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Blood Transfusion

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1. Hydroxyurea for reducing blood transfusion in non-transfusion dependent beta thalassaemias. (PubMed)

Hydroxyurea for reducing blood transfusion in non-transfusion dependent beta thalassaemias. Non-transfusion dependent beta thalassaemia is a subset of inherited haemoglobin disorders characterised by reduced production of the beta globin chain of the haemoglobin molecule leading to anaemia of varying severity. Although blood transfusion is not a necessity for survival, it is required when episodes of chronic anaemia occur. This chronic anaemia can impair growth and affect quality of life (...) . People with non-transfusion dependent beta thalassaemia suffer from iron overload due to their body's increased capability of absorbing iron from food sources. Iron overload becomes more pronounced in those requiring blood transfusion. People with a higher foetal haemoglobin level have been found to require fewer blood transfusions. Hydroxyurea has been used to increase foetal haemoglobin level; however, its efficacy in reducing transfusion, chronic anaemia complications and its safety need

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2016 Cochrane

2. Late erythropoiesis-stimulating agents to prevent red blood cell transfusion in preterm or low birth weight infants. (PubMed)

Late erythropoiesis-stimulating agents to prevent red blood cell transfusion in preterm or low birth weight infants. Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia. Darbepoetin (Darbe) and EPO are currently available ESAs.To assess the effectiveness and safety of late initiation of ESAs, between eight and 28 days after birth, in reducing the use of red blood cell (RBC (...) for this outcome (RR I² = 66%; RD I² = 58%). The quality of the evidence was very low. We obtained similar results in secondary analyses based on different combinations of high/low doses of EPO and iron supplementation. There was no significant reduction in the total volume (mL/kg) of blood transfused per infant (typical mean difference (MD) -1.6 mL/kg, 95% CI -5.8 to 2.6); 5 studies, 197 infants). There was high heterogeneity for this outcome (I² = 92%). There was a significant reduction in the number

2019 Cochrane

4. Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews. (PubMed)

Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews. Globally, sickle cell disease (SCD) is one of the commonest severe monogenic disorders, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Red blood cell (RBC) transfusions are used to treat complications of SCD, e.g. acute chest syndrome (ACS) (this often (...) involves a single transfusion episode), or they can be part of a regular long-term transfusion programme to prevent SCD complications.To summarize the evidence in Cochrane Reviews of the effectiveness and safety of RBC transfusions versus no transfusion, or restrictive (to increase the total haemoglobin) versus liberal (to decrease the haemoglobin S level below a specified percentage) transfusion, for treating or preventing complications experienced by people with SCD.We included Cochrane Reviews

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2018 Cochrane

5. Transfusion of red blood cells stored for shorter versus longer duration for all conditions. (PubMed)

Transfusion of red blood cells stored for shorter versus longer duration for all conditions. Red blood cell (RBC) transfusion is a common treatment for anaemia in many conditions. The safety and efficacy of transfusing RBC units that have been stored for different durations before a transfusion is a current concern. The duration of storage for a RBC unit can be up to 42 days. If evidence from randomised controlled trials (RCT) were to indicate that clinical outcomes are affected by storage (...) duration, the implications for inventory management and clinical practice would be significant.To assess the effects of using red blood cells (RBCs) stored for a shorter versus a longer duration, or versus RBCs stored for standard practice duration, in people requiring a RBC transfusion.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, PubMed (for epublications), LILACS, Transfusion Evidence Library, Web of Science CPCI-S and four international clinical

2018 Cochrane

6. Traumatic coagulopathy and massive transfusion: improving outcomes and saving blood

Traumatic coagulopathy and massive transfusion: improving outcomes and saving blood Traumatic coagulopathy and massive transfusion: improving outcomes and saving blood Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit

2017 NIHR HTA programme

7. Effect of Umbilical Cord Blood Sampling versus Admission Blood Sampling on Requirement of Blood Transfusion in Extremely Preterm Infants: A Randomized Controlled Trial

Effect of Umbilical Cord Blood Sampling versus Admission Blood Sampling on Requirement of Blood Transfusion in Extremely Preterm Infants: A Randomized Controlled Trial To evaluate the effect of blood sampling from the placental end of the umbilical cord compared with initial blood sampling from neonates, on the need for first packed red blood cell transfusion in extremely preterm infants. We hypothesized that cord blood sampling could delay the time to first blood transfusion.In this single (...) transfusion, and was compared using survival analysis.Eighty neonates were enrolled. The time to first transfusion was significantly delayed in the cord sampling group (30 vs 14 days, hazard ratio: 0.44, [95% CI 0.27-0.72], P < .001). Fewer neonates in the cord sampling group were transfused in the first 28 days of life (30% vs 75%, P < .001). Overall transfusion requirements and other clinical outcomes were similar in the groups.Initial blood sampling from placental end of umbilical cord, when combined

2019 EvidenceUpdates

8. Blood Transfusion in Trauma: Timing and Product Ratio

Blood Transfusion in Trauma: Timing and Product Ratio Emergency Medicine > Journal Club > Archive > February 2018 Toggle navigation February 2018 Blood Transfusion in Trauma: Timing and Product Ratio Vignette It's an active early spring afternoon in the city, and you're pretty sure that just about everyone and their sister have been shot at, with most of the pour souls ending up in your TCC. As these things tend to go, The GSWs thus far are to the extremities or benign grazes (...) : Trauma patients requring urgent blood transfusion or meeting massive transfusion protocol (MTP) criteria. Intervention #1: Balanced blood transfusion (closer to a 1:1:1 ratio of plasma:platelets:RBCs) Comparison #2: Higher blood to plasma/platelet ratio (i.e. closer to 1:1:2) Intervention #2 : Prehospital blood transfusion by EMS Comparison #2: No prehospital blood transfusion Outcome: Mortality, incidence of transfusion reaction, cost, hospital/ICU length of stay Articles Article 1: Article 2

2018 Washington University Emergency Medicine Journal Club

9. Blood Product Transfusions Prior to Surgical Interventions: Clinical Effectiveness and Guidelines

Blood Product Transfusions Prior to Surgical Interventions: Clinical Effectiveness and Guidelines Blood Product Transfusions Prior to Surgical Interventions: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Blood Product Transfusions Prior to Surgical Interventions: Clinical Effectiveness and Guidelines Blood Product Transfusions Prior to Surgical Interventions: Clinical Effectiveness and Guidelines Last updated: December 11, 2018 Project Number: RB1285-000 Product (...) Line: Research Type: Drug Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of plasma or prothrombin complex concentrate transfusions prior to surgical procedures in individuals with an elevated international normalized ratio? What is the evidence for the safety of undergoing surgical procedures for individuals with an elevated international normalized ratio? What are the evidence-based guidelines regarding pre-surgical transfusion considerations

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

10. Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn. (PubMed)

Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn. Exchange blood transfusion (EBT) is a form of whole blood transfusion in which the total blood volume is replaced within a few hours. In perinatal and neonatal medicine, EBT is most often used in the management of severe anaemia or severe hyperbilirubinaemia in the first week of life. Hypocalcaemia, one of the common morbidities associated with EBT, is thought to arise from the chelating effects (...) of the citrate commonly used as an anticoagulant in the donor's blood. This disorder manifests with muscular and nervous irritability and cardiac arrhythmias.To determine whether the use of prophylactic calcium reduces the risk of hypocalcaemia-related morbidities and death among newborn infants receiving EBT.We used the standard search strategy of the Cochrane Neonatal Review group to search the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 5), MEDLINE via PubMed (1966 to 29 June 2016

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2017 Cochrane

11. Desmopressin use for minimising perioperative blood transfusion. (PubMed)

Desmopressin use for minimising perioperative blood transfusion. Blood transfusion is administered during many types of surgery, but its efficacy and safety are increasingly questioned. Evaluation of the efficacy of agents, such as desmopressin (DDAVP; 1-deamino-8-D-arginine-vasopressin), that may reduce perioperative blood loss is needed.To examine the evidence for the efficacy of DDAVP in reducing perioperative blood loss and the need for red cell transfusion in people who do not have (...) conditions. These trials were conducted between 1986 and 2016, and 11 were funded by pharmaceutical companies or by a party with a commercial interest in the outcome of the trial.The GRADE quality of evidence was very low to moderate across all outcomes. No trial reported quality of life. DDAVP versus placebo or no treatmentTrial results showed considerable heterogeneity between surgical settings for total volume of red cells transfused (low-quality evidence) and for total blood loss (very low-quality

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2017 Cochrane

12. Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. (PubMed)

Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. Many people diagnosed with haematological malignancies experience anaemia, and red blood cell (RBC) transfusion plays an essential supportive role in their management. Different strategies have been developed for RBC transfusions. A restrictive transfusion strategy seeks (...) to maintain a lower haemoglobin level (usually between 70 g/L to 90 g/L) with a trigger for transfusion when the haemoglobin drops below 70 g/L), whereas a liberal transfusion strategy aims to maintain a higher haemoglobin (usually between 100 g/L to 120 g/L, with a threshold for transfusion when haemoglobin drops below 100 g/L). In people undergoing surgery or who have been admitted to intensive care a restrictive transfusion strategy has been shown to be safe and in some cases safer than a liberal

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2017 Cochrane

13. Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease. (PubMed)

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease. Sickle cell disease is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. Sickle cell disease can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Stroke affects around 10% of children with sickle cell anaemia (HbSS). Chronic blood transfusions may reduce the risk of vaso (...) -occlusion and stroke by diluting the proportion of sickled cells in the circulation.This is an update of a Cochrane Review first published in 2002, and last updated in 2013.To assess risks and benefits of chronic blood transfusion regimens in people with sickle cell disease for primary and secondary stroke prevention (excluding silent cerebral infarcts).We searched for relevant trials in the Cochrane Library, MEDLINE (from 1946), Embase (from 1974), the Transfusion Evidence Library (from 1980

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2017 Cochrane

14. Seroprevalence of transfusion transmitted infections among blood donors in Gash Barka Zonal Blood Transfusion Center, Barentu, Eritrea, 2014 through 2017. (PubMed)

Seroprevalence of transfusion transmitted infections among blood donors in Gash Barka Zonal Blood Transfusion Center, Barentu, Eritrea, 2014 through 2017. Transfusion-transmissible infections pose a major health risk in developing countries, including Eritrea. In the present study, we sought to determine the prevalence of specific transfusion transmitted infections (TTIs) and the associated risk factors among blood donors at a newly established regional blood transfusion center in Barentu (...) , Eritrea.The seroprevalence of markers for specific TTIs by sex, age, educational status, residence, occupation, and donor type was evaluated for donors who donated blood between July 2014 and April 2017. The relationship between TTIs and the stated factors was evaluated using the Pearson Chi-square test/Fishers exact test. Adjusted and unadjusted binary logistic regression models were employed to estimate the odds ratio (OR) and 95% confidence interval (CI) for the occurrence of TTIs. A two-sided p-value

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2019 BMC Hematology

15. Red blood cell transfusions are associated with lower mortality in patients with severe sepsis and septic shock: A propensity-matched analysis

Red blood cell transfusions are associated with lower mortality in patients with severe sepsis and septic shock: A propensity-matched analysis PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

16. Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion

Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

17. Association of Blood Donor Sex and Prior Pregnancy With Mortality Among Red Blood Cell Transfusion Recipients. (PubMed)

Association of Blood Donor Sex and Prior Pregnancy With Mortality Among Red Blood Cell Transfusion Recipients. Evidence regarding associations of blood donor sex with mortality among red blood cell transfusion recipients is conflicting.To study associations of donor sex and prior pregnancy with mortality of transfusion recipients.Data from 3 retrospective cohorts of transfusion recipients (the Kaiser Permanente Northern California [KPNC] and Recipient Epidemiology and Donor Evaluation Study-III (...) [REDS-III] databases of data from January 2013 to December 2016 and the Scandinavian Donations and Transfusions [SCANDAT] database with data from January 2003 to December 2012) were analyzed. Final dates of follow-up were December 31, 2016, for the KPNC and REDS-III cohorts and December 31, 2012, for the SCANDAT cohort. Stratified Cox regression models were used to estimate associations between donor exposure groups with risk of mortality, adjusting for the number of red blood cell unit

2019 JAMA

18. Blood and Clots Series: What are the complications of transfusion? What symptoms/signs should I worry about?

Blood and Clots Series: What are the complications of transfusion? What symptoms/signs should I worry about? Blood and Clots Series: What are the complications of transfusion? What symptoms/signs should I worry about? - CanadiEM Blood and Clots Series: What are the complications of transfusion? What symptoms/signs should I worry about? In , by Matthew Nicholson July 30, 2018 All the content from the Blood & Clots series can be found . CanMEDS Roles addressed: Medical Expert, Communicator (...) normalizing. Reticulocyte count is 45. There are no signs of bleeding clinically or on ultrasound examination of the abdomen. There is no laboratory evidence of hemolysis. You suspect the patient may be unable to produce adequate RBCs due to inflammation from her injuries and operation. To be safe you send investigations to check nutritional parameters and start folic acid empirically. The patient complains of fatigue and you decide a blood transfusion is indicated. The situation is no longer emergent

2018 CandiEM

19. Blood and Clots Series: Massive transfusion protocol: what is it, why does it exist, and when should I call one?

Blood and Clots Series: Massive transfusion protocol: what is it, why does it exist, and when should I call one? Blood and Clots Series: Massive transfusion protocol: what is it, why does it exist, and when should I call one? - CanadiEM Blood and Clots Series: Massive transfusion protocol: what is it, why does it exist, and when should I call one? In , by Matthew Nicholson July 16, 2018 All the content from the Blood & Clots series can be found . CanMEDS Roles addressed: Medical Expert Case (...) administration and minimize coagulopathy by administering RBCs, platelets, and plasma in a balanced ratio (approximating 1:1:1 or 1:1:2 per the PROPPR trial) 7 . Administration of either cryoprecipitate or fibrinogen concentrate are also common in MTP. Key Concepts in MTPs The patient remains tachycardic with labile blood pressure despite two units of RBCs and two litres of crystalloid. You decide to activate the hospital’s massive transfusion protocol prior to the results of laboratory tests becoming

2018 CandiEM

20. Increased Risk of Mortality with Female to Male Blood Product Transfusions

Increased Risk of Mortality with Female to Male Blood Product Transfusions "Increased Risk of Mortality with Female to Male Blood Product Transfus" by Haley Robinson and Kiersten Sperry < > > > > > Title Author Date of Graduation 8-10-2019 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: Blood product transfusions are one of the most common procedures in the US. These transfusions are considered safe but there is still (...) a risk of complications and mortality. The most common cause of transfusion related mortality being transfusion related acute lung injury (TRALI). TRALI is an acute lung condition that results in dyspnea, cough, and hypoxemia. It is hypothesized that TRALI is an antibody mediated phenomenon that is associated with female donors, as female and multiparous women have more HLA/HNA antibodies in their blood. This review is to investigate if there is increased mortality with the use of female blood

2019 Pacific University EBM Capstone Project

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