. Prevalence rate ratios of FI and predicted NTD prevalence were estimated based on RBC folate concentrations comparing

2016 Birth defects research. Part A, Clinical and molecular teratology

84. Comparison of blood RNA isolation methods from samples stabilized in Tempus tubes and stored at a large human biobank Full Text available with Trip Pro

Comparison of blood RNA isolation methods from samples stabilized in Tempus tubes and stored at a large human biobank More than 50,000 adult and cord blood samples were collected in Tempus tubes and stored at the Norwegian Institute of Public Health Biobank for future use. In this study, we systematically evaluated and compared five blood-RNA isolation protocols: three blood-RNA isolation protocols optimized for simultaneous isolation of all blood-RNA species (MagMAX RNA Isolation Kit, both (...) manual and semi-automated protocols; and Norgen Preserved Blood RNA kit I); and two protocols optimized for large RNAs only (Tempus Spin RNA, and Tempus 6-port isolation kit). We estimated the following parameters: RNA quality, RNA yield, processing time, cost per sample, and RNA transcript stability of six selected mRNAs and 13 miRNAs using real-time qPCR.Whole blood samples from adults (n = 59 tubes) and umbilical cord blood (n = 18 tubes) samples collected in Tempus tubes were analyzed. High

2016 BMC research notes

85. The Chinese Children and Families Cohort Study: The Nutrition, Physical Activity, and Ultraviolet Radiation Data Collection Full Text available with Trip Pro

The Chinese Children and Families Cohort Study: The Nutrition, Physical Activity, and Ultraviolet Radiation Data Collection This article reports the study design, methodological issues and early results of a pilot study testing methods for collecting nutrition, physical activity, and ultraviolet (UV) radiation exposure data in a groundbreaking study in China. Epidemiological studies suggest that exposures across the entire life course, including in utero, early childhood, and adolescence, may (...) be important in the etiology of adult cancers and other chronic diseases. The Chinese Children and Families Cohort Study intends to follow-up subjects from the 1993 to 1995 Community Intervention Program of folic acid supplementation for the prevention of neural tube defects. This cohort is unique in that only folic acid exposure during pregnancy varies between groups as other supplements were not available, and there were nutrient deficiencies in the populations. Prior to launching a large-scale follow-up

2018 Nutrition today

86. RNase H2-Dependent Polymerase Chain Reaction and Elimination of Confounders in Sample Collection, Storage, and Analysis Strengthen Evidence That microRNAs in Bovine Milk Are Bioavailable in Humans. Full Text available with Trip Pro

participants before and 6 h after consumption of 1.0 L of 1%-fat bovine milk.The use of heparin tubes for blood collection resulted in a complete loss of miRs. Circadian variations did not affect the concentrations of 8 select miRs. Erythrocyte hemolysis caused artifacts for some miRs if plasma absorbance at 414 nm was >0.300. The stability of plasma miRs depended greatly on the matrix in which the miRs were stored and whether the plasma was frozen before analysis. Purified miR-16, miR-200c, and cel-miR-39 (...) were to assess potential confounders of plasma miR analysis and to detect miRs from bovine milk in human plasma.Potential confounders of plasma miR analysis (circadian rhythm, sample collection and storage, calibration, and erythrocyte hemolysis) were assessed by quantitative reverse transcriptase polymerase chain reaction (PCR) by using blood from healthy adults (7 men, 6 women; aged 23-57 y). Bovine miRs were analyzed by RNase H2-dependent PCR (rhPCR) in plasma collected from a subcohort of 11

2018 Journal of Nutrition

87. Sample collection and sample handling errors submitted to the transfusion error surveillance system, 2006 to 2015. (Abstract)

information regarding institutional policies. Samples received in the blood bank were used to calculate rates. "Wrong blood in tube" (WBIT) errors are blood taken from wrong patient and labeled with intended patient's information, or blood taken from intended patient but labeled with another patient's information.A total of 42,363 SC and 14,666 SH errors were reported. Predefined low-severity (low potential for harm) and high-severity errors (potential for fatal outcomes) increased from 2006 to 2015 (low (...) Sample collection and sample handling errors submitted to the transfusion error surveillance system, 2006 to 2015. In Canada, transfusion-related errors are voluntarily reported to a tracking system with the goal to systematically improve transfusion safety. This report provides an analysis of sample collection (SC) and sample handling (SH) errors from this national error-tracking system.Errors from 2006 to 2015 from 23 participating sites were extracted. A survey was conducted to obtain

2018 Transfusion

88. Sample Collection From Healthy Volunteers for Assay Optimization

, participants will be asked to give one or more of these samples: Blood will be drawn from an arm vein with a needle and syringe. Mucus and skin will be collected by rubbing the area with a cotton swab. The areas may include the top of the tongue, inside the cheek, nostrils, behind the ear, elbow pit, or vagina. Participants will spit into a tube to collect saliva. Participants will pass stool into a plastic container that fits in the toilet under the seat. They will get sampling kits and instructions. Over (...) samples like blood and cells. In order to do its work, LISB needs to have a lot of these samples available. Objective: To collect biological specimens to use for designing and improving research tests. Specimens include blood, stool, saliva, and skin/mucosal swabs. Eligibility: Healthy people ages 18-80 Design: Participants will be screened with an interview about their general health and their medical history. They will have a physical exam and blood tests. If the results of the screening are normal

2018 Clinical Trials

89. Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients Full Text available with Trip Pro

of the delay in processing, storage temperatures, different blood collection tubes, centrifugation protocols, and sample shipment on cfDNA levels. Peripheral blood (n = 231) from cancer patients (n = 62) were collected into K3EDTA or Cell-free DNA BCT tubes and analyzed by digital PCR, targeted amplicon, or shallow whole-genome sequencing. To assess pre-analytic effects, plasma was processed under different conditions after 0, 6, 24, 48, 96 hours, and 1 week at room temperature or 4°C, or using different (...) Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients Circulating tumor DNA (ctDNA) offers new opportunities for noninvasive cancer management. Detecting ctDNA in plasma is challenging because it constitutes only a minor fraction of the total cell-free DNA (cfDNA). Pre-analytical factors affect cfDNA levels contributed from leukocyte lysis, hence the ability to detect low-frequency mutant alleles. This study investigates the effects

2018 The Journal of molecular diagnostics : JMD

90. Collection of cell-free DNA for genomic analysis of solid tumors in a clinical laboratory setting. Full Text available with Trip Pro

different cancer types. We verify that the distribution and DNA sequences of fragmentation sites in cfDNA from both normal-germline and tumor-derived cfDNA are non-random. A broad survey of cfDNA from healthy donors suggests that average individuals possess ~6 ng of cfDNA per mL of plasma. Importantly, the cfDNA present in plasma samples that were initially collected as whole blood in K2-EDTA tubes and subsequently processed by centrifugation is stable for several days at ambient temperatures (...) Collection of cell-free DNA for genomic analysis of solid tumors in a clinical laboratory setting. The breadth of diagnostic procedures that utilize cell free DNA (cfDNA) from human plasma has increased dramatically in recent years. Here, we confirm that tumor-derived cfDNA fragments are similar in size distribution to cfDNA derived from normal tissues. Therefore, collection procedures optimized with healthy donor specimens are likely to be applicable to the diagnosis and monitoring of many

2017 PLoS ONE

91. Jehovah's Witnesses and patients who refuse blood

normovolaemic haemodilution [23]; blood is siphoned off by gravity into a collection bag containing anticoagulant, and replaced with crystalloid or colloid solution; if crystalloid is used it is likely that a larger volume will need to be administered than the volume of blood withdrawn in order to maintain normovolaemia. Surgicalbloodloss,therefore,hasalowerhaematocritand theblood removedfrom thepatient is re-infused during or attheendofsurgery.Localpolicyandguidelinesshouldbe (...) considered according to the individual clinical situation [29]. The volume of blood samples should be minimised by using paediatric sampling tubes if possible, and point-of-care testingshouldbeavailable. Following surgical procedures that employed a tourniquet intra-operatively there may be excessive blood lossafteritsreleasethatmaycontinueintothepostoperative period. In these situations, postoperative CS can be employed. In case of bleeding, a postoperative dose of intravenoustranexamicacid(1 g

2018 Association of Anaesthetists of GB and Ireland

92. Association of Anaesthetists guidelines: cell salvage for peri-operative blood conservation 2018 Full Text available with Trip Pro

objection to receiving an allogeneic transfusion. If there is doubt about expected blood loss, then we recommend that the most cost effective measure is to set up only the suction and anticoagulation tubing and reservoir of the CS device (so‐called ‘collect only’). The blood processing system is then set up during surgery only if enough blood has been collected for processing to be worthwhile, usually more than 500 ml . Cell salvage is commonly used during the following types of surgery: cardiac; major (...) that reduces the requirement for and amount of allogeneic blood transfusion and maintains postoperative haemoglobin concentration. Cell salvage is a method of autologous blood transfusion. It involves the collection of shed blood during and immediately after surgery, which is re‐infused back to the same patient. Intra‐operative CS usually involves the use of a device which processes shed blood; however, postoperatively, unwashed filtered blood can be re‐infused under certain circumstances. Currently, NICE

2018 Association of Anaesthetists of GB and Ireland

93. Carglumic acid (Ucedane) - hyperammonaemia (high blood levels of ammonia) in patients with N?acetylglutamate synthase (NAGS) deficiency

on the % Difference between the repeat analysis result and the mean of the two results. Long term stability of carglumic acid in biological matrix at -70°C was proven for a period that spanned the time from the first study sample collection to the completion of study sample analysis. Pharmacokinetic variables Blood samples for the determination of carglumic acid in plasma were obtained at pre-determined time points up to 48 hours post-dose in each treatment period. The plasma concentration-time data were used (...) Carglumic acid (Ucedane) - hyperammonaemia (high blood levels of ammonia) in patients with N?acetylglutamate synthase (NAGS) deficiency 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 21 April 2017 EMA/CHMP/404487/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment report Ucedane International non-proprietary

2017 European Medicines Agency - EPARs

94. Endotracheal Tube Placement Using Totaltrack Video Laryngeal Mask Use Versus Macintosh Laryngoscope in Low Risk Patients

Endotracheal Tube Placement Using Totaltrack Video Laryngeal Mask Use Versus Macintosh Laryngoscope in Low Risk Patients Endotracheal Tube Placement Using Totaltrack Video Laryngeal Mask Use Versus Macintosh Laryngoscope in Low Risk Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Endotracheal Tube Placement Using Totaltrack Video Laryngeal Mask Use Versus Macintosh Laryngoscope in Low Risk Patients (VLM) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2018 Clinical Trials

95. Nasotracheal Tube Stenting by Nelaton Catheter in Pediatric Dental Surgery

pharyngeal wall 4- severe epistaxis , large amount of blood in the pharynx impeding nasotracheal intubation and necessitating urgent orotracheal intubation. Secondary Outcome Measures : Histopathology of the endotracheal tube contents after extubation [ Time Frame: immediately after extubation ] after extubation the tube contents will be collected in a 5 ml syringe by using sterile swab then tissues will be separated and will be sent for histopathology , the remnant contents will be sent for microscopy (...) Go to Primary Outcome Measures : incidence and severity of Epistaxis [ Time Frame: immediately after nasotracheal intubation ] An independent anesthesiologist who did not observe the tube insertion will assess the incidence and severity of epistaxis using a laryngoscope immediately after tube passage through the nasal cavity , four grades to evaluate epistaxis 1- no epistaxis 2- mild epistaxis ,blood apparent on the surface of the tube 3-moderate epistaxis pooling of blood on the posterior

2018 Clinical Trials

96. Physical Activity Monitored by Fitbit Charge 2 in Improving Quality of Life in Participants With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

) performance status of 0, 1 Have recurrent epithelial ovarian, primary peritoneal or fallopian tube cancer (serous, clear cell, endometrioid or mucinous) Patient is willing to wear activity tracking device at least 70% of the time for the duration of the study (9 months) Patient is getting cancer treatment and surveillance visit at Roswell Park Cancer Institute during the study period Patient is willing to participate in quality of life (QOL) questionnaires and blood and stool collection throughout (...) cells in blood, and bacterial composition in gut. Condition or disease Intervention/treatment Phase Fallopian Tube Endometrioid Tumor Fallopian Tube Mucinous Neoplasm Fallopian Tube Serous Neoplasm Ovarian Clear Cell Tumor Ovarian Endometrioid Tumor Ovarian Mucinous Tumor Ovarian Serous Tumor Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Other: Laboratory Biomarker Analysis Device: Monitoring Device Other: Physical Activity Other: Quality

2018 Clinical Trials

97. NY-ESO-1 TCR Engineered T Cell and HSC After Melphalan Conditioning Regimen in Treating Participants With Recurrent or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

for new blood cells and blood-forming cells (stem cells) to grow. Giving NY-ESO-1 TCR T cells and stem cells after the conditioning chemotherapy is intended to replace the immune system with new immune cells that have been redirected to attack and kill the cancer cells and thereby improve immune system function against cancer. Giving NY-ESO-1 TCR engineered T cells and HSCs after melphalan may work better in treating participants with ovarian, fallopian tube, or primary peritoneal cancer. Condition (...) NY-ESO-1 TCR Engineered T Cell and HSC After Melphalan Conditioning Regimen in Treating Participants With Recurrent or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer NY-ESO-1 TCR Engineered T Cell and HSC After Melphalan Conditioning Regimen in Treating Participants With Recurrent or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration

2018 Clinical Trials

98. Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction

Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03728686 Recruitment Status : Completed First Posted : November 2, 2018 Last Update Posted : November 6, 2018 Sponsor: Chien

2018 Clinical Trials

99. Specialized Immune Cells (nCTLs) and a Vaccine (Alpha-type-1 Polarized Dendritic Cells) in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study Description Go to Brief Summary: This phase I/IIa trial studies the side effects and best dose of a type of specialized immune cell (natural killer cell-like cytotoxic T-lymphocytes (CTLs) (nCTLs) and how well they work when given with a vaccine (alpha-type-1 polarized dendritic cells) in treating patients with stage II-IV ovarian, fallopian tube, or primary peritoneal cancer. nCTLs are immune cells that are isolated from each patient?s blood and "taught" in the laboratory how to recognize (...) Specialized Immune Cells (nCTLs) and a Vaccine (Alpha-type-1 Polarized Dendritic Cells) in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Specialized Immune Cells (nCTLs) and a Vaccine (Alpha-type-1 Polarized Dendritic Cells) in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results

2018 Clinical Trials

100. Advanced glycation end products induce neural tube defects through elevating oxidative stress in mice Full Text available with Trip Pro

Advanced glycation end products induce neural tube defects through elevating oxidative stress in mice Our previous study showed an association between advanced glycation end products (AGEs) and neural tube defects (NTDs). To understand the molecular mechanisms underlying the effect of AGEs on neural tube development, C57BL/6 female mice were fed for 4 weeks with commercial food containing 3% advanced glycation end product bovine serum albumin (AGE-BSA) or 3% bovine serum albumin (BSA (...) . Collectively, these results suggest that AGE-BSA could induce NTDs in the absence of hyperglycemia by an underlying mechanism that is at least partially associated with its capacity to increase embryonic oxidative stress levels.

2018 Neural Regeneration Research

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