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21. Expanded feasibility of ferritin testing: stability of ferritin stored as whole blood and validation of plastic tubes. (Abstract)

the feasibility of ferritin testing on a broader scale.Thirty blood donors provided a research donation of 12, 4-mL sample tubes of whole blood. Six pairs of serum and K2 -EDTA-plasma tubes were centrifuged and samples tested in triplicate on day of collection and on each of the next 5 days following storage at 4°C. Comparison of ferritin values for serum versus K2 -EDTA-plasma at baseline was performed to validate plastic EDTA-containing tubes. Variation of ferritin values during storage was assessed (...) Expanded feasibility of ferritin testing: stability of ferritin stored as whole blood and validation of plastic tubes. Ferritin testing is a recommended strategy to mitigate iron depletion in blood donors. A barrier for some testing platforms is a requirement to complete sample management and testing within a temporal window incompatible with the logistics of many blood collectors. The ability to delay separation of plasma/serum from red cells and subsequent testing would enhance

2019 Transfusion

22. Society of Interventional Radiology Quality Improvement Standards for Image-Guided Percutaneous Drainage and Aspiration of Abscesses and Fluid Collections Full Text available with Trip Pro

tubes placed with imaging guidance: effectiveness and risk for hemorrhage. Radiology . 2008 ; 246 : 956–963 23 ). Decisions regarding percutaneous versus surgical drainage of complex collections should be made in concert with other physicians involved in the patient’s care. Some have advocated the possibility of draining abscesses with the use of needles alone ( x 24 Giorgio, A., de Stefano, G., Di Sarno, A., Liorre, G., and Ferraioli, G. Percutaneous needle aspiration of multiple pyogenic abscesses (...) Society of Interventional Radiology Quality Improvement Standards for Image-Guided Percutaneous Drainage and Aspiration of Abscesses and Fluid Collections Society of Interventional Radiology Quality Improvement Standards for Image-Guided Percutaneous Drainage and Aspiration of Abscesses and Fluid Collections - Journal of Vascular and Interventional Radiology Email/Username: Password: Remember me Available now: Use your SIR login to access JVIR. Search Terms Search within Search Share this page

2020 Society of Interventional Radiology

23. Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer

for use within the Cancer Drugs Fund as an option for treating relapsed, platinum-sensitive ovarian cancer in these 2 groups while further data are collected. Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer (TA528) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 222 2 Information about nir Information about niraparib aparib Mark Marketing eting (...) , platinum-sensitive ovarian, fallopian tube and peritoneal cancer (TA528) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 17 of 22with further evidence, it may be possible to gain a more complete understanding of who would benefit most from treatment using somatic and other testing use in the NHS would allow collection of data on the duration of treatment in clinical practice. Nir Niraparib meets the criteria

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

24. Impact of blood collection and processing on peripheral blood gene expression profiling in type 1 diabetes Full Text available with Trip Pro

may lead to variances in the results. Here, we examined whether the choice of blood collection tube and RNA extraction kit leads to differences in the expression of genes that are changed during the progression of T1D, and if these differences could be minimized by measuring gene expression directly from the lysate of whole blood.Microarray analysis showed that the expression of 901 genes is highly influenced by sample processing using the PAXgene versus the Tempus system. These included (...) Impact of blood collection and processing on peripheral blood gene expression profiling in type 1 diabetes The natural history of type 1 diabetes (T1D) is challenging to investigate, especially as pre-diabetic individuals are difficult to identify. Numerous T1D consortia have been established to collect whole blood for gene expression analysis from individuals with or at risk to develop T1D. However, with no universally accepted protocol for their collection, differences in sample processing

2017 BMC genomics

25. Human Blood Specimen Collection to Evaluate Immune Cell Function

Human Blood Specimen Collection to Evaluate Immune Cell Function Human Blood Specimen Collection to Evaluate Immune Cell Function - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Human Blood Specimen (...) of this program is to obtain consent for and to outline the process for collection of fresh blood sample from healthy humans and colorectal cancer patients before and after surgical resection. Procurement of fresh human blood is required for the following: To compare NK cell function, measured by two different assays, in healthy humans and newly diagnosed colorectal cancer patients at the Ottawa Hospital. To compare NK cell function, measure by two different assays in colorectal surgery patients

2018 Clinical Trials

26. Time, trust, and transparency: Lessons learned from collecting blood biospecimens for cancer research from the Asian American community. Full Text available with Trip Pro

American patients with cancer) and outreach (external to institution to the general Asian American community). Participants received in-language biospecimen education followed by the opportunity to donate blood biospecimens. Outreach participants donated through our community biospecimen blood drives, and in-reach participants consented to donating an extra tube of blood during their routine blood draws as a patient. Donated blood biospecimens were spun down to serum and plasma to be stored (...) in a biorepository or were sent to the laboratory to test for cancer-related risk factors.Three hundred eighty-eight Asian Americans donated 1127 blood biospecimens for cancer research. Four hundred twenty tubes of plasma and serum are currently being stored at the cancer center's biorepository, 39 tubes have been used for cancer genomic research, and 668 tubes were used to characterize cancer-related risk factors.Building upon the past decade of the National Cancer Institute-funded Asian American Network

2018 Cancer

27. Spina bifida and neural tube defects

Spina bifida and neural tube defects Spina bifida and neural tube defects - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Spina bifida and neural tube defects Last reviewed: February 2019 Last updated: February 2018 Summary A spectrum of birth defects that result from abnormal neurulation during the first 4 weeks of embryogenesis. Caused by interaction of genetic and environmental factors. Preventable with maternal (...) neural tube defects are detected antenatally on ultrasound or clinically at birth. Antenatal treatment in selected cases involves repair of the defect at an experienced fetal surgery centre. More typically, cele repair is performed within 1 to 3 days of term delivery. A multi-disciplinary approach to care is important across the lifespan. Definition Neural tube defects are a spectrum of disorders that can affect the brain or the spinal cord. They are caused by interaction of genetic and environmental

2018 BMJ Best Practice

28. Electronic patient identification for sample labeling reduces wrong blood in tube errors. (Abstract)

Electronic patient identification for sample labeling reduces wrong blood in tube errors. Wrong blood in tube (WBIT) errors are a preventable cause of ABO-mismatched RBC transfusions. Electronic patient identification systems (e.g., scanning a patient's wristband barcode before pretransfusion sample collection) are thought to reduce WBIT errors, but the effectiveness of these systems is unclear.Part 1: Using retrospective data, we compared pretransfusion sample WBIT rates at hospitals using (...) manual patient identification (n = 16 sites; >1.6 million samples) with WBIT rates at hospitals using electronic patient identification for some or all sample collections (n = 4 sites; >0.5 million samples). Also, we compared WBIT rates after implementation of electronic patient identification with preimplementation WBIT rates. Causes and frequencies of WBIT errors were evaluated at each site. Part 2: Transfusion service laboratories (n = 18) prospectively typed mislabeled (rejected) samples (n

2018 Transfusion

29. Radiologic Management of Infected Fluid Collections

and perirenal abscesses may otherwise require PCD, surgical drainage, or nephrectomy. Variant 5: Chest Collections Parenchymal lung abscesses most often occur from aspiration of anaerobic oropharyngeal bacteria or from fungal organisms. Alcoholics, immunocompromised patients, and patients with bronchial obstruction are predisposed. The organism is usually determined by culture of sputum or blood and, less optimally, by culture of cavitary fluid obtained by needle aspiration or bronchoscopy. The majority (...) drainage of splenic abscess. J Vasc Interv Radiol. 2010;21(2):307-309. 28. Laborda A, De Gregorio MA, Miguelena JM, et al. Percutaneous treatment of intrabdominal abscess: urokinase versus saline serum in 100 cases using two surgical scoring systems in a randomized trial. Eur Radiol. 2009;19(7):1772-1779. ACR Appropriateness Criteria ® 10 Radiologic Management of Infected Fluid Collections 29. Cheng D, Nagata KT, Yoon HC. Randomized prospective comparison of alteplase versus saline solution

2019 American College of Radiology

30. Specimen collection – microbiology and virology

three separate collection tubes of CSF when investigating for evidence of subarachnoid haemorrhage, as the initial part of the sample may be contaminated with blood from outside the sub-arachnoid space. If this is performed, it is important to label the tubes as such and specifically request counts on the first and third samples. It is also important to remember that a CSF glucose level (sent separately to chemical pathology) can only be accurately interpreted in conjunction with a simultaneous (...) , central venous catheter) When taking samples from intact skin the swab should be moistened with sterile 0.9% saline solution before sampling as this assists in the transfer of bacteria from the sampling site to swab and can increase the number of microorganisms collected ( ). Requests have to be discussed with a Consultant Microbiologist or Clinical Scientist if uncertain of the suitability of a specimen or the availability of a test. Specimen collection: Blood should be sent in an EDTA tube. All

2017 Publication 1593

31. ACR/SIR/SPR Practice Parameter for Specifications and Performance of Image-Guided Percutaneous Drainage/Aspiration of Abscesses and Fluid Collections (PDAFC)

) If guidance was by CT, a tailored postprocedure CT scan should be obtained. ii. Peritoneal and other cavities: confirmation of appropriate tube placement. iii. Postprocedure imaging and follow-up may involve injection of contrast material to confirm catheter placement within the abscess or symptomatic fluid collection cavity, catheter patency, assess fistulae to bowel or other structures, or documentation of the reduction in cavity size. iv. Appropriate adjunct drainage maneuvers may often include (...) irrigation of the abscess cavity, drainage tube repositioning, drainage tube upsizing or downsizing, antibiotic therapy, fibrinolytics, etc. c. Clinical and imaging follow-up i. The patient should be informed of which provider will be following the drainage tube and who the patient should contact for questions about or issues with the drain. ii. Periodic imaging follow-up may be appropriate to evaluate for resolution or persistence of an abscess or symptomatic fluid collection and for development of new

2018 Society of Interventional Radiology

32. Niraparib (Zejula) - Fallopian Tube Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms

Niraparib (Zejula) - Fallopian Tube Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 14 September 2017 EMA/648982/2017 Committee for Medicinal Products for Human Use (CHMP) Assessment report Zejula International non-proprietary name: niraparib Procedure No. EMEA/H/C/004249/0000 (...) reactions AE adverse event AESI adverse event of special interest ALT alanine aminotransferase AME absorption, metabolism, excretion AML acute myeloid leukemia ANC absolute neutrophil count ASCN allele specific copy number AST aspartate aminotransferase ATM ataxia telangiectasia mutated AUC area under the plasma concentration-time curve AUCtau area under the plasma concentration-time curve over the dosing interval BBB blood brain barrier BCS Biopharmaceutics Classification System BER base excision

2017 European Medicines Agency - EPARs

33. Collection of non-meconium stool on fecal occult blood cards is an effective method for fecal microbiota studies in infants Full Text available with Trip Pro

Collection of non-meconium stool on fecal occult blood cards is an effective method for fecal microbiota studies in infants Effective methods are needed to collect fecal samples from children for large-scale microbiota studies. Stool collected on fecal occult blood test (FOBT) cards that can be mailed provides an effective solution; however, the quality of sequencing resulting from this method is unknown. The aim of this study is to compare microbiota metrics of 16S ribosomal RNA (rRNA) gene (...) sequencing from stool and meconium collected on FOBT cards with stool collected in an Eppendorf tube (ET) under different conditions.Eight stool samples from children in diapers aged 0 month-2 years and three meconium samples were collected and stored as follows: (1) ≤ 2 days at room temperature (RT) in an ET, (2) 7 days at - 80 °C in an ET, (3) 3-5 days at RT on a FOBT card, (4) 7 days at RT on a FOBT card, and (5) 7 days at - 80 °C on a FOBT card. Samples stored at - 80 °C were frozen immediately. Each

2017 Microbiome

34. Collection of Malignant Ascites, Pleural Fluid, and Blood From People With Solid Tumors

Collection of Malignant Ascites, Pleural Fluid, and Blood From People With Solid Tumors Collection of Malignant Ascites, Pleural Fluid, and Blood From People With Solid Tumors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Collection of Malignant Ascites, Pleural Fluid, and Blood From People With Solid Tumors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03189108 Recruitment Status : Recruiting First Posted : June 16

2017 Clinical Trials

35. Compare the Q-Cup With Other Umbilical Cord Blood Collection Techniques

by (Responsible Party): Michael Schaffer, Texas Tech University Health Sciences Center, El Paso Study Details Study Description Go to Brief Summary: Currently there is no standardized method of collecting and transferring umbilical cord blood to laboratory vacuum tubes. Current methods are messy and may require needles to draw the blood presenting risk of blood exposure and percutaneous injury to obstetrical personnel. A safer, more efficient method of collecting cord blood is needed. The investigators (...) propose to use the Q-Cup technology for collecting cord blood. The Q-Cup device is a two-piece injection molded blood collection and transfer device that enables safe and easy collection of blood from the newborn's umbilical cord and readily transfers the blood into a laboratory vacuum tube. The device consists of a collection cup with a wide opening to easily collect blood from the umbilical cord and a guide tube with a recessed needle which is attached to the collection cup. The operator is enabled

2017 Clinical Trials

36. Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug therapy Full Text available with Trip Pro

thromboplastin time (APTT), and fibrinogen.Venous blood was collected into six 4.5 mL VACUETTE® 9NC coagulation sodium citrate 3.8% tubes (Greiner Bio-One International GmbH, Kremsmünster, Austria) from 49 intensive care unit (ICU) patients on dual anti-platelet therapy and immediately hand carried to the central laboratory. Blood samples were divided into 2 Groups: Group 1 samples (N = 49) underwent PTS (4 m/s) transport from the central laboratory to the distant laboratory and back to the central (...) Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug therapy The aim of this study was to assess pneumatic tube system (PTS) alteration on platelet function by the light transmission aggregometry (LTA) and whole blood aggregometry (WBA) method, and on the results of platelet count, prothrombin time (PT), activated partial

2017 Biochemia medica

37. Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks Full Text available with Trip Pro

Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks Gene expression profiling from blood is sensitive to technology choices. For example, the main blood RNA collection systems-the PAXgene and Tempus tubes-differently influence RNA expression signatures. The aim of this study was to establish a common RNA isolation protocol for these two systems and investigate if it could reduce the differences in gene (...) expression between them.We collected identical blood samples on the PAXgene and Tempus systems and retrieved blood samples from two independent biobanks-NOWAC and HUNT3-which are based on PAXgene and Tempus, respectively. High-quality RNA was extracted from both sampling systems by using their original protocols and our common modified protocol, and were profiled on Illumina microarrays. Regardless of the protocol used, we found most of the measured transcripts to be differently affected by the two

2017 BMC research notes

38. Variable temporal sampling and tube current modulation for myocardial blood flow estimation from dose-reduced dynamic computed tomography Full Text available with Trip Pro

Variable temporal sampling and tube current modulation for myocardial blood flow estimation from dose-reduced dynamic computed tomography Quantification of myocardial blood flow (MBF) can aid in the diagnosis and treatment of coronary artery disease. However, there are no widely accepted clinical methods for estimating MBF. Dynamic cardiac perfusion computed tomography (CT) holds the promise of providing a quick and easy method to measure MBF quantitatively. However, the need for repeated scans (...) the tube current and/or sampling intervals can yield more accurate MBF estimates for a given dose. Specifically, we try to minimize the dose and obtain the most accurate MBF estimate by addressing the following questions: when in the TAC should the CT data be collected and at what tube current(s)? We hypothesize that increasing the sampling rate and/or tube current during the time frames when the myocardial CT number is most sensitive to the flow rate, while reducing them elsewhere, can achieve better

2017 Journal of Medical Imaging

39. A Problem with the Separating Gel in a Blood Sample Tube in a Patient with Multiple Myeloma Full Text available with Trip Pro

A Problem with the Separating Gel in a Blood Sample Tube in a Patient with Multiple Myeloma 28818186 2018 12 11 2018 12 11 1866-0452 114 29-30 2017 Jul 24 Deutsches Arzteblatt international Dtsch Arztebl Int Problem with the Separating Gel in a Blood Sample Tube in a Patient with Multiple Myeloma. 507 10.3238/arztebl.2017.0507 arztebl.2017.0507 Maire Bernd B Schlüter Kathrin K eng Case Reports Journal Article Germany Dtsch Arztebl Int 101475967 1866-0452 IM Blood Specimen Collection Humans Male

2017 Deutsches Ärzteblatt international

40. Use of Pediatric Size Phlebotomy Tubes in Adult Critically Ill Patients to Reduce Red Blood Cell Transfusions

Cell Transfusions Actual Study Start Date : November 7, 2017 Estimated Primary Completion Date : October 1, 2018 Estimated Study Completion Date : October 1, 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Pediatric phlebotomy tubes Use of pediatric size tubes for diagnostic blood collection. Device: Pediatric phlebotomy tubes Use of pediatric size tubes for diagnostic blood collection. Active (...) Comparator: Adult phlebotomy tubes Use of adult size tubes for diagnostic blood collection. Device: Adult phlebotomy tubes Use of adult size tubes for diagnostic blood collection. Outcome Measures Go to Primary Outcome Measures : Time from randomization to hemoglobin less than 7 g/dL or red blood cell (RBC) transfusion order [ Time Frame: anywhere from admission to intensive care unit (ICU) up until 30 days after admission ] Secondary Outcome Measures : Rate of change in hemoglobin (g/dL/patient/day

2017 Clinical Trials

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