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Blood Urea Nitrogen

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1. Relationship between nitrogen loss and blood urea nitrogen concentrations in patients requiring continuous renal replacement therapy (PubMed)

Relationship between nitrogen loss and blood urea nitrogen concentrations in patients requiring continuous renal replacement therapy It is well known that continuous renal replacement therapy (CRRT) produces some amount of nitrogen loss, but there are few tools that are easily applied to measure it. This study aimed to evaluate nitrogen loss using blood urea nitrogen (BUN) measurement in patients receiving CRRT.The subjects were 28 patients who received CRRT (except for liver failure) between (...) 2010 and 2012. Nutrition data and nitrogen excretion in dialysate and urine were measured.The median age of the patients was 61 years, with an Acute Physiology and Chronic Health Evaluation score of 27 points and a Sequential Organ Failure Assessment score of 12 points. All-cause hospital mortality was 50%. Median protein intake was 40 g/day. The daily urinary volume was 245 mL and volume of dialysate was 26,000 mL/day. The median amount of nitrogen loss was 10.58 g/day, with BUN showing a strong

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2016 Acute medicine & surgery

2. Persistent high blood urea nitrogen level is associated with increased risk of cardiovascular events in patients with acute heart failure (PubMed)

Persistent high blood urea nitrogen level is associated with increased risk of cardiovascular events in patients with acute heart failure The association between kinetics of blood urea nitrogen (BUN) levels in hospital and cardiovascular outcomes in patients with acutely decompensated congestive heart failure (HF) is unclear. We aimed to estimate the impact of changes in BUN level during hospitalization on clinical prognosis in patients with acute HF.A total of 353 consecutive patients

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2017 ESC heart failure

3. Blood Urea Nitrogen (BUN) is independently associated with mortality in critically ill patients admitted to ICU. (PubMed)

Blood Urea Nitrogen (BUN) is independently associated with mortality in critically ill patients admitted to ICU. Blood urea nitrogen (BUN) was reported to be associated with mortality in heart failure patients. We aimed to evaluate admission BUN concentration in a heterogeneous critically ill patient collective admitted to an intensive care unit (ICU) for prognostic relevance.A total of 4176 medical patients (67±13 years) admitted to a German ICU between 2004 and 2009 were included. Follow-up

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2018 PLoS ONE

4. Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: a prospective observational study. (PubMed)

Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: a prospective observational study. Blood urea nitrogen (BUN) is one of the substances that affects the calculated serum osmolality (cSosm). A previous study demonstrated that BUN and cSosm were independently associated with the development of chronic kidney disease (CKD) in patients with preserved kidney function. In advanced CKD stages, there is a concomitant increase

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2019 BMC Nephrology

5. Effects of the blood urea nitrogen to creatinine ratio on haemorrhagic transformation in AIS patients with diabetes mellitus. (PubMed)

Effects of the blood urea nitrogen to creatinine ratio on haemorrhagic transformation in AIS patients with diabetes mellitus. The effect of the blood urea nitrogen (BUN) to creatinine (Cr) ratio (henceforth BUN/Cr) on haemorrhagic transformation (HT) of acute ischaemic stroke (AIS) patients is unclear.AIS patients in the West China Hospital, Sichuan University, Chengdu, China, admitted within seven days from stroke onset (2012-2016) were included in the study. Baseline data, including BUN (...) and Cr levels, were collected. The outcome was defined as HT during hospitalization.In this study, 1738 participants with an average age of 62.7 ± 14.0 years were included. After adjusting potential confounders (age, blood platelet, albumin, stroke severity, triglycerides and low-density lipoprotein [LDL]), multivariate logistic regression analyses indicated that BUN/Cr is independently associated with HT. The nonlinear relation between BUN/Cr and HT was explored in a dose-dependent manner

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2019 BMC Neurology

6. Point of care testing for human chorionic gonadotropin, creatinine, and blood urea nitrogen: cost-effectiveness

Point of care testing for human chorionic gonadotropin, creatinine, and blood urea nitrogen: cost-effectiveness Point of care testing for human chorionic gonadotropin, creatinine, and blood urea nitrogen: cost-effectiveness Point of care testing for human chorionic gonadotropin, creatinine, and blood urea nitrogen: cost-effectiveness CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality (...) of this assessment has been made for the HTA database. Citation CADTH. Point of care testing for human chorionic gonadotropin, creatinine, and blood urea nitrogen: cost-effectiveness. Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). Rapid Response. 2013 Authors' conclusions One economic evaluation was identified regarding the cost-effectiveness of point of care testing for creatinine; no literature was identified regarding the cost-effectiveness of point of care testing for human chorionic

2014 Health Technology Assessment (HTA) Database.

7. Point of Care Testing for Human Chorionic Gonadotropin, Creatinine, and Blood Urea Nitrogen: Cost-Effectiveness

Point of Care Testing for Human Chorionic Gonadotropin, Creatinine, and Blood Urea Nitrogen: Cost-Effectiveness TITLE: Point of Care Testing for Human Chorionic Gonadotropin, Creatinine, and Blood Urea Nitrogen: Cost-Effectiveness DATE: 24 June 2013 RESEARCH QUESTIONS 1. What is the cost-effectiveness of point of care testing for human chorionic gonadotropin? 2. What is the cost-effectiveness of point of care testing for creatinine? 3. What is the cost-effectiveness of point of care testing (...) for blood urea nitrogen? KEY MESSAGE One economic evaluation was identified regarding the cost-effectiveness of point of care testing for creatinine; no literature was identified regarding the cost-effectiveness of point of care testing for human chorionic gonadotropin or blood urea nitrogen. METHODS A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2013, Issue 5), University of York Centre for Reviews and Dissemination (CRD) databases, ECRI (Health

2013 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Predictive Value of Serum Creatinine, Blood Urea Nitrogen, Uric Acid, and β2-Microglobulin in the Evaluation of Acute Kidney Injury after Orthotopic Liver Transplantation (PubMed)

Predictive Value of Serum Creatinine, Blood Urea Nitrogen, Uric Acid, and β2-Microglobulin in the Evaluation of Acute Kidney Injury after Orthotopic Liver Transplantation As a major complication after orthotopic liver transplantation (OLT), the occurrence of acute kidney injury (AKI) is frequently defined by serum creatinine (Cr); however, the accuracy of commonly used blood urea nitrogen (BUN), uric acid (UA), and β2-microglobulin (β2-MG) remains to be explored. This retrospective study

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2018 Chinese medical journal

9. Role of blood urea nitrogen in predicting the post-discharge prognosis in elderly patients with acute decompensated heart failure (PubMed)

Role of blood urea nitrogen in predicting the post-discharge prognosis in elderly patients with acute decompensated heart failure Blood urea nitrogen (BUN) is a surrogate marker for neurohormonal activation, but the association between BUN and the post-discharge prognosis in elderly patients with acute decompensated heart failure (ADHF) is not well defined. We explored the association between BUN and post-discharge all-cause mortality in 652 elderly patients (73.9 ± 7.8 yr) with ADHF. All

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2018 Scientific reports

10. Blood urea nitrogen has additive value beyond estimated glomerular filtration rate for prediction of long-term mortality in patients with acute myocardial infarction. (PubMed)

Blood urea nitrogen has additive value beyond estimated glomerular filtration rate for prediction of long-term mortality in patients with acute myocardial infarction. Blood urea nitrogen (BUN) has been shown to independently predict short- and intermediate-term outcomes in patients with acute myocardial infarction (AMI). We aimed to assess the additive predictive value of BUN beyond estimated glomerular filtration rate (eGFR) in AMI patients with an 8.6-year follow-up.This retrospective

2018 European journal of internal medicine

11. Effect of dietary replacement of alfalfa with urea-treated almond hulls on intake, growth, digestibility, microbial nitrogen, nitrogen retention, ruminal fermentation, and blood parameters in fattening lambs. (PubMed)

Effect of dietary replacement of alfalfa with urea-treated almond hulls on intake, growth, digestibility, microbial nitrogen, nitrogen retention, ruminal fermentation, and blood parameters in fattening lambs. The objective of this study was to assess the effect of dietary replacement of alfalfa with urea-treated almond hulls (UAH) on DM and nutrients intakes, growth performance, diet digestibility, microbial N supply (MNS), N retention, rumen fermentation parameters, and blood metabolites (...) (linear, = 0.62; quadratic, = 0.22) were not influenced by the experimental diets. Substituting alfalfa with UAH had no effects on the plasma concentrations of glucose (linear, = 0.55; quadratic, = 0.91), triglycerides (linear, = 0.97; quadratic, = 0.44), cholesterol (linear, = 0.71; quadratic, = 0.70), urea N (linear, = 0.084; quadratic, = 0.12), total protein (linear, = 0.53; quadratic, = 0.96), albumin (linear, = 0.43; quadratic, = 0.39), and globulin (linear, = 0.39; quadratic, = 0.25

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2016 Journal of animal science

12. Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus. (PubMed)

Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus. Experimental evidence suggests that higher levels of urea may increase insulin resistance and suppress insulin secretion. However, whether higher levels of blood urea nitrogen (BUN) are associated with increased risk of incident diabetes mellitus in humans is not known. To study this, we built a national cohort of 1,337,452 United States Veterans without diabetes to characterize the association of BUN

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2017 Kidney International

13. Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department. (PubMed)

Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department. The blood urea nitrogen to creatinine ratio (BCR) has been used since the early 1940s to help clinicians differentiate between prerenal acute kidney injury (PR AKI) and intrinsic AKI (I AKI). This ratio is simple to use and often put forward as a reliable diagnostic tool even though little scientific evidence supports this. The aim

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2017 BMC Nephrology

14. Association between an increase in blood urea nitrogen at 24 hours and worse outcomes in acute nonvariceal upper GI bleeding. (PubMed)

Association between an increase in blood urea nitrogen at 24 hours and worse outcomes in acute nonvariceal upper GI bleeding. An increase in blood urea nitrogen (BUN) at 24 hours is a solitary and significant predictor of mortality in patients with acute pancreatitis, which may predict worse outcomes in the similarly resuscitation-requiring condition of acute nonvariceal upper GI bleeding (UGIB). The aim of our study was to assess whether an increase in BUN at 24 hours is predictive of worse

2017 Gastrointestinal endoscopy

15. Influence of various levels of milk by-products in weaner diets on growth performance, blood urea nitrogen, diarrhea incidence, and pork quality of weaning to finishing pigs (PubMed)

Influence of various levels of milk by-products in weaner diets on growth performance, blood urea nitrogen, diarrhea incidence, and pork quality of weaning to finishing pigs This study was conducted to evaluate various levels of milk by-product in weaning pig diet on growth performance, blood profiles, carcass characteristics and economic performance for weaning to finishing pigs.A total of 160 weaning pigs ([Yorkshire×Landrace]×Duroc), average 7.01±1.32 kg body weight (BW), were allotted (...) feed intake (ADFI) in the nursery period (5 weeks) increased as the milk by-product level in the diet increased (linear, p<0.05). Linear increases of pig BW with increasing the milk product levels were observed until late growing period (linear, p = 0.01). However, there were no significant differences in BW at the finishing periods, ADG, ADFI, and gain:feed ratio during the entire growing-finishing periods. The blood urea nitrogen concentration had no significant difference among dietary

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2017 Asian-Australasian journal of animal sciences

16. Elevated Blood Urea Nitrogen/Creatinine Ratio Is Associated with Venous Thromboembolism in Patients with Acute Ischemic Stroke (PubMed)

Elevated Blood Urea Nitrogen/Creatinine Ratio Is Associated with Venous Thromboembolism in Patients with Acute Ischemic Stroke Although venous thromboembolism (VTE) is frequently related to dehydration, the impact of dehydration on VTE in acute ischemic stroke (AIS) is not clear. This study investigated whether dehydration, as measured by blood urea nitrogen (BUN)/creatinine (Cr) ratio, influences the occurrence of VTE in patients with AIS.This is a retrospective study of patients with AIS (...) urea nitrogen BUN/Cr ratio on admission. In a multivariate analysis, BUN/Cr ratio >15 (odds ratio [OR] 8.75) and severe lower limb weakness (OR 4.38) were independent risk factors for VTE.Dehydration on admission in cases of AIS might be a significant independent risk factor for VTE.

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2017 Journal of Korean Neurosurgical Society

17. Blood Urea Nitrogen as a Predictor of Severe Acute Pancreatitis Based on the Revised Atlanta Criteria: Timing of Measurement and Cutoff Points (PubMed)

Blood Urea Nitrogen as a Predictor of Severe Acute Pancreatitis Based on the Revised Atlanta Criteria: Timing of Measurement and Cutoff Points Background and Aims. This study evaluated the prognostic accuracy of BUN for severe acute pancreatitis (SAP) and in-hospital mortality (IHM) in terms of the best timing for BUN measurement and the optimal BUN cutoff points. Methods. BUN determinants at the time of admission and 24 hrs after hospital admission were recorded and analyzed statistically

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2017 Canadian journal of gastroenterology & hepatology

18. High-Density Lipoprotein Cholesterol, Blood Urea Nitrogen, and Serum Creatinine Can Predict Severe Acute Pancreatitis (PubMed)

High-Density Lipoprotein Cholesterol, Blood Urea Nitrogen, and Serum Creatinine Can Predict Severe Acute Pancreatitis Early prediction of disease severity of acute pancreatitis (AP) would be helpful for triaging patients to the appropriate level of care and intervention. The aim of the study was to develop a model able to predict Severe Acute Pancreatitis (SAP).A total of 647 patients with AP were enrolled. The demographic data, hematocrit, High-Density Lipoprotein Cholesterol (HDL-C (...) ) determinant at time of admission, Blood Urea Nitrogen (BUN), and serum creatinine (Scr) determinant at time of admission and 24 hrs after hospitalization were collected and analyzed statistically.Multivariate logistic regression indicated that HDL-C at admission and BUN and Scr at 24 hours (hrs) were independently associated with SAP. A logistic regression function (LR model) was developed to predict SAP as follows: -2.25-0.06 HDL-C (mg/dl) at admission + 0.06 BUN (mg/dl) at 24 hours + 0.66 Scr (mg/dl

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2017 BioMed research international

19. Associations of estimated glomerular filtration rate and blood urea nitrogen with incident coronary heart disease: the Dongfeng-Tongji Cohort Study (PubMed)

Associations of estimated glomerular filtration rate and blood urea nitrogen with incident coronary heart disease: the Dongfeng-Tongji Cohort Study Estimated glomerular filtration rate (eGFR) has been reported to be associated with risk of incident coronary heart disease (CHD), and blood urea nitrogen (BUN) has been shown to be a strong predictor of mortality in patients with heart failure (HF). However, such epidemiological evidence from Chinese population was still limited. We used Cox

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2017 Scientific reports

20. Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients: The Q-Cohort Study (PubMed)

Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients: The Q-Cohort Study The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR with overall survival was analyzed using a Cox regression

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2017 Scientific reports

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